4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Meningioma D008579 11 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Retinal Detachment D012163 10 associated lipids
Morphine Dependence D009021 9 associated lipids
Cleft Palate D002972 9 associated lipids
Tooth, Impacted D014095 9 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Cerebellar Neoplasms D002528 9 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Substance Withdrawal Syndrome D013375 9 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Basal Ganglia Diseases D001480 8 associated lipids
Hepatitis A D006506 8 associated lipids
Fetal Diseases D005315 8 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Psychoses, Substance-Induced D011605 7 associated lipids
Scrapie D012608 7 associated lipids
Varicose Veins D014648 7 associated lipids
Decerebrate State D003655 7 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Tachycardia D013610 7 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Muscular Diseases D009135 7 associated lipids
Creutzfeldt-Jakob Syndrome D007562 7 associated lipids
Hypokalemia D007008 6 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Filariasis D005368 6 associated lipids
Hypoxia, Brain D002534 5 associated lipids
Sclerosis D012598 5 associated lipids
Respiration Disorders D012120 5 associated lipids
Epilepsy, Absence D004832 5 associated lipids
Hyperammonemia D022124 5 associated lipids
Sleep Deprivation D012892 5 associated lipids
Asphyxia D001237 5 associated lipids
Diabetes Insipidus D003919 5 associated lipids
Muscle Spasticity D009128 5 associated lipids
Cushing Syndrome D003480 5 associated lipids
Sarcoma, Yoshida D012517 5 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Supranuclear Palsy, Progressive D013494 5 associated lipids
Embryo Loss D020964 5 associated lipids
Granuloma, Foreign-Body D015745 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

Download all related citations
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Authors Title Published Journal PubMed Link
Guptill JT et al. Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy. 2014 Muscle Nerve pmid:24639235
Park SA et al. Kinetic characterization and molecular modeling of NAD(P)(+)-dependent succinic semialdehyde dehydrogenase from Bacillus subtilis as an ortholog YneI. 2014 J. Microbiol. Biotechnol. pmid:24809290
Bailey JN et al. Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. 2014 Hum. Genet. pmid:25037249
Pollock E et al. Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis. 2014 Neurobiol. Dis. pmid:24946277
Blake CB and Smith BN cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24990858
Liu ZP et al. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. 2014 Mol Brain pmid:24758222
Ikeda K et al. Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care. 2014 Biomed. Chromatogr. pmid:24889681
Kumamaru E et al. Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons. 2014 Neurosci. Lett. pmid:24708928
Wilkins HM et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. 2014 Hum. Mol. Genet. pmid:25027327
Marahatta A et al. Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study. 2014 Sci Rep pmid:24618639