Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Neoplasms, Muscle Tissue D009379 2 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Teratoma D013724 4 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Abscess D000038 13 associated lipids
Neoplasms D009369 13 associated lipids
Ischemia D007511 18 associated lipids
Brain Edema D001929 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Bacterial Infections D001424 21 associated lipids
Hyperglycemia D006943 21 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Brain Diseases D001927 27 associated lipids
Catalepsy D002375 30 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Diarrhea D003967 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Memory Disorders D008569 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Asanuma T et al. Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping. 2002 Neurosci. Lett. pmid:12183031
pmid:12183100
pmid:12203348
pmid:12206751
Kim YS Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application. 2002 J. Biochem. Mol. Biol. pmid:12359084
Loopuijt LD Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta. 2002 J Neural Transm pmid:12373561
Lash LH et al. Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. 2002 J. Pharmacol. Exp. Ther. pmid:12388626
pmid:12392401
Dickins RS et al. Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. 2002 J. Am. Chem. Soc. pmid:12392417
Burckhardt BC et al. The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. 2002 J. Am. Soc. Nephrol. pmid:12397032
pmid:12434365
An JH et al. Symbiotic effects of deltamatB Rhizobium leguminosarum bv. trifolii mutant on clovers. 2002 Mol. Cells pmid:12442899
Pomytkin IA and Kolesova OE Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases. 2002 Bull. Exp. Biol. Med. pmid:12447467
Saraswathi NT and Vijayan M X-ray studies on crystalline complexes involving amino acids and peptides. XL. Conformational variability, recurring and new features of aggregation, and effect of chirality in the malonic acid complexes of DL- and L-arginine. 2002 Acta Crystallogr., B pmid:12456986
Petersén A et al. Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice. 2002 Neurobiol. Dis. pmid:12460553
Cervellati R et al. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. 2002 J. Agric. Food Chem. pmid:12475261
Colsenet R et al. A straightforward detection of deprotonated conformers of malonic acid by solid-state 13C NMR spectroscopy. 2002 Angew. Chem. Int. Ed. Engl. pmid:12481345
Basak K and Majumdar SK Effect of some inhibitors on kanamycin formation by Streptomyces kanamyceticus. 1976 Folia Microbiol. (Praha) pmid:1248783
Sweet DH et al. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. 2003 Am. J. Physiol. Renal Physiol. pmid:12488248
Armentero MT et al. Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat. 2002 Exp. Neurol. pmid:12504889