L-norvaline is a lipid of Fatty Acyls (FA) class. L-norvaline is associated with abnormalities such as Celiac Disease, Exanthema, Atherosclerosis, Plasmodium falciparum infection and Parasitemia. The involved functions are known as Anabolism, Saturated, Stimulus, Physiologic Organization and arginase activity. L-norvaline often locates in Extracellular, Protoplasm, soluble, viral nucleocapsid location and Cell Wall. The associated genes with L-norvaline are norvaline, Amino Acids, Basic, ARG1 gene, Escherichia coli Proteins and Operon. The related lipids are Lipopolysaccharides.
To understand associated biological information of L-norvaline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
L-norvaline is suspected in Exanthema, Parasitemia, Celiac Disease, Atherosclerosis, Plasmodium falciparum infection and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with L-norvaline
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Marek Disease | D008380 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cvetesic N et al. | The physiological target for LeuRS translational quality control is norvaline. | 2014 | EMBO J. | pmid:24935946 |
| Sener A et al. | The stimulus-secretion coupling of amino acid-induced insulin release. Biosynthetic and secretory responses of rat pancreatic islet to L-leucine and L-glutamine. | 1981 | Diabetologia | pmid:7021285 |
| Rodas PC et al. | Glutamine and glutathione at ICU admission in relation to outcome. | 2012 | Clin. Sci. | pmid:22248298 |
| Turnell DC and Cooper JD | Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed-phase liquid chromatography. | 1982 | Clin. Chem. | pmid:7067099 |
| Ming XF et al. | Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. | 2004 | Circulation | pmid:15569838 |
| Abe Y et al. | Chiral discrimination of N-carbazole-carbonyl derivatives of alpha-amino acids with a short linear alkyl side chain by bovine serum albumin. | 2000 | Chirality | pmid:10861956 |
| Ogata K et al. | Synthesis and self-assembly of NCN-pincer Pd-complex-bound norvalines. | 2013 | Chemistry | pmid:23907820 |
| Valentincic T et al. | Olfactory discrimination of amino acids in brown bullhead catfish. | 2000 | Chem. Senses | pmid:10667990 |
| Valentincic T et al. | Correlations between olfactory discrimination, olfactory receptor neuron responses and chemotopy of amino acids in fishes. | 2005 | Chem. Senses | pmid:15738176 |
| Dwyer MA et al. | Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. | 2000 | Chem. Biol. | pmid:10780926 |
| Isozaki K et al. | Synthesis and Applications of (ONO Pincer)Ruthenium-Complex-Bound Norvalines. | 2016 | Chem Asian J | pmid:26879368 |
| Chang CI et al. | Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. | 2001 | Cancer Res. | pmid:11221839 |
| El-Bassossy HM et al. | Arginase inhibition alleviates hypertension in the metabolic syndrome. | 2013 | Br. J. Pharmacol. | pmid:23441715 |
| van Rijn J et al. | Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells. | 2003 | Br. J. Cancer | pmid:12569390 |
| Peng Y et al. | A blue native-PAGE analysis of membrane protein complexes in Clostridium thermocellum. | 2011 | BMC Microbiol. | pmid:21269440 |
| Ming XF et al. | Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. | 2009 | BMC Cardiovasc Disord | pmid:19284655 |
| Tkaczuk KL et al. | Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. | 2007 | BMC Bioinformatics | pmid:17338813 |
| Vacca RA et al. | Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme. | 2008 | BMC Biochem. | pmid:18565210 |
| Russell EW et al. | Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A. | 1986 | Biophys. J. | pmid:2421794 |
| Córdova A et al. | Convenient synthesis of L-proline benzyl ester. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560736 |