L-norvaline

L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with L-norvaline?

L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with L-norvaline

MeSH term MeSH ID Detail
Marek Disease D008380 4 associated lipids
Celiac Disease D002446 16 associated lipids
Kidney Diseases D007674 29 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Adenocarcinoma D000230 166 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with L-norvaline

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with L-norvaline?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with L-norvaline?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with L-norvaline?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with L-norvaline?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with L-norvaline?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with L-norvaline

Download all related citations
Per page 10 20 50 100 | Total 202
Authors Title Published Journal PubMed Link
Ji QQ et al. Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain. 2017 Nucleic Acids Res. pmid:28575390
Isozaki K et al. Synthesis and Applications of (ONO Pincer)Ruthenium-Complex-Bound Norvalines. 2016 Chem Asian J pmid:26879368
Ye Q et al. Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase. 2015 J. Biol. Chem. pmid:26272616
Dalal S and Klemba M Amino acid efflux by asexual blood-stage Plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo. 2015 Mol. Biochem. Parasitol. pmid:26215764
Veeravalli K and Laird MW Toward an era of utilizing methionine overproducing hosts for recombinant protein production in Escherichia coli. 2015 Bioengineered pmid:25801611
Kuznetsov NA et al. Pre-steady-state kinetic and structural analysis of interaction of methionine γ-lyase from Citrobacter freundii with inhibitors. 2015 J. Biol. Chem. pmid:25398880
Yu X et al. The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis. 2014 FEBS J. pmid:24206068
Ribas de Pouplana L Not an inside job: non-coded amino acids compromise the genetic code. 2014 EMBO J. pmid:24952895
Cvetesic N et al. The physiological target for LeuRS translational quality control is norvaline. 2014 EMBO J. pmid:24935946
Biermann M et al. Simultaneous analysis of the non-canonical amino acids norleucine and norvaline in biopharmaceutical-related fermentation processes by a new ultra-high performance liquid chromatography approach. 2013 Amino Acids pmid:23306451
Biermann M et al. Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation. 2013 Microb. Cell Fact. pmid:24261588
Ogata K et al. Synthesis and self-assembly of NCN-pincer Pd-complex-bound norvalines. 2013 Chemistry pmid:23907820
El-Bassossy HM et al. Arginase inhibition alleviates hypertension in the metabolic syndrome. 2013 Br. J. Pharmacol. pmid:23441715
Alvarez-Carreño C et al. Norvaline and norleucine may have been more abundant protein components during early stages of cell evolution. 2013 Orig Life Evol Biosph pmid:24013929
Zhou XL et al. Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity. 2013 Nucleic Acids Res. pmid:23969415
El-Bassossy HM et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. 2012 Nov-Dec Vascul. Pharmacol. pmid:22281732
Liebeke M et al. Metabolome analysis of gram-positive bacteria such as Staphylococcus aureus by GC-MS and LC-MS. 2012 Methods Mol. Biol. pmid:22131006
Cvetesic N et al. Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps. 2012 J. Biol. Chem. pmid:22648413
Kamal SM Combination of valproate and paroxetine in mice exposed to picrotoxin. 2012 Int J Nanomedicine pmid:22679369
Rodas PC et al. Glutamine and glutathione at ICU admission in relation to outcome. 2012 Clin. Sci. pmid:22248298
Polo LM et al. New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine. 2012 PLoS ONE pmid:22363663
Chen X et al. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. 2011 Nucleic Acids Res. pmid:20805241
Ren P et al. Understanding the molecular dynamics associated with polymorphic transitions of DL-norvaline with solid-state NMR methods. 2011 J Phys Chem B pmid:21391536
Görbitz CH Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction. 2011 J Phys Chem B pmid:21332110
Dupuis SN et al. Jadomycins derived from the assimilation and incorporation of norvaline and norleucine. 2011 J. Nat. Prod. pmid:22050382
Bailey J et al. A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. 2011 FEBS J. pmid:21749647
Smith KM and Liao JC An evolutionary strategy for isobutanol production strain development in Escherichia coli. 2011 Metab. Eng. pmid:21911074
Pokrovskiy MV et al. Arginase inhibitor in the pharmacological correction of endothelial dysfunction. 2011 Int J Hypertens pmid:21747978
Peng Y et al. A blue native-PAGE analysis of membrane protein complexes in Clostridium thermocellum. 2011 BMC Microbiol. pmid:21269440
Wacker SA et al. Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation. 2010 Protein Sci. pmid:20665690
Deshmukh M et al. A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. 2010 J. Med. Chem. pmid:20063889
Chatzigeorgiou P et al. Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy. 2010 J Phys Chem B pmid:20043648
Behnke K et al. RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis. 2010 Plant Mol. Biol. pmid:20526857
Dolensek J and Valentincic T Specificities of olfactory receptor neuron responses to amino acids in the black bullhead catfish (Ameiurus melas). 2010 Pflugers Arch. pmid:19756721
Ming XF et al. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. 2009 BMC Cardiovasc Disord pmid:19284655
Kuzma M et al. Cyclosporins from Mycelium sterilae MS 2929. 2009 J. Nat. Prod. pmid:19102681
Matthews ML et al. Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19815524
Sankaranarayanan R et al. The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. 2008 J. Mol. Biol. pmid:18062991
Vacca RA et al. Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. 2008 BMC Biochem. pmid:18565210
Tkaczuk KL et al. Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. 2007 BMC Bioinformatics pmid:17338813
Cruz C et al. Enzymatic evidence for the key role of arginine in nitrogen translocation by arbuscular mycorrhizal fungi. 2007 Plant Physiol. pmid:17142485
Sosroseno W et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. 2006 Oral Microbiol. Immunol. pmid:16626370
Virnau P et al. Intricate knots in proteins: Function and evolution. 2006 PLoS Comput. Biol. pmid:16978047
Valentincic T et al. Correlations between olfactory discrimination, olfactory receptor neuron responses and chemotopy of amino acids in fishes. 2005 Chem. Senses pmid:15738176
Bergseng E et al. Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule. 2005 J. Biol. Chem. pmid:15826953
Hunter L et al. Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B. 2005 Org. Biomol. Chem. pmid:15731856
Link AJ et al. Presentation and detection of azide functionality in bacterial cell surface proteins. 2004 J. Am. Chem. Soc. pmid:15327317
Ishii N et al. High glucose augments arginase activity and nitric oxide production in the renal cortex. 2004 Metab. Clin. Exp. pmid:15254879
Bachetti T et al. Arginase pathway in human endothelial cells in pathophysiological conditions. 2004 J. Mol. Cell. Cardiol. pmid:15276021
Níbeilliú ME and Malthouse JP The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids. 2004 Biochem. J. pmid:15107013
Crisma M et al. Meteoritic C alpha-methylated alpha-amino acids and the homochirality of life: searching for a link. 2004 Angew. Chem. Int. Ed. Engl. pmid:15593146
Ming XF et al. Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. 2004 Circulation pmid:15569838
Wheatley DN et al. Arginine deprivation and tumour cell death: arginase and its inhibition. 2003 Mol. Cell. Biochem. pmid:12701828
Seah SY et al. Kinetic analysis of phenylalanine dehydrogenase mutants designed for aliphatic amino acid dehydrogenase activity with guidance from homology-based modelling. 2003 Eur. J. Biochem. pmid:14622249
van Rijn J et al. Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells. 2003 Br. J. Cancer pmid:12569390
Pawełczak K et al. Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity. 2002 Acta Biochim. Pol. pmid:12362982
Djeraba A et al. Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. 2002 Vet. Microbiol. pmid:11900957
Wu J et al. Synthesis and biological evaluations of brain-targeted chemical delivery systems of [Nva2]-TRH. 2002 J. Pharm. Pharmacol. pmid:12162713
Eymann C et al. Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis. 2002 J. Bacteriol. pmid:11948165
Wang XG et al. Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis. 2001 Eur. J. Biochem. pmid:11722565
Shi D et al. Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes. 2001 Biochem. J. pmid:11237854
Chang CI et al. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. 2001 Cancer Res. pmid:11221839
Sato K and Suzuki N The contribution of a Ca(2+)-activated Cl(-) conductance to amino-acid-induced inward current responses of ciliated olfactory neurons of the rainbow trout. 2000 J. Exp. Biol. pmid:10607535
Sasada T et al. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide. 2000 Eur. J. Immunol. pmid:10820373
Dwyer MA et al. Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. 2000 Chem. Biol. pmid:10780926
Shi D et al. Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution. 2000 Proteins pmid:10813810
Berkowitz DB et al. Engineering acyclic stereocontrol in the alkylation of vinylglycine-derived dianions: asymmetric synthesis of higher alpha-vinyl amino acids. 2000 J. Org. Chem. pmid:10814177
LaPlante SR et al. NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain. 2000 Bioorg. Med. Chem. Lett. pmid:11055336
Andruszkiewicz R et al. N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid and their peptides; novel inhibitors of glucosamine-6-phosphate synthase. 2000 J. Enzym. Inhib. pmid:11030083
Fullbright G and Büllesbach EE The receptor binding conformation of bombyxin is induced by alanine(B15). 2000 Biochemistry pmid:10933788
Abe Y et al. Chiral discrimination of N-carbazole-carbonyl derivatives of alpha-amino acids with a short linear alkyl side chain by bovine serum albumin. 2000 Chirality pmid:10861956
Chang CI et al. The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production. 2000 J. Immunol. pmid:10925299
Kang ES et al. Normal circulating adult human red blood cells contain inactive NOS proteins. 2000 J. Lab. Clin. Med. pmid:10850643
Buñuel E et al. Two new conformationally restricted 4,5-dihydroxynorvaline analogues with a norbornane skeleton. 2000 Acta Crystallogr C pmid:10851628
Valentincic T et al. Olfactory discrimination of amino acids in brown bullhead catfish. 2000 Chem. Senses pmid:10667990
Pizzarello S and Cronin JR Non-racemic amino acids in the Murray and Murchison meteorites. 2000 Geochim. Cosmochim. Acta pmid:11543420
Córdova A et al. Convenient synthesis of L-proline benzyl ester. 1999 Bioorg. Med. Chem. Lett. pmid:10560736
Fritsche E et al. The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. 1999 J. Biol. Chem. pmid:9915841
De Gregorio A et al. Evidence of carbamoylphosphate induced conformational changes upon binding to human ornithine carbamoyltransferase. 1999 Biochem. Mol. Biol. Int. pmid:10410242
Abe Y et al. Enantioselective binding sites on bovine serum albumin to dansyl amino acids. 1999 Biochim. Biophys. Acta pmid:10446371
Chang CI et al. Arginase modulates nitric oxide production in activated macrophages. 1998 Am. J. Physiol. pmid:9458885
Soboll S et al. Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analyzed by top-down metabolic control analysis. 1998 Eur. J. Biochem. pmid:9652414
Weickert MJ and Apostol I High-fidelity translation of recombinant human hemoglobin in Escherichia coli. 1998 Appl. Environ. Microbiol. pmid:9572921
Kinoshita H and Shimizu K Prediction of the GTPase activities by using the semiempirical molecular orbital theory. 1998 Bioorg. Med. Chem. Lett. pmid:9871712
Peyrin E et al. Retention behavior of D,L-dansyl-amino acids on a human serum albumin chiral stationary phase: effect of a mobile phase modifier. 1998 J Chromatogr A pmid:9652113
Ostergaard S and Holm A Synthesis and screening of an indexed motif-library containing non-proteinogenic amino acids. 1997 Mar-Apr J. Pept. Sci. pmid:9230477
Love SG et al. Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. 1997 Biochem. J. pmid:9169606
Apostol I et al. Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli. 1997 J. Biol. Chem. pmid:9360970
Wallace CJ and Clark-Lewis I A rationale for the absolute conservation of Asn70 and Pro71 in mitochondrial cytochromes c suggested by protein engineering. 1997 Biochemistry pmid:9398193
Martinis SA and Fox GE Non-standard amino acid recognition by Escherichia coli leucyl-tRNA synthetase. 1997 Nucleic Acids Symp. Ser. pmid:11541249
Nieto R et al. Method for the determination of 15NH3 enrichment in biological samples by gas chromatography/electron impact ionization mass spectrometry. 1996 J Mass Spectrom pmid:8799279
Penverne B et al. In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. 1994 Arch. Biochem. Biophys. pmid:8117117
Bode AM et al. Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide. 1994 J. Biol. Chem. pmid:8132505
Padmanabhan S and Baldwin RL Tests for helix-stabilizing interactions between various nonpolar side chains in alanine-based peptides. 1994 Protein Sci. pmid:7703846
Picur B et al. Comparison of thermodynamic and kinetic effects between the Leu32-->norvaline and Leu35-->norvaline substitutions of the three-fragment complex of cytochrome c. 1994 Arch. Biochem. Biophys. pmid:7986101
Goldsmith JO and Kuo LC Protonation of arginine 57 of Escherichia coli ornithine transcarbamoylase regulates substrate binding and turnover. 1993 J. Biol. Chem. pmid:8395503
Bigler TL et al. Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues. 1993 Protein Sci. pmid:8495199
Arslan M et al. Studies of the role of the N-methyl-D-aspartate (NMDA) receptor in the hypothalamic control of prolactin secretion. 1992 Life Sci. pmid:1531081
Telegdi J et al. Effect of a remote chiral carbon atom in the substrate on the stereospecificity of aminoacylase. 1990 Acta Biochim. Biophys. Hung. pmid:2130576
Angliker H et al. Pseudoarginine: synthesis and properties of derivatives of delta-(1-imidazolyl)norvaline. 1990 Biochem. J. pmid:2327968