4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with 4-aminobutyric acid?

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What functions are associated with 4-aminobutyric acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Scharfman HE and MacLusky NJ Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. 2014 Neuropharmacology pmid:23660230
Zhu Y et al. Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats. 2014 Neuroscience pmid:24135545
Vashchinkina E et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. 2014 Neuropsychopharmacology pmid:24077066
Mango D et al. Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions. 2014 Neuropharmacology pmid:23973317
Chukwu J et al. Weight change, genetics and antiepileptic drugs. 2014 Expert Rev Clin Pharmacol pmid:24308788
Dambach H et al. Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. 2014 Epilepsia pmid:24299259
Chou HT et al. Functional characterization of the agtABCD and agtSR operons for 4-aminobutyrate and 5-aminovalerate uptake and regulation in Pseudomonas aeruginosa PAO1. 2014 Curr. Microbiol. pmid:23982201
Sancheti H et al. Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. 2014 J. Cereb. Blood Flow Metab. pmid:24220168
Di Giorgio NP et al. Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. 2014 Endocrinology pmid:24424047
Vanelderen P et al. Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. 2013 Mar-Apr Reg Anesth Pain Med pmid:23337936
Zhang Y et al. Correlation of domestic violence during pregnancy with plasma amino-acid neurotransmitter, cortisol levels and catechol-o-methyltransferase Val(158)Met polymorphism in neonates. 2013 Asia Pac Psychiatry pmid:23857785
Summa M et al. Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. 2013 Neuropharmacology pmid:22564442
Nihei S et al. [Efficacy and safety of pregabalin for oxaliplatin- and paclitaxel-induced peripheral neuropathy]. 2013 Gan To Kagaku Ryoho pmid:24047777
Casas S et al. Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease. 2013 Neurol. Res. pmid:23561326
Platt SR et al. Effect of treatment with simvastatin and cyclosporine on neurotransmitter concentrations in cerebrospinal fluid after subarachnoid hemorrhage in dogs. 2013 Am. J. Vet. Res. pmid:23879849
Tian Z et al. Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress. 2013 Psychoneuroendocrinology pmid:23669322
Omole F et al. Easing the burden of premenstrual dysphoric disorder. 2013 J Fam Pract pmid:23326823
Rapinesi C et al. Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. 2013 Brain Inj pmid:23782232
de Souza LM and Franci CR Differential immunoreactivity of glucocorticoid receptor and GABA in GABAergic afferents to parvocellular neurons in the paraventricular nucleus. 2013 Neurosci. Lett. pmid:23276637
Anneken JH et al. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. 2013 J Neuroimmune Pharmacol pmid:23179355
Giuliani FA et al. Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3α-hydroxysteroid oxidoreductase in the hypothalamus of female rats. 2013 Neuroscience pmid:23562943
Egashira N et al. Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system. 2013 Psychopharmacology (Berl.) pmid:23086022
Inoue M et al. Regulation of α3-containing GABAA receptors in guinea-pig adrenal medullary cells by adrenal steroids. 2013 Neuroscience pmid:24012744
Lee CY et al. Relationship between adiponectin and leptin, and blood lipids in hyperlipidemia patients treated with red yeast rice. 2013 Forsch Komplementmed pmid:23860021
Forni S et al. Quantitation of gamma-hydroxybutyric acid in dried blood spots: feasibility assessment for newborn screening of succinic semialdehyde dehydrogenase (SSADH) deficiency. 2013 Mol. Genet. Metab. pmid:23742746
Esser D et al. Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus. 2013 Extremophiles pmid:23296511
Beigi M et al. TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation. 2013 Org. Lett. pmid:23317369
Vogensen SB et al. New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. 2013 J. Med. Chem. pmid:24053696
Huehnchen P et al. Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice. 2013 PLoS ONE pmid:24143194
Choi C et al. A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors. 2013 NMR Biomed pmid:23592268
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
McNamara RK et al. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. 2013 Nutr Neurosci pmid:23582513
Owada K [Therapeuetic aspects of cluster headache in the practical clinical site]. 2013 Rinsho Shinkeigaku pmid:24291904
Prud'homme GJ et al. GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. 2013 Transplantation pmid:23851932
Higgins A et al. Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids. 2013 Mol Pain pmid:23725095
Lin JN et al. Chemical constituents and anticancer activity of yellow camellias against MDA-MB-231 human breast cancer cells. 2013 J. Agric. Food Chem. pmid:24001127
Reddy K et al. SGE-102: a novel therapy for refractory status epilepticus. 2013 Epilepsia pmid:24001082
Liu J et al. Pharmacological treatment for pain in Guillain-Barré syndrome. 2013 Cochrane Database Syst Rev pmid:24142399
Han B et al. Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. 2013 Anal. Biochem. pmid:23044255
Michelson JD et al. Multimodal analgesia therapy reduces length of hospitalization in patients undergoing fusions of the ankle and hindfoot. 2013 Foot Ankle Int pmid:23836812
Nizeica V et al. Bortezomib induced a phrenic palsy in a multiple myeloma patient. 2013 Ann. Hematol. pmid:23370597
Dionisio L et al. GABAA receptor plasticity in Jurkat T cells. 2013 Biochimie pmid:24012548
Derbenev AV and Smith BN Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity. 2013 PLoS ONE pmid:23936221
Fraccaro E et al. A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin Eâ‚‚ levels in calves undergoing dehorning. 2013 Res. Vet. Sci. pmid:23434065
Hasan A et al. Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors. 2013 Eur Arch Psychiatry Clin Neurosci pmid:23381549
Kanbayashi Y et al. Statistical identification of predictors for paclitaxel-induced peripheral neuropathy in patients with breast or gynaecological cancer. 2013 Anticancer Res. pmid:23482795
Kostić N et al. Effects of derivatization reagents consisting of n-alkyl chloroformate/n-alcohol combinations in LC-ESI-MS/MS analysis of zwitterionic antiepileptic drugs. 2013 Talanta pmid:24148378
Baglo Y et al. Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy. 2013 PLoS ONE pmid:23762315
Gialanella B et al. Low back pain radiating to the leg: an atypical cause. 2013 Clin Ter pmid:24217828
Rajak H et al. Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity. 2013 Bioorg. Med. Chem. Lett. pmid:23265873
Arora DS et al. Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. 2013 Neuropsychopharmacology pmid:23474591
Shamsi Meymandi M and Keyhanfar F Assessment of the antinociceptive effects of pregabalin alone or in combination with morphine during acetic acid-induced writhing in mice. 2013 Pharmacol. Biochem. Behav. pmid:23921185
Muhammad SI et al. Upregulation of genes related to bone formation by γ-amino butyric acid and γ-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats. 2013 Clin Interv Aging pmid:24098073
Koo J and Zavras A Antiepileptic drugs (AEDs) during pregnancy and risk of congenital jaw and oral malformation. 2013 Oral Dis pmid:23305414
Jang HJ et al. Layer- and cell-type-specific tonic GABAergic inhibition of pyramidal neurons in the rat visual cortex. 2013 Pflugers Arch. pmid:23812164
Shamsi Meymandi M and Keyhanfar F Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. 2013 Can J Anaesth pmid:23132044
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Das UN Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. 2013 Nutrition pmid:23911220
Owusu-Ware SK et al. Novel analytical approaches for the study of mobility and relaxation phenomena in positional isomers of GABA. 2013 Phys Chem Chem Phys pmid:24154789
Jin Z et al. Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons. 2013 Planta Med. pmid:23975867
Thangamani D et al. The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents. 2013 ScientificWorldJournal pmid:24385872
Nakane S et al. Successful treatment of stiff person syndrome with sequential use of tacrolimus. 2013 J. Neurol. Neurosurg. Psychiatr. pmid:23715915
Siebel AM et al. Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. 2013 Pharmacol. Biochem. Behav. pmid:23287800
Guo H et al. Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. 2013 Bioorg. Med. Chem. Lett. pmid:24018188
Bhattarai JP et al. Genistein excitation of gonadotrophin-releasing hormone neurones in juvenile female mice. 2013 J. Neuroendocrinol. pmid:23351167
Ganguly A and Lee D Suppression of inhibitory GABAergic transmission by cAMP signaling pathway: alterations in learning and memory mutants. 2013 Eur. J. Neurosci. pmid:23387411
Heo H et al. Upregulation of TrkB by forskolin facilitated survival of MSC and functional recovery of memory deficient model rats. 2013 Biochem. Biophys. Res. Commun. pmid:23313493
Anderson W et al. Investigation of the anxiolytic effects of naringenin, a component of Mentha aquatica, in the male Sprague-Dawley rat. 2012 Jan-Feb Holist Nurs Pract pmid:22157509
Reese EA et al. Gabapentin's minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22841517
Arapitsas P et al. A metabolomic approach to the study of wine micro-oxygenation. 2012 PLoS ONE pmid:22662221
King AM et al. 4-aminopyridine toxicity: a case report and review of the literature. 2012 J Med Toxicol pmid:22782458
Desrues L et al. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. 2012 PLoS ONE pmid:22563490
McElroy SL et al. Pharmacological management of binge eating disorder: current and emerging treatment options. 2012 Ther Clin Risk Manag pmid:22654518
Khan I et al. Hemichorea-hemiballismus as the presenting manifestation of nonketotic hyperglycemia in an adolescent with undiagnosed type 2 diabetes mellitus. 2012 Indian J Endocrinol Metab pmid:22701838
Gökcan H and Konuklar FA Theoretical study on HF elimination and aromatization mechanisms: a case of pyridoxal 5' phosphate-dependent enzyme. 2012 J. Org. Chem. pmid:22646918
Camp BW et al. High serum androstenedione levels correlate with impaired memory in the surgically menopausal rat: a replication and new findings. 2012 Eur. J. Neurosci. pmid:22758646
Cserép C et al. NMDA receptors in GABAergic synapses during postnatal development. 2012 PLoS ONE pmid:22662211
Kamal SM Combination of valproate and paroxetine in mice exposed to picrotoxin. 2012 Int J Nanomedicine pmid:22679369
Nakashima T et al. [A case of neurotoxicity reduced with pregabalin in R-CHOP chemotherapy for diffuse large B-cell lymphoma]. 2012 Gan To Kagaku Ryoho pmid:22584337
Jeelani G et al. Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation. 2012 PLoS ONE pmid:22662204
Nakashima T et al. [A case of paclitaxel-induced peripheral neuropathy successfully treated with pregabalin]. 2012 Gan To Kagaku Ryoho pmid:22996788
Rueda N et al. Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. 2012 Neural Plast. pmid:22685678
Ormerod KG et al. Cholesterol-independent effects of methyl-β-cyclodextrin on chemical synapses. 2012 PLoS ONE pmid:22590538
Sotoing Taïwe G et al. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents. 2012 J Ethnopharmacol pmid:22750453
Wang G et al. AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades. 2012 Neural Plast. pmid:22655210
Chaparro LE et al. Combination pharmacotherapy for the treatment of neuropathic pain in adults. 2012 Cochrane Database Syst Rev pmid:22786518
Newman EL et al. Cholinergic modulation of cognitive processing: insights drawn from computational models. 2012 Front Behav Neurosci pmid:22707936
Al-Harbi KS Treatment-resistant depression: therapeutic trends, challenges, and future directions. 2012 Patient Prefer Adherence pmid:22654508
Do Rego JL et al. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. 2012 Front Endocrinol (Lausanne) pmid:22654849
Kim J et al. Insect eggs can enhance wound response in plants: a study system of tomato Solanum lycopersicum L. and Helicoverpa zea Boddie. 2012 PLoS ONE pmid:22616005
Tolson KP and Chappell PE The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty. 2012 Front Endocrinol (Lausanne) pmid:22645521
Helms CM et al. Neurosteroid influences on sensitivity to ethanol. 2012 Front Endocrinol (Lausanne) pmid:22654852
Shalaby AM and Kamal SM Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. 2012 J Pharmacol Pharmacother pmid:22629087
Hansen N Action mechanisms of transcranial direct current stimulation in Alzheimer's disease and memory loss. 2012 Front Psychiatry pmid:22615703
Yu X et al. Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism. 2012 Life Sci. pmid:22634324
Davis MP Drug management of visceral pain: concepts from basic research. 2012 Pain Res Treat pmid:22619712
Ryu CH et al. Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells. 2012 J. Biomed. Biotechnol. pmid:22701311
Wani KA et al. D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons. 2012 PLoS ONE pmid:22629462
Villanueva C et al. DLK1 is a somato-dendritic protein expressed in hypothalamic arginine-vasopressin and oxytocin neurons. 2012 PLoS ONE pmid:22563444
Å vob Å trac D et al. The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats. 2012 Croat. Med. J. pmid:22661134