| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abscess | D000038 | 13 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Edema | D004487 | 152 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| Xu JY et al. | Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea. | 2016 | J. Proteome Res. | pmid:27090497 |
| ZubirÃa MG et al. | Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model. | 2016 | Nutrients | pmid:27384583 |
| Chatnaparat T et al. | Global Pattern of Gene Expression of Xanthomonas axonopodis pv. glycines Within Soybean Leaves. | 2016 | Mol. Plant Microbe Interact. | pmid:27003800 |
| Guan X and Nikolau BJ | AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis. | 2016 | Plant J. | pmid:26836315 |
| Fu X et al. | Malonate induces the assembly of cytoplasmic stress granules. | 2016 | FEBS Lett. | pmid:26787461 |
| Németh B et al. | Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. | 2016 | FASEB J. | pmid:26358042 |
| Colak G et al. | Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. | 2015 | Mol. Cell Proteomics | pmid:26320211 |
| Lewin R et al. | Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates. | 2015 | Chemistry | pmid:25766433 |
| Mukaida M et al. | Stability order of caffeine co-crystals determined by co-crystal former exchange reaction and its application for the validation of in silico models. | 2015 | Chem. Pharm. Bull. | pmid:25743190 |
| Pandey MK et al. | Composite-180° pulse-based symmetry sequences to recouple proton chemical shift anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. | 2015 | J. Magn. Reson. | pmid:25497846 |
| Akopova OV et al. | [Estimation of ATP-dependent K(+)-channel contribution to potential-dependent potassium uptake in the rat brain mitochondria]. | 2014 Jan-Feb | Ukr Biochem J | pmid:24834715 |
| Zhang Y et al. | Organic acids enhance bioavailability of tetracycline in water to Escherichia coli for uptake and expression of antibiotic resistance. | 2014 | Water Res. | pmid:25100186 |
| Stevens JS et al. | Proton transfer and hydrogen bonding in the organic solid state: a combined XRD/XPS/ssNMR study of 17 organic acid-base complexes. | 2014 | Phys Chem Chem Phys | pmid:24292812 |
| Shibata N et al. | Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids. | 2014 | Org. Biomol. Chem. | pmid:24445698 |
| Xiao D et al. | Distinct effects of oxalate versus malonate on the iron redox chemistry: Implications for the photo-Fenton reaction. | 2014 | Chemosphere | pmid:24359921 |
| Aboudzadeh A et al. | Ionic supramolecular networks fully based on chemicals coming from renewable sources. | 2014 | Macromol Rapid Commun | pmid:24285575 |
| Klopries S et al. | Biosynthesis with fluorine. | 2014 | Chembiochem | pmid:24504732 |
| Borer P and Hug SJ | Photo-redox reactions of dicarboxylates and α-hydroxydicarboxylates at the surface of Fe(III)(hydr)oxides followed with in situ ATR-FTIR spectroscopy. | 2014 | J Colloid Interface Sci | pmid:24370400 |
| Beyer KD et al. | Temperature-dependent deliquescence relative humidities and water activities using humidity controlled thermogravimetric analysis with application to malonic acid. | 2014 | J Phys Chem A | pmid:24628358 |
| Hara Y et al. | Generative force of self-oscillating gel. | 2014 | J Phys Chem B | pmid:24524539 |
| Preska Steinberg A et al. | Target Turing patterns and growth dynamics in the chlorine dioxide-iodine-malonic acid reaction. | 2014 | J Phys Chem A | pmid:24601764 |
| Ghorai S et al. | Hygroscopic properties of internally mixed particles composed of NaCl and water-soluble organic acids. | 2014 | Environ. Sci. Technol. | pmid:24437520 |
| Wang Y et al. | Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers. | 2014 | Int J Clin Exp Pathol | pmid:25120785 |
| Gueguen C et al. | Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. | 2014 | PLoS ONE | pmid:24586272 |
| Barros-Miñones L et al. | Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. | 2013 | Biochim. Biophys. Acta | pmid:23415811 |
| Bew SP et al. | Malonic acid half oxyesters and thioesters: solvent-free synthesis and DFT analysis of their enols. | 2013 | Org. Lett. | pmid:23876089 |
| Chen WN and Tan KY | "Malonate uptake and metabolism in Saccharomyces cerevisiae". | 2013 | Appl. Biochem. Biotechnol. | pmid:23813405 |
| Li J et al. | Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. | 2013 | Protein Cell | pmid:23807634 |
| Karunakaran R et al. | Malonate catabolism does not drive N2 fixation in legume nodules. | 2013 | Appl. Environ. Microbiol. | pmid:23666330 |
| Belenki C et al. | Cleavable surfactants to tune the stability of W/O miniemulsions. | 2013 | J Colloid Interface Sci | pmid:23218239 |
| Martins N et al. | Changes on organic acid secretion and accumulation in Plantago almogravensis Franco and Plantago algarbiensis Samp. under aluminum stress. | 2013 | Plant Sci. | pmid:23199681 |
| Zheng P et al. | Identification and validation of urinary metabolite biomarkers for major depressive disorder. | 2013 | Mol. Cell Proteomics | pmid:23111923 |
| Bao X et al. | A chemical probe for lysine malonylation. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23533089 |
| Kumar A et al. | Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats. | 2013 | Eur. J. Pharmacol. | pmid:23562615 |
| MacCrehan WA and White CM | Simplified ultrasonically- and microwave-assisted solvent extractions for the determination of ginsenosides in powdered Panax ginseng rhizomes using liquid chromatography with UV absorbance or electrospray mass spectrometric detection. | 2013 | Anal Bioanal Chem | pmid:23564283 |
| Darvas M et al. | Molecular dynamics simulations of the water adsorption around malonic acid aerosol models. | 2013 | Phys Chem Chem Phys | pmid:23702947 |
| Zhou S et al. | Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans. | 2013 | Biotechnol. Bioeng. | pmid:23775313 |
| Minato Y et al. | Malonate inhibits virulence gene expression in Vibrio cholerae. | 2013 | PLoS ONE | pmid:23675480 |
| Zhang X et al. | Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. | 2013 | Chem Asian J | pmid:23929723 |
| Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
| Yuan HN et al. | Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of β-amino esters and anti-HIV drug DPC 083. | 2013 | Chemistry | pmid:24150893 |
| Sundermann U et al. | Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. | 2013 | ACS Chem. Biol. | pmid:23181268 |
| Barros-Miñones L et al. | Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. | 2013 | Br. J. Pharmacol. | pmid:23186227 |
| Salem AA et al. | Application of quantitative nuclear magnetic resonance spectroscopy for the determination ofamantadine and acyclovir in plasma and pharmaceutical samples. | 2012 Nov-Dec | J AOAC Int | pmid:23451380 |
| Mahendradas P et al. | Unilateral conjunctival ulcer due to Stenotrophomonas maltophilia infection. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446910 |
| Jang YJ et al. | Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine. | 2012 | Molecules | pmid:22446986 |
| Giorgio V et al. | The effects of idebenone on mitochondrial bioenergetics. | 2012 | Biochim. Biophys. Acta | pmid:22086148 |
| Schlüter A et al. | Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. | 2012 | Hum. Mol. Genet. | pmid:22095690 |
| Führs H et al. | Functional associations between the metabolome and manganese tolerance in Vigna unguiculata. | 2012 | J. Exp. Bot. | pmid:21934118 |
| Yang J et al. | One-step hydrothermal synthesis of carboxyl-functionalized upconversion phosphors for bioapplications. | 2012 | Chemistry | pmid:22996059 |
| Ghosh SK et al. | Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media. | 2012 | Org. Biomol. Chem. | pmid:22976596 |
| Bonhomme C et al. | 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. | 2012 | J. Am. Chem. Soc. | pmid:22738329 |
| Bauwens M et al. | Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. | 2012 | PLoS ONE | pmid:22719886 |
| Callahan DL et al. | Elemental and metabolite profiling of nickel hyperaccumulators from New Caledonia. | 2012 | Phytochemistry | pmid:22795763 |
| Shevchenko A et al. | A new cocrystal and salts of itraconazole: comparison of solid-state properties, stability and dissolution behavior. | 2012 | Int J Pharm | pmid:22750429 |
| Liu Q et al. | Structural effect and mechanism of C70-carboxyfullerenes as efficient sensitizers against cancer cells. | 2012 | Small | pmid:22508680 |
| Mitra T et al. | Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions. | 2012 | J Mater Sci Mater Med | pmid:22367159 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Du X et al. | [Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors]. | 2012 | Yao Xue Xue Bao | pmid:22645761 |
| Park SY et al. | An analysis of the concentration change of intermediate metabolites by gene manipulation in fatty acid biosynthesis. | 2012 | Enzyme Microb. Technol. | pmid:22664193 |
| Liu Z et al. | The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. | 2012 | J Pharm Biomed Anal | pmid:22387101 |
| Ward RA et al. | Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. | 2012 | J. Med. Chem. | pmid:22417091 |
| Sand A et al. | Synthesis of graft copolymer (CgOH-g-AGA): physicochemical properties, characterization and application. | 2012 | Carbohydr Polym | pmid:22840018 |
| Chojkier M et al. | Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. | 2012 | PLoS ONE | pmid:22412837 |
| Valdeolivas S et al. | Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors. | 2012 | ACS Chem Neurosci | pmid:22860209 |
| Batur M et al. | Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. | 2012 | J Tradit Chin Med | pmid:22594115 |
| Martin FP et al. | Metabolomic applications to decipher gut microbial metabolic influence in health and disease. | 2012 | Front Physiol | pmid:22557976 |
| Kubicek J et al. | Controlled in meso phase crystallization--a method for the structural investigation of membrane proteins. | 2012 | PLoS ONE | pmid:22536388 |
| Yadav M et al. | Synthesis, characterization and applications of graft copolymer (κ-carrageenan-g-vinylsulfonic acid). | 2012 | Int. J. Biol. Macromol. | pmid:22142792 |
| Chanumolu SK et al. | UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. | 2012 | PLoS ONE | pmid:22431985 |
| Haferkamp I and Schmitz-Esser S | The plant mitochondrial carrier family: functional and evolutionary aspects. | 2012 | Front Plant Sci | pmid:22639632 |
| Tomita Y et al. | Genome and transcriptome analysis of the food-yeast Candida utilis. | 2012 | PLoS ONE | pmid:22629373 |
| Thein M et al. | DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. | 2012 | PLoS ONE | pmid:22590556 |
| Lapanje K et al. | Bis(acetato-κO)bis-[2-(pyridin-2-yl)ethanol-κ(2)N,O]copper(II). | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22590106 |
| Benkanoun A et al. | Intra- and supra-molecular inter-actions in cis,mer-diaqua-tris-(1H-imidazole-κN(3))(terephthalato-κO)cobalt(II) monohydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22589841 |
| Liew CW et al. | Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. | 2012 | J. Biol. Chem. | pmid:22589546 |
| Anand K et al. | Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. | 2012 | PLoS ONE | pmid:22574179 |
| Moldes D et al. | Role of laccase and low molecular weight metabolites from Trametes versicolor in dye decolorization. | 2012 | ScientificWorldJournal | pmid:22566767 |
| Tao X et al. | Digital gene expression analysis based on integrated de novo transcriptome assembly of sweet potato [Ipomoea batatas (L.) Lam]. | 2012 | PLoS ONE | pmid:22558397 |
| Xiao L et al. | Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. | 2012 | PLoS ONE | pmid:22545152 |
| Queiroga CS et al. | Carbon monoxide targeting mitochondria. | 2012 | Biochem Res Int | pmid:22536507 |
| Engeham S et al. | Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet. | 2012 | J Nutr Metab | pmid:22536494 |
| Natarajan S et al. | Crystal structure of L-histidinium 2-nitrobenzoate. | 2012 | J Amino Acids | pmid:22536482 |
| Scalliet G et al. | Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. | 2012 | PLoS ONE | pmid:22536383 |
| Laurido C et al. | Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model. | 2012 | ScientificWorldJournal | pmid:22536130 |
| Jin YW and Zhu HL | Poly[[penta-aqua-(μ(4)-pyridine-2,4,6-tri-carboxyl-ato)(μ(3)-pyridine-2,4,6-tri-carboxyl-ato)disamarium(III)] mono-hydrate]. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412433 |
| Zhang XJ and Guo ML | catena-Poly[[bis-(1-methyl-1H-imidazole-κN)zinc]-μ-3-nitro-phthalato-κO:O]. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412416 |
| Ashrafian H et al. | Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. | 2012 | Cell Metab. | pmid:22405071 |
| Trushina E et al. | Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. | 2012 | PLoS ONE | pmid:22393443 |
| Tran QM et al. | Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase. | 2012 | PLoS ONE | pmid:22393428 |
| Totir M et al. | Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. | 2012 | PLoS ONE | pmid:22393408 |
| Hackett NR et al. | RNA-Seq quantification of the human small airway epithelium transcriptome. | 2012 | BMC Genomics | pmid:22375630 |
| Tovar-y-Romo LB and Tapia R | Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo. | 2012 | ASN Neuro | pmid:22369757 |
| Zuno-Floriano FG et al. | Effect of Acinetobacter sp on metalaxyl degradation and metabolite profile of potato seedlings (Solanum tuberosum L.) alpha variety. | 2012 | PLoS ONE | pmid:22363586 |
| Fujii T and Albarède F | Ab initio calculation of the Zn isotope effect in phosphates, citrates, and malates and applications to plants and soil. | 2012 | PLoS ONE | pmid:22363478 |
| Frankel S and Rogina B | Indy mutants: live long and prosper. | 2012 | Front Genet | pmid:22363340 |
| Wang N et al. | Changes in soybean global gene expression after application of lipo-chitooligosaccharide from Bradyrhizobium japonicum under sub-optimal temperature. | 2012 | PLoS ONE | pmid:22348109 |
| Merewitz EB et al. | Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. | 2012 | J. Exp. Bot. | pmid:22131157 |
| Peng Y et al. | Poly[[μ(2)-1,3-bis-(imidazol-1-ylmeth-yl)benzene][μ(2)-2,2'-dihy-droxy-1,1'-methyl-enebis(naphthalene-3-carboxyl-ato)]zinc]. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22346812 |