4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Migraine Disorders D008881 11 associated lipids
Mitral Valve Prolapse D008945 1 associated lipids
Morphine Dependence D009021 9 associated lipids
Motion Sickness D009041 1 associated lipids
Movement Disorders D009069 3 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Muscle Cramp D009120 3 associated lipids
Muscle Hypertonia D009122 1 associated lipids
Muscle Rigidity D009127 4 associated lipids
Muscle Spasticity D009128 5 associated lipids
Muscular Diseases D009135 7 associated lipids
Myoclonus D009207 3 associated lipids
Myofascial Pain Syndromes D009209 1 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Nelson Syndrome D009347 1 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Malformations D009421 1 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuritis D009443 4 associated lipids
Newcastle Disease D009521 4 associated lipids
Obesity D009765 29 associated lipids
Occupational Diseases D009784 42 associated lipids
Olivopontocerebellar Atrophies D009849 2 associated lipids
Pain D010146 64 associated lipids
Pain, Intractable D010148 4 associated lipids
Pain, Postoperative D010149 13 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Bulbar Palsy, Progressive D010244 1 associated lipids
Parkinson Disease D010300 53 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Perceptual Disorders D010468 3 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Phantom Limb D010591 1 associated lipids
Pituitary Diseases D010900 2 associated lipids
Polyneuropathies D011115 3 associated lipids
Polyradiculopathy D011128 1 associated lipids
Prader-Willi Syndrome D011218 2 associated lipids
Presbycusis D011304 1 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Psychomotor Agitation D011595 3 associated lipids
Psychoses, Alcoholic D011604 2 associated lipids
Psychoses, Substance-Induced D011605 7 associated lipids
Puerperal Disorders D011644 4 associated lipids
Rabies D011818 4 associated lipids
Reflex Sympathetic Dystrophy D012019 4 associated lipids
Respiration Disorders D012120 5 associated lipids
Respiratory Paralysis D012133 1 associated lipids
Restless Legs Syndrome D012148 2 associated lipids
Retinal Detachment D012163 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Deeb S et al. Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases. 2014 J Anal Toxicol pmid:25217536
Ari C et al. Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. 2014 PLoS ONE pmid:25061944
Cusmano DM and Mong JA In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism. 2014 Sleep pmid:25142574
Bailey JN et al. Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. 2014 Hum. Genet. pmid:25037249
Mititelu Tartau L et al. Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. 2014 Pharmacology pmid:25059844
Pollock E et al. Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis. 2014 Neurobiol. Dis. pmid:24946277
Blake CB and Smith BN cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24990858
Ikeda K et al. Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care. 2014 Biomed. Chromatogr. pmid:24889681
Melis M et al. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. 2014 J. Neurosci. pmid:25232109
Wilkins HM et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. 2014 Hum. Mol. Genet. pmid:25027327