Lipoic acid

Lipoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Lipoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Lead Poisoning D007855 4 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 50 100 | Total 177

PubChem Biomolecular Interactions and Pathways

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All references with Lipoic acid

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Per page 10 20 50 100 | Total 4476
Authors Title Published Journal PubMed Link
pmid:
Burner U et al. Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II. 1999 FEBS Lett. pmid:10025950
Kozlov AV et al. Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. 1999 Arch. Biochem. Biophys. pmid:10049509
Anuradha B and Varalakshmi P Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. 1999 Pharmacol. Res. pmid:10051379
Hofmann MA et al. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. 1999 Diabetologia pmid:10064103
Traber KE et al. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. 1999 Int. Immunol. pmid:10069412
Breithaupt-Grögler K et al. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data. 1999 Eur J Pharm Sci pmid:10072479
Conlon BJ et al. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. 1999 Hear. Res. pmid:10082281
Dubel L et al. Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis. 1999 Hepatology pmid:10094940
Keegan A et al. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. 1999 Diabetologia pmid:10096788
Khanna S et al. Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. 1999 J. Appl. Physiol. pmid:10194202
Fischer S et al. Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. 1999 Am. J. Physiol. pmid:10199811
Khamaisi M et al. Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. 1999 Metab. Clin. Exp. pmid:10206446
Palmer JM et al. T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC). 1999 Clin. Exp. Immunol. pmid:10209517
Marley R et al. Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis. 1999 Hepatology pmid:10216116
Beekman NJ et al. Highly immunogenic and fully synthetic peptide-carrier constructs targetting GnRH. 1999 Vaccine pmid:10217605
Hong YS et al. The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. 1999 Free Radic. Biol. Med. pmid:10218658
Rybak LP et al. Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. 1999 Toxicol. Sci. pmid:10220857
Balijepalli S et al. Inhibition of mitochondrial complex I by haloperidol: the role of thiol oxidation. 1999 Neuropharmacology pmid:10221760
Mitsui Y et al. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. 1999 J. Neurol. Sci. pmid:10223404
Novotny L et al. Polarographic properties and potential carcinogenicity of some natural nucleosides and their synthetic analogues. 1999 Bioelectrochem Bioenerg pmid:10228579
Khanna S et al. Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid. 1999 Am. J. Physiol. pmid:10233023
Reche P and Perham RN Structure and selectivity in post-translational modification: attaching the biotinyl-lysine and lipoyl-lysine swinging arms in multifunctional enzymes. 1999 EMBO J. pmid:10329614
Konrad T et al. alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. 1999 Diabetes Care pmid:10333946
Junquera E and Aicart E Thermodynamic analysis of the binding of a hepatoprotectant drug, thioctic acid, by beta-cyclodextrin. 1999 J Pharm Sci pmid:10350499
Otto DM et al. Regulation of cytochrome P4501A metabolism by glutathione. 1999 Pharmacol. Toxicol. pmid:10361976
Wu L and de Champlain J Superoxide anion-induced formation of inositol phosphates involves tyrosine kinase activation in smooth muscle cells from rat mesenteric artery. 1999 Biochem. Biophys. Res. Commun. pmid:10362493
Vilas GL et al. Effect of alpha lipoic acid amide on hexachlorobenzene porphyria. 1999 Biochem. Mol. Biol. Int. pmid:10365252
Shohami E et al. Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile. 1999 J. Neurotrauma pmid:10369557
Di Rocco A A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment. 1999 Neurology pmid:10371553
Roesler R et al. A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment. 1999 Neurology pmid:10371554
Sen CK et al. Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. 1999 Cell Death Differ. pmid:10381641
Guilhaudis L et al. Investigation of the local structure and dynamics of the H subunit of the mitochondrial glycine decarboxylase using heteronuclear NMR spectroscopy. 1999 Biochemistry pmid:10387079
Haak ES et al. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. 1999 Microvasc. Res. pmid:10388600
Rathmann W et al. [Drug prescriptions and costs in diabetic polyneuropathy]. 1999 Dtsch. Med. Wochenschr. pmid:10394347
Roche O et al. Theoretical study of the conformation of the H-protein lipoamide arm as a function of its terminal group. 1999 Proteins pmid:10398369
Tirosh O et al. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue. 1999 Free Radic. Biol. Med. pmid:10401605
Borcea V et al. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. 1999 Free Radic. Biol. Med. pmid:10401614
Aevarsson A et al. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. 1999 Nat. Struct. Biol. pmid:10426958
Strokov IA et al. [The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy]. 1999 Zh Nevrol Psikhiatr Im S S Korsakova pmid:10441861
Gurer H et al. Antioxidant role of alpha-lipoic acid in lead toxicity. 1999 Free Radic. Biol. Med. pmid:10443922
Reddi AS et al. Plasma alpha-lipoic acid and total glutathione levels in patients on maintenance hemodialysis. 1999 Nephron pmid:10450040
Jacob S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. 1999 Free Radic. Biol. Med. pmid:10468203
Jordan F Interplay of organic and biological chemistry in understanding coenzyme mechanisms: example of thiamin diphosphate-dependent decarboxylations of 2-oxo acids. 1999 FEBS Lett. pmid:10471796
Gueguen V et al. Structural and functional characterization of H protein mutants of the glycine decarboxylase complex. 1999 J. Biol. Chem. pmid:10473591
Ziegler D et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. 1999 Diabetes Care pmid:10480774
Rudich A et al. Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. 1999 Diabetologia pmid:10491755
Reljanovic M et al. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. 1999 Free Radic. Res. pmid:10499773
Kishi Y et al. Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. 1999 Diabetes pmid:10512372
Anuradha B and Varalakshmi P Activities of glucose-metabolizing enzymes in experimental neurotoxic models with lipoate as an alleviator. 1999 Nov-Dec J Appl Toxicol pmid:10547622