L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Marek Disease | D008380 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ji QQ et al. | Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. | 2017 | Nucleic Acids Res. | pmid:28575390 |
| Isozaki K et al. | Synthesis and Applications of (ONO Pincer)Ruthenium-Complex-Bound Norvalines. | 2016 | Chem Asian J | pmid:26879368 |
| Ye Q et al. | Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase. | 2015 | J. Biol. Chem. | pmid:26272616 |
| Dalal S and Klemba M | Amino acid efflux by asexual blood-stage Plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo. | 2015 | Mol. Biochem. Parasitol. | pmid:26215764 |
| Veeravalli K and Laird MW | Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli. | 2015 | Bioengineered | pmid:25801611 |
| Kuznetsov NA et al. | Pre-steady-state kinetic and structural analysis of interaction of methionine γ-lyase from Citrobacter freundii with inhibitors. | 2015 | J. Biol. Chem. | pmid:25398880 |
| Yu X et al. | The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis. | 2014 | FEBS J. | pmid:24206068 |
| Ribas de Pouplana L | Not an inside job: non-coded amino acids compromise the genetic code. | 2014 | EMBO J. | pmid:24952895 |
| Cvetesic N et al. | The physiological target for LeuRS translational quality control is norvaline. | 2014 | EMBO J. | pmid:24935946 |
| Biermann M et al. | Simultaneous analysis of the non-canonical amino acids norleucine and norvaline in biopharmaceutical-related fermentation processes by a new ultra-high performance liquid chromatography approach. | 2013 | Amino Acids | pmid:23306451 |