Lipoic acid

Lipoic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Lipoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoic acid

MeSH term MeSH ID Detail
Alcoholic Neuropathy D020269 3 associated lipids
Chromosome Breakage D019457 2 associated lipids
Infectious Bovine Rhinotracheitis D007241 1 associated lipids
Chromosomal Instability D043171 5 associated lipids
Failed Back Surgery Syndrome D055111 3 associated lipids
Binge Drinking D063425 1 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Per page 10 20 50 100 | Total 177

PubChem Biomolecular Interactions and Pathways

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All references with Lipoic acid

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Per page 10 20 50 100 | Total 4476
Authors Title Published Journal PubMed Link
Villasana LE et al. Effects of alpha-lipoic acid on associative and spatial memory of sham-irradiated and 56Fe-irradiated C57BL/6J male mice. 2013 Pharmacol. Biochem. Behav. pmid:23051895
Somi MH et al. Lipoic acid prevents hepatic and intestinal damage induced by obstruction of the common bile duct in rats. 2013 Eur Rev Med Pharmacol Sci pmid:23740441
Inman DM et al. α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. 2013 PLoS ONE pmid:23755225
Tsai CJ et al. Dispersive liquid-liquid microextraction combined with microwave-assisted derivatization for determining lipoic acid and its metabolites in human urine. 2013 J Chromatogr A pmid:23993748
Ahmadi A et al. Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients. 2013 Iran J Kidney Dis pmid:24241092
Milward MR et al. Micronutrient modulation of NF-κB in oral keratinocytes exposed to periodontal bacteria. 2013 Innate Immun pmid:22890546
Yang L et al. [Effect of alpha-lipoic acid combined with transient intensive insulin therapy on adipokine level in patients with type 2 diabetic perineuropathy]. 2013 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:23827078
Kaya-Dagistanli F et al. The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids. 2013 Food Chem. Toxicol. pmid:23200892
Tang G et al. Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells. 2013 Diabetologia pmid:23275972
Tang X et al. Effects of heat treatment on structural modification and in vivo antioxidant capacity of soy protein. 2012 Nov-Dec Nutrition pmid:22858204
Plotnikov M et al. Influence of antioxidant complex on the adhesion of leukocytes in chronic venous insufficiency of lower limbs in rats. 2012 Nov-Dec Indian J Pharmacol pmid:23248399
Zur E Burning mouth syndrome: a discussion of a complex pathology. 2012 May-Jun Int J Pharm Compd pmid:23050296
Campos PM et al. Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. 2012 May-Jun Photochem. Photobiol. pmid:22236139
Lee SG et al. Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina. 2012 Jan-Feb Clin. Experiment. Ophthalmol. pmid:21902786
Terent'eva NV [The clinic, diagnosis, complex treatment of diabetic polyneuropathy]. 2012 Lik. Sprava pmid:23350148
Lee YJ et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. 2012 J Neuroinflammation pmid:22339795
Rio RV et al. Insight into the transmission biology and species-specific functional capabilities of tsetse (Diptera: glossinidae) obligate symbiont Wigglesworthia. 2012 MBio pmid:22334516
Mijnhout GS et al. Alpha lipoic Acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials. 2012 Int J Endocrinol pmid:22331979
de la Monte SM Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. 2012 Curr Alzheimer Res pmid:22329651
Cai D and Liu T Inflammatory cause of metabolic syndrome via brain stress and NF-κB. 2012 Aging (Albany NY) pmid:22328600
Sears ME and Genuis SJ Environmental determinants of chronic disease and medical approaches: recognition, avoidance, supportive therapy, and detoxification. 2012 J Environ Public Health pmid:22315626
Snoussi S et al. Adaptation of Salmonella enterica Hadar under static magnetic field: effects on outer membrane protein pattern. 2012 Proteome Sci pmid:22304719
Al Abdan M Alfa-lipoic acid controls tumor growth and modulates hepatic redox state in Ehrlich-ascites-carcinoma-bearing mice. 2012 ScientificWorldJournal pmid:23002387
Veljkovic AR et al. Protective effects of glutathione and lipoic acid against cadmium-induced oxidative stress in rat's kidney. 2012 Ren Fail pmid:23009295
Mischley LK et al. Coenzyme Q10 deficiency in patients with Parkinson's disease. 2012 J. Neurol. Sci. pmid:22542608
Henry SA et al. Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. 2012 Genetics pmid:22345606
Herzig S et al. Identification and functional expression of the mitochondrial pyruvate carrier. 2012 Science pmid:22628554
Yang Y et al. α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells. 2012 Dev. Growth Differ. pmid:22620683
Storm J and Müller S Lipoic acid metabolism of Plasmodium--a suitable drug target. 2012 Curr. Pharm. Des. pmid:22607141
Harding SV et al. Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk. 2012 J Diet Suppl pmid:22607646
Keith DJ et al. Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. 2012 Pharmacol. Res. pmid:22609537
Kaya M et al. Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits. 2012 Acta Neurochir (Wien) pmid:22610532
Queiroz TM et al. α-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats. 2012 Molecules pmid:23143148
Wang YM et al. α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt. 2012 J. Bioenerg. Biomembr. pmid:22528396
Bucak MN et al. Methionine supplementation improves ram sperm parameters during liquid storage at 5°C. 2012 Cryobiology pmid:23010484
Tsai FJ et al. Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum. 2012 J. Photochem. Photobiol. B, Biol. pmid:22537778
Okuyucu S et al. Thioctacid is effective for neuropathy symptoms and hyperglycemia control without pronounced electromyographic changes. 2012 Neurosciences (Riyadh) pmid:23022909
Röhnert P et al. Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion. 2012 J. Neurosci. Res. pmid:21971686
Abolhassani M et al. Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice. 2012 Invest New Drugs pmid:21655919
Halıcı M et al. Effects of α-lipoic acid, vitamins E and C upon the heat stress in Japanese quails. 2012 J Anim Physiol Anim Nutr (Berl) pmid:21535234
Lu BB and Li KH Lipoic acid prevents steroid-induced osteonecrosis in rabbits. 2012 Rheumatol. Int. pmid:21431293
Madeddu C et al. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. 2012 Clin Nutr pmid:22047681
Cui J et al. Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression. 2012 Nutrition pmid:22305006
Pickering AM et al. Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. 2012 J. Biol. Chem. pmid:22308036
Kono Y et al. Antiproliferative effects of a new α-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro. 2012 Expert Opin. Ther. Targets pmid:22313417
Lee WR et al. Alpha-lipoic acid attenuates atherosclerotic lesions and inhibits proliferation of vascular smooth muscle cells through targeting of the Ras/MEK/ERK signaling pathway. 2012 Mol. Biol. Rep. pmid:22302393
Papanas N and Maltezos E α-Lipoic acid, diabetic neuropathy, and Nathan's prophecy. 2012 Angiology pmid:22253286
Tahira A et al. Evaluation of protective and curative role of α-lipoic acid and selenium in gentamicin-induced nephrotoxicity in rabbits. 2012 Pak J Pharm Sci pmid:22186316
Palui G et al. Photoinduced phase transfer of luminescent quantum dots to polar and aqueous media. 2012 J. Am. Chem. Soc. pmid:22938162
Fernández-Galilea M et al. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. 2012 J. Lipid Res. pmid:22941773
Lee JE et al. α-Lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats. 2012 Cardiovasc Diabetol pmid:22992429
Astiz M et al. The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain. 2012 Neurochem. Int. pmid:22995786
Choi HJ et al. Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line. 2012 Nucl. Med. Biol. pmid:22995901
Spindler SR Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. 2012 Age (Dordr) pmid:21424790
Yamada M et al. alpha-lipoic acid prevents the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes. 2012 Dig. Dis. Sci. pmid:22212728
Talebi A et al. The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles. 2012 J. Assist. Reprod. Genet. pmid:22231012
Wei R et al. Reduction-responsive disassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release. 2012 Biomacromolecules pmid:22746534
Lee TH et al. Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia. 2012 Cell. Mol. Neurobiol. pmid:22814803
Wołyniec E et al. Determination of lipoic acid by flow-injection and high-performance liquid chromatography with chemiluminescence detection. 2012 Talanta pmid:22817954
Kuo YT et al. Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. 2012 Eur. J. Pharmacol. pmid:22819708
Qin ZY et al. α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway. 2012 J. Bioenerg. Biomembr. pmid:22820890
Li CJ et al. Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid. 2012 Cardiovasc Diabetol pmid:22713251
Chen X et al. Crosslinked self-assemblies of lipoid acid-substituted low molecular weight (1800 Da) polyethylenimine as reductive-sensitive non-viral gene vectors. 2012 Nanotechnology pmid:23011042
Sun YD et al. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. 2012 Ann. Nutr. Metab. pmid:22678104
Yu X et al. Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid. 2012 Ren Fail pmid:22687142
Huang X et al. Gold nanoparticles as a probe for prion determination via resonance light scattering method. 2012 Anal Sci pmid:22687927
Ghann WE et al. Syntheses and characterization of lisinopril-coated gold nanoparticles as highly stable targeted CT contrast agents in cardiovascular diseases. 2012 Langmuir pmid:22702239
Sohaib M et al. Enhancement of lipid stability of broiler breast meat and meat products fed on alpha lipoic acid and alpha tocopherol acetate supplemented feed. 2012 Lipids Health Dis pmid:22640892
Wagner AE et al. A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. 2012 Oxid Med Cell Longev pmid:22655115
Liu J et al. Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid. 2012 Toxicol In Vitro pmid:22580158
Porasuphatana S et al. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. 2012 Asia Pac J Clin Nutr pmid:22374556
Muro E et al. Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells. 2012 Small pmid:22378567
Ji X et al. On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine. 2012 J. Am. Chem. Soc. pmid:22394283
Kube M et al. Current view on phytoplasma genomes and encoded metabolism. 2012 ScientificWorldJournal pmid:22550465
Lu H et al. Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice. 2012 Toxicol. Mech. Methods pmid:22871220
Cui Y et al. High-fat diets impair spatial learning of mice in the Y-maze paradigm: ameliorative potential of α-lipoic acid. 2012 J Med Food pmid:22784184
Külkamp-Guerreiro IC et al. Development and stability of innovative semisolid formulations containing nanoencapsulated lipoic acid for topical use. 2012 J Nanosci Nanotechnol pmid:23421133
Rosa FT et al. Bioactive compounds with effects on inflammation markers in humans. 2012 Int J Food Sci Nutr pmid:22248031
de Moraes M et al. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. 2012 J. Oral Pathol. Med. pmid:22092585
Mirjana M et al. Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats. 2012 Eur J Nutr pmid:22094580
Finlay LA et al. R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. 2012 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:22049228
Cheng PY et al. Role of AMP-activated protein kinase in α-lipoic acid-induced vasodilatation in spontaneously hypertensive rats. 2012 Am. J. Hypertens. pmid:22052076
Sadi G et al. Changes in expression profiles of antioxidant enzymes in diabetic rat kidneys. 2012 Diabetes Metab. Res. Rev. pmid:22057777
Kaki SS et al. Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid. 2012 J. Biotechnol. pmid:22138637
Smith S et al. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. 2012 PLoS ONE pmid:23077570
Fisher DJ et al. Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT). 2012 PLoS ONE pmid:23029384
Guo W et al. Development of quinoxaline 1, 4-dioxides resistance in Escherichia coli and molecular change under resistance selection. 2012 PLoS ONE pmid:22952665
Park SJ et al. L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF). 2012 Int J Mol Sci pmid:22942681
Vadlapudi AD et al. Functional and molecular aspects of biotin uptake via SMVT in human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells. 2012 AAPS J pmid:22927035
Yamasaki M et al. Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. 2012 J Clin Biochem Nutr pmid:22573927
Ledesma JC and Aragon CM α-Lipoic acid, a scavenging agent for H₂O₂, reduces ethanol-stimulated locomotion in mice. 2012 Psychopharmacology (Berl.) pmid:21769567
Kanatsuna N et al. Etiopathogenesis of insulin autoimmunity. 2012 Anat Res Int pmid:22567309
Esrefoglu M Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis. 2012 Hepat Mon pmid:22550523
Sánchez A et al. Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats. 2012 PLoS ONE pmid:22540017
Fimognari C et al. Sulforaphane potentiates RNA damage induced by different xenobiotics. 2012 PLoS ONE pmid:22539965
Braakman R and Smith E The emergence and early evolution of biological carbon-fixation. 2012 PLoS Comput. Biol. pmid:22536150
Rydkina E et al. Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis. 2012 Microb. Pathog. pmid:22522044
Chatterjee N and Bohmann D A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture. 2012 PLoS ONE pmid:22509270
Daiber A et al. Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress. 2012 Int J Hypertens pmid:22506100
Quaranta N et al. The effect of alpha-lipoic acid on temporary threshold shift in humans: a preliminary study. 2012 Acta Otorhinolaryngol Ital pmid:23349557