4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Neuroaxonal Dystrophies D019150 3 associated lipids
Porphyria, Acute Intermittent D017118 3 associated lipids
Cerebellar Ataxia D002524 3 associated lipids
Urinary Bladder, Neurogenic D001750 3 associated lipids
Myoclonus D009207 3 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Tuberculosis, Meningeal D014390 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Hyperglycemic Hyperosmolar Nonketotic Coma D006944 4 associated lipids
Retrograde Degeneration D012183 4 associated lipids
Rabies D011818 4 associated lipids
Muscle Rigidity D009127 4 associated lipids
Newcastle Disease D009521 4 associated lipids
Mercury Poisoning D008630 4 associated lipids
Pain, Intractable D010148 4 associated lipids
Tinnitus D014012 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Confusion D003221 4 associated lipids
Puerperal Disorders D011644 4 associated lipids
Vertigo D014717 4 associated lipids
Neuritis D009443 4 associated lipids
Reflex Sympathetic Dystrophy D012019 4 associated lipids
Huntington Disease D006816 4 associated lipids
Spinal Cord Diseases D013118 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Hypoxia, Brain D002534 5 associated lipids
Sclerosis D012598 5 associated lipids
Respiration Disorders D012120 5 associated lipids
Epilepsy, Absence D004832 5 associated lipids
Sleep Deprivation D012892 5 associated lipids
Hyperammonemia D022124 5 associated lipids
Muscle Spasticity D009128 5 associated lipids
Asphyxia D001237 5 associated lipids
Diabetes Insipidus D003919 5 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Cushing Syndrome D003480 5 associated lipids
Sarcoma, Yoshida D012517 5 associated lipids
Supranuclear Palsy, Progressive D013494 5 associated lipids
Granuloma, Foreign-Body D015745 5 associated lipids
Embryo Loss D020964 5 associated lipids
Skin Diseases, Vesiculobullous D012872 5 associated lipids
Asthenia D001247 5 associated lipids
Epilepsy, Reflex D020195 5 associated lipids
Hypokalemia D007008 6 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Filariasis D005368 6 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Scharfman HE and MacLusky NJ Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. 2014 Neuropharmacology pmid:23660230
Vashchinkina E et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. 2014 Neuropsychopharmacology pmid:24077066
Mango D et al. Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions. 2014 Neuropharmacology pmid:23973317
Chou HT et al. Functional characterization of the agtABCD and agtSR operons for 4-aminobutyrate and 5-aminovalerate uptake and regulation in Pseudomonas aeruginosa PAO1. 2014 Curr. Microbiol. pmid:23982201
Kumar A et al. Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations. 2014 May-Jun Indian J Pharmacol pmid:24987179
Rizk NN et al. Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis. 2014 May-Jun Pain Physician pmid:24850125
Bönnighausen J et al. Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum. 2015 Mol. Microbiol. pmid:26305050
Groundwater PW et al. The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. 2015 J Pharm Pharm Sci pmid:26626239
Lee KH et al. Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus. 2015 J. Neurosci. pmid:26674872
Wang H et al. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. 2015 Cell Rep pmid:26365195