Lipoic acid

Lipoic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Lipoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Lead Poisoning D007855 4 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Hyperglycemia D006943 21 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Bone Resorption D001862 7 associated lipids
Carbon Tetrachloride Poisoning D002252 12 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Corneal Diseases D003316 13 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Testicular Diseases D013733 15 associated lipids
Hypothyroidism D007037 32 associated lipids
Hypercapnia D006935 5 associated lipids
Osteoporosis D010024 12 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Kidney Calculi D007669 7 associated lipids
Weight Gain D015430 101 associated lipids
Burning Mouth Syndrome D002054 2 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Obesity D009765 29 associated lipids
Peritonitis D010538 38 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Intervertebral Disc Displacement D007405 2 associated lipids
Per page 10 20 50 100 | Total 177

PubChem Biomolecular Interactions and Pathways

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All references with Lipoic acid

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Per page 10 20 50 100 | Total 4476
Authors Title Published Journal PubMed Link
Zhu YY et al. A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism. 2013 Proteomics pmid:23161516
Jayakar SS and Singhal RS Kinetic modeling and scale up of lipoic acid (LA) production from Saccharomyces cerevisiae in a stirred tank bioreactor. 2013 Bioprocess Biosyst Eng pmid:23178984
Wu L et al. Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions. 2013 Biomaterials pmid:23570719
Yan GR et al. Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-mβ cell death by inducing ROS generation. 2013 PLoS ONE pmid:23750203
Bryk R et al. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. 2013 Biochemistry pmid:24251446
Kumazaki M et al. α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. 2013 Eur. J. Pharmacol. pmid:23474023
Trevisan G et al. Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. 2013 Cancer Res. pmid:23477783
Koizumi R et al. Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling. 2013 J Toxicol Sci pmid:23665930
Volchegorskii IA et al. Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. 2013 Bull. Exp. Biol. Med. pmid:23667872
Tang X et al. Effects of heat treatment on structural modification and in vivo antioxidant capacity of soy protein. 2012 Nov-Dec Nutrition pmid:22858204
Plotnikov M et al. Influence of antioxidant complex on the adhesion of leukocytes in chronic venous insufficiency of lower limbs in rats. 2012 Nov-Dec Indian J Pharmacol pmid:23248399
Zur E Burning mouth syndrome: a discussion of a complex pathology. 2012 May-Jun Int J Pharm Compd pmid:23050296
Campos PM et al. Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. 2012 May-Jun Photochem. Photobiol. pmid:22236139
Lee SG et al. Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina. 2012 Jan-Feb Clin. Experiment. Ophthalmol. pmid:21902786
Bruin JE et al. Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. 2012 J Diabetes pmid:22385833
Rouault TA Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease. 2012 Dis Model Mech pmid:22382365
Miller SL et al. Antioxidant therapies: a potential role in perinatal medicine. 2012 Neuroendocrinology pmid:22377769
Ko SH and Cha BY Diabetic peripheral neuropathy in type 2 diabetes mellitus in Korea. 2012 Diabetes Metab J pmid:22363916
Kim JI et al. Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines. 2012 Korean J Thorac Cardiovasc Surg pmid:22363901
Guerra SM et al. LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor. 2012 PLoS ONE pmid:22363654
Yeni D et al. Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats. 2012 Andrologia pmid:21919941
Martins AR et al. Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. 2012 Lipids Health Dis pmid:22360800
Galea E et al. Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases? 2012 Biochim. Biophys. Acta pmid:22353463
Lee YJ et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. 2012 J Neuroinflammation pmid:22339795
Zhang HJ et al. Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein. 2012 Talanta pmid:22284509
Gerlinger I [Burning sensation in oral cavity--burning mouth syndrome in everyday medical practice]. 2012 Ideggyogy Sz pmid:23126213
Han Z et al. Robust photogeneration of H2 in water using semiconductor nanocrystals and a nickel catalyst. 2012 Science pmid:23138979
Kaplan KA et al. Alpha-lipoic acid protects against indomethacin-induced gastric oxidative toxicity by modulating antioxidant system. 2012 J. Food Sci. pmid:23057764
Al Abdan M Alfa-lipoic acid controls tumor growth and modulates hepatic redox state in Ehrlich-ascites-carcinoma-bearing mice. 2012 ScientificWorldJournal pmid:23002387
Mazza A et al. The role of metformin in the management of NAFLD. 2012 Exp Diabetes Res pmid:22194737
Kharbanda KK et al. Betaine treatment attenuates chronic ethanol-induced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome. 2012 Int J Hepatol pmid:22187660
Liu DS et al. Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells. 2012 J. Am. Chem. Soc. pmid:22176354
Narisawa A et al. Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. 2012 Hum. Mol. Genet. pmid:22171071
Sha SH et al. Antioxidant-enriched diet does not delay the progression of age-related hearing loss. 2012 Neurobiol. Aging pmid:22154190
Henry SA et al. Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. 2012 Genetics pmid:22345606
Othman AI et al. Alfa-lipoic acid protects testosterone secretion pathway and sperm quality against 4-tert-octylphenol induced reproductive toxicity. 2012 Ecotoxicol. Environ. Saf. pmid:22560493
Degola F et al. Development of a simple and high-throughput method for detecting aflatoxins production in culture media. 2012 Lett. Appl. Microbiol. pmid:22568641
Shimoda S et al. The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis. 2012 Clin. Exp. Immunol. pmid:22519590
Shay KP et al. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. 2012 Biochim. Biophys. Acta pmid:22521877
Ponte F et al. Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine. 2012 Orphanet J Rare Dis pmid:22591656
Veskoukis AS et al. Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration. 2012 Cell Stress Chaperones pmid:21956695
Fuchs TM et al. Toward a Systemic Understanding of Listeria monocytogenes Metabolism during Infection. 2012 Front Microbiol pmid:22347216
He L et al. Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. 2012 Eur. J. Pharmacol. pmid:22266491
Yao H et al. Reaction characteristics of andrographolide and its analogue AL-1 with GSH, as a simple chemical simulation of NF-κB inhibition. 2012 Molecules pmid:22241468
Pfeffer G et al. Treatment for mitochondrial disorders. 2012 Cochrane Database Syst Rev pmid:22513923
Gao J et al. Colloidal stability of gold nanoparticles modified with thiol compounds: bioconjugation and application in cancer cell imaging. 2012 Langmuir pmid:22276658
Connell BJ et al. UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion. 2012 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:22277933
Al-Mulla F et al. A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. 2012 PLoS ONE pmid:22279539
Valdecantos MP et al. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. 2012 Obesity (Silver Spring) pmid:22327056
Bertolotto F and Massone A Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. 2012 Drugs R D pmid:22329607
Cui J et al. Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression. 2012 Nutrition pmid:22305006
Breuer ME et al. Modeling mitochondrial dysfunctions in the brain: from mice to men. 2012 J. Inherit. Metab. Dis. pmid:21755361
Bitar MS and Al-Mulla F ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes. 2012 Dis Model Mech pmid:22362362
Chen SA et al. Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products. 2012 Eur J Pharm Sci pmid:22985875
Montero O et al. Determination of lipoic acid, Trolox methyl ether and tocopherols in human plasma by liquid-chromatography and ion-trap tandem mass spectrometry. 2012 Biomed. Chromatogr. pmid:22222855
Mollo R et al. Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. 2012 Diabetes Care pmid:22228743
Terán R et al. The life span of Drosophila melanogaster is affected by melatonin and thioctic acid. 2012 Invest Clin pmid:23248969
Palui G et al. Poly(ethylene glycol)-based multidentate oligomers for biocompatible semiconductor and gold nanocrystals. 2012 Langmuir pmid:22201293
Larkin J et al. A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world. 2012 Nephrol News Issues pmid:22870564
St-Louis R et al. Reactive oxygen species are required for the hypothalamic osmoregulatory response. 2012 Endocrinology pmid:22202167
Yu AL et al. TGF-β(2)- and H(2)O(2)-induced biological changes in optic nerve head astrocytes are reduced by the antioxidant alpha-lipoic acid. 2012 Ophthalmic Res. pmid:22710901
Min AK et al. Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. 2012 Life Sci. pmid:22154902
Connell BJ and Saleh TM Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion. 2012 Neurosci. Lett. pmid:22155048
Imik H et al. Effects of ascorbic acid and α-lipoic acid on performance and meat quality of broilers subjected to heat stress. 2012 Br. Poult. Sci. pmid:23398425
Ahmed HH Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model. 2012 Exp. Toxicol. Pathol. pmid:21183322
Munasinghe VS et al. New advances in the in-vitro culture of Dientamoeba fragilis. 2012 Parasitology pmid:22336222
DU SC et al. ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. 2012 Cell. Mol. Biol. (Noisy-le-grand) pmid:22455982
Chen WL et al. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. 2012 Diabetologia pmid:22456698
Shang L et al. Microwave-assisted rapid synthesis of luminescent gold nanoclusters for sensing Hg2+ in living cells using fluorescence imaging. 2012 Nanoscale pmid:22460520
Nunnery JK et al. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. 2012 J. Org. Chem. pmid:22489775
Cohen JD et al. Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation. 2012 Chembiochem pmid:22492621
Galasko DR et al. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. 2012 Arch. Neurol. pmid:22431837
Valdecantos MP et al. Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function. 2012 J. Nutr. Biochem. pmid:22464149
Sun YD et al. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. 2012 Ann. Nutr. Metab. pmid:22678104
Gokce EH et al. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. 2012 Int J Nanomedicine pmid:22605933
Schalkwijk CG and Miyata T Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics. 2012 Amino Acids pmid:20960212
Tournebize J et al. Impact of gold nanoparticle coating on redox homeostasis. 2012 Int J Pharm pmid:22841848
Jung TS et al. α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. 2012 Liver Int. pmid:22863080
Macêdo DS et al. Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine. 2012 Bipolar Disord pmid:22897629
Mrakic-Sposta S et al. Assessment of a standardized ROS production profile in humans by electron paramagnetic resonance. 2012 Oxid Med Cell Longev pmid:22900129
Thakurta IG et al. Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain. 2012 Biogerontology pmid:22851277
Colligris B et al. Recent patents and developments in glaucoma biomarkers. 2012 Recent Pat Endocr Metab Immune Drug Discov pmid:22827637
Kodama S et al. Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl-β-cyclodextrin as a chiral selector. 2012 Electrophoresis pmid:22887166
Hussein A et al. Ameliorating effect of DL-α-lipoic acid against cisplatin-induced nephrotoxicity and cardiotoxicity in experimental animals. 2012 Drug Discov Ther pmid:22890205
Lu H et al. Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice. 2012 Toxicol. Mech. Methods pmid:22871220
López-Erauskin J et al. Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy. 2012 Brain pmid:23250880
Yi X et al. Reduced alpha-lipoic acid synthase gene expression exacerbates atherosclerosis in diabetic apolipoprotein E-deficient mice. 2012 Atherosclerosis pmid:22658261
Rosa FT et al. Bioactive compounds with effects on inflammation markers in humans. 2012 Int J Food Sci Nutr pmid:22248031
Kim H et al. α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. 2012 J. Cell. Mol. Med. pmid:21362131
de Moraes M et al. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. 2012 J. Oral Pathol. Med. pmid:22092585
Gürpınar T et al. The effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain. 2012 ScientificWorldJournal pmid:22654617
Mishra P and Samanta L Oxidative stress and heart failure in altered thyroid States. 2012 ScientificWorldJournal pmid:22649319
Rahman ST et al. The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. 2012 J. Cardiovasc. Pharmacol. Ther. pmid:21750253
Gude D Tackling Chemotherapy-induced Alopecia. 2012 Int J Trichology pmid:22628994
Sarchielli P et al. Italian guidelines for primary headaches: 2012 revised version. 2012 J Headache Pain pmid:22581120
Kawashima J et al. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. 2012 PLoS ONE pmid:22590531
Unal B et al. Trace elements affect methanogenic activity and diversity in enrichments from subsurface coal bed produced water. 2012 Front Microbiol pmid:22590465
Ozbek E Induction of oxidative stress in kidney. 2012 Int J Nephrol pmid:22577546
Pitchaimani V et al. Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats. 2012 J Clin Biochem Nutr pmid:22573928
Yamasaki M et al. Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. 2012 J Clin Biochem Nutr pmid:22573927