| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abscess | D000038 | 13 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemoglobinopathies | D006453 | 7 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hemorrhagic Fever with Renal Syndrome | D006480 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Furin A et al. | Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates. | 2003 Jul-Aug | Eur J Med Chem | pmid:12932905 |
| pmid:12950184 | ||||
| Ehrhart J and Zeevalk GD | Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. | 2003 | J. Neurochem. | pmid:12950457 |
| pmid:12971763 | ||||
| pmid:12971787 | ||||
| Kölker S et al. | Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain. | 2003 | J. Biol. Chem. | pmid:12972416 |
| BUSCH H and POTTER VR | Studies on tissue metabolism by means of in vivo metabolic blocking technics. I. A survey of changes induced by malonate in tissues of tumor-bearing rats. | 1952 | Cancer Res. | pmid:12978997 |
| pmid:12999621 | ||||
| pmid:12999622 | ||||
| BUSCH H and POTTER VR | Succinate accumulation in vivo following injection of malonate. | 1952 | J. Biol. Chem. | pmid:12999717 |
| THORN MB | Malonate inhibition of succinic dehydrogenase. | 1953 | Biochem. J. | pmid:13037647 |
| BUSCH H and POTTER VR | Studies on tissue metabolism by means of in vivo metabolic blocking technics. II. Metabolism of acetate-1-C14 in malonate-treated rats. | 1953 | Cancer Res. | pmid:13042804 |
| Davydov VV et al. | [The antihypoxic action of malonic acid]. | 1992 Nov-Dec | Eksp Klin Farmakol | pmid:1305881 |
| THORN MB | Inhibition by malonate of succinic dehydrogenase in heart-muscle preparations. | 1953 | Biochem. J. | pmid:13058948 |
| pmid:13076217 | ||||
| Shigematsu T et al. | Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:13130036 |
| WOLFE JB et al. | Malonate decarboxylation by Pseudomonas fluorescens. I. Observations with dry cells and cell-free preparations. | 1954 | J. Biol. Chem. | pmid:13192141 |
| WOLFE JB et al. | Malonate decarboxylation by Pseudomonas fluorescens. II. Magnesium dependency and trapping of active intermediates. | 1954 | J. Biol. Chem. | pmid:13192142 |
| WOLFE JB and RITTENBERG SC | Malonate decarboxylation by Pseudomonas fluorescens. III. The rôle of acetyl coenzyme A. | 1954 | J. Biol. Chem. | pmid:13192143 |
| MOOKERJEA S and SADHU DP | Metabolic depression by arsenite and malonate and cholesterologenesis. | 1955 | Arch. Biochem. Biophys. | pmid:13259694 |
| Kraker AJ et al. | Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups. | 1992 | J. Med. Chem. | pmid:1335074 |
| pmid:13358057 | ||||
| VICKERY HB and PALMER JK | The metabolism of the organic acids of tobacco leaves. XII. Effect of culture of excised leaves in solutions of malonate at pH 4 to pH 7. | 1957 | J. Biol. Chem. | pmid:13416266 |
| NAKADA HI et al. | Degradation of malonic acid by rat tissues. | 1957 | J. Biol. Chem. | pmid:13428746 |
| ROSTENBERG A and GONZALEZ EL | The inhibition of perspiration by means of the topical application of malonic acid salts. | 1957 | J. Invest. Dermatol. | pmid:13491887 |
| pmid:13534680 | ||||
| pmid:13572052 | ||||
| VICKERY HB | The metabolism of the organic acids of tobacco leaves. XVI. Effect of culture of excised leaves in solutions of malonate. | 1959 | J. Biol. Chem. | pmid:13654379 |
| Nikiforov AA and Ostretsova IB | Effects of metabolic substrates and inhibitors on weak organic anion transport in rat renal proximal tubules. | 1997 May-Jun | Ross Fiziol Zh Im I M Sechenova | pmid:13677672 |
| HOSOYA N and KAWADA N | Effect of estradiol, nucleotides and bicarbonate on the metabolism of glucose and malonate. | 1961 | J. Biochem. | pmid:13716089 |
| pmid:13716584 | ||||
| pmid:13741238 | ||||
| pmid:13842636 | ||||
| pmid:13843244 | ||||
| BU'LOCK JD et al. | Malonate as a biosynthetic intermediate in Penicillium urticae. | 1962 | J. Biol. Chem. | pmid:13874181 |
| FAWAZ EN and FAWAZ G | Inhibition of glycolysis in rat skeletal muscle by malonate. | 1962 | Biochem. J. | pmid:13891870 |
| pmid:13952695 | ||||
| pmid:13969381 | ||||
| pmid:13969382 | ||||
| pmid:13980177 | ||||
| pmid:13999968 | ||||
| pmid:14016247 | ||||
| CRAWFORD MA | The effects of fluoroacetate, malonate and acid-base balance on the renal disposal of citrate. | 1963 | Biochem. J. | pmid:14023730 |
| GOLLAKOTA KG and HALVORSON HO | BIOCHEMICAL CHANGES OCCURRING DURING SPORULATION OF BACILLUS CEREUS T. II. EFFECT OF ESTERS OF ORGANIC ACIDS ON SPORULATION. | 1963 | J. Bacteriol. | pmid:14047234 |
| SMITH JA and DELUCA HF | STRUCTURAL CHANGES IN ISOLATED LIVER MITOCHONDRIA OF RATS DURING ESSENTIAL FATTY ACID DEFICIENCY. | 1964 | J. Cell Biol. | pmid:14154491 |
| ROBBINS E et al. | DYNAMICS OF ACRIDINE ORANGE-CELL INTERACTION. II. DYE-INDUCED ULTRASTRUCTURAL CHANGES IN MULTIVESICULAR BODIES (ACRIDINE ORANGE PARTICLES). | 1964 | J. Cell Biol. | pmid:14154495 |
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| FRIEDMAN SM et al. | ANTIBIOTIC GLYCOSIDES. V. A COMPARISON OF 2-METHYLMALONATE AND PROPIONATE AS PERCURSORS OF THE C21 BRANCHED CHAIN LACTONE IN ERYTHROMYCIN. | 1964 | J. Biol. Chem. | pmid:14209973 |
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