4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ozbek Z et al. | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. | 2017 | Turk Neurosurg | pmid:27759874 |
El-Habr EA et al. | A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. | 2017 | Acta Neuropathol. | pmid:28032215 |
Moghbelinejad S et al. | The effects of quercetin on the gene expression of the GABA receptor α5 subunit gene in a mouse model of kainic acid-induced seizure. | 2017 | J Physiol Sci | pmid:27743178 |
Xu Z et al. | From the Cover: Functional Analysis Reveals Glutamate and Gamma-Aminobutyric Acid-Gated Chloride Channels as Targets of Avermectins in the Carmine Spider Mite. | 2017 | Toxicol. Sci. | pmid:27742867 |
Xie M et al. | Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury. | 2017 | Chem. Biol. Interact. | pmid:28456544 |
Rowlands BD et al. | Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation. | 2017 | J. Neurochem. | pmid:27925207 |
Kaufmann D et al. | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. | 2017 | Pharmacol. Res. | pmid:27890817 |
Roberts LD et al. | Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release. | 2017 | Diabetes | pmid:28028076 |
Li Z et al. | Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy. | 2017 | Neurosci Bull | pmid:28161868 |
Beydemir Åž and Demir Y | Antiepileptic drugs: Impacts on human serum paraoxonase-1. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28032682 |
Silva VO et al. | Oral microbe-host interactions: influence of β-glucans on gene expression of inflammatory cytokines and metabolome profile. | 2017 | BMC Microbiol. | pmid:28270109 |
Malongane F et al. | The synergistic potential of various teas, herbs and therapeutic drugs in health improvement: a review. | 2017 | J. Sci. Food Agric. | pmid:28585285 |
Daghestani MH et al. | The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene. | 2017 | Biomed. Pharmacother. | pmid:28622594 |
Khongrum J and Wattanathorn J | Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism. | 2017 | J Acupunct Meridian Stud | pmid:28889839 |
Lee NK and Paik HD | Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds. | 2017 | J. Microbiol. Biotechnol. | pmid:28297748 |
Androsova G et al. | Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. | 2017 | Epilepsia | pmid:28857179 |
Moradi-Afrapoli F et al. | HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor Assay. | 2017 | Planta Med. | pmid:28511229 |
Nevitt SJ et al. | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. | 2017 | Cochrane Database Syst Rev | pmid:28661008 |
He A et al. | Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. | 2017 | J Headache Pain | pmid:28220376 |
Lin M et al. | Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems. | 2017 | Molecules | pmid:28362353 |
Cantaut-Belarif Y et al. | Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord. | 2017 | J. Cell Biol. | pmid:28716844 |
Turner DP et al. | Using a graphical risk tool to examine willingness to take migraine prophylactic medications. | 2016 | Pain | pmid:27820159 |
Smetana KS et al. | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. | 2016 | J Crit Care | pmid:27546759 |
Wang C et al. | Succinic Semialdehyde Promotes Prosurvival Capability of Agrobacterium tumefaciens. | 2016 | J. Bacteriol. | pmid:26755630 |
Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
Simm B et al. | Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus. | 2016 | Neuroscience | pmid:26608124 |
Ikarashi Y and Mizoguchi K | Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. | 2016 | Pharmacol. Ther. | pmid:27373856 |
Lai EC et al. | Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. | 2016 | Medicine (Baltimore) | pmid:27583857 |
Chinnici F et al. | Discrimination of some European vinegars with protected denomination of origin as a function of their amino acid and biogenic amine content. | 2016 | J. Sci. Food Agric. | pmid:26676828 |
Motoyama K et al. | Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells. | 2016 | Biol. Pharm. Bull. | pmid:27601082 |
Wongsamitkul N et al. | Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors. | 2016 | J. Biol. Chem. | pmid:27382064 |
Deligiannidis KM et al. | Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression. | 2016 | Psychoneuroendocrinology | pmid:27209438 |
Olexová L et al. | Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. | 2016 | Neurosci. Lett. | pmid:27353514 |
Setoyama D et al. | Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis. | 2016 | PLoS ONE | pmid:27984586 |
Donvito G et al. | Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27608657 |
Martin BS et al. | Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. | 2016 | J. Neurosci. Res. | pmid:26308557 |
Wang L et al. | Metabolic Responses of Poplar to Apripona germari (Hope) as Revealed by Metabolite Profiling. | 2016 | Int J Mol Sci | pmid:27331808 |
Aseervatham GS et al. | Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. | 2016 | Biomed. Pharmacother. | pmid:27470339 |
Kantrowitz JT et al. | d-Cycloserine, an NMDA Glutamate Receptor Glycine Site Partial Agonist, Induces Acute Increases in Brain Glutamate Plus Glutamine and GABA Comparable to Ketamine. | 2016 | Am J Psychiatry | pmid:27903101 |
Piplani S et al. | Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid. | 2016 | Biomed. Pharmacother. | pmid:27261619 |
Vazquez-DeRose J et al. | Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. | 2016 | Brain Struct Funct | pmid:25431268 |
Tessarin P et al. | Influence of canopy-applied chitosan on the composition of organic cv. Sangiovese and Cabernet Sauvignon berries and wines. | 2016 | Food Chem | pmid:27211677 |
Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
Mettang T | Uremic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578082 |
Vanya M et al. | [Preconceptional and perinatal challenges of pregnancy in women with epilepsy]. | 2016 | Orv Hetil | pmid:27039994 |
Dadsetan S et al. | Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy. | 2016 | J Neuroinflammation | pmid:27623772 |
Volk DW and Lewis DA | The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. | 2016 | Biol. Psychiatry | pmid:26210060 |
Groundwater PW et al. | The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. | 2015 | J Pharm Pharm Sci | pmid:26626239 |
Lee KH et al. | Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus. | 2015 | J. Neurosci. | pmid:26674872 |
Wang H et al. | Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. | 2015 | Cell Rep | pmid:26365195 |