4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Meige Syndrome D008538 1 associated lipids
Carcinoma, Acinar Cell D018267 1 associated lipids
Meningitis, Viral D008587 1 associated lipids
Arachnoid Cysts D016080 1 associated lipids
alpha-Mannosidosis D008363 1 associated lipids
Hiccup D006606 1 associated lipids
Chorea D002819 1 associated lipids
Congenital Disorders of Glycosylation D018981 1 associated lipids
Tongue, Fissured D014063 1 associated lipids
Neuroectodermal Tumors, Primitive D018242 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Carlsson KC and Reubsaet JL Sample preparation and determination of gabapentin in venous and capillary blood using liquid chromatography-tandem mass spectrometry. 2004 J Pharm Biomed Anal pmid:15013156
Breitling R Pathogenesis of peroxisomal deficiency disorders (Zellweger syndrome) may be mediated by misregulation of the GABAergic system via the diazepam binding inhibitor. 2004 BMC Pediatr pmid:15102341
Sánchez ME et al. Surface activity of thymol: implications for an eventual pharmacological activity. 2004 Colloids Surf B Biointerfaces pmid:15261077
Seagard JL et al. Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14615281
Hänsel A [Neuritis of the maxillary nerve. A 55-year-old housewife]. 2004 Praxis (Bern 1994) pmid:15495755
Tongjaroenbungam W et al. Opioid modulation of GABA release in the rat inferior colliculus. 2004 BMC Neurosci pmid:15353008
Lopez LM et al. Valproic acid induces manifestations of simultaneous dopamine enhancement and reduction in schizophrenia. 2004 Neuropsychopharmacology pmid:15154001
Xu Y and Krukoff TL Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA. 2004 Regul. Pept. pmid:15093693
Rathenberg J et al. Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. 2004 Mol. Cell. Neurosci. pmid:15207850
Williams AJ et al. Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. 2004 J. Pharmacol. Exp. Ther. pmid:15140918
D'Amico M et al. Inhibition by anandamide and synthetic cannabimimetics of the release of [3H]D-aspartate and [3H]GABA from synaptosomes isolated from the rat hippocampus. 2004 Neurochem. Res. pmid:15260134
Alger BE Endocannabinoids: getting the message across. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15173576
Paoletti AM et al. Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol. 2004 Fertil. Steril. pmid:15037415
Centonze D et al. A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission. 2004 Neuropsychopharmacology pmid:15100701
Riché EL et al. Novel long-circulating liposomes containing peptide library-lipid conjugates: synthesis and in vivo behavior. 2004 J Drug Target pmid:15545085
Follesa P et al. Modulation of GABA(A) receptor gene expression by allopregnanolone and ethanol. 2004 Eur. J. Pharmacol. pmid:15464049
Gago N et al. 3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation. 2004 J. Neurosci. Res. pmid:15523635
Stahl SM Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA. 2004 J Clin Psychiatry pmid:15096065
Sliwinski A et al. Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors. 2004 J. Neurosci. Res. pmid:15505794
Woo TU et al. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. 2004 Arch. Gen. Psychiatry pmid:15237077
Frediani F Anticonvulsant drugs in primary headaches prophylaxis. 2004 Neurol. Sci. pmid:15549529
Cook CJ Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala. 2004 Physiol. Behav. pmid:15327926
Bosch M et al. Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease. 2004 Exp. Neurol. pmid:15473979
Gernert M et al. Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy. 2004 Eur. J. Neurosci. pmid:15525279
Maayan R et al. Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women. 2004 Brain Res. pmid:15312799
Yang K et al. Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons. 2004 J. Neurophysiol. pmid:15201307
Wu SP et al. Interaction between anticonvulsants and human placental carnitine transporter. 2004 Epilepsia pmid:15009220
Gordon N Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). 2004 Eur. J. Paediatr. Neurol. pmid:15341910
Soares K et al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. 2004 Cochrane Database Syst Rev pmid:15494993
McMillan PJ et al. Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus. 2004 J. Neurochem. pmid:15525338
Wong CG et al. From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid. 2004 Trends Pharmacol. Sci. pmid:14723976
Vasiliou V et al. Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism. 2004 Drug Metab. Rev. pmid:15237855
Liou LS et al. Microarray gene expression profiling and analysis in renal cell carcinoma. 2004 BMC Urol pmid:15212686
Masuo Y et al. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. 2004 Regul. Pept. pmid:15518916
Odagaki Y and Yamauchi T Gamma-hydroxybutyric acid, unlike gamma-aminobutyric acid, does not stimulate Gi/Go proteins in rat brain membranes. 2004 Basic Clin. Pharmacol. Toxicol. pmid:14748852
Funchal C et al. Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system. 2004 J. Neurol. Sci. pmid:14675604
Kaminski RM et al. Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice. 2004 Toxicol. Lett. pmid:15475178
Steckelbroeck S et al. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. 2004 J. Biol. Chem. pmid:14672942
Carai MA et al. Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, DL-dithiothreitol (DTT). 2004 Psychopharmacology (Berl.) pmid:14760512
Grazia Cascio M et al. A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase. 2004 Biochem. Biophys. Res. Commun. pmid:14715265
Guptarak J et al. GABAA-5-HT1A receptor interaction in the mediobasal hypothalamus. 2004 Brain Res. pmid:15494165
Stahl SM and Grady MM A critical review of atypical antipsychotic utilization: comparing monotherapy with polypharmacy and augmentation. 2004 Curr. Med. Chem. pmid:14965234
Magnaghi V et al. GABAB receptors in Schwann cells influence proliferation and myelin protein expression. 2004 Eur. J. Neurosci. pmid:15147298
Harvey VL and Stephens GJ Mechanism of GABA receptor-mediated inhibition of spontaneous GABA release onto cerebellar Purkinje cells. 2004 Eur. J. Neurosci. pmid:15255979
Satake S et al. AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms. 2004 Eur. J. Neurosci. pmid:15128400
Waseem TV et al. Influence of hypotonic shock on glutamate and GABA uptake in rat brain synaptosomes. 2004 Neurochem. Res. pmid:15453259
Kalamatianos T et al. Cellular expression of V1a vasopressin receptor mRNA in the female rat preoptic area: effects of oestrogen. 2004 J. Neuroendocrinol. pmid:15189327
Kokotos G et al. Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo. 2004 J. Med. Chem. pmid:15214789
Root AR et al. In vitro and in vivo effects of GABA, muscimol, and bicuculline on lamprey GnRH concentration in the brain of the sea lamprey (Petromyzon marinus). 2004 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:15369839
Ottem EN et al. Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function. 2004 J. Neurosci. pmid:15371511
Cunningham MO et al. Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro. 2004 Eur. J. Neurosci. pmid:15355323
Peinado V et al. Effect of 17-beta-estradiol on dopamine, serotonine and GABA striatal levels in 6-hydroxydopamine-treated rats. 2004 Toxicology pmid:15388241
Friedman SD et al. Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. 2004 Biol. Psychiatry pmid:15336516
Goutman JD and Calvo DJ Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor. 2004 Br. J. Pharmacol. pmid:14732759
Harvey BH et al. Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. 2004 Psychopharmacology (Berl.) pmid:15138761
Jarry H et al. Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal amino acid neurotransmitter concentrations in male rats. 2004 Inhal Toxicol pmid:15204768
Hall BJ et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. 2004 Eur. J. Pharmacol. pmid:15102527
King SC The "Transport Specificity Ratio": a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis. 2004 BMC Biochem. pmid:15548327
Ohtsuki S [Physiological function of blood-brain barrier transporters as the CNS supporting and protecting system]. 2004 Yakugaku Zasshi pmid:15516806
Laeng P et al. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. 2004 J. Neurochem. pmid:15379904
Ohtsuki S New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. 2004 Biol. Pharm. Bull. pmid:15467183
Kalsbeek A et al. Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. 2004 J. Neurosci. pmid:15342726
Darbandi-Tonkabon R et al. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. 2004 J. Pharmacol. Exp. Ther. pmid:14593090
Castelli MP et al. A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor. 2004 CNS Drug Rev pmid:15492774
Kishimoto W et al. Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. 2004 Endocrinology pmid:14563706
Torres JM and Ortega E Alcohol intoxication increases allopregnanolone levels in male adolescent humans. 2004 Psychopharmacology (Berl.) pmid:14647956
Turkmen S et al. 3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone. 2004 Eur. J. Neurosci. pmid:15355327
Philippe A et al. Neurodevelopmental pattern of succinic semialdehyde dehydrogenase deficiency (gamma-hydroxybutyric aciduria). 2004 Dev Med Child Neurol pmid:15287248
Ugale RR et al. Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. 2004 Brain Res. pmid:15364024
Huang SH et al. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. 2004 Eur. J. Pharmacol. pmid:15212966
Patte-Mensah C et al. Impact of neuropathic pain on the gene expression and activity of cytochrome P450side-chain-cleavage in sensory neural networks. 2004 Cell. Mol. Life Sci. pmid:15338057
Bhattacharya I and Boje KM GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier. 2004 J. Pharmacol. Exp. Ther. pmid:15173314
Lin SC and Bergles DE Synaptic signaling between neurons and glia. 2004 Glia pmid:15252819
Nguyen VH and Lawrence HJ Use of gabapentin in the prevention of taxane-induced arthralgias and myalgias. 2004 J. Clin. Oncol. pmid:15118009
Carboni G et al. Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation. 2004 Neuropharmacology pmid:15111013
Frye CA et al. Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors. 2004 Pharmacol. Biochem. Behav. pmid:15251249
Dettling A et al. Absinthe: attention performance and mood under the influence of thujone. 2004 J. Stud. Alcohol pmid:15536765
Yatham LN Newer anticonvulsants in the treatment of bipolar disorder. 2004 J Clin Psychiatry pmid:15242330
Campbell EL et al. The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. 2004 Biochem. Pharmacol. pmid:15451406
Hull C and von Gersdorff H Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 2004 Neuron pmid:15504327
Smith AJ et al. Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors. 2004 J. Pharmacol. Exp. Ther. pmid:15210837
Kaminski RM et al. Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. 2004 Epilepsia pmid:15230714
González-Flores O et al. Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat. 2004 Psychopharmacology (Berl.) pmid:14685643
Li ZP et al. Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus. 2004 Neurochem. Int. pmid:14602089
Ethofer T et al. Proton MR spectroscopy in succinic semialdehyde dehydrogenase deficiency. 2004 Neurology pmid:15037717
Leal SM et al. GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport. 2004 J. Neurobiol. pmid:15389689
Ugale RR et al. Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents. 2004 Neuropsychopharmacology pmid:15100702
Rao SP and Sikdar SK Estradiol-induced changes in the activity of hippocampal neurons in network culture are suppressed by co-incubation with gabapentin. 2004 Brain Res. pmid:15353222
Seiffert E et al. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. 2004 J. Neurosci. pmid:15356194
Miles GB et al. Functional properties of motoneurons derived from mouse embryonic stem cells. 2004 J. Neurosci. pmid:15356197
Hu JH et al. Impaired reproduction in transgenic mice overexpressing Gamma-aminobutyric acid transporter I (GAT1). 2004 Cell Res. pmid:15040890
Li JX et al. Valproate prevents the induction, but not the expression of morphine sensitization in mice. 2004 Behav. Brain Res. pmid:15196792
Xia Y and Nawy S The gap junction blockers carbenoxolone and 18beta-glycyrrhetinic acid antagonize cone-driven light responses in the mouse retina. 2003 Jul-Aug Vis. Neurosci. pmid:14658771
Rewal M et al. Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal. 2003 Aug-Oct Alcohol pmid:14615011
Alfinito PD et al. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. 2003 J. Neurosci. pmid:14645494
Gruber CJ and Huber JC Differential effects of progestins on the brain. 2003 Maturitas pmid:14670648
Hossain SJ et al. Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes. 2003 J. Agric. Food Chem. pmid:14664509
Kelly MJ et al. Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system. 2003 Ann. N. Y. Acad. Sci. pmid:14993035
Bianchi MT and Macdonald RL Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. 2003 J. Neurosci. pmid:14645489
Hinkle DJ and Macdonald RL Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents. 2003 J. Neurosci. pmid:14684872