4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Ozbek Z et al. Neuroprotective Effect of Genistein in Peripheral Nerve Injury. 2017 Turk Neurosurg pmid:27759874
El-Habr EA et al. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. 2017 Acta Neuropathol. pmid:28032215
Moghbelinejad S et al. The effects of quercetin on the gene expression of the GABA receptor α5 subunit gene in a mouse model of kainic acid-induced seizure. 2017 J Physiol Sci pmid:27743178
Xu Z et al. From the Cover: Functional Analysis Reveals Glutamate and Gamma-Aminobutyric Acid-Gated Chloride Channels as Targets of Avermectins in the Carmine Spider Mite. 2017 Toxicol. Sci. pmid:27742867
Xie M et al. Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury. 2017 Chem. Biol. Interact. pmid:28456544
Rowlands BD et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation. 2017 J. Neurochem. pmid:27925207
Kaufmann D et al. sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. 2017 Pharmacol. Res. pmid:27890817
Roberts LD et al. Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release. 2017 Diabetes pmid:28028076
Li Z et al. Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy. 2017 Neurosci Bull pmid:28161868
Beydemir Åž and Demir Y Antiepileptic drugs: Impacts on human serum paraoxonase-1. 2017 J. Biochem. Mol. Toxicol. pmid:28032682
Silva VO et al. Oral microbe-host interactions: influence of β-glucans on gene expression of inflammatory cytokines and metabolome profile. 2017 BMC Microbiol. pmid:28270109
Malongane F et al. The synergistic potential of various teas, herbs and therapeutic drugs in health improvement: a review. 2017 J. Sci. Food Agric. pmid:28585285
Daghestani MH et al. The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene. 2017 Biomed. Pharmacother. pmid:28622594
Khongrum J and Wattanathorn J Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism. 2017 J Acupunct Meridian Stud pmid:28889839
Lee NK and Paik HD Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds. 2017 J. Microbiol. Biotechnol. pmid:28297748
Androsova G et al. Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 2017 Epilepsia pmid:28857179
Moradi-Afrapoli F et al. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor Assay. 2017 Planta Med. pmid:28511229
Nevitt SJ et al. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. 2017 Cochrane Database Syst Rev pmid:28661008
He A et al. Unveiling the relative efficacy, safety and tolerability of prophylactic medications for migraine: pairwise and network-meta analysis. 2017 J Headache Pain pmid:28220376
Lin M et al. Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems. 2017 Molecules pmid:28362353
Cantaut-Belarif Y et al. Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord. 2017 J. Cell Biol. pmid:28716844
Turner DP et al. Using a graphical risk tool to examine willingness to take migraine prophylactic medications. 2016 Pain pmid:27820159
Smetana KS et al. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. 2016 J Crit Care pmid:27546759
Wang C et al. Succinic Semialdehyde Promotes Prosurvival Capability of Agrobacterium tumefaciens. 2016 J. Bacteriol. pmid:26755630
Åžavk E Neurologic Itch Management. 2016 Curr. Probl. Dermatol. pmid:27578080
Simm B et al. Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus. 2016 Neuroscience pmid:26608124
Ikarashi Y and Mizoguchi K Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. 2016 Pharmacol. Ther. pmid:27373856
Lai EC et al. Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. 2016 Medicine (Baltimore) pmid:27583857
Chinnici F et al. Discrimination of some European vinegars with protected denomination of origin as a function of their amino acid and biogenic amine content. 2016 J. Sci. Food Agric. pmid:26676828
Motoyama K et al. Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells. 2016 Biol. Pharm. Bull. pmid:27601082
Wongsamitkul N et al. Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors. 2016 J. Biol. Chem. pmid:27382064
Deligiannidis KM et al. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression. 2016 Psychoneuroendocrinology pmid:27209438
Olexová L et al. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. 2016 Neurosci. Lett. pmid:27353514
Setoyama D et al. Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis. 2016 PLoS ONE pmid:27984586
Donvito G et al. Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice. 2016 J. Pharmacol. Exp. Ther. pmid:27608657
Martin BS et al. Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. 2016 J. Neurosci. Res. pmid:26308557
Wang L et al. Metabolic Responses of Poplar to Apripona germari (Hope) as Revealed by Metabolite Profiling. 2016 Int J Mol Sci pmid:27331808
Aseervatham GS et al. Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. 2016 Biomed. Pharmacother. pmid:27470339
Kantrowitz JT et al. d-Cycloserine, an NMDA Glutamate Receptor Glycine Site Partial Agonist, Induces Acute Increases in Brain Glutamate Plus Glutamine and GABA Comparable to Ketamine. 2016 Am J Psychiatry pmid:27903101
Piplani S et al. Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid. 2016 Biomed. Pharmacother. pmid:27261619
Vazquez-DeRose J et al. Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. 2016 Brain Struct Funct pmid:25431268
Tessarin P et al. Influence of canopy-applied chitosan on the composition of organic cv. Sangiovese and Cabernet Sauvignon berries and wines. 2016 Food Chem pmid:27211677
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
Mettang T Uremic Itch Management. 2016 Curr. Probl. Dermatol. pmid:27578082
Vanya M et al. [Preconceptional and perinatal challenges of pregnancy in women with epilepsy]. 2016 Orv Hetil pmid:27039994
Dadsetan S et al. Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy. 2016 J Neuroinflammation pmid:27623772
Volk DW and Lewis DA The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. 2016 Biol. Psychiatry pmid:26210060
Luca G et al. Central and peripheral metabolic changes induced by gamma-hydroxybutyrate. 2015 Sleep pmid:25515097
Tao W et al. Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. 2015 Mol. Pharmacol. pmid:25852071
Trotti LM et al. Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. 2015 Ann. Neurol. pmid:26094838
Cui SQ et al. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. 2015 Braz. J. Med. Biol. Res. pmid:25831201
Kardamakis AA et al. Tectal microcircuit generating visual selection commands on gaze-controlling neurons. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25825743
Zhao W et al. A study on quality components and sleep-promoting effects of GABA black tea. 2015 Food Funct pmid:26290415
Bönnighausen J et al. Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum. 2015 Mol. Microbiol. pmid:26305050
Mirabella R et al. WRKY40 and WRKY6 act downstream of the green leaf volatile E-2-hexenal in Arabidopsis. 2015 Plant J. pmid:26243404
Alatorre A et al. The local application of a flavonoid, (-)-epicatechin, increases the spiking of globus pallidus neurons in a dose-dependent manner and diminishes the catalepsy induced by haloperidol. 2015 Behav Pharmacol pmid:25503260
Groundwater PW et al. The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. 2015 J Pharm Pharm Sci pmid:26626239
Lee KH et al. Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus. 2015 J. Neurosci. pmid:26674872
Sikoglu EM et al. Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders. 2015 J Child Adolesc Psychopharmacol pmid:26091195
Yan X et al. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. 2015 J Neuroinflammation pmid:25571780
Montserrat-de la Paz S et al. Validation and additional support for an experimental animal model of fibromyalgia. 2015 Mod Rheumatol pmid:24983406
Villumsen IS et al. Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. 2015 BMC Neurosci pmid:25887256
Brown AR et al. Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones. 2015 J. Physiol. (Lond.) pmid:25556800
Sabaliauskas N et al. Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse. 2015 Brain Res. pmid:25542386
Chen B et al. Cosmetic side effects of antiepileptic drugs in adults with epilepsy. 2015 Epilepsy Behav pmid:25513768
Ordoñez L et al. Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs. 2015 Eur Rev Med Pharmacol Sci pmid:26221907
Zhang Y et al. Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. 2015 J. Neurochem. pmid:25314677
Wang H et al. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. 2015 Cell Rep pmid:26365195
Hieda K et al. Pharmacological effect of functional foods with a hypotensive action. 2015 Nippon Yakurigaku Zasshi pmid:26165340
Lee SH et al. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. 2015 J. Neurosci. pmid:26157003
Mettang T and Kremer AE Uremic pruritus. 2015 Kidney Int. pmid:24402092
Inkpen H Chronic progressive polyarthritis in a domestic shorthair cat. 2015 Can. Vet. J. pmid:26028686
Kumar A et al. Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations. 2014 May-Jun Indian J Pharmacol pmid:24987179
Rizk NN et al. Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis. 2014 May-Jun Pain Physician pmid:24850125
Guptill JT et al. Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy. 2014 Muscle Nerve pmid:24639235
Thompson AJ et al. Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. 2014 Biochemistry pmid:25238029
Tyzio R et al. Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. 2014 Science pmid:24503856
Deeb S et al. Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases. 2014 J Anal Toxicol pmid:25217536
Ari C et al. Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. 2014 PLoS ONE pmid:25061944
Cusmano DM and Mong JA In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism. 2014 Sleep pmid:25142574
Peng Q et al. Activation of gab cluster transcription in Bacillus thuringiensis by γ-aminobutyric acid or succinic semialdehyde is mediated by the Sigma 54-dependent transcriptional activator GabR. 2014 BMC Microbiol. pmid:25527261
Park SA et al. Kinetic characterization and molecular modeling of NAD(P)(+)-dependent succinic semialdehyde dehydrogenase from Bacillus subtilis as an ortholog YneI. 2014 J. Microbiol. Biotechnol. pmid:24809290
Tarhonskaya H et al. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. 2014 Nat Commun pmid:24594748
Kang YM et al. Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 2014 Toxicol. Appl. Pharmacol. pmid:24342267
Bailey JN et al. Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. 2014 Hum. Genet. pmid:25037249
West S and Kenedi C Strategies to prevent the neuropsychiatric side-effects of corticosteroids: a case report and review of the literature. 2014 Curr Opin Organ Transplant pmid:24553497
Mititelu Tartau L et al. Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. 2014 Pharmacology pmid:25059844
Pollock E et al. Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis. 2014 Neurobiol. Dis. pmid:24946277
Blake CB and Smith BN cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24990858
Liu ZP et al. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. 2014 Mol Brain pmid:24758222
Ikeda K et al. Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care. 2014 Biomed. Chromatogr. pmid:24889681
Mennerick S et al. Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. 2014 Psychopharmacology (Berl.) pmid:24553581
Melis M et al. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. 2014 J. Neurosci. pmid:25232109
Naito A et al. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. 2014 Mol. Pharmacol. pmid:25245406
Pava MJ et al. Endocannabinoid modulation of cortical up-states and NREM sleep. 2014 PLoS ONE pmid:24520411
Kumamaru E et al. Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons. 2014 Neurosci. Lett. pmid:24708928
Wilkins HM et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. 2014 Hum. Mol. Genet. pmid:25027327
Baniasadi M et al. Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. 2014 J Psychiatr Pract pmid:25406046
Gassel M et al. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. 2014 Insect Biochem. Mol. Biol. pmid:24365472
Marahatta A et al. Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study. 2014 Sci Rep pmid:24618639