Dl-leucine

Dl-leucine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 544 references associated with Dl-leucine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Dl-leucine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dl-leucine

MeSH term MeSH ID Detail
Communicable Diseases, Emerging D021821 3 associated lipids
Myoclonic Epilepsies, Progressive D020191 3 associated lipids
Nerve Degeneration D009410 53 associated lipids
Influenza in Birds D005585 1 associated lipids
Total 4

NCBI Entrez Crosslinks

All references with Dl-leucine

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Authors Title Published Journal PubMed Link
Keszthelyi L Asymmetric degradation of DL-leucine with longitudinally polarised electrons. 1976 Nature pmid:995207
Monné M et al. Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix. 1998 J. Mol. Biol. pmid:9837735
Lew S and London E Simple procedure for reversed-phase high-performance liquid chromatographic purification of long hydrophobic peptides that form transmembrane helices. 1997 Anal. Biochem. pmid:9300091
Hatsuzawa K et al. The hydrophobic region of signal peptides is a determinant for SRP recognition and protein translocation across the ER membrane. 1997 J. Biochem. pmid:9089400
Takei T et al. Characterization of poly-leucine substituted analogues of the human surfactant protein SP-C. 1996 Biol. Pharm. Bull. pmid:8996637
Whitley P et al. A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane. 1996 J. Biol. Chem. pmid:8631791
Kwapiszewski W and Kolwas J [Synthesis of amino acid antipyrine-4-amides. II. 4-antipyrinamides of DL-leucine, phenylalanine, tyrosine, glutaminic acid and epsilon-aminocaproic acid]. 1977 Acta Pol Pharm pmid:848320
Lemmon MA et al. A dimerization motif for transmembrane alpha-helices. 1994 Nat. Struct. Biol. pmid:7656033
Oliver AE and Deamer DW Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers. 1994 Biophys. J. pmid:7520289
Blair NE and Bonner WA The radiolysis of tryptophan and leucine with 32P beta-radiation. 1980 J. Mol. Evol. pmid:7365806
Blair NE and Bonner WA A model for the enantiomeric enrichment of polypeptides on the primitive earth. 1981 Orig. Life pmid:7329653
Bonner WA et al. Experiments on the abiotic amplification of optical activity. 1981 Mar-Jun Orig. Life pmid:7231975
Gavrilova LP and Rutkevitch NM Ribosomal synthesis of polyleucine on polyuridylic acid as a template: contribution of the elongation factors. 1980 FEBS Lett. pmid:7002608
Shiba K et al. [Comparative distribution study of 14C labeled amino acids, glucose-analogue and precursor of nuclei acid, as tumor seeking agents]. 1984 Radioisotopes pmid:6505304
Go M and Scheraga HA Molecular theory of the helix-coil transition in polyamino acids. V. Explanation of the different conformational behavior of valine, isoleucine, and leucine in aqueous solution. 1984 Biopolymers pmid:6498288
Gavrilova LP et al. Stoichiometry of GTP hydrolysis in a poly(U)-dependent cell-free translation system. Determination of GTP/peptide bond ratios during codon-specific elongation and misreading. 1984 FEBS Lett. pmid:6391958
Kohn FE et al. New perspectives in myringoplasty. 1984 Int J Artif Organs pmid:6329963
Bonner WA et al. The radiolysis and racemization of leucine on proton irradiation. 1982 Orig. Life pmid:6290959
Lemmon RM et al. Search for effect of longitudinally polarized protons on optically active amino acid. 1981 Orig. Life pmid:6276838
Smailov SK and Gavrilova LP Effect of streptomycin on the stoichiometry of GTP hydrolysis in a poly(U)-dependent cell-free translation system. 1985 FEBS Lett. pmid:3902505
Kakhniashvili DG et al. The excess GTP hydrolyzed during mistranslation is expended at the stage of EF-Tu-promoted binding of non-cognate aminoacyl-tRNA. 1986 FEBS Lett. pmid:3510907
Hirayama C et al. Chromatographic resolution of dipeptide enantiomers and diastereomers on chiral stationary phases from poly(L-leucine) or poly(L-phenylalanine). 1988 J. Chromatogr. pmid:3235592
Hashimura T et al. Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters. 1987 Jpn. J. Cancer Res. pmid:3112059
pmid:26876808
Bañez-Coronel M et al. RAN Translation in Huntington Disease. 2015 Neuron pmid:26590344
Chen P et al. pH-Responsive chimaeric pepsomes based on asymmetric poly(ethylene glycol)-b-poly(l-leucine)-b-poly(l-glutamic acid) triblock copolymer for efficient loading and active intracellular delivery of doxorubicin hydrochloride. 2015 Biomacromolecules pmid:25759951
Zhang S et al. Design and synthesis of nonionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties. 2015 Biomacromolecules pmid:25748800
Han SS et al. Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery. 2015 Small pmid:25626995
Ding J et al. Chirality-mediated polypeptide micelles for regulated drug delivery. 2015 Acta Biomater pmid:25278445
pmid:25154484
Miranda RA et al. Synthesis and characterization of poly-L-leucine initialized and immobilized by rehydrated hydrotalcite: understanding stability and the nature of interaction. 2013 Phys Chem Chem Phys pmid:23942769
Suzuki Y et al. Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein. 2013 Neurosci. Lett. pmid:23933208
Swathi A et al. Homology modeling and structural comparison of leucine rich repeats of Toll like receptors 1-10 of ruminants. 2013 J Mol Model pmid:23812948
Choe UJ et al. Endocytosis and intracellular trafficking properties of transferrin-conjugated block copolypeptide vesicles. 2013 Biomacromolecules pmid:23581747
Romen W and Hempel K Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study. 1975 Virchows Arch B Cell Pathol pmid:235171
Nakano M et al. Study of the aggregation mechanism of polyglutamine peptides using replica exchange molecular dynamics simulations. 2013 J Mol Model pmid:23288093
Deng J et al. Self-assembled cationic micelles based on PEG-PLL-PLLeu hybrid polypeptides as highly effective gene vectors. 2012 Biomacromolecules pmid:23013102
pmid:22446078
Poreba M et al. Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. 2012 PLoS ONE pmid:22359643
Gu PF et al. Polymeric micelles based on poly(ethylene glycol) block poly(racemic amino acids) hybrid polypeptides: conformation-facilitated drug-loading behavior and potential application as effective anticancer drug carriers. 2012 Int J Nanomedicine pmid:22275827
Juhász A et al. Role of conserved non-coding regulatory elements in LMW glutenin gene expression. 2011 PLoS ONE pmid:22242127
Drummond ML et al. The importance of secondary structure in determining CO2-protein binding patterns. 2012 J Mol Model pmid:22038461
van Eyk CL et al. Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease. 2012 Hum. Mol. Genet. pmid:22021427
Dutta P and Dey J Drug solubilization by amino acid based polymeric nanoparticles: Characterization and biocompatibility studies. 2011 Int J Pharm pmid:22001838
pmid:21858327
pmid:21365690
Gumbart J et al. Free-energy cost for translocon-assisted insertion of membrane proteins. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21317362
Nakajima Y et al. Greatly improved activity of staphylococcal ribosomes in polyadenylate directed polylysine synthesis: as an assay system for investigating their sensitivity to macrolide antibiotics. 1990 J. Pharmacobio-dyn. pmid:2121953
Wang R et al. Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water. 2011 Colloids Surf B Biointerfaces pmid:21144714
Sun VZ et al. Intracellular fates of cell-penetrating block copolypeptide vesicles. 2011 Biomacromolecules pmid:21128599