4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Imamura M and Prasad C | Increased GABA-gated chloride ion influx in the hypothalamus of low-anxiety rats. | 1998 | Physiol. Behav. | pmid:9748113 |
Onofrj M et al. | Gabapentin in orthostatic tremor: results of a double-blind crossover with placebo in four patients. | 1998 | Neurology | pmid:9748048 |
Sieghart W and Heckl K | Potassium-evoked release of taurine from synaptosomal fractions of rat cerebral cortex. | 1976 | Brain Res. | pmid:974789 |
Pycock C et al. | The behavioural effects of manipulating GABA function in the globus pallidus. | 1976 | Brain Res. | pmid:974781 |
Schousboe A et al. | Taurine uptake in astrocytes cultured from dissociated mouse brain hemispheres. | 1976 | Brain Res. | pmid:974765 |
Renaud LP | Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat. | 1976 | Brain Res. | pmid:974751 |
Enna SJ and Snyder SH | Gamma-aminobutyric acid (GABA) receptor binding in mammalian retina. | 1976 | Brain Res. | pmid:974741 |
Parker AP et al. | Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. | 1998 | Dev Med Child Neurol | pmid:9746003 |
pmid:9744934 | ||||
Akopian A et al. | Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina. | 1998 | J. Neurophysiol. | pmid:9744925 |
Arbuthnott GW et al. | Is the striato-nigral pathway responsible for 'feed-back' control of dopamine release [proceedings]? | 1976 | Br. J. Pharmacol. | pmid:974393 |
Brown DA and Garthwaite J | Action of surugatoxin on nicotinic receptors in the superior cervical ganglion of the rat. | 1976 | Br. J. Pharmacol. | pmid:974373 |
Parker D and Grillner S | Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network. | 1998 | J. Neurosci. | pmid:9742176 |
Joseph JA et al. | Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. | 1998 | J. Neurosci. | pmid:9742171 |
Steffensen SC et al. | Electrophysiological characterization of GABAergic neurons in the ventral tegmental area. | 1998 | J. Neurosci. | pmid:9742167 |
van den Pol AN et al. | Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. | 1998 | J. Neurosci. | pmid:9742163 |
Alcántara S et al. | Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. | 1998 | J. Neurosci. | pmid:9742148 |
Carriedo SG et al. | Rapid Ca2+ entry through Ca2+-permeable AMPA/Kainate channels triggers marked intracellular Ca2+ rises and consequent oxygen radical production. | 1998 | J. Neurosci. | pmid:9742143 |
Romey G et al. | Scorpion neurotoxin. Mode of action on neuromuscular junctions and synaptosomes. | 1976 | Biochim. Biophys. Acta | pmid:974149 |
van den Pol AN et al. | Early synaptogenesis in vitro: role of axon target distance. | 1998 | J. Comp. Neurol. | pmid:9741482 |
Rohwedel J et al. | Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro. | 1998 | Dev. Biol. | pmid:9740657 |
Bourgeois BF | New antiepileptic drugs. | 1998 | Arch. Neurol. | pmid:9740111 |
Goldenberg G et al. | Gabapentin for disruptive behaviour in an elderly demented patient. | 1998 | Drugs Aging | pmid:9739506 |
Dumba JS et al. | Electron microscopic analysis of gamma-aminobutyric acid and glycine colocalization in rat trigeminal subnucleus caudalis. | 1998 | Brain Res. | pmid:9739101 |
Petroianu G et al. | [ETICS Study: Empirical therapy of idiopathic chronic singultus]. | 1998 | Z Gastroenterol | pmid:9738303 |
Leppik IE | Role of new and established antiepileptic drugs. | 1998 | Epilepsia | pmid:9737436 |
Murphy DD et al. | Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9736750 |
Vicario-Abejón C et al. | Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. | 1998 | J. Neurosci. | pmid:9736647 |
Svoboda KR and Lupica CR | Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents. | 1998 | J. Neurosci. | pmid:9736632 |
Weiller HG and Radler F | [On the metabolism of amino acids by lactic acid bacteria isolated from wine (author's transl)]. | 1976 | Z Lebensm Unters Forsch | pmid:973463 |
Kenigsberg RL et al. | Cholinergic cell expression in the developing rat medial septal nucleus in vitro is differentially controlled by GABAA and GABAB receptors. | 1998 | Brain Res. | pmid:9733945 |
Zhai J et al. | Phosphorylation of the GABAA receptor gamma2L subunit in rat sensory neurons may not be necessary for ethanol sensitivity. | 1998 | Brain Res. | pmid:9733942 |
Hall CW and Behbehani MM | Synaptic effects of nitric oxide on enkephalinergic, GABAergic, and glutamatergic networks of the rat periaqueductal gray. | 1998 | Brain Res. | pmid:9733923 |
Ritta MN et al. | Occurrence of GABA and GABA receptors in human spermatozoa. | 1998 | Mol. Hum. Reprod. | pmid:9733434 |
Levkovitz Y and Segal M | Age-dependent local modulation of hippocampal-evoked responses to perforant path stimulation. | 1998 Jul-Aug | Neurobiol. Aging | pmid:9733164 |
Van Lente F and Gatautis V | Cost-efficient use of gas chromatography-mass spectrometry: a "piggyback" method for analysis of gabapentin. | 1998 | Clin. Chem. | pmid:9733003 |
Farmer MR et al. | A central gamma-aminobutyric acid mechanism in cardiac vagal control in man revealed by studies with intravenous midazolam. | 1998 | Clin. Sci. | pmid:9730842 |
DÃez-Ariza M et al. | Differential interaction between 5-HT3 receptors and GABAergic neurons inhibiting acetylcholine release in rat entorhinal cortex slices. | 1998 | Brain Res. | pmid:9729402 |
Grimm JW and See RE | Unique activation of extracellular striato-pallidal neurotransmitters in rats following acute risperidone. | 1998 | Brain Res. | pmid:9729373 |
Bueno OF et al. | Functional characterization and visualization of a GABAA receptor-GFP chimera expressed in Xenopus oocytes. | 1998 | Brain Res. Mol. Brain Res. | pmid:9729362 |
Nuñez A et al. | Neurotransmitter actions on oral pontine tegmental neurons of the rat: an in vitro study. | 1998 | Brain Res. | pmid:9729346 |
Tan SS et al. | Separate progenitors for radial and tangential cell dispersion during development of the cerebral neocortex. | 1998 | Neuron | pmid:9728911 |
Kubová H et al. | Anticonvulsant effect of SL 75 102 in adult and immature rats. | 1997 | Physiol Res | pmid:9728525 |
Stanková L et al. | Anticonvulsant effect of progabide in rats during ontogenesis. | 1997 | Physiol Res | pmid:9728521 |
Zhang K and Patel KP | Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. | 1998 | Am. J. Physiol. | pmid:9728069 |
Hurd RE et al. | Proton spectroscopy without water suppression: the oversampled J-resolved experiment. | 1998 | Magn Reson Med | pmid:9727935 |
Williams A et al. | Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin. | 1998 | J Paediatr Child Health | pmid:9727187 |
Bentareha R et al. | Pharmacological properties of the GABA(A) receptor complex from brain regions of (hypoemotional) Roman high- and (hyperemotional) low-avoidance rats. | 1998 | Eur. J. Pharmacol. | pmid:9726635 |
Andressen C et al. | Beta1 integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons. | 1998 | Neurosci. Lett. | pmid:9726369 |
Meshul CK et al. | Cocaine-induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens. | 1998 | Synapse | pmid:9723791 |
Bubser M et al. | Disinhibition of the mediodorsal thalamus induces fos-like immunoreactivity in both pyramidal and GABA-containing neurons in the medial prefrontal cortex of rats, but does not affect prefrontal extracellular GABA levels. | 1998 | Synapse | pmid:9723785 |
Dewey SL et al. | A novel strategy for the treatment of cocaine addiction. | 1998 | Synapse | pmid:9723781 |
Rando RR and Bangerter FW | The irreversible inhibition of mouse brain gamma-aminobutyric acid (GABA)-alpha-ketoglutaric acid transaminase by gabaculine. | 1976 | J. Am. Chem. Soc. | pmid:972233 |
Bianchi L et al. | The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis. | 1998 | Neuroscience | pmid:9722150 |
Pearlstein E et al. | Inhibitory connections between antagonistic motor neurones of the crayfish walking legs. | 1998 | J. Comp. Neurol. | pmid:9721906 |
Ghaemi SN et al. | Gabapentin treatment of mood disorders: a preliminary study. | 1998 | J Clin Psychiatry | pmid:9721823 |
Brown MJ et al. | Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment. | 1998 | J. Neurochem. | pmid:9721749 |
Guezennec CY et al. | Effects of prolonged exercise on brain ammonia and amino acids. | 1998 | Int J Sports Med | pmid:9721055 |
Jones NM et al. | Type I and II metabotropic glutamate receptors regulate the outflow of [3H]D-aspartate and [14C]gamma-aminobutyric acid in rat solitary nucleus. | 1998 | Eur. J. Pharmacol. | pmid:9721038 |
Opacka-Juffry J et al. | Modulatory effects of L-DOPA on D2 dopamine receptors in rat striatum, measured using in vivo microdialysis and PET. | 1998 | J Neural Transm | pmid:9720967 |
Li D | Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues. | 1998 | Hokkaido Igaku Zasshi | pmid:9719948 |
Charara A and Parent A | Chemoarchitecture of the primate dorsal raphe nucleus. | 1998 | J. Chem. Neuroanat. | pmid:9719363 |
Tunnicliff G et al. | Brain gamma-aminobutyric acid metabolism and behaviour in the mouse and rat. | 1976 | Gen. Pharmacol. | pmid:971801 |
Witten JL and Truman JW | Distribution of GABA-like immunoreactive neurons in insects suggests lineage homology. | 1998 | J. Comp. Neurol. | pmid:9717706 |
Wise RA | Drug-activation of brain reward pathways. | 1998 Jun-Jul | Drug Alcohol Depend | pmid:9716927 |
Mahanty NK and Sah P | Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. | 1998 | Nature | pmid:9716132 |
Baulac M et al. | Severe visual-field constriction and side-effects of GABA-mimetic antiepileptic agents. | 1998 | Lancet | pmid:9716066 |
pmid:9715219 | ||||
Zhu WJ et al. | Lanthanum-mediated modification of GABAA receptor deactivation, desensitization and inhibitory synaptic currents in rat cerebellar neurons. | 1998 | J. Physiol. (Lond.) | pmid:9714849 |
Gidal BE et al. | Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy. | 1998 | Epilepsy Res. | pmid:9714500 |
Meza G | Gaba as an afferent neurotransmitter in the vestibular sensory periphery of vertebrates. | 1998 | Neurobiology (Bp) | pmid:9713835 |
Marder M et al. | Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712722 |
Chieng B and Williams JT | Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal. | 1998 | J. Neurosci. | pmid:9712672 |
Ferraro L et al. | The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop. | 1998 | J. Neurosci. | pmid:9712666 |
Kawaguchi Y and Shindou T | Noradrenergic excitation and inhibition of GABAergic cell types in rat frontal cortex. | 1998 | J. Neurosci. | pmid:9712665 |
Benson DL and Tanaka H | N-cadherin redistribution during synaptogenesis in hippocampal neurons. | 1998 | J. Neurosci. | pmid:9712659 |
Park D and Dunlap K | Dynamic regulation of calcium influx by G-proteins, action potential waveform, and neuronal firing frequency. | 1998 | J. Neurosci. | pmid:9712647 |
Ratnaraj N and Patsalos PN | A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum. | 1998 | Ther Drug Monit | pmid:9712469 |
GarcÃa-Flores E and FarÃas R | gamma-Amino-beta-hydroxybutyric acid as add-on therapy in adult patients with severe focal epilepsy. | 1997 | Stereotact Funct Neurosurg | pmid:9711762 |
Yamashiro K et al. | Characteristics of neurons with high-frequency discharge in the central nervous system and their relationship to chronic pain. Experimental and clinical investigations. | 1997 | Stereotact Funct Neurosurg | pmid:9711708 |
Meyerson BA et al. | Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy. | 1997 | Stereotact Funct Neurosurg | pmid:9711706 |
Hilgemann DW and Lu CC | Giant membrane patches: improvements and applications. | 1998 | Meth. Enzymol. | pmid:9711613 |
Csernus VJ et al. | Dynamic insulin secretion from perifused rat pancreatic islets. | 1998 | Cell. Mol. Life Sci. | pmid:9711240 |
Kuzniecky R et al. | Topiramate increases cerebral GABA in healthy humans. | 1998 | Neurology | pmid:9710056 |
Khan OA | Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. | 1998 | Neurology | pmid:9710050 |
Solaro C et al. | An open-label trial of gabapentin treatment of paroxysmal symptoms in multiple sclerosis patients. | 1998 | Neurology | pmid:9710049 |
Dinkel K et al. | Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome. | 1998 | Ann. Neurol. | pmid:9708541 |
Malizia AL et al. | Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. | 1998 | Arch. Gen. Psychiatry | pmid:9707382 |
Wohlrab G et al. | Vigabatrin as a first-line drug in West syndrome: clinical and electroencephalographic outcome. | 1998 | Neuropediatrics | pmid:9706623 |
Engelborghs S et al. | Behavioral effects of vigabatrin correlated with whole brain gamma-aminobutyric acid metabolism in audiogenic sensitive rats. | 1998 | Arzneimittelforschung | pmid:9706369 |
Williams SR et al. | The dynamics of synchronized neurotransmitter release determined from compound spontaneous IPSCs in rat dentate granule neurones in vitro. | 1998 | J. Physiol. (Lond.) | pmid:9705998 |
Nicoll RA and Malenka RC | A tale of two transmitters. | 1998 | Science | pmid:9705712 |
Walther C and Zittlau KE | Resting membrane properties of locust muscle and their modulation II. Actions of the biogenic amine octopamine. | 1998 | J. Neurophysiol. | pmid:9705469 |
Trombley PQ | Selective modulation of GABAA receptors by aluminum. | 1998 | J. Neurophysiol. | pmid:9705466 |
Shoji Y et al. | Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat. | 1998 | J. Neurophysiol. | pmid:9705457 |
Khvotchev M and Südhof TC | Newly synthesized phosphatidylinositol phosphates are required for synaptic norepinephrine but not glutamate or gamma-aminobutyric acid (GABA) release. | 1998 | J. Biol. Chem. | pmid:9705272 |
Akopian VP et al. | [Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis]. | 1998 May-Jun | Vopr. Med. Khim. | pmid:9703626 |
Hashimoto T | [GABA receptor chloride ion channel]. | 1998 | Nippon Rinsho | pmid:9702060 |
Ishihara K et al. | Ethanol reduces spontaneous firing and potentiates GABA-induced currents in acutely dissociated rat medial vestibular nucleus neurons. | 1998 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:9702003 |
George B and Kulkarni SK | Protective effect of clozapine against pentylenetetrazol convulsions and kindling. | 1998 | Methods Find Exp Clin Pharmacol | pmid:9701777 |