Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

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Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

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What functions are associated with Malonic acid?


Related references are published most in these journals:

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What lipids are associated with Malonic acid?

Related references are published most in these journals:

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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

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Authors Title Published Journal PubMed Link
Thaller MC et al. Notes on the appearance of double and triple anomalies in Escherichia coli strains. 1981 Boll Ist Sieroter Milan pmid:7023500
Marzulli D et al. N-ethylmaleimide as oxidizing agent in biological and non-biological systems. 1985 Boll. Soc. Ital. Biol. Sper. pmid:2983741
Kuch H Clobazam: chemical aspects of the 1,4 and 1,5-benzodiazepines. 1979 Br J Clin Pharmacol pmid:35199
Karuri AR et al. Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. 1993 Br. J. Cancer pmid:8260358
Elferink F et al. Pharmacokinetics of ethylenediaminemalonatoplatinum(II) (JM-40) during phase I trial. 1987 Br. J. Cancer pmid:3689665
Newell DR et al. Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. 2003 Br. J. Cancer pmid:12888809
Fernandez-Gomez FJ et al. Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway. 2005 Br. J. Pharmacol. pmid:15655518
Toulmond S et al. Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. 2004 Br. J. Pharmacol. pmid:14744804
Barros-Miñones L et al. Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. 2013 Br. J. Pharmacol. pmid:23186227
Ando M and Itoh T Changes of amino acid by the deprivation of energy sources in the cerebral cortex. 1989 Brain Dev. pmid:2751063
Kanki R et al. Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. 2004 Brain Res. pmid:15223368
Sonsalla PK et al. Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra. 1997 Brain Res. pmid:9409726
Messam CA et al. Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. 1995 Brain Res. pmid:7583227
Henshaw R et al. Malonate produces striatal lesions by indirect NMDA receptor activation. 1994 Brain Res. pmid:8069700
Maragos WF et al. Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. 1999 Brain Res. pmid:10407109
Kiss C et al. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. 2004 Brain Res. pmid:14988042
Takenaka T et al. Fatty acids as an energy source for the operation of axoplasmic transport. 2003 Brain Res. pmid:12711076
Darvesh AS and Gudelsky GA Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT. 2005 Brain Res. pmid:16098955
Albers DS et al. Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. 1996 Brain Res. pmid:8773791
Bazzett TJ et al. Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. 1996 Brain Res. pmid:8773793
Lorenc-Koci E et al. 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. 2005 Brain Res. pmid:16004976
Malcon C et al. Neuroprotective effects of creatine administration against NMDA and malonate toxicity. 2000 Brain Res. pmid:10727643
Maragos WF and Silverstein FS The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. 1995 Brain Res. Dev. Brain Res. pmid:7493402
Murphy RC and Messer A A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease. 2004 Brain Res. Mol. Brain Res. pmid:14969746
Carnieri EG et al. The mechanism and biological role of calcium transport by plant mitochondria. 1987 Braz. J. Med. Biol. Res. pmid:3452457
Li J et al. A genome-wide association scan on estrogen receptor-negative breast cancer. 2010 Breast Cancer Res. pmid:21062454
Ross JA and Tweedy BG Malonic acid conjugation by soil microorganisms of a pesticide-derived aniline moiety. 1973 Bull Environ Contam Toxicol pmid:4755262
Aoyama H Distribution and excretion of thallium after oral and intraperitoneal administration of thallous malonate and thallous sulfate in hamsters. 1989 Bull Environ Contam Toxicol pmid:2706357
Lukyanova LD et al. Energotropic effect of succinate-containing derivatives of 3-hydroxypyridine. 2009 Bull. Exp. Biol. Med. pmid:20396747
Pomytkin IA and Kolesova OE Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases. 2002 Bull. Exp. Biol. Med. pmid:12447467
Shefer TV et al. Effect of sodium succinate on gas exchange in rats with barbiturate-induced coma. 2003 Bull. Exp. Biol. Med. pmid:12910308
LINDSAY JG et al. C13 isotope effect in the decarboxylation of normal malonic acid. 1951 Can J Chem pmid:14821851
Parvin R et al. Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. 1980 Can. J. Biochem. pmid:7459685
Vanni P et al. Studies on isocitrate lyase isolated from Lupinus cotyledons. 1979 Can. J. Biochem. pmid:509354
Garcia-Delgado GA et al. A comparison of various Haemophilus somnus strains. 1977 Can. J. Comp. Med. pmid:922555
Murrin SF and Nolan RA Ultrastructural localization of succinate dehydrogenase in a self-parasitic isolate of Saprolegnia megasperma. 1977 Can. J. Microbiol. pmid:871965
Fitzgerald JW et al. Reversal of succinate-mediated catabolite repression of alkylsulfatase in Pseudomonas aeruginosa by 2,4-dinitrophenol and by sodium malonate. 1978 Can. J. Microbiol. pmid:106946
Deegan C et al. In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)]x2H2O, [Cu(phen)2(mal)]x2H2O and [Mn(phen)2(mal)]x2H2O (malH2=malonic acid) using human cancer cells. 2007 Cancer Lett. pmid:16740357
Winograd B et al. Phase I study of ethylenediamine platinum(II) malonate (NSC 146 068), a second generation platinum analogue. 1986 Cancer Res. pmid:3948186
BUSCH H and POTTER VR Studies on tissue metabolism by means of in vivo metabolic blocking technics. II. Metabolism of acetate-1-C14 in malonate-treated rats. 1953 Cancer Res. pmid:13042804
BUSCH H and POTTER VR Studies on tissue metabolism by means of in vivo metabolic blocking technics. I. A survey of changes induced by malonate in tissues of tumor-bearing rats. 1952 Cancer Res. pmid:12978997
Andrews PA et al. Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion. 1985 Cancer Res. pmid:4063975
Ito E et al. Effects of 2,4-dinitrophenol and other metabolic inhibitors on the thermograms of Ehrlich ascites carcinoma cells registered with a microcalorimeter. 1984 Cancer Res. pmid:6713397
Khan A et al. Atopic hypersensitivity to cis-dichlorodiammineplatinum(II) and other platinum complexes. 1975 Cancer Res. pmid:50881
Mauldin SK et al. Effects of the bidentate malonate ligand on the utilization and cytotoxicity of platinum compounds in the L1210 cell line. 1986 Cancer Res. pmid:3698013
Wozniak AJ et al. Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents. 1984 Cancer Res. pmid:6318974
van Hennik MB et al. Comparative pharmacokinetics of cisplatin and three analogues in mice and humans. 1987 Cancer Res. pmid:3315183
Ghosh Dastidar T and Netravali AN 'Green' crosslinking of native starches with malonic acid and their properties. 2012 Carbohydr Polym pmid:22944425
Sand A et al. Synthesis of graft copolymer (CgOH-g-AGA): physicochemical properties, characterization and application. 2012 Carbohydr Polym pmid:22840018
Tran QT et al. Chemical genomics of cancer chemopreventive dithiolethiones. 2009 Carcinogenesis pmid:19126641
Huber KW and Lutz WK Methylation of DNA by incubation with methylamine and nitrite. 1984 Carcinogenesis pmid:6705144
Rosca MG et al. Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. 2008 Cardiovasc. Res. pmid:18710878
Miller SE et al. The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. 2011 Cell pmid:22118466
Lau SK et al. Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis. 2011 Cell Biosci pmid:21849034
Boquist L and Alehagen U Ca2+ transport in isolated mouse liver mitochondria; role of reductive carboxylation and citrate? 1986 Cell Calcium pmid:3768942
Whitaker-Menezes D et al. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. 2011 Cell Cycle pmid:22134189
Schulz JB et al. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. 1998 Cell Death Differ. pmid:10203688
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
Ashrafian H et al. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. 2012 Cell Metab. pmid:22405071
Cohen A et al. From the Gla domain to a novel small-molecule detector of apoptosis. 2009 Cell Res. pmid:19223854
Vaughan AM et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. 2009 Cell. Microbiol. pmid:19068099
Burckhardt BC et al. Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. 2004 Cell. Physiol. Biochem. pmid:15319545
Vanag VK and Epstein IR Design and control of patterns in reaction-diffusion systems. 2008 Chaos pmid:18601509
Moore PK and Horsthemke W Three-dimensional patterns in the Lengyel-Rabai-Epstein model of the chlorine dioxide-iodine-malonic acid reaction. 2009 Chaos pmid:20059212
Manz N and Steinbock O Propagation failures, breathing pulses, and backfiring in an excitable reaction-diffusion system. 2006 Chaos pmid:17014246
Furutachi M et al. A heterobimetallic Ni/La-salan complex for catalytic asymmetric decarboxylative 1,4-addition of malonic acid half-thioester. 2010 Chem Asian J pmid:20839279
Zhang X et al. Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. 2013 Chem Asian J pmid:23929723
Kobayashi S et al. Chiral zirconium complex as Brønsted base catalyst in asymmetric direct-type Mannich reactions. 2010 Chem Asian J pmid:20099294
Padalkar VS et al. Synthesis and characterization of novel 2, 2'-bipyrimidine fluorescent derivative for protein binding. 2011 Chem Cent J pmid:22067202
Ewais HA et al. Inner-sphere oxidation of ternary iminodiacetatochromium(III) complexes involving DL-valine and L-arginine as secondary ligands. Isokinetic relationship for the oxidation of ternary iminodiacetato-chromium(III) complexes by periodate. 2009 Chem Cent J pmid:19193241
Rachid S et al. Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens. 2009 Chem. Biol. pmid:19171307
Sonawane ND et al. Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. 2008 Chem. Biol. pmid:18635008
Lopanik NB et al. In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. 2008 Chem. Biol. pmid:19022178
Hughes AJ and Keatinge-Clay A Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB. 2011 Chem. Biol. pmid:21338915
Matharu AL et al. MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. 1998 Chem. Biol. pmid:9862793
Arthur CJ et al. The malonyl transferase activity of type II polyketide synthase acyl carrier proteins. 2006 Chem. Biol. pmid:16793516
Prigol M et al. Protective effect of unsymmetrical dichalcogenide, a novel antioxidant agent, in vitro and an in vivo model of brain oxidative damage. 2008 Chem. Biol. Interact. pmid:18722362
Lash LH Mitochondrial glutathione transport: physiological, pathological and toxicological implications. 2006 Chem. Biol. Interact. pmid:16600197
De M and Rotello VM Synthetic "chaperones": nanoparticle-mediated refolding of thermally denatured proteins. 2008 Chem. Commun. (Camb.) pmid:18654694
Hulcoop DG and Burton JW Synthesis of fused tricyclic gamma-lactones mediated by manganese(III) acetate. 2005 Chem. Commun. (Camb.) pmid:16175293
Xue ZY et al. exo-Selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with alkylidene malonates catalyzed by AgOAc/TF-BiphamPhos. 2010 Chem. Commun. (Camb.) pmid:20177630
Tillman AL et al. Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative. 2006 Chem. Commun. (Camb.) pmid:16518487
Kawatsura M et al. Retention of regiochemistry of monosubstituted allyl acetates in the ruthenium catalysed allylic alkylation with malonate anion. 2007 Chem. Commun. (Camb.) pmid:18217606
Wang YH et al. Diastereoselective gamma-vinyl butyrolactone synthesis via gold catalyzed cyclization of allylic acetate. 2010 Chem. Commun. (Camb.) pmid:20062867
Nemoto T Transition metal-catalyzed asymmetric reactions using P-chirogenic diaminophosphine oxides: DIAPHOXs. 2008 Chem. Pharm. Bull. pmid:18758091
Liu W et al. Preparation, characterization and in vitro anticancer activity of platinum(II) complexes with N-Cyclohexyl-1,3-propanediamine as the carrier. 2008 Chem. Pharm. Bull. pmid:18451553
Niwayama S and Cho H Practical large scale synthesis of half-esters of malonic acid. 2009 Chem. Pharm. Bull. pmid:19420784
Ninomiya K et al. Amino acids and peptides. XII. Phosphorus in organic synthesis. VIII. Reaction of malonic acid half esters with diphenyl phosphorazidate. 1974 Chem. Pharm. Bull. pmid:4422651
Ninomiya K et al. Phosphorus in organic synthesis. IX. On the mechanism of esterification of malonic acid half esters by diphenyl phosphorazidate. 1974 Chem. Pharm. Bull. pmid:4430027
Ohshima T Enantioselective total syntheses of several bioactive natural products based on the development of practical asymmetric catalysis. 2004 Chem. Pharm. Bull. pmid:15340187
Kato F and Hiroi K Stereochemistry of the asymmetric carbopalladation of allenes followed by nucleophilic substitution reactions with carbo- and aminonucleophiles. 2004 Chem. Pharm. Bull. pmid:14709874
Uenishi J and Hamada M Stereospecific substitution of enantiomerically pure 1-(2-pyridinyl)ethyl methanesulfonate with beta-dicarbony compounds. 2002 Chem. Pharm. Bull. pmid:12036035
DoganKoruznjak J et al. Synthesis, photochemical synthesis and antitumor evaluation of novel derivatives of thieno[3',2':4,5]thieno[2,3-c]quinolones. 2002 Chem. Pharm. Bull. pmid:12036023
Mukaida M et al. Stability order of caffeine co-crystals determined by co-crystal former exchange reaction and its application for the validation of in silico models. 2015 Chem. Pharm. Bull. pmid:25743190
Ojha B and Das G Role of hydrophobic and polar interactions for BSA-amphiphile composites. 2011 Chem. Phys. Lipids pmid:21185815
Brown SP and Spiess HW Advanced solid-state NMR methods for the elucidation of structure and dynamics of molecular, macromolecular, and supramolecular systems. 2001 Chem. Rev. pmid:11740929
Klopries S et al. Biosynthesis with fluorine. 2014 Chembiochem pmid:24504732
Dickschat JS et al. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. 2004 Chembiochem pmid:15174160
Ma Y et al. Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase. 2006 Chembiochem pmid:17086560
Yang J et al. One-step hydrothermal synthesis of carboxyl-functionalized upconversion phosphors for bioapplications. 2012 Chemistry pmid:22996059