Dl-serine

Dl-serine is a lipid of Fatty Acyls (FA) class. Dl-serine is associated with abnormalities such as Spastic syndrome, Machado-Joseph Disease, Huntington Disease, Infection and Gram positive septicemia. The involved functions are known as Lipid Binding, Proteolysis, Protein Processing, Post-Translational, Cytokinesis and Phosphorylation. Dl-serine often locates in Anatomic Site, Membrane, Cytoplasmic Domain, Extracellular and Blood. The associated genes with Dl-serine are polyserine, lipovitellin, Polypeptides, CSNK2A1 wt Allele and Spider Proteins. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Dl-serine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dl-serine?

Dl-serine is suspected in Huntington Disease, Infection, Spastic syndrome, Machado-Joseph Disease, Gram positive septicemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dl-serine

MeSH term MeSH ID Detail
Kidney Neoplasms D007680 29 associated lipids
Body Weight D001835 333 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Dl-serine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dl-serine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Dl-serine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dl-serine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Dl-serine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dl-serine?

Mouse Model

Mouse Model are used in the study 'Polyalanine and polyserine frameshift products in Huntington's disease.' (Davies JE and Rubinsztein DC, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Dl-serine

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Authors Title Published Journal PubMed Link
Gleeson DJ et al. Genetic covariance between indices of body condition and immunocompetence in a passerine bird. 2005 BMC Evol. Biol. pmid:16274488
Langenickel TH et al. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:15155264
Almeida L et al. Plasminogen interaction with Trypanosoma cruzi. 2004 Mem. Inst. Oswaldo Cruz pmid:15057349
Howard MB et al. Identification and analysis of polyserine linker domains in prokaryotic proteins with emphasis on the marine bacterium Microbulbifer degradans. 2004 Protein Sci. pmid:15075401
Oliveira MJ et al. Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. 2003 EMBO J. pmid:14609961
El-Awady RA et al. Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. 2003 Br. J. Cancer pmid:12888835
Barisone GA et al. The envelopes of amphibian oocytes: physiological modifications in Bufo arenarum. 2003 Reprod. Biol. Endocrinol. pmid:12694627
Bonneterre J et al. Docetaxel vs 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure. 2002 Br. J. Cancer pmid:12439707
Masuda Y et al. Synthesis of (2S,2'R,3S,4R)-2-(2'-hydroxy-21'-methyidocosanoylamino)-1,3,4-pentadecanetriol, the ceramide sex pheromone of the female hair crab, Erimacrus isenbeckii. 2002 Biosci. Biotechnol. Biochem. pmid:12224637
Célérier J et al. Angiotensinogen and its cleaved derivatives inhibit angiogenesis. 2002 Hypertension pmid:11847188
Esposito A et al. First stereocontrolled synthesis of (S)-cleonin and related cyclopropyl-substituted amino acids. 2001 Org. Lett. pmid:11594812
Kimura T et al. Effect of serine residue on the effectiveness of cationic polypeptide-based gene delivery. 2000 Nucleic Acids Symp. Ser. pmid:12903387
Schöttelndreier H et al. Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways. 1999 Cell. Signal. pmid:10433522
Hasper A et al. Modification of the N-terminal polyserine cluster alters stability of the plasma membrane H(+)-ATPase from Saccharomyces cerevisiae. 1999 Biochim. Biophys. Acta pmid:10446304
Aoki Y et al. Anti-proliferative effects of unmodified antisense oligodeoxynucleotides targeted against c-raf mRNA: use of poly (lysine/serine) copolymers or cationic lipopolyamines. 1998 Clin. Exp. Pharmacol. Physiol. pmid:9750959
Gonsalves KE et al. Synthesis and surface characterization of functionalized polylactide copolymer microparticles. 1998 Biomaterials pmid:9794526
Bates PA and DeLuca NA The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. 1998 J. Virol. pmid:9696805
Doruker P and Bahar I Role of water on unfolding kinetics of helical peptides studied by molecular dynamics simulations. 1997 Biophys. J. pmid:9168021
Evans JS et al. Prediction of polyelectrolyte polypeptide structures using Monte Carlo conformational search methods with implicit solvation modeling. 1995 Protein Sci. pmid:8535238
Picking WD et al. Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation. 1992 Biochemistry pmid:1540593