L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Marek Disease | D008380 | 4 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Cruz C et al. | Enzymatic evidence for the key role of arginine in nitrogen translocation by arbuscular mycorrhizal fungi. | 2007 | Plant Physiol. | pmid:17142485 |
| Sankaranarayanan R et al. | The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. | 2008 | J. Mol. Biol. | pmid:18062991 |
| Vacca RA et al. | Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. | 2008 | BMC Biochem. | pmid:18565210 |
| Ming XF et al. | Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. | 2009 | BMC Cardiovasc Disord | pmid:19284655 |
| Kuzma M et al. | Cyclosporins from Mycelium sterilae MS 2929. | 2009 | J. Nat. Prod. | pmid:19102681 |
| Matthews ML et al. | Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19815524 |
| Wacker SA et al. | Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation. | 2010 | Protein Sci. | pmid:20665690 |
| Deshmukh M et al. | A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. | 2010 | J. Med. Chem. | pmid:20063889 |
| Chatzigeorgiou P et al. | Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy. | 2010 | J Phys Chem B | pmid:20043648 |
| Behnke K et al. | RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis. | 2010 | Plant Mol. Biol. | pmid:20526857 |
| Dolensek J and Valentincic T | Specificities of olfactory receptor neuron responses to amino acids in the black bullhead catfish (Ameiurus melas). | 2010 | Pflugers Arch. | pmid:19756721 |
| Chen X et al. | Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. | 2011 | Nucleic Acids Res. | pmid:20805241 |
| Görbitz CH | Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction. | 2011 | J Phys Chem B | pmid:21332110 |
| Dupuis SN et al. | Jadomycins derived from the assimilation and incorporation of norvaline and norleucine. | 2011 | J. Nat. Prod. | pmid:22050382 |
| Bailey J et al. | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. | 2011 | FEBS J. | pmid:21749647 |
| Smith KM and Liao JC | An evolutionary strategy for isobutanol production strain development in Escherichia coli. | 2011 | Metab. Eng. | pmid:21911074 |
| Pokrovskiy MV et al. | Arginase inhibitor in the pharmacological correction of endothelial dysfunction. | 2011 | Int J Hypertens | pmid:21747978 |
| Peng Y et al. | A blue native-PAGE analysis of membrane protein complexes in Clostridium thermocellum. | 2011 | BMC Microbiol. | pmid:21269440 |