| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abscess | D000038 | 13 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemoglobinopathies | D006453 | 7 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hemorrhagic Fever with Renal Syndrome | D006480 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Malonic acid
Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Malonic acid?
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Malonic acid
PubChem Associated disorders and diseases
What pathways are associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Malonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Malonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Malonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Malonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Malonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Malonic acid
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|---|---|---|---|---|
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| Romanowski MJ et al. | Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. | 2004 | Structure | pmid:15296730 |
| Stock I et al. | Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. | 2004 | Clin. Microbiol. Infect. | pmid:15301675 |
| pmid:15303849 | ||||
| pmid:15310214 | ||||
| Maciel EN et al. | Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition. | 2004 | J. Neurochem. | pmid:15312158 |
| pmid:15315452 | ||||
| Burckhardt BC et al. | Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. | 2004 | Cell. Physiol. Biochem. | pmid:15319545 |
| pmid:15323800 | ||||
| pmid:15326518 | ||||
| pmid:15337853 | ||||
| Ohshima T | Enantioselective total syntheses of several bioactive natural products based on the development of practical asymmetric catalysis. | 2004 | Chem. Pharm. Bull. | pmid:15340187 |
| pmid:15350645 | ||||
| Nelson J et al. | Steric complementarity in carboxylate anion recognition. | 2004 | Dalton Trans | pmid:15356717 |
| Yurgel SN and Kahn ML | Dicarboxylate transport by rhizobia. | 2004 | FEMS Microbiol. Rev. | pmid:15374663 |
| pmid:15387540 | ||||
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| LIFSON N and STOLEN JA | Metabolism of C13-carboxyl-labeled malonate by the intact mouse. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:15440851 |
| Darvesh AS et al. | Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15456837 |
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| Yang L et al. | A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. | 2004 | Neurobiol. Dis. | pmid:15474362 |
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| de Rijke E et al. | Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. | 2004 | J Sep Sci | pmid:15495407 |
| Chen H and Harrison PH | Investigation of the origin of C2 units in biosynthesis of streptolydigin. | 2004 | Org. Lett. | pmid:15496092 |
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| Lin Y et al. | The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. | 2005 | J. Biol. Chem. | pmid:15536073 |
| pmid:15540137 | ||||
| Morland C et al. | Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. | 2004 | J. Cereb. Blood Flow Metab. | pmid:15545916 |
| Cornet S et al. | Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline. | 2004 | Eur. J. Pharmacol. | pmid:15556143 |
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| Burckhardt BC et al. | Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15561973 |
| pmid:15575671 | ||||
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| Rahman AS et al. | Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series. | 2005 | J. Biol. Chem. | pmid:15583005 |
| Comer E et al. | Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. | 2004 | J. Am. Chem. Soc. | pmid:15584744 |
| Brandner K et al. | The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. | 2005 | J. Biol. Chem. | pmid:15591051 |
| Gunnlaugsson T et al. | Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate. | 2005 | Org. Biomol. Chem. | pmid:15602598 |
| Ma HW et al. | Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. | 2004 | BMC Bioinformatics | pmid:15603590 |
| pmid:15606100 | ||||
| Fatland BL et al. | Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis. | 2005 | Plant Cell | pmid:15608338 |
| Calkins MJ et al. | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15611470 |
| pmid:15624922 | ||||
| pmid:15643906 | ||||
| Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
| Goñi-Allo B et al. | In vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or N-methyl-d-aspartate. | 2005 | Exp. Neurol. | pmid:15649488 |
| pmid:15649514 |