L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Marek Disease | D008380 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Bode AM et al. | Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide. | 1994 | J. Biol. Chem. | pmid:8132505 |
| Rognstad R | Sources of ammonia for urea synthesis in isolated rat liver cells. | 1977 | Biochim. Biophys. Acta | pmid:836898 |
| Goldsmith JO and Kuo LC | Protonation of arginine 57 of Escherichia coli ornithine transcarbamoylase regulates substrate binding and turnover. | 1993 | J. Biol. Chem. | pmid:8395503 |
| Young JD and Ellory JC | Substrate specificity of amino acid transport in sheep erythrocytes. | 1977 | Biochem. J. | pmid:849280 |
| Bigler TL et al. | Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues. | 1993 | Protein Sci. | pmid:8495199 |
| Nishizawa R et al. | Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase B. | 1977 | J. Med. Chem. | pmid:850237 |
| Nieto R et al. | Method for the determination of 15NH3 enrichment in biological samples by gas chromatography/electron impact ionization mass spectrometry. | 1996 | J Mass Spectrom | pmid:8799279 |
| Pausch J et al. | Protective effect of ammonium ions and L-norvaline on galactosamine induced liver injury. | 1977 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:881166 |
| Pierson DL et al. | Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reye's syndrome patient. | 1977 | J. Biol. Chem. | pmid:893420 |
| Ivanov CP and Slavcheva NN | Formation of amino acids on heating glycine with alumina. | 1977 | Orig. Life | pmid:896188 |
| Love SG et al. | Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. | 1997 | Biochem. J. | pmid:9169606 |
| Ostergaard S and Holm A | Synthesis and screening of an indexed motif-library containing non-proteinogenic amino acids. | 1997 Mar-Apr | J. Pept. Sci. | pmid:9230477 |
| Apostol I et al. | Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli. | 1997 | J. Biol. Chem. | pmid:9360970 |
| Wallace CJ and Clark-Lewis I | A rationale for the absolute conservation of Asn70 and Pro71 in mitochondrial cytochromes c suggested by protein engineering. | 1997 | Biochemistry | pmid:9398193 |
| Chang CI et al. | Arginase modulates nitric oxide production in activated macrophages. | 1998 | Am. J. Physiol. | pmid:9458885 |
| Weickert MJ and Apostol I | High-fidelity translation of recombinant human hemoglobin in Escherichia coli. | 1998 | Appl. Environ. Microbiol. | pmid:9572921 |
| Peyrin E et al. | Retention behavior of D,L-dansyl-amino acids on a human serum albumin chiral stationary phase: effect of a mobile phase modifier. | 1998 | J Chromatogr A | pmid:9652113 |
| Soboll S et al. | Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analyzed by top-down metabolic control analysis. | 1998 | Eur. J. Biochem. | pmid:9652414 |
| Kinoshita H and Shimizu K | Prediction of the GTPase activities by using the semiempirical molecular orbital theory. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871712 |