Lipoic acid

Lipoic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 18962 references associated with Lipoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Lipoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Lipoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Lead Poisoning D007855 4 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 50 100 | Total 177

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Lipoic acid

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Per page 10 20 50 100 | Total 4476
Authors Title Published Journal PubMed Link
Ma QL et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. 2014 J. Neurosci. pmid:24849348
Macias-Barragan J et al. [Effects of alpha lipoic acid and pirfenidone on liver cells antioxidant modulation against oxidative damage]. 2014 Rev Med Chil pmid:25693438
Mendes PR et al. Effect of alpha lipoic acid on the blood cell count and iron kinetics in hypertensive patients. 2014 Nutr Hosp pmid:25617577
Zhao L and Hu FX α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction. 2014 Eur Rev Med Pharmacol Sci pmid:25535146
Mathias RA et al. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. 2014 Cell pmid:25525879
Jung JH et al. Alpha lipoic acid attenuates radiation-induced thyroid injury in rats. 2014 PLoS ONE pmid:25401725
Ikuta N et al. Spectroscopic studies of R(+)-α-lipoic acid--cyclodextrin complexes. 2014 Int J Mol Sci pmid:25387076
Kamarudin MN et al. (R)-(+)-α-lipoic acid protected NG108-15 cells against H₂O₂-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines. 2014 Drug Des Devel Ther pmid:25336920
Costantino M et al. Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation. 2014 Eur Rev Med Pharmacol Sci pmid:25317815
Karaytug S et al. Comparison of the protective effects of antioxidant compounds in the liver and kidney of Cd- and Cr-exposed common carp. 2014 Environ. Toxicol. pmid:21987389
Chen X et al. Determination of newly synthesized lipoic acid-niacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study. 2014 Biomed. Chromatogr. pmid:23934776
Thakurta IG et al. Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats. 2014 Exp. Gerontol. pmid:24291247
Carter SE et al. The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans. 2014 J. Hypertens. pmid:24296519
Fernández-Galilea M et al. α-lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects. 2014 Obesity (Silver Spring) pmid:25045030
Al-Rasheed NM et al. Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat's liver. 2014 Eur Rev Med Pharmacol Sci pmid:24992626
Scumpia PO et al. Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling. 2014 Neurochem. Int. pmid:24269587
Thomas S et al. Stability, cutaneous delivery, and antioxidant potential of a lipoic acid and α-tocopherol codrug incorporated in microemulsions. 2014 J Pharm Sci pmid:24961388
Lim KS et al. Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model. 2014 J Cardiol pmid:24852847
Hatami S et al. Total oxidative status of mouse vitrified pre-antral follicles with pre-treatment of alpha lipoic acid. 2014 Iran. Biomed. J. pmid:24842145
Fu Y et al. In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. 2014 Free Radic. Biol. Med. pmid:24816294
Shinto L et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. 2014 J. Alzheimers Dis. pmid:24077434
Kates SA et al. Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. 2014 Basic Clin. Pharmacol. Toxicol. pmid:24751172
Wang J et al. Synergetic effect of α-lipoic acid with keratinocyte growth factor on protecting alveolar epithelial type II cells of rat fetus from hyperoxia -induced injury. 2014 Cell. Physiol. Biochem. pmid:24713997
Li Y et al. Effects of lipoic acid on immune function, the antioxidant defense system, and inflammation-related genes expression of broiler chickens fed aflatoxin contaminated diets. 2014 Int J Mol Sci pmid:24699046
Hiller S et al. α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. 2014 Free Radic. Biol. Med. pmid:24675228
Gębka A et al. Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. 2014 Mediators Inflamm. pmid:24665163
Bassi E et al. Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis. 2014 Braz. J. Med. Biol. Res. pmid:24519127
Braakman R and Smith E Metabolic evolution of a deep-branching hyperthermophilic chemoautotrophic bacterium. 2014 PLoS ONE pmid:24516572
Borziak K et al. Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. 2014 PLoS ONE pmid:24489835
Saleh MC et al. Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion. 2014 PLoS ONE pmid:24498217
Wang J et al. Physicochemical characterization, identification and improved photo-stability of α-lipoic acid-loaded nanostructured lipid carrier. 2014 Drug Dev Ind Pharm pmid:23336811
Connell BJ et al. UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion. 2014 Neurosci. Lett. pmid:24394910
Ledesma JC et al. Reduction in central H2O2 levels prevents voluntary ethanol intake in mice: a role for the brain catalase-H2O2 system in alcohol binge drinking. 2014 Alcohol. Clin. Exp. Res. pmid:24033657
Chen C et al. 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. 2014 J. Biol. Chem. pmid:24784139
Monserrat JM et al. Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity. 2014 Pestic Biochem Physiol pmid:24485309
Schwartz L et al. Metabolic treatment of cancer: intermediate results of a prospective case series. 2014 Anticancer Res. pmid:24511042
Nicolson GL Mitochondrial dysfunction and chronic disease: treatment with natural supplements. 2014 Altern Ther Health Med pmid:24473982
Ali SO et al. Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. 2014 Chem. Biol. Interact. pmid:24704557
Sancheti H et al. Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. 2014 J. Cereb. Blood Flow Metab. pmid:24220168
Li Y et al. Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux. 2014 Mol Med Rep pmid:24220720
Phillipson OT Management of the aging risk factor for Parkinson's disease. 2014 Neurobiol. Aging pmid:24246717
Stanković MN et al. The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. 2014 J Med Food pmid:24325457
Carrier B et al. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. 2014 PLoS ONE pmid:24595397
He F et al. Comment on Xu et al.: Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. 2014 Diabetes Res. Clin. Pract. pmid:24602352
Sherif S et al. The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. 2014 Eur J Pharm Biopharm pmid:24056055
Nasole E et al. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. 2014 J Enzyme Inhib Med Chem pmid:23360079
Liu J et al. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. 2014 Free Radic. Biol. Med. pmid:24418157
Amin KA et al. Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E. 2014 J Complement Integr Med pmid:24413220
Zhao L et al. Systemic administration of the antioxidant/iron chelator α-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25146987
Kates SA et al. Lipoic acid analogs with enhanced pharmacological activity. 2014 Bioorg. Med. Chem. pmid:24316353