| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hearing Loss, Sensorineural | D006319 | 8 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Acidosis, Lactic | D000140 | 8 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Lipoic acid
Lipoic acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Lipoic acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoic acid
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with Lipoic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zalejska-Fiolka J et al. | The Influence of α-Lipoic Acid and Garlic Administration on Biomarkers of Oxidative Stress and Inflammation in Rabbits Exposed to Oxidized Nutrition Oils. | 2015 | Biomed Res Int | pmid:26634212 |
| Chaudhary P et al. | Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model. | 2015 | J. Neuroimmunol. | pmid:26616873 |
| Nebbioso M et al. | Biomolecular Modulation of Neurodegenerative Events during Ageing. | 2015 | Oxid Med Cell Longev | pmid:26583065 |
| Ke C et al. | Plasma Metabolic Profiles in Women are Menopause Dependent. | 2015 | PLoS ONE | pmid:26580805 |
| Favero G et al. | A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. | 2015 | Age (Dordr) | pmid:26250907 |
| El Batsh MM et al. | Protective effects of alpha-lipoic acid against benzene induced toxicity in experimental rats. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26221905 |
| Scaramuzza A et al. | Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. | 2015 | J Diabetes Res | pmid:26171398 |
| Zou H et al. | Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. | 2015 | J Toxicol Sci | pmid:26165643 |
| Çakır T et al. | The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26125279 |
| Kafara P et al. | Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death. | 2015 | J Ovarian Res | pmid:26063499 |
| Santos CL et al. | Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways. | 2015 | Toxicol In Vitro | pmid:26043815 |
| Liu N et al. | Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase. | 2015 | Molecules | pmid:26035096 |
| Palacios-Sánchez B et al. | Alpha lipoic acid efficacy in burning mouth syndrome. A controlled clinical trial. | 2015 | Med Oral Patol Oral Cir Bucal | pmid:26034927 |
| Zhao L et al. | Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. | 2015 | PLoS ONE | pmid:26030919 |
| Tong X et al. | Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid. | 2015 | J. Nutr. Biochem. | pmid:26007286 |
| Zehnpfennig B et al. | Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT). | 2015 | J. Biol. Chem. | pmid:25971966 |
| Agostinis C et al. | The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis. | 2015 | Mediators Inflamm. | pmid:25960622 |
| Skibska B and Goraca A | The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress. | 2015 | Oxid Med Cell Longev | pmid:25949771 |
| Huerta AE et al. | Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. | 2015 | Obesity (Silver Spring) | pmid:25594166 |
| Berkowitz BA et al. | Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25574049 |
| Ying Z et al. | Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway. | 2015 | Vascul. Pharmacol. | pmid:25460366 |
| Ergür BU et al. | The effects of α-lipoic acid on aortic injury and hypertension in the rat remnant kidney (5/6 nephrectomy) model. | 2015 | Anatol J Cardiol | pmid:25430409 |
| Dominguez JM et al. | Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats. | 2015 | Diabetes | pmid:25204979 |
| Veskovic M et al. | Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency. | 2015 | Exp. Biol. Med. (Maywood) | pmid:25193852 |
| Steliou K et al. | Bioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age. | 2015 | Drug Dev. Res. | pmid:26109467 |
| Kan E et al. | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. | 2015 | Int Ophthalmol | pmid:25488016 |
| Mirza AZ | A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy. | 2015 | J Drug Target | pmid:25148611 |
| Li BJ et al. | Effect of lipoic acid combined with paclitaxel on breast cancer cells. | 2015 | Genet. Mol. Res. | pmid:26782439 |
| Ma Q et al. | Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin Bâ‚-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers. | 2015 | Toxins (Basel) | pmid:26694462 |
| Wood SH et al. | Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. | 2015 | Genome Biol. | pmid:26694192 |
| Ajith TA et al. | Effect of palladium α-lipoic acid complex on energy in the brain mitochondria of aged rats. | 2014 May-Jun | Altern Ther Health Med | pmid:24755568 |
| Silva MC et al. | Central effects of lipoic acid associated with paroxetine in mice. | 2014 Mar-Apr | Am J Ther | pmid:23797756 |
| Ivanov IS et al. | Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro. | 2014 Jul-Aug | Indian J Pharmacol | pmid:25097284 |
| Feng Y and Cronan JE | PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. | 2014 Jul-Aug | Res. Microbiol. | pmid:24816490 |
| Kharchenko OA et al. | [Oxidative stress and antioxidant therapy with alpha-lipoic acid inclusion in acute poisoning by herbicide based on 2,4-dichlorphenoxyacetic acid]. | 2014 Jan-Feb | Lik. Sprava | pmid:24908976 |
| Gregorio LL et al. | Olfaction disorders: retrospective study. | 2014 Jan-Feb | Braz J Otorhinolaryngol | pmid:24626886 |
| Ma QL et al. | Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. | 2014 | J. Neurosci. | pmid:24849348 |
| Macias-Barragan J et al. | [Effects of alpha lipoic acid and pirfenidone on liver cells antioxidant modulation against oxidative damage]. | 2014 | Rev Med Chil | pmid:25693438 |
| Mendes PR et al. | Effect of alpha lipoic acid on the blood cell count and iron kinetics in hypertensive patients. | 2014 | Nutr Hosp | pmid:25617577 |
| Zhao L and Hu FX | α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25535146 |
| Mathias RA et al. | Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. | 2014 | Cell | pmid:25525879 |
| Jung JH et al. | Alpha lipoic acid attenuates radiation-induced thyroid injury in rats. | 2014 | PLoS ONE | pmid:25401725 |
| Garcia Lde B et al. | Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. | 2014 | Acta Cir Bras | pmid:25185050 |
| Yang Y et al. | Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. | 2014 | Acta Pharmacol. Sin. | pmid:25152027 |
| Gonzalez P et al. | Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease. | 2014 | Metallomics | pmid:25144522 |
| Yang Y et al. | Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. | 2014 | J. Nutr. Biochem. | pmid:25123628 |
| Karaytug S et al. | Comparison of the protective effects of antioxidant compounds in the liver and kidney of Cd- and Cr-exposed common carp. | 2014 | Environ. Toxicol. | pmid:21987389 |
| Tsou PS et al. | Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts. | 2014 | Arthritis Res. Ther. | pmid:25123250 |
| Sancheti H et al. | Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study. | 2014 | J. Cereb. Blood Flow Metab. | pmid:25099753 |
| Chen X et al. | Determination of newly synthesized lipoic acid-niacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study. | 2014 | Biomed. Chromatogr. | pmid:23934776 |
| Bharucha AE et al. | Effects of aspirin & simvastatin and aspirin, simvastatin, & lipoic acid on heme oxygenase-1 in healthy human subjects. | 2014 | Neurogastroenterol. Motil. | pmid:25093998 |
| Ekinci M et al. | Reduction of conjunctival fibrosis after trabeculectomy using topical α-lipoic acid in rabbit eyes. | 2014 | J. Glaucoma | pmid:25055213 |
| Thakurta IG et al. | Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats. | 2014 | Exp. Gerontol. | pmid:24291247 |
| Pérez-Rentero S et al. | Thioctic acid derivatives as building blocks to incorporate DNA oligonucleotides onto gold nanoparticles. | 2014 | Molecules | pmid:25045890 |
| Carter SE et al. | The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans. | 2014 | J. Hypertens. | pmid:24296519 |
| Fernández-Galilea M et al. | α-lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects. | 2014 | Obesity (Silver Spring) | pmid:25045030 |
| Al-Rasheed NM et al. | Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat's liver. | 2014 | Eur Rev Med Pharmacol Sci | pmid:24992626 |
| Scumpia PO et al. | Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling. | 2014 | Neurochem. Int. | pmid:24269587 |
| Thomas S et al. | Stability, cutaneous delivery, and antioxidant potential of a lipoic acid and α-tocopherol codrug incorporated in microemulsions. | 2014 | J Pharm Sci | pmid:24961388 |
| Lim KS et al. | Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model. | 2014 | J Cardiol | pmid:24852847 |
| Hatami S et al. | Total oxidative status of mouse vitrified pre-antral follicles with pre-treatment of alpha lipoic acid. | 2014 | Iran. Biomed. J. | pmid:24842145 |
| Fu Y et al. | In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. | 2014 | Free Radic. Biol. Med. | pmid:24816294 |
| Shinto L et al. | A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. | 2014 | J. Alzheimers Dis. | pmid:24077434 |
| Kates SA et al. | Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24751172 |
| Wang J et al. | Synergetic effect of α-lipoic acid with keratinocyte growth factor on protecting alveolar epithelial type II cells of rat fetus from hyperoxia -induced injury. | 2014 | Cell. Physiol. Biochem. | pmid:24713997 |
| Li Y et al. | Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets. | 2014 | Int J Mol Sci | pmid:24699046 |
| Hiller S et al. | α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. | 2014 | Free Radic. Biol. Med. | pmid:24675228 |
| Gębka A et al. | Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. | 2014 | Mediators Inflamm. | pmid:24665163 |
| Bassi E et al. | Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis. | 2014 | Braz. J. Med. Biol. Res. | pmid:24519127 |
| Ibrahim S et al. | Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells. | 2014 | Nutr Cancer | pmid:24063429 |
| Grasso S et al. | Effect of lipoic acid and α-glyceryl-phosphoryl-choline on astroglial cell proliferation and differentiation in primary culture. | 2014 | J. Neurosci. Res. | pmid:24166560 |
| Kim J et al. | Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24796665 |
| Huk-Kolega H et al. | [Influence of lipoic acid on the level of TNF-alpha in spleen homogenates]. | 2014 | Pol. Merkur. Lekarski | pmid:25095635 |
| Keith D et al. | Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24944020 |
| Ide T | Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. | 2014 | Br. J. Nutr. | pmid:24787548 |
| Ghosal A et al. | Biotin uptake by mouse and human pancreatic beta cells/islets: a regulated, lipopolysaccharide-sensitive carrier-mediated process. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:24904078 |
| Saleh MC et al. | Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion. | 2014 | PLoS ONE | pmid:24498217 |
| Wang J et al. | Physicochemical characterization, identification and improved photo-stability of α-lipoic acid-loaded nanostructured lipid carrier. | 2014 | Drug Dev Ind Pharm | pmid:23336811 |
| Connell BJ et al. | UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion. | 2014 | Neurosci. Lett. | pmid:24394910 |
| Nikolai S et al. | R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: a 4-month feeding study in mice. | 2014 | Nutrition | pmid:24377457 |
| Mehrotra A and Sandhir R | Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation. | 2014 | Behav. Brain Res. | pmid:24393741 |
| Andrade AS et al. | Alpha-lipoic acid restores tear production in an animal model of dry eye. | 2014 | Exp. Eye Res. | pmid:24394592 |
| Castro MC et al. | Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress. | 2014 | Biochim. Biophys. Acta | pmid:24361606 |
| Guo Y et al. | Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. | 2014 | Support Care Cancer | pmid:24362907 |
| Monserrat JM et al. | Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity. | 2014 | Pestic Biochem Physiol | pmid:24485309 |
| Schwartz L et al. | Metabolic treatment of cancer: intermediate results of a prospective case series. | 2014 | Anticancer Res. | pmid:24511042 |
| Nicolson GL | Mitochondrial dysfunction and chronic disease: treatment with natural supplements. | 2014 | Altern Ther Health Med | pmid:24473982 |
| Ali SO et al. | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. | 2014 | Chem. Biol. Interact. | pmid:24704557 |
| Sancheti H et al. | Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. | 2014 | J. Cereb. Blood Flow Metab. | pmid:24220168 |
| Li Y et al. | Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. | 2014 | Mol Med Rep | pmid:24220720 |
| Deslauriers J et al. | Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells. | 2014 | J. Mol. Neurosci. | pmid:24203573 |
| Weng CY et al. | Arsenic trioxide induces unfolded protein response in vascular endothelial cells. | 2014 | Arch. Toxicol. | pmid:23892647 |
| Vidović B et al. | Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. | 2014 | Psychiatr Danub | pmid:25191766 |
| Carrier B et al. | Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. | 2014 | PLoS ONE | pmid:24595397 |
| He F et al. | Comment on Xu et al.: Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. | 2014 | Diabetes Res. Clin. Pract. | pmid:24602352 |
| Sherif S et al. | The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. | 2014 | Eur J Pharm Biopharm | pmid:24056055 |
| Nasole E et al. | Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. | 2014 | J Enzyme Inhib Med Chem | pmid:23360079 |
| Liu J et al. | Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. | 2014 | Free Radic. Biol. Med. | pmid:24418157 |
| Amin KA et al. | Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E. | 2014 | J Complement Integr Med | pmid:24413220 |
| Zhao L et al. | Systemic administration of the antioxidant/iron chelator α-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25146987 |