2-amino-isobutyric acid

2-amino-isobutyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 3622 references associated with 2-amino-isobutyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 2-amino-isobutyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-amino-isobutyric acid

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Hypotension D007022 41 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Brain Neoplasms D001932 15 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 47

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-amino-isobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 1224
Authors Title Published Journal PubMed Link
Jones JE et al. Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers. 2016 J. Am. Chem. Soc. pmid:26699898
Tamaki H et al. Targeting Hormone-Related Pathways to Improve Grain Yield in Rice: A Chemical Approach. 2015 PLoS ONE pmid:26098557
Kosinová L et al. Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. 2014 Biochemistry pmid:24819248
Gessmann R et al. The peptide Z-Aib-Aib-Aib-L-Ala-OtBu. 2014 Acta Crystallogr C Struct Chem pmid:24705058
Gozes I et al. NAP alpha-aminoisobutyric acid (IsoNAP). 2014 J. Mol. Neurosci. pmid:24458740
Baird CH et al. L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 2013 Nov-Dec Nutrition pmid:24103518
Hentrich M et al. YUCCA8 and YUCCA9 overexpression reveals a link between auxin signaling and lignification through the induction of ethylene biosynthesis. 2013 Plant Signal Behav pmid:24022251
Vogel KR et al. Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice. 2013 J. Inherit. Metab. Dis. pmid:22976763
Demizu Y et al. Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions. 2013 Bioorg. Med. Chem. Lett. pmid:23806555
De Poli M et al. Left-handed helical preference in an achiral peptide chain is induced by an L-amino acid in an N-terminal type II β-turn. 2013 J. Org. Chem. pmid:23316729
Caruso M et al. Fibrils or globules? Tuning the morphology of peptide aggregates from helical building blocks. 2013 J Phys Chem B pmid:23581652
Untiet V et al. ABC transport is inactivated by the PTS(Ntr) under potassium limitation in Rhizobium leguminosarum 3841. 2013 PLoS ONE pmid:23724079
Kaplan JM et al. Conformationally constrained functional peptide monolayers for the controlled display of bioactive carbohydrate ligands. 2013 Langmuir pmid:23782319
Ceccacci F et al. Deracemization and the first CD spectrum of a 3(10)-helical peptide made of achiral α-amino-isobutyric acid residues in a chiral membrane mimetic environment. 2013 Chem. Commun. (Camb.) pmid:24049772
Fremaux J et al. Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers. 2013 Chem. Commun. (Camb.) pmid:23862177
Vogel KR et al. Characterization of 2-(methylamino)alkanoic acid capacity to restrict blood-brain phenylalanine transport in Pah enu2 mice: preliminary findings. 2013 Mol. Genet. Metab. pmid:23999161
Panizel I et al. Eight new peptaibols from sponge-associated Trichoderma atroviride. 2013 Mar Drugs pmid:24335521
Wada S et al. Effect of Ala replacement with Aib in amphipathic cell-penetrating peptide on oligonucleotide delivery into cells. 2013 Bioorg. Med. Chem. pmid:24216093
Parween S et al. Non-natural amino acids containing peptide-capped gold nanoparticles for drug delivery application. 2013 ACS Appl Mater Interfaces pmid:23767970
Islam MS et al. Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition. 2012 Amino Acids pmid:21638021
Sopasis GJ et al. Heptanuclear heterometallic [Cu6Ln] clusters: trapping lanthanides into copper cages with artificial amino acids. 2012 Inorg Chem pmid:22548650
Demizu Y et al. Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid. 2012 J. Pept. Sci. pmid:22619002
De Zotti M et al. Antimicrobial lipopeptaibol trichogin GA IV: role of the three Aib residues on conformation and bioactivity. 2012 Amino Acids pmid:22484376
Tsuji AB et al. Comparison of 2-amino-[3-¹¹C]isobutyric acid and 2-deoxy-2-[¹⁸F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation. 2012 Nucl Med Commun pmid:22797465
Day JW et al. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. 2012 Biopolymers pmid:23203689
Demizu Y et al. Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments. 2012 J. Org. Chem. pmid:23006337
Huber KL et al. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. 2012 Biopolymers pmid:23203690
Mikkola R et al. 20-Residue and 11-residue peptaibols from the fungus Trichoderma longibrachiatum are synergistic in forming Na+/K+ -permeable channels and adverse action towards mammalian cells. 2012 FEBS J. pmid:22994321
Khunweeraphong N et al. Establishment of stable cell lines with high expression of heterodimers of human 4F2hc and human amino acid transporter LAT1 or LAT2 and delineation of their differential interaction with α-alkyl moieties. 2012 J. Pharmacol. Sci. pmid:22850614
Kim GB and Kim YP Analysis of protease activity using quantum dots and resonance energy transfer. 2012 Theranostics pmid:22375154
Chi OZ et al. Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia. 2011 J. Neurol. Sci. pmid:21094956
Goj A and Bittner ER Mixed quantum classical simulations of excitons in peptide helices. 2011 J Chem Phys pmid:21639483
Donoli A et al. Charge mapping in 3(10)-helical peptide chains by oxidation of the terminal ferrocenyl group. 2011 Org. Lett. pmid:21341757
Kato K et al. An efficient and expedient method for the synthesis of 11C-labeled α-aminoisobutyric acid: a tumor imaging agent potentially useful for cancer diagnosis. 2011 Bioorg. Med. Chem. Lett. pmid:21392981
Kar S et al. Formation of vesicles through solvent assisted self-assembly of hydrophobic pentapeptides: encapsulation and pH responsive release of dyes by the vesicles. 2011 Protein Pept. Lett. pmid:21443496
Elsila JE et al. Distribution and stable isotopic composition of amino acids from fungal peptaibiotics: assessing the potential for meteoritic contamination. 2011 Astrobiology pmid:21417942
Shennan DB and Thomson J Specificity of the volume-activated amino acid efflux pathway in cultured human breast cancer cells. 2011 Gen. Physiol. Biophys. pmid:21460411
Jacobsen Ø et al. Stapling of a 3(10)-helix with click chemistry. 2011 J. Org. Chem. pmid:21275402
Van den Eynden J et al. Glycine enhances microglial intracellular calcium signaling. A role for sodium-coupled neutral amino acid transporters. 2011 Pflugers Arch. pmid:21350800
Yu M et al. Methyl jasmonate-induced defense responses are associated with elevation of 1-aminocyclopropane-1-carboxylate oxidase in Lycopersicon esculentum fruit. 2011 J. Plant Physiol. pmid:21788095
Carlotto S et al. In silico interpretation of cw-ESR at 9 and 95 GHz of mono- and bis- TOAC-labeled Aib-homopeptides in fluid and frozen acetonitrile. 2011 J Phys Chem B pmid:21970372
Wada S et al. Cellular uptake of Aib-containing amphipathic helix peptide. 2011 Bioorg. Med. Chem. Lett. pmid:21875799
Porth I et al. Defense mechanisms against herbivory in Picea: sequence evolution and expression regulation of gene family members in the phenylpropanoid pathway. 2011 BMC Genomics pmid:22177423
Fletcher SP et al. Synthesis of enantiomerically enriched (R)-C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine. 2011 Beilstein J Org Chem pmid:22043239
Ramapanicker R et al. Applications of propargyl esters of amino acids in solution-phase Peptide synthesis. 2011 Int J Pept pmid:21760822
Gran P and Cameron-Smith D The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes. 2011 BMC Physiol. pmid:21702994
Nagaraja TN et al. MRI and quantitative autoradiographic studies following bolus injections of unlabeled and (14)C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants. 2011 NMR Biomed pmid:21674656
Lu HL et al. A calcium bioluminescence assay for functional analysis of mosquito (Aedes aegypti) and tick (Rhipicephalus microplus) G protein-coupled receptors. 2011 J Vis Exp pmid:21540818
Gao X et al. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. 2011 J. Am. Chem. Soc. pmid:21299212
Mukherjee PK et al. Two classes of new peptaibols are synthesized by a single non-ribosomal peptide synthetase of Trichoderma virens. 2011 J. Biol. Chem. pmid:21123172
Demizu Y et al. Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues. 2010 J. Pept. Sci. pmid:20853311
Geotti-Bianchini P et al. Replacement of Ala by Aib improves structuration and biological stability in thymine-based alpha-nucleopeptides. 2010 Org. Biomol. Chem. pmid:20204202
Becucci L et al. Effect of a strong interfacial electric field on the orientation of the dipole moment of thiolated aib-oligopeptides tethered to mercury on either the N- or C-terminus. 2010 J. Am. Chem. Soc. pmid:20392067
Chi OZ et al. The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. 2010 Anesth. Analg. pmid:20304986
Stalport F et al. UVolution, a photochemistry experiment in low earth orbit: investigation of the photostability of carboxylic acids exposed to mars surface UV radiation conditions. 2010 Astrobiology pmid:20528199
Kadono T et al. Increased anion channel activity is an unavoidable event in ozone-induced programmed cell death. 2010 PLoS ONE pmid:20967217
Xie J et al. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. 2010 BMC Dev. Biol. pmid:20653957
Smith SM et al. The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors. 2010 Open Med Chem J pmid:20648222
Potier B et al. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. 2010 Front Aging Neurosci pmid:20552041
Fogle EJ and Toney MD Mutational analysis of substrate interactions with the active site of dialkylglycine decarboxylase. 2010 Biochemistry pmid:20540501
Schuster A and Schmoll M Biology and biotechnology of Trichoderma. 2010 Appl. Microbiol. Biotechnol. pmid:20461510
Sadowska GB et al. Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep. 2010 Am. J. Physiol. Heart Circ. Physiol. pmid:19855054
Maekawa H et al. Couplings between peptide linkages across a 3(10)-helical hydrogen bond revealed by two-dimensional infrared spectroscopy. 2009 J. Am. Chem. Soc. pmid:19199613
Brückner H et al. Aib and iva in the biosphere: neither rare nor necessarily extraterrestrial. 2009 Chem. Biodivers. pmid:19180454
Malek A and Leiser R Influence of the magnesium aspartate hydrochloride administration to the maternal circuit on the aspartate concentration of the fetal circuit under in vitro perfusion of human placenta. 2009 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:18951687
Choi SH et al. Crystallographic characterization of helical secondary structures in 2:1 and 1:2 alpha/beta-peptides. 2009 J. Am. Chem. Soc. pmid:19203269
Banerjee R et al. Conformational preferences of a short Aib/Ala-based water-soluble peptide as a function of temperature. 2009 Proteins pmid:19137603
Chi OZ et al. Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia. 2009 Neurochem. Res. pmid:19127429
Kar S et al. Overlapping double turn conformations adopted by tetrapeptides containing non-coded alpha-amino isobutyric acid (Aib) and formation of tape-like structures through supramolecular helix mediated self-assembly. 2009 Protein Pept. Lett. pmid:19508219
Salnikov E et al. Analysis of the amide (15)N chemical shift tensor of the C(alpha) tetrasubstituted constituent of membrane-active peptaibols, the alpha-aminoisobutyric acid residue, compared to those of di- and tri-substituted proteinogenic amino acid residues. 2009 J. Biomol. NMR pmid:19823773
Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. 2009 Orig Life Evol Biosph pmid:19468860
Kawasaki T et al. Asymmetric autocatalysis induced by meteoritic amino acids with hydrogen isotope chirality. 2009 Chem. Commun. (Camb.) pmid:19597604
Salnikov ES et al. Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy. 2009 Biophys. J. pmid:18835909
Prabhakaran P et al. Sequence-specific unusual (1-->2)-type helical turns in alpha/beta-hybrid peptides. 2008 J. Am. Chem. Soc. pmid:19061328
Chi OZ et al. Effects of deferoxamine on blood-brain barrier disruption and VEGF in focal cerebral ischemia. 2008 Neurol. Res. pmid:17767813
Wada S et al. Translocation of an Aib-containing peptide through cell membranes. 2008 Bioorg. Med. Chem. Lett. pmid:18565748
Sekizaki H et al. Trypsin-catalyzed synthesis of dipeptide containing alpha-aminoisobutyric acid using p- and m-(amidinomethyl)phenyl esters as acyl donor. 2008 Chem. Pharm. Bull. pmid:18451559
Stoppacher N et al. Characterisation of the peptaibiome of the biocontrol fungus Trichoderma atroviride by liquid chromatography/tandem mass spectrometry. 2008 Rapid Commun. Mass Spectrom. pmid:18470867
Danger G and Ross D Development of a temperature gradient focusing method for in situ extraterrestrial biomarker analysis. 2008 Electrophoresis pmid:18654978
Ousaka N et al. Chain-terminus triggered chiral memory in an optically inactive 3(10)-helical peptide. 2008 J. Am. Chem. Soc. pmid:18722436
Chi OZ et al. Effects of VEGF on the blood-brain barrier disruption caused by hyperosmolarity. 2008 Pharmacology pmid:18708733
Popkov A et al. {2-[(S)-({2-[(S)-1-Benzyl-pyrrolidine-2-carboxamido]phen-yl}(phen-yl)methyl-ene)amino]-4-hydroxy-butanoato-κN,N',N'',O}nickel(II). 2008 Acta Crystallogr Sect E Struct Rep Online pmid:21201323
Gómez-Nuñez M et al. Non-natural and photo-reactive amino acids as biochemical probes of immune function. 2008 PLoS ONE pmid:19079589
Bueso E et al. The lithium tolerance of the Arabidopsis cat2 mutant reveals a cross-talk between oxidative stress and ethylene. 2007 Plant J. pmid:17931347
Schweitzer-Stenner R et al. Conformational manifold of alpha-aminoisobutyric acid (Aib) containing alanine-based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic circular dichroism spectroscopy, and molecular dynamics simulations. 2007 J. Am. Chem. Soc. pmid:17918837
Masterson LR et al. Nonstereogenic alpha-aminoisobutyryl-glycyl dipeptidyl unit nucleates type I' beta-turn in linear peptides in aqueous solution. 2007 Biopolymers pmid:17427180
Krug AW et al. Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective? 2007 Am. J. Physiol. Renal Physiol. pmid:17429029
Boal AK et al. Facile and E-selective intramolecular ring-closing metathesis reactions in 3(10)-helical peptides: a 3D structural study. 2007 J. Am. Chem. Soc. pmid:17497781
Demizu Y et al. Controlling 3(10)-helix and alpha-helix of short peptides in the solid state. 2007 Chem. Pharm. Bull. pmid:17473484
Prasad S et al. Bombesin analogs containing alpha-amino-isobutyric acid with potent anticancer activity. 2007 J. Pept. Sci. pmid:17031871
Chi OZ et al. Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia. 2007 Exp. Neurol. pmid:17188266
Hoare SR Allosteric modulators of class B G-protein-coupled receptors. 2007 Curr Neuropharmacol pmid:19305799
Fang J et al. IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): evidence for MAP kinase-dependent and MAP kinase-independent mechanisms. 2006 Oct-Dec Growth Horm. IGF Res. pmid:17035059
Fabris L et al. Gold nanoclusters protected by conformationally constrained peptides. 2006 J. Am. Chem. Soc. pmid:16390162
Mahalakshmi R and Balaram P Non-protein amino acids in the design of secondary structure scaffolds. 2006 Methods Mol. Biol. pmid:16957333
Venanzi M et al. Peptide folding dynamics: a time-resolved study from the nanosecond to the microsecond time regime. 2006 J Phys Chem B pmid:17092035
Holm AH et al. Effect of peptide ligand dipole moments on the redox potentials of Au38 and Au140 nanoparticles. 2006 Langmuir pmid:17129033
Rhee Y et al. In vitro and in vivo effect of parathyroid hormone analogue (1-14) containing -amino-iso-butyric acid residue (Aib)1,3. 2006 Yonsei Med. J. pmid:16642551
Tran TT et al. Designing amino acid residues with single-conformations. 2006 Protein Eng. Des. Sel. pmid:16799150
Tarabek P et al. Time-resolved FT EPR and optical spectroscopy study on photooxidation of aliphatic alpha-amino acids in aqueous solutions; electron transfer from amino vs carboxylate functional group. 2006 J Phys Chem A pmid:16737283