4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Occupational Diseases D009784 42 associated lipids
Hypotension D007022 41 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Arthritis D001168 41 associated lipids
Adenoma D000236 40 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Nervous System Diseases D009422 37 associated lipids
Epilepsy D004827 35 associated lipids
Fever D005334 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Per page 10 20 50 100 | Total 280

PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 40318
Authors Title Published Journal PubMed Link
Landmark CJ Targets for antiepileptic drugs in the synapse. 2007 Med. Sci. Monit. pmid:17179916
Köfalvi A et al. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. 2007 Br. J. Pharmacol. pmid:17435795
Marinelli S et al. N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors. 2007 Neuropsychopharmacology pmid:16760924
Grover S et al. Pharmacoprophylaxis of alcohol dependence: Review and update Part I: Pharmacology. 2007 Indian J Psychiatry pmid:20640061
Christian CA and Moenter SM Estradiol induces diurnal shifts in GABA transmission to gonadotropin-releasing hormone neurons to provide a neural signal for ovulation. 2007 J. Neurosci. pmid:17314287
Akirav I NMDA Partial agonist reverses blocking of extinction of aversive memory by GABA(A) agonist in the amygdala. 2007 Neuropsychopharmacology pmid:16541088
Yamada J et al. Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. 2007 Cereb. Cortex pmid:16997904
Sauer SW et al. Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice). 2007 Neurochem. Int. pmid:17303287
Kempa S et al. A plastid-localized glycogen synthase kinase 3 modulates stress tolerance and carbohydrate metabolism. 2007 Plant J. pmid:17319843
Manent JB et al. Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. 2007 Epilepsia pmid:17437411
Tolmacheva EA and van Luijtelaar G Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats. 2007 Neurosci. Lett. pmid:17280780
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Gutteridge A et al. Regulation of metabolic networks by small molecule metabolites. 2007 BMC Bioinformatics pmid:17352833
Strawn JR and Geracioti TD The treatment of generalized anxiety disorder with pregabalin, an atypical anxiolytic. 2007 Neuropsychiatr Dis Treat pmid:19300556
An P and Grabowski PJ Exon silencing by UAGG motifs in response to neuronal excitation. 2007 PLoS Biol. pmid:17298175
Abdel-Salam OM Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine. 2007 Drug Target Insights pmid:21901060
Predieri B et al. High basal serum allopregnanolone levels in overweight girls. 2007 Int J Obes (Lond) pmid:16847473
Wang C et al. Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17190904
Goel A et al. Electrochemical recognition of anions by 1,1'-N,N'-ferrocenoylbisamino acid esters. 2007 Biosens Bioelectron pmid:17015010
Pascual J et al. Antiepileptic drugs for the treatment of chronic and episodic cluster headache: a review. 2007 Headache pmid:17355498
Wu J et al. Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma. 2007 J. Neurophysiol. pmid:17428906
Zhou L et al. Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors. 2007 Exp. Neurol. pmid:17005180
Calabresi P et al. Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. 2007 Trends Pharmacol. Sci. pmid:17337068
Tribble ND et al. Identification of the genes encoding for putative gamma aminobutyric acid (GABA) and glutamate-gated chloride channel (GluCl) alpha receptor subunits in sea lice (Lepeophtheirus salmonis). 2007 J. Vet. Pharmacol. Ther. pmid:17348903
Káradóttir R and Attwell D Neurotransmitter receptors in the life and death of oligodendrocytes. 2007 Neuroscience pmid:17049173
Gaidatzis D et al. Inference of miRNA targets using evolutionary conservation and pathway analysis. 2007 BMC Bioinformatics pmid:17331257
Pytel M et al. 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro. 2007 Neuropharmacology pmid:17418284
Zeevalk GD et al. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease. 2007 Exp. Neurol. pmid:17049515
Hsin YL et al. Adult-onset autosomal dominant myoclonic epilepsy: report of a family with an overlooked epileptic syndrome. 2007 Seizure pmid:17174115
Zhou X and Smith SS Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model. 2007 Neurosci. Lett. pmid:17081691
Liu GX et al. Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1. 2007 Neuropsychopharmacology pmid:17164814
Xiao W et al. Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. 2007 Neuroscience pmid:17084535
Mondria T et al. New device to control combined lingual and palatal myoclonus. 2007 Mov. Disord. pmid:17260342
Kurita M et al. Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. 2007 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:17258372
Miura Y [A new aspect in the research on antiepileptic drugs]. 2007 Nippon Yakurigaku Zasshi pmid:17299237
Kalinin VV Suicidality and antiepileptic drugs: is there a link? 2007 Drug Saf pmid:17253878
Belyaeva OV et al. Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues. 2007 Endocrinology pmid:17289849
Leuzzi V et al. Vigabatrin improves paroxysmal dystonia in succinic semialdehyde dehydrogenase deficiency. 2007 Neurology pmid:17438226
Wang C et al. Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 2007 Neurosci. Lett. pmid:17275189
Moy LY et al. Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter. 2007 J. Pharmacol. Exp. Ther. pmid:17090704
Shen H et al. Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty. 2007 Nat. Neurosci. pmid:17351635
Hadley SH and Amin J Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. 2007 J. Physiol. (Lond.) pmid:17395622
Wang DS et al. Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. 2007 J. Biol. Chem. pmid:17405877
Eisenman LN et al. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. 2007 Nat. Neurosci. pmid:17322875
Perrot-Sinal TS et al. Sex differences in the chloride cotransporters, NKCC1 and KCC2, in the developing hypothalamus. 2007 J. Neuroendocrinol. pmid:17355320
Xiang TX et al. Molecular dynamics simulations and experimental studies of binding and mobility of 7-tert-butyldimethylsilyl-10-hydroxycamptothecin and its 20(S)-4-aminobutyrate ester in DMPC membranes. 2006 Sep-Oct Mol. Pharm. pmid:17009858
Baroni T et al. Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype. 2006 Sep-Oct Mol. Med. pmid:17225872
Chang CW et al. Potentiation of inhibitory amino acid receptors-mediated responses by lanthanum in rat sacral dorsal commissural neurons. 2006 Nov-Dec Neurotoxicol Teratol pmid:17045457
Wang MD et al. Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABA(A) receptor through different channel property. 2006 Nov-Dec Acta Physiol (Oxf) pmid:17054655
Schindelman G et al. Initiation of male sperm-transfer behavior in Caenorhabditis elegans requires input from the ventral nerve cord. 2006 BMC Biol. pmid:16911797
Pibiri F et al. Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids. 2006 Neuroreport pmid:16957604
Datta SS and Kumar S Hypomania as an aura in migraine. 2006 Neurol India pmid:16804272
Seitz CS et al. Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. 2006 Ann. Allergy Asthma Immunol. pmid:17165282
Karanjia R et al. Cross-inhibitory interactions between GABAA and P2X channels in myenteric neurones. 2006 Eur. J. Neurosci. pmid:16820016
Blurton-Jones M and Tuszynski MH Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. 2006 J. Comp. Neurol. pmid:17029253
Kanazawa I Therapeutic Strategies in Huntington's Disease. 2006 J Clin Neurol pmid:20396523
Cysique LA et al. Valproic acid is associated with cognitive decline in HIV-infected individuals: a clinical observational study. 2006 BMC Neurol pmid:17150108
Wilfong AA and Willmore LJ Zonisamide - a review of experience and use in partial seizures. 2006 Neuropsychiatr Dis Treat pmid:19412474
Xu H et al. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. 2006 Mol Pain pmid:16948848
Iqbal U et al. Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal guinea pig. 2006 J. Neuroendocrinol. pmid:17026532
Saxena K et al. Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder. 2006 J Child Adolesc Psychopharmacol pmid:16768633
Zhang B and Osborne NN Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate. 2006 Brain Res. pmid:17084820
Womack MD et al. Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. 2006 Br. J. Pharmacol. pmid:17001301
Talaty ER et al. Collision-induced dissociation of protonated tetrapeptides containing beta-alanine, gamma-aminobutyric acid, epsilon-aminocaproic acid or 4-aminomethylbenzoic acid residues. 2006 Rapid Commun. Mass Spectrom. pmid:17066369
Borghese CM et al. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. 2006 J. Pharmacol. Exp. Ther. pmid:16807363
Hussar DA New drugs 06, part II. 2006 Nursing pmid:16888514
Wang C et al. Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. 2006 Mol. Microbiol. pmid:16942602
Bialer M New antiepileptic drugs that are second generation to existing antiepileptic drugs. 2006 Expert Opin Investig Drugs pmid:16732716
Ikeda T et al. Estrogen produced in cultured hippocampal neurons is a functional regulator of a GABAergic machinery. 2006 J. Neurosci. Res. pmid:17044036
Biggio F et al. Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies. 2006 Pharmacol. Biochem. Behav. pmid:16914187
Takahashi A et al. GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord. 2006 Neuroreport pmid:16951580
Wright TM and Myrick H Acamprosate: a new tool in the battle against alcohol dependence. 2006 Neuropsychiatr Dis Treat pmid:19412493
Mucignat-Caretta C et al. Species-specific chemosignals evoke delayed excitation of the vomeronasal amygdala in freely-moving female rats. 2006 J. Neurochem. pmid:16956376
Sasaki S et al. Protective role of gamma-aminobutyric acid against chronic renal failure in rats. 2006 J. Pharm. Pharmacol. pmid:17132215
Finn DA et al. A new look at the 5alpha-reductase inhibitor finasteride. 2006 CNS Drug Rev pmid:16834758
Rahman M et al. Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte. 2006 Eur. J. Pharmacol. pmid:16934248
Strömberg J et al. Neurosteroid modulation of allopregnanolone and GABA effect on the GABA-A receptor. 2006 Neuroscience pmid:16938407
Lee EJ et al. Dark-rearing-induced reduction of GABA and GAD and prevention of the effect by BDNF in the mouse retina. 2006 Eur. J. Neurosci. pmid:17074038
Shastry S et al. GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells. 2006 Cell Biochem. Biophys. pmid:16757816
Li S and Li XJ Multiple pathways contribute to the pathogenesis of Huntington disease. 2006 Mol Neurodegener pmid:17173700
Halász J et al. The activation of prefrontal cortical neurons in aggression--a double labeling study. 2006 Behav. Brain Res. pmid:16978716
Xie W et al. [Saikosaponins inhibit increased glutamate and GABA expressions in the hippocampus of pentetrazole-induced slow kindling rats]. 2006 Nan Fang Yi Ke Da Xue Xue Bao pmid:16939901
Lüscher C and Ungless MA The mechanistic classification of addictive drugs. 2006 PLoS Med. pmid:17105338
Rasmusson AM et al. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. 2006 Biol. Psychiatry pmid:16934764
Viéro C et al. Rapid inhibition of Ca2+ influx by neurosteroids in murine embryonic sensory neurones. 2006 Cell Calcium pmid:16769113
Hernández-Fisac I et al. Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets. 2006 Biochem. J. pmid:16819942
Houde M et al. Wheat EST resources for functional genomics of abiotic stress. 2006 BMC Genomics pmid:16772040
Garza I and Swanson JW Prophylaxis of migraine. 2006 Neuropsychiatr Dis Treat pmid:19412475
Arnold LM Biology and therapy of fibromyalgia. New therapies in fibromyalgia. 2006 Arthritis Res. Ther. pmid:16762044
Mayerhofer A et al. FSH regulates acetycholine production by ovarian granulosa cells. 2006 Reprod. Biol. Endocrinol. pmid:16846505
Bastías A MJ et al. [Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]. 2006 Rev Med Chil pmid:17277866
Steffensen SC et al. Dehydroepiandrosterone sulfate and estrone sulfate reduce GABA-recurrent inhibition in the hippocampus via muscarinic acetylcholine receptors. 2006 Hippocampus pmid:17024678
Davies A et al. The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. 2006 J. Neurosci. pmid:16928863
Scaglione JB et al. Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. 2006 J. Med. Chem. pmid:16854065
Maurice T et al. Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection. 2006 Pharmacol. Biochem. Behav. pmid:16945406
Saransaari P and Oja SS Modulation of GABA release by second messenger substances and NO in mouse brain stem slices under normal and ischemic conditions. 2006 Neurochem. Res. pmid:17053971
Silva MA et al. Arginine and urea metabolism in the liver graft: A study using microdialysis in human orthotopic liver transplantation. 2006 Transplantation pmid:17130779
Eguchi Y et al. Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes. 2006 Insect Mol. Biol. pmid:17201770
Morrow AL et al. Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior. 2006 Dialogues Clin Neurosci pmid:17290803
Vignes M et al. Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG). 2006 Brain Res. pmid:16859659