Lipoic acid

Lipoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Lipoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Lead Poisoning D007855 4 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 50 100 | Total 177

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Lipoic acid

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Per page 10 20 50 100 | Total 4476
Authors Title Published Journal PubMed Link
Rousseau AS et al. α-Lipoic acid up-regulates expression of peroxisome proliferator-activated receptor β in skeletal muscle: involvement of the JNK signaling pathway. 2016 FASEB J. pmid:26655383
Choi JH et al. α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells. 2016 Yonsei Med. J. pmid:26632410
Madias JE A-lipoic acid therapy mediated amelioration of sympathetic heart denervation in patients with takotsubo syndrome. 2016 J Cardiol pmid:26603324
Roberts JD et al. An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention. 2016 Nutrients pmid:27869661
Tao Y et al. α-Lipoic Acid Treatment Improves Vision-Related Quality of Life in Patients with Dry Age-Related Macular Degeneration. 2016 Tohoku J. Exp. Med. pmid:27840374
Derosa G et al. A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients. 2016 Int J Mol Sci pmid:27801825
Zhang J and McCullough PA Lipoic Acid in the Prevention of Acute Kidney Injury. 2016 Nephron pmid:27603173
Arikan M et al. Histomorphometric and Ultrastructural Evaluation of Long-Term Alpha Lipoic Acid and Vitamin B12 Use After Experimental Sciatic Nerve Injury in Rats. 2016 Turk Neurosurg pmid:27476916
Niska K et al. Capping Agent-Dependent Toxicity and Antimicrobial Activity of Silver Nanoparticles: An In Vitro Study. Concerns about Potential Application in Dental Practice. 2016 Int J Med Sci pmid:27766027
Zhang L et al. Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction. 2016 Eur Rev Med Pharmacol Sci pmid:27735021
Zorzoli A et al. Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid. 2016 PLoS Pathog. pmid:27701474
Gao S et al. Oxidative stress increases the risk of pancreatic β cell damage in chronic renal hypertensive rats. 2016 Physiol Rep pmid:27535482
Güleş Ö and Eren Ü Protective role of alpha lipoic acid against polychlorobiphenyl (Aroclor 1254)-induced testicular toxicity in rats. 2016 Rom J Morphol Embryol pmid:27516018
Bilska-Wilkosz A et al. The effect of lipoic acid administration on the urinary excretion of thiocyanate in rats exposed to potassium cyanide. 2015 Jan-Feb Acta Pol Pharm pmid:25850200
Ikuta N et al. Structural Analysis of Crystalline R(+)-α-Lipoic Acid-α-cyclodextrin Complex Based on Microscopic and Spectroscopic Studies. 2015 Int J Mol Sci pmid:26501268
Ghinis-Hozumi Y et al. Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures. 2015 J. Anim. Sci. pmid:26440162
Porcaro G et al. Alpha Lipoic Acid (ALA) effects on subchorionic hematoma: preliminary clinical results. 2015 Eur Rev Med Pharmacol Sci pmid:26439038
Uchida R et al. Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats. 2015 Int J Mol Sci pmid:26402669
Lo MC et al. Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy cause decreased insulin secretion from β-cells. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26394662
Bai W et al. Cross talk between poly(ADP-ribose) polymerase 1 methylation and oxidative stress involved in the toxic effect of anatase titanium dioxide nanoparticles. 2015 Int J Nanomedicine pmid:26366077
Garcia-Alcala H et al. Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading. 2015 J Diabetes Res pmid:26345602
Xiong S et al. PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases. 2015 Cell Rep pmid:26299964
Okanović A et al. Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus. 2015 Med Glas (Zenica) pmid:26276648
Verma H and Garg R Comment on "Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial". 2015 J Diabetes Res pmid:26273673
de Queiroz TM et al. α-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. 2015 Am. J. Physiol. Heart Circ. Physiol. pmid:26254330
Favero G et al. A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. 2015 Age (Dordr) pmid:26250907
El Batsh MM et al. Protective effects of alpha-lipoic acid against benzene induced toxicity in experimental rats. 2015 Eur Rev Med Pharmacol Sci pmid:26221905
Scaramuzza A et al. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. 2015 J Diabetes Res pmid:26171398
Zou H et al. Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. 2015 J Toxicol Sci pmid:26165643
Mazroa SA et al. Effect of alpha lipoic acid co-administration on structural and immunohistochemical changes in subcutaneous tissue of anterior abdominal wall of adult male albino rat in response to polypropylene mesh implantation. 2015 Int J Exp Pathol pmid:25891652
Aguilar CA et al. Organic-inorganic hybrid nanoparticles for bacterial inhibition: synthesis and characterization of doped and undoped ONPs with Ag/Au NPs. 2015 Molecules pmid:25853317
Diken Allahverdi T et al. Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model. 2015 Ulus Travma Acil Cerrahi Derg pmid:25779706
Choi KH et al. Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats. 2015 Mol Brain pmid:25761600
Goraca A et al. Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver. 2015 Postepy Hig Med Dosw (Online) pmid:25748617
Coletta C et al. Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid. 2015 Mol. Med. pmid:25715337
Li Y et al. Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway. 2015 Br. J. Pharmacol. pmid:25712508
Zhang J et al. α-Lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy. 2015 Mol Med Rep pmid:25684163
Yildirim CH et al. Alpha-lipoic acid inhibits peridural fibrosis following laminectomy through the inactivation of TGF-β1, PDGF, PAI-1 and IL-6 expressions. 2015 Turk Neurosurg pmid:25640552
Cao X and Cronan JE The Streptomyces coelicolor lipoate-protein ligase is a circularly permuted version of the Escherichia coli enzyme composed of discrete interacting domains. 2015 J. Biol. Chem. pmid:25631049
Huerta AE et al. Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. 2015 Obesity (Silver Spring) pmid:25594166
Berkowitz BA et al. Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy. 2015 Invest. Ophthalmol. Vis. Sci. pmid:25574049
El-Gowelli HM et al. Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade. 2015 Toxicol. Appl. Pharmacol. pmid:26276312
Plemel JR et al. Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review. 2015 Mult. Scler. pmid:26286700
Notarnicola A et al. Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome. 2015 Int J Immunopathol Pharmacol pmid:25953494
Parameshwaran K et al. Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition. 2015 Drug Dev. Res. pmid:25847731
Pilar Valdecantos M et al. Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. 2015 Free Radic. Biol. Med. pmid:25841776
Zhong Y et al. Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts. 2015 J Control Release pmid:25596560
Li G et al. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. 2015 Inflammation pmid:24962643
Isaac VL et al. Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging. 2015 Biomed Res Int pmid:26788510
Li BJ et al. Effect of lipoic acid combined with paclitaxel on breast cancer cells. 2015 Genet. Mol. Res. pmid:26782439