MeSH term | MeSH ID | Detail |
---|---|---|
Kidney Neoplasms | D007680 | 29 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Spinocerebellar Ataxias | D020754 | 4 associated lipids |
Dl-serine is a lipid of Fatty Acyls (FA) class. Dl-serine is associated with abnormalities such as Spastic syndrome, Machado-Joseph Disease, Huntington Disease, Infection and Gram positive septicemia. The involved functions are known as Lipid Binding, Proteolysis, Protein Processing, Post-Translational, Cytokinesis and Phosphorylation. Dl-serine often locates in Anatomic Site, Membrane, Cytoplasmic Domain, Extracellular and Blood. The associated genes with Dl-serine are polyserine, lipovitellin, Polypeptides, CSNK2A1 wt Allele and Spider Proteins. The related experimental models are Mouse Model.
To understand associated biological information of Dl-serine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dl-serine is suspected in Huntington Disease, Infection, Spastic syndrome, Machado-Joseph Disease, Gram positive septicemia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Dl-serine
MeSH term | MeSH ID | Detail |
---|---|---|
Kidney Neoplasms | D007680 | 29 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Spinocerebellar Ataxias | D020754 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Polyalanine and polyserine frameshift products in Huntington's disease.' (Davies JE and Rubinsztein DC, 2006).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Takeda K et al. | Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. | 2008 | BMC Cancer | pmid:18992165 |
Zhang Z et al. | Gene expression patterns of sulfur starvation in Synechocystis sp. PCC 6803. | 2008 | BMC Genomics | pmid:18644144 |
Kehe K et al. | Sulfur mustard research--strategies for the development of improved medical therapy. | 2008 | Eplasty | pmid:18615149 |
Ali S et al. | High performance microbiological transformation of L-tyrosine to L-dopa by Yarrowia lipolytica NRRL-143. | 2007 | BMC Biotechnol. | pmid:17705832 |
Kim TS et al. | Nonsurgical and surgical periodontal therapy in single-rooted teeth. | 2007 | Clin Oral Investig | pmid:17690922 |
Lobsiger CS et al. | Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17463094 |
Mizejewski GJ et al. | Anticancer versus antigrowth activities of three analogs of the growth-inhibitory peptide: relevance to physicochemical properties. | 2006 Jul-Aug | Anticancer Res. | pmid:16886636 |
Nagata H et al. | Structural scaffold of 18-crown-6 tetracarboxylic Acid for optical resolution of chiral amino acid: x-ray crystal analyses of complexes of D- and L-isomers of serine and glutamic acid. | 2006 | Chem. Pharm. Bull. | pmid:16595944 |
Li C | Voltammetric determination of tyrosine based on an L-serine polymer film electrode. | 2006 | Colloids Surf B Biointerfaces | pmid:16797945 |
Davies JE and Rubinsztein DC | Polyalanine and polyserine frameshift products in Huntington's disease. | 2006 | J. Med. Genet. | pmid:16801344 |
Adam P et al. | Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers. | 2005 | BMC Biochem. | pmid:16285881 |
Gleeson DJ et al. | Genetic covariance between indices of body condition and immunocompetence in a passerine bird. | 2005 | BMC Evol. Biol. | pmid:16274488 |
Rautengarten C et al. | Inferring hypotheses on functional relationships of genes: Analysis of the Arabidopsis thaliana subtilase gene family. | 2005 | PLoS Comput. Biol. | pmid:16193095 |
Biro JC | Nucleic acid chaperons: a theory of an RNA-assisted protein folding. | 2005 | Theor Biol Med Model | pmid:16137324 |
Scherübl C et al. | Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2. | 2005 | J Inflamm (Lond) | pmid:15996269 |
Lefebvre-Lavoie J et al. | Profiling of differentially expressed genes in wound margin biopsies of horses using suppression subtractive hybridization. | 2005 | Physiol. Genomics | pmid:15870397 |
Rementeria A et al. | Genes and molecules involved in Aspergillus fumigatus virulence. | 2005 | Rev Iberoam Micol | pmid:15813678 |
Schmitz KJ et al. | High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. | 2005 | Breast Cancer Res. | pmid:15743500 |
Funding M et al. | Proteomic analysis of aqueous humour from patients with acute corneal rejection. | 2005 | Acta Ophthalmol Scand | pmid:15715554 |
Hujová J et al. | Characterization of gana-1, a Caenorhabditis elegans gene encoding a single ortholog of vertebrate alpha-galactosidase and alpha-N-acetylgalactosaminidase. | 2005 | BMC Cell Biol. | pmid:15676072 |
Bogár F et al. | Density functional study of infinite polyserine chains. | 2005 | Phys Chem Chem Phys | pmid:16189618 |
Langenickel TH et al. | Rat corin gene: molecular cloning and reduced expression in experimental heart failure. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15155264 |
Almeida L et al. | Plasminogen interaction with Trypanosoma cruzi. | 2004 | Mem. Inst. Oswaldo Cruz | pmid:15057349 |
Howard MB et al. | Identification and analysis of polyserine linker domains in prokaryotic proteins with emphasis on the marine bacterium Microbulbifer degradans. | 2004 | Protein Sci. | pmid:15075401 |
Oliveira MJ et al. | Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. | 2003 | EMBO J. | pmid:14609961 |
El-Awady RA et al. | Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. | 2003 | Br. J. Cancer | pmid:12888835 |
Barisone GA et al. | The envelopes of amphibian oocytes: physiological modifications in Bufo arenarum. | 2003 | Reprod. Biol. Endocrinol. | pmid:12694627 |
Bonneterre J et al. | Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure. | 2002 | Br. J. Cancer | pmid:12439707 |
Masuda Y et al. | Synthesis of (2S,2'R,3S,4R)-2-(2'-hydroxy-21'-methyidocosanoylamino)-1,3,4-pentadecanetriol, the ceramide sex pheromone of the female hair crab, Erimacrus isenbeckii. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224637 |
Célérier J et al. | Angiotensinogen and its cleaved derivatives inhibit angiogenesis. | 2002 | Hypertension | pmid:11847188 |
Esposito A et al. | First stereocontrolled synthesis of (S)-cleonin and related cyclopropyl-substituted amino acids. | 2001 | Org. Lett. | pmid:11594812 |
Kimura T et al. | Effect of serine residue on the effectiveness of cationic polypeptide-based gene delivery. | 2000 | Nucleic Acids Symp. Ser. | pmid:12903387 |
Schöttelndreier H et al. | Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways. | 1999 | Cell. Signal. | pmid:10433522 |
Hasper A et al. | Modification of the N-terminal polyserine cluster alters stability of the plasma membrane H(+)-ATPase from Saccharomyces cerevisiae. | 1999 | Biochim. Biophys. Acta | pmid:10446304 |
Aoki Y et al. | Anti-proliferative effects of unmodified antisense oligodeoxynucleotides targeted against c-raf mRNA: use of poly (lysine/serine) copolymers or cationic lipopolyamines. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9750959 |
Gonsalves KE et al. | Synthesis and surface characterization of functionalized polylactide copolymer microparticles. | 1998 | Biomaterials | pmid:9794526 |
Bates PA and DeLuca NA | The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. | 1998 | J. Virol. | pmid:9696805 |
Doruker P and Bahar I | Role of water on unfolding kinetics of helical peptides studied by molecular dynamics simulations. | 1997 | Biophys. J. | pmid:9168021 |
Evans JS et al. | Prediction of polyelectrolyte polypeptide structures using Monte Carlo conformational search methods with implicit solvation modeling. | 1995 | Protein Sci. | pmid:8535238 |
Picking WD et al. | Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation. | 1992 | Biochemistry | pmid:1540593 |
Picking W et al. | The use of synthetic tRNAs as probes for examining nascent peptides on Escherichia coli ribosomes. | 1991 Jul-Aug | Biochimie | pmid:1742354 |
Weber AL | Stereoselective formation of a 2'(3')-aminoacyl ester of a nucleotide. | 1987 | J. Mol. Evol. | pmid:3114501 |
Wells IC et al. | Experimental study of chronic ambulatory peritoneal dialysis. I. Inhibition of protein and amino acid losses by single amino acids. | 1985 | Clin Physiol Biochem | pmid:3995871 |
Hiasa Y et al. | DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats. | 1984 | J. Natl. Cancer Inst. | pmid:6429402 |
Kovác L et al. | Membrane mutants: a yeast mutant with a lesion in phosphatidylserine biosynthesis. | 1980 | Eur. J. Biochem. | pmid:6780341 |
Joshi SV et al. | Gamma-irradiation studies with synthetic poly-L-serine in the megarad dose range. | 1980 | Cancer Biochem. Biophys. | pmid:7438027 |
Scott TA and Hockney RC | Synthesis of vitamin B6 by a mutant of Escherichia coli K12 and the action of 4'-deoxypyridoxine. | 1979 | J. Gen. Microbiol. | pmid:374679 |
Mahmoud SA et al. | Production and chemical studies of protease from Bacillus subtilis (SH-6) Egyptian strain. | 1978 | Zentralbl Bakteriol Naturwiss | pmid:98932 |
Nakagawa M and Uchiyama M | Effect of organophosphate pesticides on lecithin-cholesterol acyltransferase in human plasma. | 1974 | Biochem. Pharmacol. | pmid:4847537 |
Janjić TJ and Milovanović GA | New kinetic method for determination of ultramicro quantities of organic substances. Determination of amino acids (glycine, DL-serine, DL-phenylalanine, DL-glutamic acid, and L-arginine). | 1973 | Anal. Chem. | pmid:4762355 |