L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Marek Disease | D008380 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| NÃbeilliú ME and Malthouse JP | The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids. | 2004 | Biochem. J. | pmid:15107013 |
| Ming XF et al. | Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. | 2004 | Circulation | pmid:15569838 |
| Wheatley DN et al. | Arginine deprivation and tumour cell death: arginase and its inhibition. | 2003 | Mol. Cell. Biochem. | pmid:12701828 |
| Seah SY et al. | Kinetic analysis of phenylalanine dehydrogenase mutants designed for aliphatic amino acid dehydrogenase activity with guidance from homology-based modelling. | 2003 | Eur. J. Biochem. | pmid:14622249 |
| van Rijn J et al. | Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells. | 2003 | Br. J. Cancer | pmid:12569390 |
| Pawełczak K et al. | Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity. | 2002 | Acta Biochim. Pol. | pmid:12362982 |
| Djeraba A et al. | Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance. | 2002 | Vet. Microbiol. | pmid:11900957 |
| Wu J et al. | Synthesis and biological evaluations of brain-targeted chemical delivery systems of [Nva2]-TRH. | 2002 | J. Pharm. Pharmacol. | pmid:12162713 |
| Eymann C et al. | Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis. | 2002 | J. Bacteriol. | pmid:11948165 |
| Wang XG et al. | Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis. | 2001 | Eur. J. Biochem. | pmid:11722565 |
| Shi D et al. | Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes. | 2001 | Biochem. J. | pmid:11237854 |
| Chang CI et al. | Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. | 2001 | Cancer Res. | pmid:11221839 |
| Sato K and Suzuki N | The contribution of a Ca(2+)-activated Cl(-) conductance to amino-acid-induced inward current responses of ciliated olfactory neurons of the rainbow trout. | 2000 | J. Exp. Biol. | pmid:10607535 |
| Sasada T et al. | Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide. | 2000 | Eur. J. Immunol. | pmid:10820373 |
| Dwyer MA et al. | Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. | 2000 | Chem. Biol. | pmid:10780926 |
| Shi D et al. | Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution. | 2000 | Proteins | pmid:10813810 |
| Berkowitz DB et al. | Engineering acyclic stereocontrol in the alkylation of vinylglycine-derived dianions: asymmetric synthesis of higher alpha-vinyl amino acids. | 2000 | J. Org. Chem. | pmid:10814177 |
| LaPlante SR et al. | NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain. | 2000 | Bioorg. Med. Chem. Lett. | pmid:11055336 |
| Andruszkiewicz R et al. | N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid and their peptides; novel inhibitors of glucosamine-6-phosphate synthase. | 2000 | J. Enzym. Inhib. | pmid:11030083 |
| Fullbright G and Büllesbach EE | The receptor binding conformation of bombyxin is induced by alanine(B15). | 2000 | Biochemistry | pmid:10933788 |
| Abe Y et al. | Chiral discrimination of N-carbazole-carbonyl derivatives of alpha-amino acids with a short linear alkyl side chain by bovine serum albumin. | 2000 | Chirality | pmid:10861956 |
| Chang CI et al. | The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production. | 2000 | J. Immunol. | pmid:10925299 |
| Kang ES et al. | Normal circulating adult human red blood cells contain inactive NOS proteins. | 2000 | J. Lab. Clin. Med. | pmid:10850643 |
| Buñuel E et al. | Two new conformationally restricted 4,5-dihydroxynorvaline analogues with a norbornane skeleton. | 2000 | Acta Crystallogr C | pmid:10851628 |
| Valentincic T et al. | Olfactory discrimination of amino acids in brown bullhead catfish. | 2000 | Chem. Senses | pmid:10667990 |
| Pizzarello S and Cronin JR | Non-racemic amino acids in the Murray and Murchison meteorites. | 2000 | Geochim. Cosmochim. Acta | pmid:11543420 |
| Córdova A et al. | Convenient synthesis of L-proline benzyl ester. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560736 |
| Fritsche E et al. | The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. | 1999 | J. Biol. Chem. | pmid:9915841 |
| De Gregorio A et al. | Evidence of carbamoylphosphate induced conformational changes upon binding to human ornithine carbamoyltransferase. | 1999 | Biochem. Mol. Biol. Int. | pmid:10410242 |
| Abe Y et al. | Enantioselective binding sites on bovine serum albumin to dansyl amino acids. | 1999 | Biochim. Biophys. Acta | pmid:10446371 |
| Chang CI et al. | Arginase modulates nitric oxide production in activated macrophages. | 1998 | Am. J. Physiol. | pmid:9458885 |
| Soboll S et al. | Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analyzed by top-down metabolic control analysis. | 1998 | Eur. J. Biochem. | pmid:9652414 |
| Weickert MJ and Apostol I | High-fidelity translation of recombinant human hemoglobin in Escherichia coli. | 1998 | Appl. Environ. Microbiol. | pmid:9572921 |
| Kinoshita H and Shimizu K | Prediction of the GTPase activities by using the semiempirical molecular orbital theory. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871712 |
| Peyrin E et al. | Retention behavior of D,L-dansyl-amino acids on a human serum albumin chiral stationary phase: effect of a mobile phase modifier. | 1998 | J Chromatogr A | pmid:9652113 |
| Ostergaard S and Holm A | Synthesis and screening of an indexed motif-library containing non-proteinogenic amino acids. | 1997 Mar-Apr | J. Pept. Sci. | pmid:9230477 |
| Love SG et al. | Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. | 1997 | Biochem. J. | pmid:9169606 |
| Apostol I et al. | Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli. | 1997 | J. Biol. Chem. | pmid:9360970 |
| Wallace CJ and Clark-Lewis I | A rationale for the absolute conservation of Asn70 and Pro71 in mitochondrial cytochromes c suggested by protein engineering. | 1997 | Biochemistry | pmid:9398193 |
| Martinis SA and Fox GE | Non-standard amino acid recognition by Escherichia coli leucyl-tRNA synthetase. | 1997 | Nucleic Acids Symp. Ser. | pmid:11541249 |
| Nieto R et al. | Method for the determination of 15NH3 enrichment in biological samples by gas chromatography/electron impact ionization mass spectrometry. | 1996 | J Mass Spectrom | pmid:8799279 |
| Penverne B et al. | In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. | 1994 | Arch. Biochem. Biophys. | pmid:8117117 |
| Bode AM et al. | Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide. | 1994 | J. Biol. Chem. | pmid:8132505 |
| Padmanabhan S and Baldwin RL | Tests for helix-stabilizing interactions between various nonpolar side chains in alanine-based peptides. | 1994 | Protein Sci. | pmid:7703846 |
| Picur B et al. | Comparison of thermodynamic and kinetic effects between the Leu32-->norvaline and Leu35-->norvaline substitutions of the three-fragment complex of cytochrome c. | 1994 | Arch. Biochem. Biophys. | pmid:7986101 |
| Goldsmith JO and Kuo LC | Protonation of arginine 57 of Escherichia coli ornithine transcarbamoylase regulates substrate binding and turnover. | 1993 | J. Biol. Chem. | pmid:8395503 |
| Bigler TL et al. | Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues. | 1993 | Protein Sci. | pmid:8495199 |
| Arslan M et al. | Studies of the role of the N-methyl-D-aspartate (NMDA) receptor in the hypothalamic control of prolactin secretion. | 1992 | Life Sci. | pmid:1531081 |
| Telegdi J et al. | Effect of a remote chiral carbon atom in the substrate on the stereospecificity of aminoacylase. | 1990 | Acta Biochim. Biophys. Hung. | pmid:2130576 |
| Angliker H et al. | Pseudoarginine: synthesis and properties of derivatives of delta-(1-imidazolyl)norvaline. | 1990 | Biochem. J. | pmid:2327968 |