| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Ketosis | D007662 | 13 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Bone Resorption | D001862 | 7 associated lipids |
| Carbon Tetrachloride Poisoning | D002252 | 12 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
Lipoic acid
Lipoic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Lipoic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Lipoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xing ZG et al. | Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells. | 2015 | Genet. Mol. Res. | pmid:26535703 |
| Kishita Y et al. | Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. | 2015 | Am. J. Hum. Genet. | pmid:26522469 |
| Ikuta N et al. | Structural Analysis of Crystalline R(+)-α-Lipoic Acid-α-cyclodextrin Complex Based on Microscopic and Spectroscopic Studies. | 2015 | Int J Mol Sci | pmid:26501268 |
| Ghinis-Hozumi Y et al. | Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures. | 2015 | J. Anim. Sci. | pmid:26440162 |
| Porcaro G et al. | Alpha Lipoic Acid (ALA) effects on subchorionic hematoma: preliminary clinical results. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26439038 |
| Uchida R et al. | Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats. | 2015 | Int J Mol Sci | pmid:26402669 |
| Lo MC et al. | Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy cause decreased insulin secretion from β-cells. | 2015 | Am. J. Physiol. Endocrinol. Metab. | pmid:26394662 |
| Bai W et al. | Cross talk between poly(ADP-ribose) polymerase 1 methylation and oxidative stress involved in the toxic effect of anatase titanium dioxide nanoparticles. | 2015 | Int J Nanomedicine | pmid:26366077 |
| Garcia-Alcala H et al. | Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. | 2015 | J Diabetes Res | pmid:26345602 |
| Xiong S et al. | PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases. | 2015 | Cell Rep | pmid:26299964 |
| Okanović A et al. | Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus. | 2015 | Med Glas (Zenica) | pmid:26276648 |
| Uchida R et al. | Effect of γ-Cyclodextrin Inclusion Complex on the Absorption of R-α-Lipoic Acid in Rats. | 2015 | Int J Mol Sci | pmid:25946345 |
| Brandt YI et al. | Quantum dot assisted tracking of the intracellular protein Cyclin E in Xenopus laevis embryos. | 2015 | J Nanobiotechnology | pmid:25925383 |
| Çakır T et al. | Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats? | 2015 | Acta Cir Bras | pmid:25923257 |
| Hackert ML et al. | Lester Reed: A "complex" man who loved science. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25901319 |
| Mazroa SA et al. | Effect of alpha lipoic acid co-administration on structural and immunohistochemical changes in subcutaneous tissue of anterior abdominal wall of adult male albino rat in response to polypropylene mesh implantation. | 2015 | Int J Exp Pathol | pmid:25891652 |
| Aguilar CA et al. | Organic-inorganic hybrid nanoparticles for bacterial inhibition: synthesis and characterization of doped and undoped ONPs with Ag/Au NPs. | 2015 | Molecules | pmid:25853317 |
| Diken Allahverdi T et al. | Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model. | 2015 | Ulus Travma Acil Cerrahi Derg | pmid:25779706 |
| Choi KH et al. | Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats. | 2015 | Mol Brain | pmid:25761600 |
| Goraca A et al. | Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver. | 2015 | Postepy Hig Med Dosw (Online) | pmid:25748617 |
| Coletta C et al. | Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid. | 2015 | Mol. Med. | pmid:25715337 |
| Li Y et al. | Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway. | 2015 | Br. J. Pharmacol. | pmid:25712508 |
| Zhang J et al. | α-Lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy. | 2015 | Mol Med Rep | pmid:25684163 |
| Yildirim CH et al. | Alpha-lipoic acid inhibits peridural fibrosis following laminectomy through the inactivation of TGF-β1, PDGF, PAI-1 and IL-6 expressions. | 2015 | Turk Neurosurg | pmid:25640552 |
| El-Gowelli HM et al. | Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade. | 2015 | Toxicol. Appl. Pharmacol. | pmid:26276312 |
| Plemel JR et al. | Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review. | 2015 | Mult. Scler. | pmid:26286700 |
| Notarnicola A et al. | Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome. | 2015 | Int J Immunopathol Pharmacol | pmid:25953494 |
| Parameshwaran K et al. | Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition. | 2015 | Drug Dev. Res. | pmid:25847731 |
| Zhong Y et al. | Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts. | 2015 | J Control Release | pmid:25596560 |
| Li G et al. | Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. | 2015 | Inflammation | pmid:24962643 |
| Ajith TA et al. | Effect of palladium α-lipoic acid complex on energy in the brain mitochondria of aged rats. | 2014 May-Jun | Altern Ther Health Med | pmid:24755568 |
| Silva MC et al. | Central effects of lipoic acid associated with paroxetine in mice. | 2014 Mar-Apr | Am J Ther | pmid:23797756 |
| Ivanov IS et al. | Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro. | 2014 Jul-Aug | Indian J Pharmacol | pmid:25097284 |
| Feng Y and Cronan JE | PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. | 2014 Jul-Aug | Res. Microbiol. | pmid:24816490 |
| Kharchenko OA et al. | [Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid]. | 2014 Jan-Feb | Lik. Sprava | pmid:24908976 |
| Gregorio LL et al. | Olfaction disorders: retrospective study. | 2014 Jan-Feb | Braz J Otorhinolaryngol | pmid:24626886 |
| Mendes PR et al. | Effect of alpha lipoic acid on the blood cell count and iron kinetics in hypertensive patients. | 2014 | Nutr Hosp | pmid:25617577 |
| Zhao L and Hu FX | α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25535146 |
| Mathias RA et al. | Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. | 2014 | Cell | pmid:25525879 |
| Jung JH et al. | Alpha lipoic acid attenuates radiation-induced thyroid injury in rats. | 2014 | PLoS ONE | pmid:25401725 |
| Ikuta N et al. | Spectroscopic studies of R(+)-α-lipoic acid--cyclodextrin complexes. | 2014 | Int J Mol Sci | pmid:25387076 |
| Kamarudin MN et al. | (R)-(+)-α-lipoic acid protected NG108-15 cells against H₂O₂-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines. | 2014 | Drug Des Devel Ther | pmid:25336920 |
| Costantino M et al. | Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25317815 |
| Arroll MA et al. | Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review. | 2014 | Nutr J | pmid:25228271 |
| Byun E et al. | α-Lipoic acid inhibits Helicobacter pylori-induced oncogene expression and hyperproliferation by suppressing the activation of NADPH oxidase in gastric epithelial cells. | 2014 | Mediators Inflamm. | pmid:25210229 |
| Garcia Lde B et al. | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. | 2014 | Acta Cir Bras | pmid:25185050 |
| Yang Y et al. | Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. | 2014 | Acta Pharmacol. Sin. | pmid:25152027 |
| Gonzalez P et al. | Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease. | 2014 | Metallomics | pmid:25144522 |
| Yang Y et al. | Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. | 2014 | J. Nutr. Biochem. | pmid:25123628 |
| Tsou PS et al. | Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts. | 2014 | Arthritis Res. Ther. | pmid:25123250 |
| Sancheti H et al. | Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study. | 2014 | J. Cereb. Blood Flow Metab. | pmid:25099753 |
| Bharucha AE et al. | Effects of aspirin & simvastatin and aspirin, simvastatin, & lipoic acid on heme oxygenase-1 in healthy human subjects. | 2014 | Neurogastroenterol. Motil. | pmid:25093998 |
| Ekinci M et al. | Reduction of conjunctival fibrosis after trabeculectomy using topical α-lipoic acid in rabbit eyes. | 2014 | J. Glaucoma | pmid:25055213 |
| Pérez-Rentero S et al. | Thioctic acid derivatives as building blocks to incorporate DNA oligonucleotides onto gold nanoparticles. | 2014 | Molecules | pmid:25045890 |
| Scumpia PO et al. | Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling. | 2014 | Neurochem. Int. | pmid:24269587 |
| Fu Y et al. | In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. | 2014 | Free Radic. Biol. Med. | pmid:24816294 |
| Shinto L et al. | A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. | 2014 | J. Alzheimers Dis. | pmid:24077434 |
| Kates SA et al. | Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24751172 |
| Wang J et al. | Synergetic effect of α-lipoic acid with keratinocyte growth factor on protecting alveolar epithelial type II cells of rat fetus from hyperoxia -induced injury. | 2014 | Cell. Physiol. Biochem. | pmid:24713997 |
| Li Y et al. | Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets. | 2014 | Int J Mol Sci | pmid:24699046 |
| Hiller S et al. | α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. | 2014 | Free Radic. Biol. Med. | pmid:24675228 |
| Gębka A et al. | Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. | 2014 | Mediators Inflamm. | pmid:24665163 |
| Bassi E et al. | Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis. | 2014 | Braz. J. Med. Biol. Res. | pmid:24519127 |
| Braakman R and Smith E | Metabolic evolution of a deep-branching hyperthermophilic chemoautotrophic bacterium. | 2014 | PLoS ONE | pmid:24516572 |
| Borziak K et al. | Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. | 2014 | PLoS ONE | pmid:24489835 |
| Letizia Mauro G et al. | α-Lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study. | 2014 | Drugs R D | pmid:24477618 |
| Todorovic SM and Jevtovic-Todorovic V | Redox regulation of neuronal voltage-gated calcium channels. | 2014 | Antioxid. Redox Signal. | pmid:24161125 |
| Ibrahim S et al. | Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells. | 2014 | Nutr Cancer | pmid:24063429 |
| Grasso S et al. | Effect of lipoic acid and α-glyceryl-phosphoryl-choline on astroglial cell proliferation and differentiation in primary culture. | 2014 | J. Neurosci. Res. | pmid:24166560 |
| Kim J et al. | Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24796665 |
| Huk-Kolega H et al. | [Influence of lipoic acid on the level of TNF-alpha in spleen homogenates]. | 2014 | Pol. Merkur. Lekarski | pmid:25095635 |
| Keith D et al. | Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24944020 |
| Ide T | Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. | 2014 | Br. J. Nutr. | pmid:24787548 |
| Ghosal A et al. | Biotin uptake by mouse and human pancreatic beta cells/islets: a regulated, lipopolysaccharide-sensitive carrier-mediated process. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:24904078 |
| Ledesma JC et al. | Reduction in central H2O2 levels prevents voluntary ethanol intake in mice: a role for the brain catalase-H2O2 system in alcohol binge drinking. | 2014 | Alcohol. Clin. Exp. Res. | pmid:24033657 |
| Chen C et al. | 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. | 2014 | J. Biol. Chem. | pmid:24784139 |
| Nikolai S et al. | R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: a 4-month feeding study in mice. | 2014 | Nutrition | pmid:24377457 |
| Mehrotra A and Sandhir R | Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation. | 2014 | Behav. Brain Res. | pmid:24393741 |
| Andrade AS et al. | Alpha-lipoic acid restores tear production in an animal model of dry eye. | 2014 | Exp. Eye Res. | pmid:24394592 |
| Castro MC et al. | Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress. | 2014 | Biochim. Biophys. Acta | pmid:24361606 |
| Guo Y et al. | Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. | 2014 | Support Care Cancer | pmid:24362907 |
| Ali SO et al. | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. | 2014 | Chem. Biol. Interact. | pmid:24704557 |
| Sancheti H et al. | Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. | 2014 | J. Cereb. Blood Flow Metab. | pmid:24220168 |
| Li Y et al. | Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. | 2014 | Mol Med Rep | pmid:24220720 |
| Phillipson OT | Management of the aging risk factor for Parkinson's disease. | 2014 | Neurobiol. Aging | pmid:24246717 |
| Stanković MN et al. | The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. | 2014 | J Med Food | pmid:24325457 |
| Hahm JR et al. | Alpha-lipoic acid attenuates adipocyte differentiation and lipid accumulation in 3T3-L1 cells via AMPK-dependent autophagy. | 2014 | Life Sci. | pmid:24530288 |
| Biresaw G et al. | Synthesis and tribological investigation of lipoyl glycerides. | 2014 | J. Agric. Food Chem. | pmid:24576015 |
| Meng J et al. | [Effects of lipoic acid on cytokines and chemokines in astrocytes stimulated with lipopolysaccharide]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:24721398 |
| Deslauriers J et al. | Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells. | 2014 | J. Mol. Neurosci. | pmid:24203573 |
| Weng CY et al. | Arsenic trioxide induces unfolded protein response in vascular endothelial cells. | 2014 | Arch. Toxicol. | pmid:23892647 |
| Vidović B et al. | Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. | 2014 | Psychiatr Danub | pmid:25191766 |
| Carrier B et al. | Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. | 2014 | PLoS ONE | pmid:24595397 |
| Liu J et al. | Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. | 2014 | Free Radic. Biol. Med. | pmid:24418157 |
| Amin KA et al. | Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E. | 2014 | J Complement Integr Med | pmid:24413220 |
| Zhao L et al. | Systemic administration of the antioxidant/iron chelator α-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25146987 |
| Khalili M et al. | Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: a randomized controlled clinical trial. | 2014 | Nutr Neurosci | pmid:23485514 |
| Kates SA et al. | Lipoic acid analogs with enhanced pharmacological activity. | 2014 | Bioorg. Med. Chem. | pmid:24316353 |
| Dwivedi N et al. | Alpha-lipoic acid protects oxidative stress, changes in cholinergic system and tissue histopathology during co-exposure to arsenic-dichlorvos in rats. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24291368 |
| Gras D et al. | GLUT1 deficiency syndrome: an update. | 2014 | Rev. Neurol. (Paris) | pmid:24269118 |