| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Acidosis, Lactic | D000140 | 8 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Lipoic acid
Lipoic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Here are additional resources we collected from PubChem and MeSH for Lipoic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoic acid
PubChem Biomolecular Interactions and Pathways
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All references with Lipoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Burner U et al. | Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II. | 1999 | FEBS Lett. | pmid:10025950 |
| Kozlov AV et al. | Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. | 1999 | Arch. Biochem. Biophys. | pmid:10049509 |
| Anuradha B and Varalakshmi P | Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. | 1999 | Pharmacol. Res. | pmid:10051379 |
| Hofmann MA et al. | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. | 1999 | Diabetologia | pmid:10064103 |
| Traber KE et al. | Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. | 1999 | Int. Immunol. | pmid:10069412 |
| Breithaupt-Grögler K et al. | Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. | 1999 | Eur J Pharm Sci | pmid:10072479 |
| Conlon BJ et al. | Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. | 1999 | Hear. Res. | pmid:10082281 |
| Dubel L et al. | Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. | 1999 | Hepatology | pmid:10094940 |
| Keegan A et al. | Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. | 1999 | Diabetologia | pmid:10096788 |
| Khanna S et al. | Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. | 1999 | J. Appl. Physiol. | pmid:10194202 |
| Fischer S et al. | Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. | 1999 | Am. J. Physiol. | pmid:10199811 |
| Khamaisi M et al. | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. | 1999 | Metab. Clin. Exp. | pmid:10206446 |
| Palmer JM et al. | T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC). | 1999 | Clin. Exp. Immunol. | pmid:10209517 |
| Marley R et al. | Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis. | 1999 | Hepatology | pmid:10216116 |
| Beekman NJ et al. | Highly immunogenic and fully synthetic peptide-carrier constructs targetting GnRH. | 1999 | Vaccine | pmid:10217605 |
| Hong YS et al. | The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. | 1999 | Free Radic. Biol. Med. | pmid:10218658 |
| Rybak LP et al. | Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. | 1999 | Toxicol. Sci. | pmid:10220857 |
| Balijepalli S et al. | Inhibition of mitochondrial complex I by haloperidol: the role of thiol oxidation. | 1999 | Neuropharmacology | pmid:10221760 |
| Mitsui Y et al. | Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. | 1999 | J. Neurol. Sci. | pmid:10223404 |
| Novotny L et al. | Polarographic properties and potential carcinogenicity of some natural nucleosides and their synthetic analogues. | 1999 | Bioelectrochem Bioenerg | pmid:10228579 |
| Khanna S et al. | Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid. | 1999 | Am. J. Physiol. | pmid:10233023 |
| Reche P and Perham RN | Structure and selectivity in post-translational modification: attaching the biotinyl-lysine and lipoyl-lysine swinging arms in multifunctional enzymes. | 1999 | EMBO J. | pmid:10329614 |
| Konrad T et al. | alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. | 1999 | Diabetes Care | pmid:10333946 |
| Junquera E and Aicart E | Thermodynamic analysis of the binding of a hepatoprotectant drug, thioctic acid, by beta-cyclodextrin. | 1999 | J Pharm Sci | pmid:10350499 |
| Otto DM et al. | Regulation of cytochrome P4501A metabolism by glutathione. | 1999 | Pharmacol. Toxicol. | pmid:10361976 |
| Wu L and de Champlain J | Superoxide anion-induced formation of inositol phosphates involves tyrosine kinase activation in smooth muscle cells from rat mesenteric artery. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10362493 |
| Vilas GL et al. | Effect of alpha lipoic acid amide on hexachlorobenzene porphyria. | 1999 | Biochem. Mol. Biol. Int. | pmid:10365252 |
| Shohami E et al. | Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile. | 1999 | J. Neurotrauma | pmid:10369557 |
| Di Rocco A | A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment. | 1999 | Neurology | pmid:10371553 |
| Roesler R et al. | A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment. | 1999 | Neurology | pmid:10371554 |
| Sen CK et al. | Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. | 1999 | Cell Death Differ. | pmid:10381641 |
| Guilhaudis L et al. | Investigation of the local structure and dynamics of the H subunit of the mitochondrial glycine decarboxylase using heteronuclear NMR spectroscopy. | 1999 | Biochemistry | pmid:10387079 |
| Haak ES et al. | The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. | 1999 | Microvasc. Res. | pmid:10388600 |
| Rathmann W et al. | [Drug prescriptions and costs in diabetic polyneuropathy]. | 1999 | Dtsch. Med. Wochenschr. | pmid:10394347 |
| Roche O et al. | Theoretical study of the conformation of the H-protein lipoamide arm as a function of its terminal group. | 1999 | Proteins | pmid:10398369 |
| Tirosh O et al. | Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue. | 1999 | Free Radic. Biol. Med. | pmid:10401605 |
| Borcea V et al. | alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. | 1999 | Free Radic. Biol. Med. | pmid:10401614 |
| Aevarsson A et al. | Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. | 1999 | Nat. Struct. Biol. | pmid:10426958 |
| Strokov IA et al. | [The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy]. | 1999 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:10441861 |
| Gurer H et al. | Antioxidant role of alpha-lipoic acid in lead toxicity. | 1999 | Free Radic. Biol. Med. | pmid:10443922 |
| Reddi AS et al. | Plasma alpha-lipoic acid and total glutathione levels in patients on maintenance hemodialysis. | 1999 | Nephron | pmid:10450040 |
| Jacob S et al. | Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. | 1999 | Free Radic. Biol. Med. | pmid:10468203 |
| Jordan F | Interplay of organic and biological chemistry in understanding coenzyme mechanisms: example of thiamin diphosphate-dependent decarboxylations of 2-oxo acids. | 1999 | FEBS Lett. | pmid:10471796 |
| Gueguen V et al. | Structural and functional characterization of H protein mutants of the glycine decarboxylase complex. | 1999 | J. Biol. Chem. | pmid:10473591 |
| Ziegler D et al. | Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. | 1999 | Diabetes Care | pmid:10480774 |
| Rudich A et al. | Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. | 1999 | Diabetologia | pmid:10491755 |
| Reljanovic M et al. | Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. | 1999 | Free Radic. Res. | pmid:10499773 |
| Kishi Y et al. | Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. | 1999 | Diabetes | pmid:10512372 |
| Anuradha B and Varalakshmi P | Activities of glucose-metabolizing enzymes in experimental neurotoxic models with lipoate as an alleviator. | 1999 Nov-Dec | J Appl Toxicol | pmid:10547622 |
| Yoo SK et al. | A radioimmunoassay method for detection of DNA based on chemical immobilization of anti-DNA antibody. | 1999 | Exp. Mol. Med. | pmid:10551259 |
| Berkson BM | A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. | 1999 | Med. Klin. (Munich) | pmid:10554539 |
| Wood JG et al. | Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation. | 1999 | J. Appl. Physiol. | pmid:10562616 |
| Szabados E et al. | Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart. | 1999 | Free Radic. Biol. Med. | pmid:10569643 |
| Marangon K et al. | Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. | 1999 | Free Radic. Biol. Med. | pmid:10569644 |
| Killoran PL and Walleczek J | Inhibition of store-operated calcium entry in human lymphocytes by radiation: protection by glutathione. | 1999 | Radiat. Res. | pmid:10581531 |
| Gleiter CH et al. | Lack of interaction between thioctic acid, glibenclamide and acarbose. | 1999 | Br J Clin Pharmacol | pmid:10594485 |
| Ziegler D et al. | Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. | 1999 | Exp. Clin. Endocrinol. Diabetes | pmid:10595592 |
| McCarty MF | Oxidants downstream from superoxide inhibit nitric oxide production by vascular endothelium--a key role for selenium-dependent enzymes in vascular health. | 1999 | Med. Hypotheses | pmid:10608266 |
| Jacob S et al. | Thioctic acid--effects on insulin sensitivity and glucose-metabolism. | 1999 | Biofactors | pmid:10609878 |
| Novotný L et al. | Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography. II. Nucleosides of 6-azauracil. | 1999 | Neoplasma | pmid:10613590 |
| Novotný L et al. | Separation of structurally related flavonoids by GC/MS technique and determination of their polarographic parameters and potential carcinogenicity. | 1999 | Neoplasma | pmid:10613603 |
| Dovinová I et al. | Combined effect of lipoic acid and doxorubicin in murine leukemia. | 1999 | Neoplasma | pmid:10613604 |
| Aguirre N et al. | Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity. | 1999 | Neuroreport | pmid:10619665 |
| Jones DD et al. | Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli. | 2000 | J. Mol. Biol. | pmid:10623527 |
| Ruhnau KJ et al. | Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. | 1999 | Diabet. Med. | pmid:10656234 |
| Liang JF and Akaike T | Inhibition of nitric oxide synthesis in primary cultured mouse hepatocytes by alpha-lipoic acid. | 2000 | Chem. Biol. Interact. | pmid:10658901 |
| Peth JA et al. | Effects of a unique conjugate of alpha-lipoic acid and gamma-linolenic acid on insulin action in obese Zucker rats. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10666147 |
| Ramrath S et al. | Stimulation of cardiac glucose transport by thioctic acid and insulin. | 1999 | Horm. Metab. Res. | pmid:10668913 |
| Gueguen V et al. | Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. | 2000 | J. Biol. Chem. | pmid:10671542 |
| McGahon BM et al. | Age-related changes in LTP and antioxidant defenses are reversed by an alpha-lipoic acid-enriched diet. | 1999 Nov-Dec | Neurobiol. Aging | pmid:10674431 |
| Arivazhagan P et al. | Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats. | 2000 | Pharmacol. Res. | pmid:10675281 |
| Lockhart B et al. | Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. | 2000 | Brain Res. | pmid:10677603 |
| Hamano Y et al. | Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a beta-agonist in broiler chickens. | 1999 | Br. J. Nutr. | pmid:10690165 |
| Chaiear K et al. | Fatal mushroom poisoning caused by Amanita virosa in Thailand. | 1999 | Southeast Asian J. Trop. Med. Public Health | pmid:10695805 |
| Bludovská M et al. | The influence of alpha-lipoic acid on the toxicity of cadmium. | 1999 | Gen. Physiol. Biophys. | pmid:10703716 |
| Nakagawa H et al. | Scavengers for peroxynitrite: inhibition of tyrosine nitration and oxidation with tryptamine derivatives, alpha-lipoic acid and synthetic compounds. | 2000 | Chem. Pharm. Bull. | pmid:10705515 |
| McCormick DB | A trail of research on cofactors: an odyssey with friends. | 2000 | J. Nutr. | pmid:10721897 |
| Haj-Yehia AI et al. | Determination of lipoic acid and dihydrolipoic acid in human plasma and urine by high-performance liquid chromatography with fluorimetric detection. | 2000 | J Chromatogr A | pmid:10722093 |
| Seidman MD et al. | Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. | 2000 | Am J Otol | pmid:10733178 |
| Cakatay U et al. | Effect of alpha-lipoic acid supplementation on oxidative protein damage in the streptozotocin-diabetic rat. | 2000 | Res Exp Med (Berl) | pmid:10743682 |
| Egan RW et al. | Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide. | 1978 | Prostaglandins | pmid:107544 |
| Guilhaudis L et al. | Combined structural and biochemical analysis of the H-T complex in the glycine decarboxylase cycle: evidence for a destabilization mechanism of the H-protein. | 2000 | Biochemistry | pmid:10757974 |
| Sommer D et al. | Modulation of the phosphatase activity of calcineurin by oxidants and antioxidants in vitro. | 2000 | Eur. J. Biochem. | pmid:10759856 |
| Yaworsky K et al. | Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. | 2000 | Diabetologia | pmid:10768090 |
| Kohen R et al. | Quantification of the overall reactive oxygen species scavenging capacity of biological fluids and tissues. | 2000 | Free Radic. Biol. Med. | pmid:10802217 |
| Neuburger M et al. | Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system. 1. Biochemical studies. | 2000 | Eur. J. Biochem. | pmid:10806385 |
| Faure M et al. | Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system 2. Crystal structures of H- and L-proteins. | 2000 | Eur. J. Biochem. | pmid:10806386 |
| Vasdev S et al. | Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats. | 2000 | J. Hypertens. | pmid:10826559 |
| Tabatabaie T et al. | Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone. | 2000 | Nitric Oxide | pmid:10835296 |
| Androne L et al. | In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. | 2000 Mar-Apr | In Vivo | pmid:10836205 |
| Mantovani G et al. | Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine. | 2000 | Int. J. Cancer | pmid:10842199 |
| Rybak LP and Somani S | Ototoxicity. Amelioration by protective agents. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10842591 |
| Deneke SM | Thiol-based antioxidants. | 2000 | Curr. Top. Cell. Regul. | pmid:10842751 |
| Biaglow JE et al. | A method for measuring disulfide reduction by cultured mammalian cells: relative contributions of glutathione-dependent and glutathione-independent mechanisms. | 2000 | Anal. Biochem. | pmid:10847613 |
| Leach FR | Turnover of protein-bound lipoic acid. | 1979 | Meth. Enzymol. | pmid:108509 |
| Cabiscol E et al. | Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. | 2000 | J. Biol. Chem. | pmid:10852912 |
| Obrosova IG et al. | Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid. | 2000 | Eur. J. Pharmacol. | pmid:10856458 |
| Somani SM et al. | Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: antioxidant defense system. | 2000 | Pharmacol. Toxicol. | pmid:10862506 |
| Stevens MJ et al. | Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. | 2000 | Diabetes | pmid:10866054 |