4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Wounds and Injuries D014947 20 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Colquhoun D GABA and the single oocyte: relating binding to gating. 1999 Nat. Neurosci. pmid:10195208
Chang Y and Weiss DS Channel opening locks agonist onto the GABAC receptor. 1999 Nat. Neurosci. pmid:10195213
Jo YH and Schlichter R Synaptic corelease of ATP and GABA in cultured spinal neurons. 1999 Nat. Neurosci. pmid:10195216
Weber OM et al. Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography. 1999 Magn Reson Imaging pmid:10195585
Koutsilieri E et al. Involvement of microglia in cerebrospinal fluid glutamate increase in SIV-infected rhesus monkeys (Macaca mulatta). 1999 AIDS Res. Hum. Retroviruses pmid:10195757
Mody I Interneurons and the ghost of the sea. 1998 Nat. Neurosci. pmid:10196538
Betz H Gephyrin, a major player in GABAergic postsynaptic membrane assembly? 1998 Nat. Neurosci. pmid:10196557
Cook PB and McReynolds JS Lateral inhibition in the inner retina is important for spatial tuning of ganglion cells. 1998 Nat. Neurosci. pmid:10196588
Rehman HU Stiff-man syndrome. 1998 Postgrad Med J pmid:10197191
Ferry B et al. Functional interaction between entorhinal cortex and basolateral amygdala during trace conditioning of odor aversion in the rat. 1999 Behav. Neurosci. pmid:10197911
Hebeiss K and Kilbinger H Cholinergic and GABAergic regulation of nitric oxide synthesis in the guinea pig ileum. 1999 Am. J. Physiol. pmid:10198328
Gironell A et al. A randomized placebo-controlled comparative trial of gabapentin and propranolol in essential tremor. 1999 Arch. Neurol. pmid:10199338
Paladini CA et al. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo. 1999 Neuroscience pmid:10199614
Celada P et al. GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata. 1999 Neuroscience pmid:10199615
Hu HZ et al. Enhancement of GABA-activated current by muscarine in rat dorsal root ganglion neurons. 1999 Neuroscience pmid:10199621
Steele PM and Mauk MD Inhibitory control of LTP and LTD: stability of synapse strength. 1999 J. Neurophysiol. pmid:10200191
Petty CN and Lucero MT Characterization of a Na+-dependent betaine transporter with Cl- channel properties in squid motor neurons. 1999 J. Neurophysiol. pmid:10200192
Tietz EI et al. Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. 1999 J. Neurophysiol. pmid:10200193
Sun D and Murali SG Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation. 1999 J. Neurophysiol. pmid:10200228
Cairns BE et al. Activation of peripheral GABAA receptors inhibits temporomandibular joint-evoked jaw muscle activity. 1999 J. Neurophysiol. pmid:10200231
Neufeld MY et al. Comparison of the effects of vigabatrin, lamotrigine, and topiramate on quantitative EEGs in patients with epilepsy. 1999 Mar-Apr Clin Neuropharmacol pmid:10202602
Ceseña RM and Calcutt NA Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. 1999 Neurosci. Lett. pmid:10203241
Kosaka K and Kosaka T Distinctive neuronal organization of the olfactory bulb of the laboratory shrew. 1999 Neuroreport pmid:10203320
Frye CA and Bayon LE Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures. 1999 Dev Psychobiol pmid:10204098
Gilerovich EG [Immunohistochemical study of structural basis of inhibition in central cerebellar nuclei]. 1998 Ross Fiziol Zh Im I M Sechenova pmid:10204178
Tachikawa E et al. Effects of ginseng saponins on responses induced by various receptor stimuli. 1999 Eur. J. Pharmacol. pmid:10204677
Ong J et al. Antagonism of GABA(B) receptors by morpholino-2-acetic acid derivatives Sch 54679 and Sch 51324 in rat brain. 1999 Eur. J. Pharmacol. pmid:10204678
Field MJ et al. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. 1999 Pain pmid:10204753
Filadora VA et al. Acute herpetic neuralgia and postherpetic neuralgia in the head and neck: response to gabapentin in five cases. 1999 Mar-Apr Reg Anesth Pain Med pmid:10204905
Nicholson RA et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. 1999 Br. J. Pharmacol. pmid:10204999
Golovko AI et al. [The molecular aspects of the functional heterogeneity of the GABA receptors]. 1999 Jan-Mar Usp Fiziol Nauk pmid:10205817
Valdizán EM et al. Effects of increasing doses of vigabatrin on platelet gamma-aminobutyric acid-transaminase and brain gamma-aminobutyric acid in rats. 1999 Eur. J. Pharmacol. pmid:10206175
Jones EA and Basile AS Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure? 1998 Metab Brain Dis pmid:10206826
Khan IA and Thomas P GABA exerts stimulatory and inhibitory influences on gonadotropin II secretion in the Atlantic croaker (Micropogonias undulatus). 1999 Neuroendocrinology pmid:10207278
Mañanos EL et al. Involvement of gamma-aminobutyric acid in the control of GTH-1 and GTH-2 secretion in male and female rainbow trout. 1999 Neuroendocrinology pmid:10207279
Nahata MC Development of two stable oral suspensions for gabapentin. 1999 Pediatr. Neurol. pmid:10207927
Mora Teruel F [Interaction of neurotransmitters in specific circuits of the brain]. 1998 An R Acad Nac Med (Madr) pmid:10208018
Hatzimanolis J et al. Gabapentin as monotherapy in the treatment of acute mania. 1999 Eur Neuropsychopharmacol pmid:10208297
Parent MB et al. Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory. 1999 Psychopharmacology (Berl.) pmid:10208320
Li CY et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. 1999 Neuroreport pmid:10208550
Burkhart CN and Burkhart CG Another look at ivermectin in the treatment of scabies and head lice. 1999 Int. J. Dermatol. pmid:10208630
Boyd BW and Kennedy RT Determination of trace level gamma-aminobutyric acid using an improved OPA pre-column derivatization and on-column preconcentration capillary liquid chromatography with electrochemical detection. 1998 Analyst pmid:10209896
Erdal J et al. Changes in plasma GABA concentration during vigabatrin treatment of epilepsy: a prospective study. 1999 Epilepsy Res. pmid:10210029
Brodie MJ and Mumford JP Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. 1999 Epilepsy Res. pmid:10210035
pmid:10210670
Amabeoku GJ Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. 1999 Gen. Pharmacol. pmid:10211593
Ji F et al. GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase. 1999 Neurosci. Res. pmid:10211762
Ji F and Obata K Development of the GABA system in organotypic culture of hippocampal and cerebellar slices from a 67-kDa isoform of glutamic acid decarboxylase (GAD67)-deficient mice. 1999 Neurosci. Res. pmid:10211768
Rosebush PI et al. Catatonia following gabapentin withdrawal. 1999 J Clin Psychopharmacol pmid:10211925
Neckameyer WS and Cooper RL GABA transporters in Drosophila melanogaster: molecular cloning, behavior, and physiology. 1998 Invert. Neurosci. pmid:10212397
Herrero MT et al. Mechanism by which GABA, through its GABA(A) receptor, modulates glutamate release from rat cortical neurons in culture. 1999 Neurochem. Int. pmid:10213073
Judge S and Leitch B GABA immunoreactivity in processes presynaptic to the locust wing stretch receptor neuron. 1999 J. Comp. Neurol. pmid:10213191
Arndt CF et al. Outer retinal dysfunction in patients treated with vigabatrin. 1999 Neurology pmid:10214744
Papp EC et al. Medial septal and median raphe innervation of vasoactive intestinal polypeptide-containing interneurons in the hippocampus. 1999 Neuroscience pmid:10215142
Estevez AY et al. Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex. 1999 Neurochem. Res. pmid:10215520
Rapallino MV et al. Stimulation of chloride in-->out permeation across the Deiters' neuron membrane by pentobarbital on the cytoplasmic side: additional evidence of GABA(A) receptors acting as chloride extrusion pumps. 1999 Neurochem. Res. pmid:10215521
Hu LA and King SC Identification of the amine-polyamine-choline transporter superfamily 'consensus amphipathic region' as the target for inactivation of the Escherichia coli GABA transporter GabP by thiol modification reagents. Role of Cys-300 in restoring thiol sensitivity to Gabp lacking Cys. 1999 Biochem. J. pmid:10215604
Xiong H et al. Mutual regulation between the intercellular messengers nitric oxide and brain-derived neurotrophic factor in rodent neocortical neurons. 1999 Eur. J. Neurosci. pmid:10215909
Ali AB et al. IPSPs elicited in CA1 pyramidal cells by putative basket cells in slices of adult rat hippocampus. 1999 Eur. J. Neurosci. pmid:10215927
Maruyama S and Kawasaki T Further electrophysiological evidence for the GABA-like effect of droperidol in the Purkinje cells of the cat cerebellum. 1976 Jpn. J. Pharmacol. pmid:1021614
Braga MF et al. Lead increases tetrodotoxin-insensitive spontaneous release of glutamate and GABA from hippocampal neurons. 1999 Brain Res. pmid:10216192
Braga MF et al. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. 1999 Brain Res. pmid:10216193
Jaliffa CO et al. Effect of GABA on melatonin content in golden hamster retina. 1999 J. Neurochem. pmid:10217277
Holt RA et al. Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam. 1999 J. Neurochem. pmid:10217306
Sanna E et al. Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties. 1999 Br. J. Pharmacol. pmid:10217539
García Callejo FJ et al. [Use of gabapentin in glossopharyngeal neuralgia]. 1999 Acta Otorrinolaringol Esp pmid:10217696
Burrows KB and Meshul CK High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity. 1999 Neuroscience pmid:10218784
Fassio A et al. Evidence for calcium-dependent vesicular transmitter release insensitive to tetanus toxin and botulinum toxin type F. 1999 Neuroscience pmid:10218789
Rozzo A et al. Antagonism by (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid of synaptic transmission in the neonatal rat spinal cord in vitro: an electrophysiological study. 1999 Neuroscience pmid:10218807
Shen W et al. Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. 1999 Neuropharmacology pmid:10218867
Melnick IV et al. Rat hippocampal neurons maintain their own GABAergic synaptic transmission in culture. 1999 Neurosci. Lett. pmid:10218878
Kaehler ST et al. Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus. 1999 Neurosci. Lett. pmid:10218890
Novotny EJ et al. GABA changes with vigabatrin in the developing human brain. 1999 Epilepsia pmid:10219272
Boyd RA et al. Effects of age and gender on single-dose pharmacokinetics of gabapentin. 1999 Epilepsia pmid:10219274
Pollák E and Molnár L Distribution of GABA-immunoreactive neurons in the terminal ganglion of the isopod Porcellio scaber. 1998 Neurobiology (Bp) pmid:10220781
Jelitai M et al. Non-synaptic effects of glutamic acid and GABA in cultures of developing neural cells. 1998 Neurobiology (Bp) pmid:10220788
Cabras PL et al. Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study. 1999 J Clin Psychiatry pmid:10221286
Dahl-Jørgensen A et al. Serum and CNTF stimulate oligodendroglia and reduce fiber outgrowth from striatal cultures. 1999 Exp. Neurol. pmid:10222111
Schlösser B et al. Local disinhibition of neocortical neuronal circuits causes augmentation of glutamatergic and GABAergic synaptic transmission in the rat neostriatum in vitro. 1999 Exp. Neurol. pmid:10222121
Petroff OA et al. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures. 1999 Seizure pmid:10222306
Terasawa E et al. An increase in glutamate release follows a decrease in gamma aminobutyric acid and the pubertal increase in luteinizing hormone releasing hormone release in the female rhesus monkeys. 1999 J. Neuroendocrinol. pmid:10223281
Gonzalo-Ruiz A et al. Localization of amino acids, neuropeptides and cholinergic neurotransmitter markers in identified projections from the mesencephalic tegmentum to the mammillary nuclei of the rat. 1999 J. Chem. Neuroanat. pmid:10223311
Telfeian AE et al. Lack of correlation between neuronal hyperexcitability and electrocorticographic responsiveness in epileptogenic human neocortex. 1999 J. Neurosurg. pmid:10223462
Sun B et al. [Effects of injection of GABA into lateral cerebroventricle on sleep-wakefulness of cats]. 1997 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:10223821
Kita H et al. In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system. 1999 Antimicrob. Agents Chemother. pmid:10223919
Tarakanov IA et al. [Sensitivity of the respiratory system to lung mechanoreceptor impulses during GABAergic system activation]. 1999 Biull Eksp Biol Med pmid:10225094
Chuppina LM [Chemical heterogenicity of the synaptic organization of different regions of the rabbit cerebral cortex]. 1976 Fiziol Zh SSSR Im I M Sechenova pmid:1022528
Richter A and Löscher W Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis. 1999 Eur. J. Pharmacol. pmid:10225372
Podell M and Hadjiconstantinou M Low concentrations of cerebrospinal fluid GABA correlate to a reduced response to phenobarbital therapy in primary canine epilepsy. 1999 Mar-Apr J. Vet. Intern. Med. pmid:10225597
Dupuy-Davies S and Houser CR Evidence for changing positions of GABA neurons in the developing rat dentate gyrus. 1999 Hippocampus pmid:10226778
Tian J et al. GABA(A) receptors mediate inhibition of T cell responses. 1999 J. Neuroimmunol. pmid:10227421
Jezyk N et al. Transport of pregabalin in rat intestine and Caco-2 monolayers. 1999 Pharm. Res. pmid:10227706
Colado MI et al. Studies on the neuroprotective effect of pentobarbitone on MDMA-induced neurodegeneration. 1999 Psychopharmacology (Berl.) pmid:10229068
Pollák E et al. Localization and source of gamma aminobutyric acid immunoreactivity in the isthmic nucleus of the frog Rana esculenta. 1999 Brain Res. Bull. pmid:10229344
Caviedes BE et al. [In children with refractory epilepsy: vigabatrin or lamotrigine?]. 1999 Mar 1-15 Rev Neurol pmid:10229954
Baek NI et al. Isolation and identification of succinic semialdehyde dehydrogenase inhibitory compound from the rhizome of Gastrodia elata Blume. 1999 Arch. Pharm. Res. pmid:10230516
Calogero AE et al. Gamma-aminobutyric acid (GABA) A and B receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone. 1999 Fertil. Steril. pmid:10231059
Parsons LH et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. 1999 Synapse pmid:10231132
Rocha L et al. Gabapentin modifies extracellular opioid peptide content in amygdala: a microdialysis study. 1999 Epilepsy Res. pmid:10232790
Gobbi G et al. Prospective study of first-line vigabatrin monotherapy in childhood partial epilepsies. 1999 Epilepsy Res. pmid:10232792