Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Neoplasms, Muscle Tissue D009379 2 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Teratoma D013724 4 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Neoplasms D009369 13 associated lipids
Abscess D000038 13 associated lipids
Ischemia D007511 18 associated lipids
Brain Edema D001929 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Pohl NL et al. Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. 2001 J. Am. Chem. Soc. pmid:11403625
pmid:11388410
Kremer L et al. Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. 2001 J. Biol. Chem. pmid:11373295
Hall IH et al. Specific inhibition of type II inosine monophosphate dehydrogenase activity of Tmolt4 T cell human leukaemia cells by 3-methoxy and di-benzohydroxamic acids, maleic hydrazide and malonic acids. 2001 J. Pharm. Pharmacol. pmid:11370715
Li D et al. Heterologous expression of athermostable manganese peroxidase from Dichomitus squalens in Phanerochaete chrysosporium. 2001 Arch. Biochem. Biophys. pmid:11368016
pmid:11358255
pmid:11354672
pmid:11345467
Toki K et al. Anthocyanins from the scarlet flowers of Anemone coronaria. 2001 Phytochemistry pmid:11314957
pmid:11312968
Cotton FA et al. The simplest supramolecular complexes containing pairs of Mo(2)(formamidinate)(3) units linked with various dicarboxylates: preparative methods, structures, and electrochemistry. 2001 Inorg Chem pmid:11300824
Nixdorf WL et al. Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate. 2001 J. Neurochem. pmid:11299327
Demougeot C et al. N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. 2001 J. Neurochem. pmid:11299303
pmid:11292077
Stokes AH et al. Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711. 2001 J. Neurosci. Res. pmid:11276050
McPherson A A comparison of salts for the crystallization of macromolecules. 2001 Protein Sci. pmid:11266627
Kavitha J and Subbaraju GV Synthesis of N-[3,4-dimethoxyphenyl)propanoyl]pyrrole, a metabolite of Piper brachystachyum. 2000 J Asian Nat Prod Res pmid:11252681
Lancaster CR et al. A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction. 2001 Eur. J. Biochem. pmid:11248702
Matharu A et al. Contributions of the substrate-binding arginine residues to maleate-induced closure of the active site of Escherichia coli aspartate aminotransferase. 2001 Eur. J. Biochem. pmid:11248682
pmid:11211254
Meldrum A et al. Role of corticostriatal and nigrostriatal inputs in malonate-induced striatal toxicity. 2001 Neuroreport pmid:11201098
Ruiz-Pérez C et al. Magnetic coupling through the carbon skeleton of malonate in two polymorphs of ([Cu(bpy)(H2O)][Cu(bpy)(mal)(H2O)])(ClO4)2 (H2mal = malonic acid; bpy = 2,2'-bipyridine). 2000 Inorg Chem pmid:11196779
Mossakowski MJ et al. Effect of sodium glutamate on the morphology and histochemistry of experimental gliopathy induced in vitro by ammonia and sodium malonate. 1975 Jan-Mar Neuropatol Pol pmid:1118055
Piasecka M et al. Computerized analysis of cytochemical reactions for dehydrogenases and oxygraphic studies as methods to evaluate the function of the mitochondrial sheath in rat spermatozoa. 2001 Andrologia pmid:11167513
Van Westerlaak MG et al. Chronic mitochondrial inhibition induces glutamate-mediated corticomotoneuron death in an organotypic culture model. 2001 Exp. Neurol. pmid:11161628
Andreassen OA et al. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. 2001 Exp. Neurol. pmid:11161607
Dobosz M et al. Synthesis of new derivatives of 3-benzyl-4-R-delta 2-1,2,4-triazolin-5-one and 3,3'-methylidyne bis(4-R-1,2,4-delta 2-triazolin-5-one). 2000 May-Jun Acta Pol Pharm pmid:11143710
pmid:11141054
Kamo T et al. Changes in the content and biosynthesis of phytoalexins in banana fruit. 2000 Biosci. Biotechnol. Biochem. pmid:11129580
Ramaseshan M et al. Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds. 2000 Nov-Dec J Comb Chem pmid:11126291
Ling F et al. A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA. 2000 Nucleic Acids Res. pmid:11121487
Lee HY et al. Identification and characterization of a novel transcriptional regulator, MatR, for malonate metabolism in Rhizobium leguminosarum bv. trifolii. 2000 Eur. J. Biochem. pmid:11106435
Ward OP and Singh A Enzymatic asymmetric synthesis by decarboxylases. 2000 Curr. Opin. Biotechnol. pmid:11102784
Tóth V and Emódy L Proteus virulence: involvement of the pore forming alpha-hemolysin (a short review). 2000 Acta Microbiol Immunol Hung pmid:11056765
Koo JH et al. The malonate decarboxylase operon of Acinetobacter calcoaceticus KCCM 40902 is regulated by malonate and the transcriptional repressor MdcY. 2000 J. Bacteriol. pmid:11053382
Hoenke S et al. Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. 2000 Biochemistry pmid:11052675
Meldrum A et al. Age-dependence of malonate-induced striatal toxicity. 2000 Exp Brain Res pmid:11045358
Ouyang Q et al. Transition from spirals to defect-mediated turbulence driven by a doppler instability. 2000 Phys. Rev. Lett. pmid:11017437
Chaimbault C et al. Physicochemical and crystallographic evidence for polymorphism of the racemic ethyl (2-chloromethyl-2,3-dihydro-5H-oxazolo [3, 2-a]pyrimidin-5-one)-6-carboxylate. 2000 J Pharm Sci pmid:11015694
Knobling A et al. Malonyl and palmityl transferase-less mutants of the yeast fatty-acid-synthetase complex. 1975 Eur. J. Biochem. pmid:1100391
Sawai S et al. Spontaneous symmetry breaking turing-type pattern formation in a confined Dictyostelium cell mass. 2000 Phys. Rev. Lett. pmid:10970500
Aime S et al. Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI. 2000 J. Biol. Inorg. Chem. pmid:10968620
Li J and Copeland L Role of malonate in chickpeas. 2000 Phytochemistry pmid:10963451
Jung JW et al. The active site and substrates binding mode of malonyl-CoA synthetase determined by transferred nuclear Overhauser effect spectroscopy, site-directed mutagenesis, and comparative modeling studies. 2000 Protein Sci. pmid:10933494
Dongmei H et al. Synthesis and analgesic activity of N,N'-dicarbonyltryptamines. 2000 Prep. Biochem. Biotechnol. pmid:10919562
Nath R et al. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. 2000 Biochem. Biophys. Res. Commun. pmid:10903889
Andreassen OA et al. Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant. 2000 J. Neurochem. pmid:10899963
Koo HM and Kim YS Identification of active-site residues in Bradyrhizobium japonicum malonyl-coenzyme A synthetase. 2000 Arch. Biochem. Biophys. pmid:10871057
Kuijt J et al. Quenched phosphorescence, a new detection method in capillary electrophoresis. 2000 Electrophoresis pmid:10826674
Sett S et al. Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone; levamisole gives protection. 2000 J. Biosci. pmid:10824201