4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperplasia D006965 34 associated lipids
Magnesium Deficiency D008275 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Imamura M and Prasad C Increased GABA-gated chloride ion influx in the hypothalamus of low-anxiety rats. 1998 Physiol. Behav. pmid:9748113
Onofrj M et al. Gabapentin in orthostatic tremor: results of a double-blind crossover with placebo in four patients. 1998 Neurology pmid:9748048
Sieghart W and Heckl K Potassium-evoked release of taurine from synaptosomal fractions of rat cerebral cortex. 1976 Brain Res. pmid:974789
Pycock C et al. The behavioural effects of manipulating GABA function in the globus pallidus. 1976 Brain Res. pmid:974781
Schousboe A et al. Taurine uptake in astrocytes cultured from dissociated mouse brain hemispheres. 1976 Brain Res. pmid:974765
Renaud LP Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat. 1976 Brain Res. pmid:974751
Enna SJ and Snyder SH Gamma-aminobutyric acid (GABA) receptor binding in mammalian retina. 1976 Brain Res. pmid:974741
Parker AP et al. Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. 1998 Dev Med Child Neurol pmid:9746003
pmid:9744934
Akopian A et al. Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina. 1998 J. Neurophysiol. pmid:9744925
Arbuthnott GW et al. Is the striato-nigral pathway responsible for 'feed-back' control of dopamine release [proceedings]? 1976 Br. J. Pharmacol. pmid:974393
Brown DA and Garthwaite J Action of surugatoxin on nicotinic receptors in the superior cervical ganglion of the rat. 1976 Br. J. Pharmacol. pmid:974373
Parker D and Grillner S Cellular and synaptic modulation underlying substance P-mediated plasticity of the lamprey locomotor network. 1998 J. Neurosci. pmid:9742176
Joseph JA et al. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. 1998 J. Neurosci. pmid:9742171
Steffensen SC et al. Electrophysiological characterization of GABAergic neurons in the ventral tegmental area. 1998 J. Neurosci. pmid:9742167
van den Pol AN et al. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. 1998 J. Neurosci. pmid:9742163
Alcántara S et al. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. 1998 J. Neurosci. pmid:9742148
Carriedo SG et al. Rapid Ca2+ entry through Ca2+-permeable AMPA/Kainate channels triggers marked intracellular Ca2+ rises and consequent oxygen radical production. 1998 J. Neurosci. pmid:9742143
Romey G et al. Scorpion neurotoxin. Mode of action on neuromuscular junctions and synaptosomes. 1976 Biochim. Biophys. Acta pmid:974149
van den Pol AN et al. Early synaptogenesis in vitro: role of axon target distance. 1998 J. Comp. Neurol. pmid:9741482
Rohwedel J et al. Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro. 1998 Dev. Biol. pmid:9740657
Bourgeois BF New antiepileptic drugs. 1998 Arch. Neurol. pmid:9740111
Goldenberg G et al. Gabapentin for disruptive behaviour in an elderly demented patient. 1998 Drugs Aging pmid:9739506
Dumba JS et al. Electron microscopic analysis of gamma-aminobutyric acid and glycine colocalization in rat trigeminal subnucleus caudalis. 1998 Brain Res. pmid:9739101
Petroianu G et al. [ETICS Study: Empirical therapy of idiopathic chronic singultus]. 1998 Z Gastroenterol pmid:9738303
Leppik IE Role of new and established antiepileptic drugs. 1998 Epilepsia pmid:9737436
Murphy DD et al. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9736750
Vicario-Abejón C et al. Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. 1998 J. Neurosci. pmid:9736647
Svoboda KR and Lupica CR Opioid inhibition of hippocampal interneurons via modulation of potassium and hyperpolarization-activated cation (Ih) currents. 1998 J. Neurosci. pmid:9736632
Weiller HG and Radler F [On the metabolism of amino acids by lactic acid bacteria isolated from wine (author's transl)]. 1976 Z Lebensm Unters Forsch pmid:973463
Kenigsberg RL et al. Cholinergic cell expression in the developing rat medial septal nucleus in vitro is differentially controlled by GABAA and GABAB receptors. 1998 Brain Res. pmid:9733945
Zhai J et al. Phosphorylation of the GABAA receptor gamma2L subunit in rat sensory neurons may not be necessary for ethanol sensitivity. 1998 Brain Res. pmid:9733942
Hall CW and Behbehani MM Synaptic effects of nitric oxide on enkephalinergic, GABAergic, and glutamatergic networks of the rat periaqueductal gray. 1998 Brain Res. pmid:9733923
Ritta MN et al. Occurrence of GABA and GABA receptors in human spermatozoa. 1998 Mol. Hum. Reprod. pmid:9733434
Levkovitz Y and Segal M Age-dependent local modulation of hippocampal-evoked responses to perforant path stimulation. 1998 Jul-Aug Neurobiol. Aging pmid:9733164
Van Lente F and Gatautis V Cost-efficient use of gas chromatography-mass spectrometry: a "piggyback" method for analysis of gabapentin. 1998 Clin. Chem. pmid:9733003
Farmer MR et al. A central gamma-aminobutyric acid mechanism in cardiac vagal control in man revealed by studies with intravenous midazolam. 1998 Clin. Sci. pmid:9730842
Díez-Ariza M et al. Differential interaction between 5-HT3 receptors and GABAergic neurons inhibiting acetylcholine release in rat entorhinal cortex slices. 1998 Brain Res. pmid:9729402
Grimm JW and See RE Unique activation of extracellular striato-pallidal neurotransmitters in rats following acute risperidone. 1998 Brain Res. pmid:9729373
Bueno OF et al. Functional characterization and visualization of a GABAA receptor-GFP chimera expressed in Xenopus oocytes. 1998 Brain Res. Mol. Brain Res. pmid:9729362
Nuñez A et al. Neurotransmitter actions on oral pontine tegmental neurons of the rat: an in vitro study. 1998 Brain Res. pmid:9729346
Tan SS et al. Separate progenitors for radial and tangential cell dispersion during development of the cerebral neocortex. 1998 Neuron pmid:9728911
Kubová H et al. Anticonvulsant effect of SL 75 102 in adult and immature rats. 1997 Physiol Res pmid:9728525
Stanková L et al. Anticonvulsant effect of progabide in rats during ontogenesis. 1997 Physiol Res pmid:9728521
Zhang K and Patel KP Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. 1998 Am. J. Physiol. pmid:9728069
Hurd RE et al. Proton spectroscopy without water suppression: the oversampled J-resolved experiment. 1998 Magn Reson Med pmid:9727935
Williams A et al. Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin. 1998 J Paediatr Child Health pmid:9727187
Bentareha R et al. Pharmacological properties of the GABA(A) receptor complex from brain regions of (hypoemotional) Roman high- and (hyperemotional) low-avoidance rats. 1998 Eur. J. Pharmacol. pmid:9726635
Andressen C et al. Beta1 integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons. 1998 Neurosci. Lett. pmid:9726369
Meshul CK et al. Cocaine-induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens. 1998 Synapse pmid:9723791
Bubser M et al. Disinhibition of the mediodorsal thalamus induces fos-like immunoreactivity in both pyramidal and GABA-containing neurons in the medial prefrontal cortex of rats, but does not affect prefrontal extracellular GABA levels. 1998 Synapse pmid:9723785
Dewey SL et al. A novel strategy for the treatment of cocaine addiction. 1998 Synapse pmid:9723781
Rando RR and Bangerter FW The irreversible inhibition of mouse brain gamma-aminobutyric acid (GABA)-alpha-ketoglutaric acid transaminase by gabaculine. 1976 J. Am. Chem. Soc. pmid:972233
Bianchi L et al. The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis. 1998 Neuroscience pmid:9722150
Pearlstein E et al. Inhibitory connections between antagonistic motor neurones of the crayfish walking legs. 1998 J. Comp. Neurol. pmid:9721906
Ghaemi SN et al. Gabapentin treatment of mood disorders: a preliminary study. 1998 J Clin Psychiatry pmid:9721823
Brown MJ et al. Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment. 1998 J. Neurochem. pmid:9721749
Guezennec CY et al. Effects of prolonged exercise on brain ammonia and amino acids. 1998 Int J Sports Med pmid:9721055
Jones NM et al. Type I and II metabotropic glutamate receptors regulate the outflow of [3H]D-aspartate and [14C]gamma-aminobutyric acid in rat solitary nucleus. 1998 Eur. J. Pharmacol. pmid:9721038
Opacka-Juffry J et al. Modulatory effects of L-DOPA on D2 dopamine receptors in rat striatum, measured using in vivo microdialysis and PET. 1998 J Neural Transm pmid:9720967
Li D Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues. 1998 Hokkaido Igaku Zasshi pmid:9719948
Charara A and Parent A Chemoarchitecture of the primate dorsal raphe nucleus. 1998 J. Chem. Neuroanat. pmid:9719363
Tunnicliff G et al. Brain gamma-aminobutyric acid metabolism and behaviour in the mouse and rat. 1976 Gen. Pharmacol. pmid:971801
Witten JL and Truman JW Distribution of GABA-like immunoreactive neurons in insects suggests lineage homology. 1998 J. Comp. Neurol. pmid:9717706
Wise RA Drug-activation of brain reward pathways. 1998 Jun-Jul Drug Alcohol Depend pmid:9716927
Mahanty NK and Sah P Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. 1998 Nature pmid:9716132
Baulac M et al. Severe visual-field constriction and side-effects of GABA-mimetic antiepileptic agents. 1998 Lancet pmid:9716066
pmid:9715219
Zhu WJ et al. Lanthanum-mediated modification of GABAA receptor deactivation, desensitization and inhibitory synaptic currents in rat cerebellar neurons. 1998 J. Physiol. (Lond.) pmid:9714849
Gidal BE et al. Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy. 1998 Epilepsy Res. pmid:9714500
Meza G Gaba as an afferent neurotransmitter in the vestibular sensory periphery of vertebrates. 1998 Neurobiology (Bp) pmid:9713835
Marder M et al. Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry. 1998 Biochem. Biophys. Res. Commun. pmid:9712722
Chieng B and Williams JT Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal. 1998 J. Neurosci. pmid:9712672
Ferraro L et al. The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop. 1998 J. Neurosci. pmid:9712666
Kawaguchi Y and Shindou T Noradrenergic excitation and inhibition of GABAergic cell types in rat frontal cortex. 1998 J. Neurosci. pmid:9712665
Benson DL and Tanaka H N-cadherin redistribution during synaptogenesis in hippocampal neurons. 1998 J. Neurosci. pmid:9712659
Park D and Dunlap K Dynamic regulation of calcium influx by G-proteins, action potential waveform, and neuronal firing frequency. 1998 J. Neurosci. pmid:9712647
Ratnaraj N and Patsalos PN A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum. 1998 Ther Drug Monit pmid:9712469
García-Flores E and Farías R gamma-Amino-beta-hydroxybutyric acid as add-on therapy in adult patients with severe focal epilepsy. 1997 Stereotact Funct Neurosurg pmid:9711762
Yamashiro K et al. Characteristics of neurons with high-frequency discharge in the central nervous system and their relationship to chronic pain. Experimental and clinical investigations. 1997 Stereotact Funct Neurosurg pmid:9711708
Meyerson BA et al. Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy. 1997 Stereotact Funct Neurosurg pmid:9711706
Hilgemann DW and Lu CC Giant membrane patches: improvements and applications. 1998 Meth. Enzymol. pmid:9711613
Csernus VJ et al. Dynamic insulin secretion from perifused rat pancreatic islets. 1998 Cell. Mol. Life Sci. pmid:9711240
Kuzniecky R et al. Topiramate increases cerebral GABA in healthy humans. 1998 Neurology pmid:9710056
Khan OA Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. 1998 Neurology pmid:9710050
Solaro C et al. An open-label trial of gabapentin treatment of paroxysmal symptoms in multiple sclerosis patients. 1998 Neurology pmid:9710049
Dinkel K et al. Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome. 1998 Ann. Neurol. pmid:9708541
Malizia AL et al. Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. 1998 Arch. Gen. Psychiatry pmid:9707382
Wohlrab G et al. Vigabatrin as a first-line drug in West syndrome: clinical and electroencephalographic outcome. 1998 Neuropediatrics pmid:9706623
Engelborghs S et al. Behavioral effects of vigabatrin correlated with whole brain gamma-aminobutyric acid metabolism in audiogenic sensitive rats. 1998 Arzneimittelforschung pmid:9706369
Williams SR et al. The dynamics of synchronized neurotransmitter release determined from compound spontaneous IPSCs in rat dentate granule neurones in vitro. 1998 J. Physiol. (Lond.) pmid:9705998
Nicoll RA and Malenka RC A tale of two transmitters. 1998 Science pmid:9705712
Walther C and Zittlau KE Resting membrane properties of locust muscle and their modulation II. Actions of the biogenic amine octopamine. 1998 J. Neurophysiol. pmid:9705469
Trombley PQ Selective modulation of GABAA receptors by aluminum. 1998 J. Neurophysiol. pmid:9705466
Shoji Y et al. Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat. 1998 J. Neurophysiol. pmid:9705457
Khvotchev M and Südhof TC Newly synthesized phosphatidylinositol phosphates are required for synaptic norepinephrine but not glutamate or gamma-aminobutyric acid (GABA) release. 1998 J. Biol. Chem. pmid:9705272
Akopian VP et al. [Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis]. 1998 May-Jun Vopr. Med. Khim. pmid:9703626
Hashimoto T [GABA receptor chloride ion channel]. 1998 Nippon Rinsho pmid:9702060
Ishihara K et al. Ethanol reduces spontaneous firing and potentiates GABA-induced currents in acutely dissociated rat medial vestibular nucleus neurons. 1998 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:9702003
George B and Kulkarni SK Protective effect of clozapine against pentylenetetrazol convulsions and kindling. 1998 Methods Find Exp Clin Pharmacol pmid:9701777