L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Marek Disease | D008380 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Pokrovskiy MV et al. | Arginase inhibitor in the pharmacological correction of endothelial dysfunction. | 2011 | Int J Hypertens | pmid:21747978 |
| Peng Y et al. | A blue native-PAGE analysis of membrane protein complexes in Clostridium thermocellum. | 2011 | BMC Microbiol. | pmid:21269440 |
| Wacker SA et al. | Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation. | 2010 | Protein Sci. | pmid:20665690 |
| Deshmukh M et al. | A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. | 2010 | J. Med. Chem. | pmid:20063889 |
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| Ming XF et al. | Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. | 2009 | BMC Cardiovasc Disord | pmid:19284655 |
| Kuzma M et al. | Cyclosporins from Mycelium sterilae MS 2929. | 2009 | J. Nat. Prod. | pmid:19102681 |
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| Vacca RA et al. | Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. | 2008 | BMC Biochem. | pmid:18565210 |
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| Hunter L et al. | Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B. | 2005 | Org. Biomol. Chem. | pmid:15731856 |
| Link AJ et al. | Presentation and detection of azide functionality in bacterial cell surface proteins. | 2004 | J. Am. Chem. Soc. | pmid:15327317 |
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| Ming XF et al. | Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. | 2004 | Circulation | pmid:15569838 |