2,5-diaminopentanoic acid

2,5-diaminopentanoic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Vasodilation, Intestinal Absorption and Pinocytosis. 2,5-diaminopentanoic acid often locates in Mitochondria, Microfilaments, NADH dehydrogenase complex and respiratory chain complex III location sensu Eukarya. The associated genes with 2,5-diaminopentanoic acid are GAPDH gene and iberiotoxin.

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Introduction

To understand associated biological information of 2,5-diaminopentanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2,5-diaminopentanoic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2,5-diaminopentanoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Wounds and Injuries D014947 20 associated lipids
Burns D002056 34 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2,5-diaminopentanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2,5-diaminopentanoic acid?

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What functions are associated with 2,5-diaminopentanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2,5-diaminopentanoic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with 2,5-diaminopentanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2,5-diaminopentanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2,5-diaminopentanoic acid

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Per page 10 20 50 100 | Total 4676
Authors Title Published Journal PubMed Link
van de Poll MC et al. Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. 2007 Am. J. Clin. Nutr. pmid:17209193
Brosnan ME and Brosnan JT Hepatic glutamate metabolism: a tale of 2 hepatocytes. 2009 Am. J. Clin. Nutr. pmid:19625684
Moukarzel AA et al. Growth retardation in children receiving long-term total parenteral nutrition: effects of ornithine alpha-ketoglutarate. 1994 Am. J. Clin. Nutr. pmid:8074074
Yu YM et al. Relations among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients. 1995 Am. J. Clin. Nutr. pmid:7572742
Dorf G Anorexia of aging. 1998 Am. J. Clin. Nutr. pmid:9734760
Morton HE and Monaco MA Comparison of enterotubes and routine media for the identification of enteric bacteria. 1971 Am. J. Clin. Pathol. pmid:4933668
Bottone E and Allerhand J Aeromonas and serratia. Comparative study of extracellular deoxyribonuclease production and other biochemical characteristics. 1970 Am. J. Clin. Pathol. pmid:4313646
Oberhofer TR and Hajkowski R Evaluation of non-lactose-fermenting members of the Klebsiella-Enterobacter-Serratia division. I. Biochemical characteristics. 1970 Am. J. Clin. Pathol. pmid:4920036
Shih VE et al. Hyperornithinemia, hyperammonemia, and homocitrullinuria. A new disorder of amino acid metabolism associated with myoclonic seizures and mental retardation. 1969 Am. J. Dis. Child. pmid:5782534
Fell V et al. Ornithinemia, hyperammonemia, and homocitrullinuria. A disease associated with mental retardation and possibly caused by defective mitochondrial transport. 1974 Am. J. Dis. Child. pmid:4825593
Kato T et al. Hyperdibasicaminoaciduria and hyperammonemia in familial protein intolerance. 1976 Am. J. Dis. Child. pmid:998577
WOODY NC HYPERLYSINEMIA. 1964 Am. J. Dis. Child. pmid:14209691
Shih VE et al. Ornithine ketoacid transaminase deficiency in gyrate atrophy of the choroid and retina. 1978 Am. J. Hum. Genet. pmid:655164
Lauteala T et al. Lysinuric protein intolerance (LPI) gene maps to the long arm of chromosome 14. 1997 Am. J. Hum. Genet. pmid:9199570
Kennaway NG et al. Gyrate atrophy of the choroid and retina with hyperornithinemia: biochemical and histologic studies and response to vitamin B6. 1980 Am. J. Hum. Genet. pmid:7395865
Raj DS et al. Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy. 2004 Am. J. Kidney Dis. pmid:14712439
Crawhall JC and Watts RW Cystinuria. 1968 Am. J. Med. pmid:4879834
Simell O et al. Lysinuric protein intolerance. 1975 Am. J. Med. pmid:1155480
SCHWARTZ R et al. METABOLISM OF ORNITHINE AND OTHER AMINO ACIDS IN THE CEREBRO-OCULO-RENAL SYNDROME. 1964 Am. J. Med. pmid:14141452
Chadefaux B et al. Potential for the prenatal diagnosis of hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. 1989 Am. J. Med. Genet. pmid:2929667
Giugliani R et al. Heterozygous cystinuria and urinary lithiasis. 1985 Am. J. Med. Genet. pmid:3934971
Reid DW et al. Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report. 1971 Am. J. Obstet. Gynecol. pmid:5098595
Weiner CP et al. Myometrial arginase activity increases with advancing pregnancy in the guinea pig. 1996 Am. J. Obstet. Gynecol. pmid:8623821
McCulloch C and Marliss EB Gyrate atrophy of the choroid and retina with hyperornithinemia. 1975 Am. J. Ophthalmol. pmid:1200098
Chen CJ and Furr P Bilateral keratoconus in a patient with gyrate atrophy and hyperornithinemia. 1983 Am. J. Ophthalmol. pmid:6846463
Oliveira TL et al. Cystoid macular edema in gyrate atrophy of the choroid and retina: a fluorescein angiography and optical coherence tomography evaluation. 2005 Am. J. Ophthalmol. pmid:16038665
Kaiser-Kupfer MI et al. Clinical and biochemical heterogeneity in gyrate atrophy. 1980 Am. J. Ophthalmol. pmid:7355975
Giri SN et al. The effect of alpha-difluoromethylornithine on the development of bleomycin-induced pulmonary fibrosis in hamsters. 1982 Am. J. Pathol. pmid:6181691
Toback FG et al. Alterations in renal and plasma amino acid concentrations during renal compensatory growth. 1973 Am. J. Physiol. pmid:4745228
Olson JW et al. Polyamines and the development of monocrotaline-induced pulmonary hypertension. 1984 Am. J. Physiol. pmid:6437245
Yang P et al. Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation. 1984 Am. J. Physiol. pmid:6437251
BARNES RH et al. EFFECTS OF EXERCISE AND ADMINISTRATION OF ASPARTIC ACID ON BLOOD AMMONIA IN THE RAT. 1964 Am. J. Physiol. pmid:14251926
Castillo L et al. Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. 1995 Am. J. Physiol. pmid:7864114
Preslock JP and Hampton JK Ornithine decarboxylase stimulation by 3',5'-cyclic AMP in oviduct of Coturnix quail. 1973 Am. J. Physiol. pmid:4355180
Pegg AE and McCann PP Polyamine metabolism and function. 1982 Am. J. Physiol. pmid:6814260
Goodman MW et al. Mechanism of arginine protection against ammonia intoxication in the rat. 1984 Am. J. Physiol. pmid:6476119
Binko J et al. Endothelium removal induces iNOS in rat aorta in organ culture, leading to tissue damage. 1999 Am. J. Physiol. pmid:9886958
Levillain O and Hus-Citharel A Ornithine decarboxylase along the mouse and rat nephron. 1998 Am. J. Physiol. pmid:9841492
Strickler JC and Frimpter GW Renal excretion of cystathionine in dogs. 1969 Am. J. Physiol. pmid:5824321
Seidel ER et al. Polyamines in the response to intestinal obstruction. 1984 Am. J. Physiol. pmid:6430095
Le Boucher J et al. Ornithine alpha-ketoglutarate modulates tissue protein metabolism in burn-injured rats. 1997 Am. J. Physiol. pmid:9316446
DeWitt BJ et al. Differential effects of L-N5-(1-iminoethyl)-ornithine on tone and endothelium-dependent vasodilator responses. 1997 Am. J. Physiol. pmid:9316493
Greenberg SS et al. Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats. 1997 Am. J. Physiol. pmid:9321883
Drotman RB and Freedland RA Citrulline metabolism in the perfused rat liver. 1972 Am. J. Physiol. pmid:5027108
DICKERMAN HW and WALKER WG EFFECT OF CATIONIC AMINO ACID INFUSION ON POTASSIUM METABOLISM IN VIVO. 1964 Am. J. Physiol. pmid:14120449
Scornik OA et al. Protein depletion and replenishment in mice: different roles of muscle and liver. 1997 Am. J. Physiol. pmid:9435532
Lu M and Wang WH Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct. 1996 Am. J. Physiol. pmid:8967433
Stegink LD et al. Monosodium glutamate metabolism in the neonatal monkey. 1975 Am. J. Physiol. pmid:1147051
Wu G et al. Arginine degradation in developing porcine enterocytes. 1996 Am. J. Physiol. pmid:8944707
Williams JA and Phang JM Production of ornithine by intact human erythrocytes. 1982 Am. J. Physiol. pmid:7081429
Flynn NE and Wu G An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs. 1996 Am. J. Physiol. pmid:8945947
Pardridge WM et al. Arginine metabolism and urea synthesis in cultured rat skeletal muscle cells. 1982 Am. J. Physiol. pmid:6801993
Wu G Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. 1997 Am. J. Physiol. pmid:9227473
Wolff JE et al. Net metabolism of plasma amino acids by liver and portal-drained viscera of fed sheep. 1972 Am. J. Physiol. pmid:5046759
Stewart PM et al. Effects of arginine-free meals on ureagenesis in cats. 1981 Am. J. Physiol. pmid:7315956
Hoogenraad N et al. Inhibition of intestinal citrulline synthesis causes severe growth retardation in rats. 1985 Am. J. Physiol. pmid:4083357
Tabata K and Johnson LR Ornithine decarboxylase and mucosal growth in response to feeding. 1986 Am. J. Physiol. pmid:3090896
Ródenas J et al. Nitric oxide inhibits superoxide production by inflammatory polymorphonuclear leukocytes. 1998 Am. J. Physiol. pmid:9530115
Miles PR et al. Constitutive nitric oxide production by rat alveolar macrophages. 1998 Am. J. Physiol. pmid:9530171
Faruqi TR et al. Role of nitric oxide in poly(I-C)-induced endothelial cell expression of leukocyte adhesion molecules. 1997 Am. J. Physiol. pmid:9374789
Martín-Requero A et al. On the mechanism of stimulation of ureagenesis by gluconeogenic substrates: role of pyruvate carboxylase. 1992 Am. J. Physiol. pmid:1415529
Rau EE et al. Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion. 1979 Am. J. Physiol. pmid:443452
Levillain O et al. Arginine synthesis in mouse and rabbit nephron: localization and functional significance. 1993 Am. J. Physiol. pmid:8322890
Hitier Y et al. Urea concentration and ornithine decarboxylase in liver of female rats. 1986 Am. J. Physiol. pmid:3083692
Beaumier L et al. Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans. 1995 Am. J. Physiol. pmid:7491940
Buga GM et al. NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. 1998 Am. J. Physiol. pmid:9756558
Bogle RG et al. Endothelial polyamine uptake: selective stimulation by L-arginine deprivation or polyamine depletion. 1994 Am. J. Physiol. pmid:8166241
Seidel ER et al. Attenuation of trophic response to gastrin after inhibition of ornithine decarboxylase. 1985 Am. J. Physiol. pmid:2409817
Russell DH et al. Polyamine synthesis during initial phases of stress-induced cardiac hypertrophy. 1971 Am. J. Physiol. pmid:4256528
Feldman MJ and Russell DH Polyamine biogenesis in left ventricle of the rat heart after aortic constriction. 1972 Am. J. Physiol. pmid:4259993
Wu G and Meininger CJ Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. 1995 Am. J. Physiol. pmid:7485563
Wu G and Knabe DA Arginine synthesis in enterocytes of neonatal pigs. 1995 Am. J. Physiol. pmid:7573565
Erwin BG et al. Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes. 1984 Am. J. Physiol. pmid:6422770
McLeod ME and Tyor MP Transport of basic amino acids by hamster intestine. 1967 Am. J. Physiol. pmid:6027913
Wilson OH and Scriver CR Specificity of transport of neutral and basic amino acids in rat kidney. 1967 Am. J. Physiol. pmid:6027917
Radermacher J et al. Effect of arginine depletion on glomerular and tubular kidney function: studies in isolated perfused rat kidneys. 1991 Am. J. Physiol. pmid:1951709
Sweiry JH et al. Cis-inhibition and trans-stimulation of cationic amino acid transport in the perfused rat pancreas. 1991 Am. J. Physiol. pmid:1909494
Levillain O et al. Localization of urea and ornithine production along mouse and rabbit nephrons: functional significance. 1992 Am. J. Physiol. pmid:1443176
Osowska S et al. Citrulline modulates muscle protein metabolism in old malnourished rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16608884
Marini JC et al. Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17925451
Yu YM et al. Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11171607
Bruce M et al. Glutamine supplementation promotes anaplerosis but not oxidative energy delivery in human skeletal muscle. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11254475
Tomlinson C et al. Arginine synthesis from enteral glutamine in healthy adults in the fed state. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21540446
Marini JC et al. Enteral arginase II provides ornithine for citrulline synthesis. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:20978229
Teng C et al. Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11832355
Leiss V et al. Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2). 2014 Am. J. Physiol. Endocrinol. Metab. pmid:25205820
Marini JC et al. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:23074237
Li H et al. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11120661
Urschel KL et al. Arginine synthesis does not occur during first-pass hepatic metabolism in the neonatal piglet. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15657089
Wu G et al. Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913040
O'Sullivan D et al. Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10710507
Bertolo RF et al. Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12527558
Balasubramaniyan V et al. Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:21903766
Mouillé B et al. Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15064231
Han X et al. Rat colon ornithine and arginine metabolism: coordinated effects after proliferative stimuli. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11171621
Chumanevich AA et al. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. 2011 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:21415415
Sharma V et al. Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22421619
Kristiansen RG et al. L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. 2014 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25258408
Reid KM et al. Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17023552
Renga B et al. Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids. 2015 Am. J. Physiol. Heart Circ. Physiol. pmid:25934094