4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
pmid:
Curtis DR et al. Central actions of benzodiazepines. 1976 Brain Res. pmid:1000299
Maitre M et al. In vitro studies into the effect of inhibition of rat brain succinic semialdehyde dehydrogenase on GABA synthesis and degradation. 1976 FEBS Lett. pmid:1001470
Kovalev GV et al. [Analysis of the ganglionic action of gamma-aminobutyric acid and its derivatives]. 1976 Jul-Aug Fiziol Zh pmid:1001539
Mitchell JF Release of physiologically active amino acids from intact brain and spinal-cord preparations. 1976 Biochem. Soc. Trans. pmid:1001605
Fisher SK and Davies WE 4-Aminobutyric acid in the mammalian cochlear nucleus. 1976 Biochem. Soc. Trans. pmid:1001676
Wenk M et al. Partial separation of synaptosomes accumulating 4-aminobutyrate or glutamate by zonal centrifugation on a discontinuous sucrose gradient. 1976 Hoppe-Seyler's Z. Physiol. Chem. pmid:1002126
Guirado S et al. Nucleus accumbens in the lizard Psammodromus algirus: chemoarchitecture and cortical afferent connections. 1999 J. Comp. Neurol. pmid:10022193
Tobet SA et al. Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. 1999 J. Comp. Neurol. pmid:10022198
Kushnir MM et al. Analysis of gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring. 1999 Jan-Feb J Anal Toxicol pmid:10022201
Albuquerque EX et al. Neuronal nicotinic receptors modulate synaptic function in the hippocampus and are sensitive to blockade by the convulsant strychnine and by the anti-Parkinson drug amantadine. 1998 Toxicol. Lett. pmid:10022256
Pitkänen A et al. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus. 1999 Epilepsy Res. pmid:10022367
Pérez-Cerdá F et al. Postnatal development of perisomatic GABAergic axon terminals on neurons projecting from area 17 to area 18 of the cat visual cortex. 1999 Jan-Feb Vis. Neurosci. pmid:10022476
Osborne NN Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia. 1999 Jan-Feb Vis. Neurosci. pmid:10022477
Napper GA et al. Reduced glutamate uptake by retinal glial cells under ischemic/hypoxic conditions. 1999 Jan-Feb Vis. Neurosci. pmid:10022486
Nelson R et al. Distribution of GABA(C)-like responses among acutely dissociated rat retinal neurons. 1999 Jan-Feb Vis. Neurosci. pmid:10022489
Reiriz J et al. Bone morphogenetic protein-2 promotes dissociated effects on the number and differentiation of cultured ventral mesencephalic dopaminergic neurons. 1999 J. Neurobiol. pmid:10022564
Torrealba F and Müller C Ultrastructure of glutamate and GABA immunoreactive axon terminals of the rat nucleus tractus solitarius, with a note on infralimbic cortex afferents. 1999 Brain Res. pmid:10023027
Langan Y et al. An audit of the perceived efficacy and tolerability of gabapentin therapy in an out-patient cohort with chronic epilepsy. 1999 Eur. Neurol. pmid:10023116
Blanchet F et al. Role of arachidonic acid in the regulation of the NMDA-evoked release of acetylcholine in striatal compartments. 1999 Synapse pmid:10024011
Ashby CR et al. Implication of the GABA(B) receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine. 1999 Synapse pmid:10024012
Pouzat C and Marty A Somatic recording of GABAergic autoreceptor current in cerebellar stellate and basket cells. 1999 J. Neurosci. pmid:10024354
Norekian TP GABAergic excitatory synapses and electrical coupling sustain prolonged discharges in the prey capture neural network of Clione limacina. 1999 J. Neurosci. pmid:10024370
Pérez de la Mora M et al. Effects of the vigilance promoting drug modafinil on the synthesis of GABA and glutamate in slices of rat hypothalamus. 1999 Neurosci. Lett. pmid:10025588
Shen J et al. In vivo chemical shift imaging of gamma-aminobutyric acid in the human brain. 1999 Magn Reson Med pmid:10025609
Dewey SL et al. A pharmacologic strategy for the treatment of nicotine addiction. 1999 Synapse pmid:10025686
Mathern GW et al. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. 1999 Neurology pmid:10025773
Petroff OA et al. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. 1999 Neurology pmid:10025774
Jovanović K et al. Localization and modulation of rhythmogenic locomotor network in the mudpuppy (Necturus maculatus). 1998 Ann. N. Y. Acad. Sci. pmid:10026083
Pilch DS et al. The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA. 1999 Biochemistry pmid:10026298
Tasker JG et al. Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei. 1998 Adv. Exp. Med. Biol. pmid:10026791
Thomas A and Amico JA Progesterone regulates hypothalamic oxytocin mRNA levels through gamma aminobutyric acid. 1998 Adv. Exp. Med. Biol. pmid:10026792
Wilke RA et al. Membrane excitability in the neurohypophysis. 1998 Adv. Exp. Med. Biol. pmid:10026805
Abe M and Matsuda M A correlation between changes in gamma-aminobutyric acid metabolism and seizures induced by antivitamin B6. 1976 J. Biochem. pmid:1002683
Pan HL et al. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. 1999 J. Pharmacol. Exp. Ther. pmid:10027839
Nomura M et al. Novel characteristic for distinguishing Lactococcus lactis subsp. lactis from subsp. cremoris. 1999 Int. J. Syst. Bacteriol. pmid:10028257
Rocha ES et al. An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats. 1998 Drug Chem Toxicol pmid:10028411
Patte C et al. GABA inhibits endozepine release from cultured rat astrocytes. 1999 Glia pmid:10028922
Bird M and Owen A Neurite outgrowth-regulating properties of GABA and the effect of serum on mouse spinal cord neurons in culture. 1998 J. Anat. pmid:10029183
Renno WM et al. Quantitative immunoelectron microscopic colocalization of GABA and enkephalin in the ventrocaudal periaqueductal gray of the rat. 1999 Synapse pmid:10029240
Ylinen A Antiepileptic efficacy of vigabatrin in people with severe epilepsy and intellectual disability. 1998 J Intellect Disabil Res pmid:10030432
Mikati MA et al. Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability. 1998 J Intellect Disabil Res pmid:10030434
Corrigall WA et al. Electrophysiological studies of fetal mouse olifactory bulb explants during development of synaptic functions in culture. 1976 J. Neurobiol. pmid:1003199
Perry TL and Hansen S Is GABA detectable in human CSF? 1976 J. Neurochem. pmid:1003229
Lodge D et al. The uptake of GABA and beta-alanine in slices of cat and rat CNS tissue: regional differences in susceptibility to inhibitors. 1976 J. Neurochem. pmid:1003233
Lake N and Voaden MJ Exchange versus net uptake of exogenously-applied gamma-aminobutyric acid in retina. 1976 J. Neurochem. pmid:1003234
Dumoulin A et al. Presence of the vesicular inhibitory amino acid transporter in GABAergic and glycinergic synaptic terminal boutons. 1999 J. Cell. Sci. pmid:10036231
Tredway TL et al. N-type voltage-dependent calcium channels mediate the nicotinic enhancement of GABA release in chick brain. 1999 J. Neurophysiol. pmid:10036250
Hirose N et al. Effects of propofol and fentanyl on extracellular levels of gamma-aminobutyric acid in the rat nucleus accumbens: an in vivo microdialysis study. 1998 J Oral Sci pmid:10036830
Sellstrom A et al. Functional assessment of GABA uptake or exchange by synaptosomal fractions. 1976 Nature pmid:1004608