Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ramaseshan M et al. | Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds. | 2000 Nov-Dec | J Comb Chem | pmid:11126291 |
Nguyen TH et al. | Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptors. | 2005 | J Comput Chem | pmid:15962275 |
Hidaka M and Yoshida R | Self-oscillating gel composed of thermosensitive polymer exhibiting higher LCST. | 2011 | J Control Release | pmid:21130818 |
Malik N et al. | Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. | 2000 | J Control Release | pmid:10699277 |
Pritchard DJ | Transdifferentiation of chicken embryo neural retina into pigment epithelium: indications of its biochemical basis. | 1981 | J Embryol Exp Morphol | pmid:7276821 |
Walash MI et al. | Determination of oxybutynin in pharmaceuticals via reaction with mixed acids anhydrides: application to content uniformity testing. | 2011 | J Fluoresc | pmid:21046437 |
Josyula AB et al. | Reduction in urinary arsenic with bottled-water intervention. | 2006 | J Health Popul Nutr | pmid:17366771 |
Iriyama N et al. | Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. | 2012 | J Hematol Oncol | pmid:22272800 |
GarcÃa Sabater JF et al. | Taxonomic position of Klebsiella atlantae and Klebsiella edwardsii. | 1979 | J Hyg Epidemiol Microbiol Immunol | pmid:393774 |
Kachlicki P et al. | Evaluation of glycosylation and malonylation patterns in flavonoid glycosides during LC/MS/MS metabolite profiling. | 2008 | J Mass Spectrom | pmid:18074333 |
Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
Mitra T et al. | Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions. | 2012 | J Mater Sci Mater Med | pmid:22367159 |
Di Bella S et al. | Salmonella enterica ssp. arizonae infection in a 43-year-old Italian man with hypoglobulinemia: a case report and review of the literature. | 2011 | J Med Case Rep | pmid:21781321 |
Ruangpornvisuti V and Wanno B | Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study. | 2007 | J Mol Model | pmid:16738872 |
Chojnacki H | Proton transfer in some periodic molecular systems. | 2007 | J Mol Model | pmid:17479303 |
Wang GW and Li FB | Radical reactions of [60]fullerene mediated by manganese(III) acetate dihydrate. | 2007 Apr-May | J Nanosci Nanotechnol | pmid:17450885 |
Loopuijt LD | Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta. | 2002 | J Neural Transm | pmid:12373561 |
Engeham S et al. | Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a MaternalLow-ProteinDiet. | 2012 | J Nutr Metab | pmid:22536494 |
Gauniya A et al. | Comparative bioavailability studies of citric acid and malonic acid based aspirin effervescent tablets. | 2010 | J Pharm Bioallied Sci | pmid:21814444 |
Kim SC et al. | Sensitive HPLC method for quantitation of paclitaxel (Genexol in biological samples with application to preclinical pharmacokinetics and biodistribution. | 2005 | J Pharm Biomed Anal | pmid:16085137 |
Liu Z et al. | The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer. | 2012 | J Pharm Biomed Anal | pmid:22387101 |
de Spiegeleer B et al. | Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography. | 1986 | J Pharm Biomed Anal | pmid:16867607 |
Connors KA and Ifan A | Chromogenic reactions of tertiary amines with polycarboxylic acids and acetic anhydride: carbon suboxide as the reactive species in the malonic acid reagent. | 1987 | J Pharm Sci | pmid:3430350 |
Chaimbault C et al. | Physicochemical and crystallographic evidence for polymorphism of the racemic ethyl (2-chloromethyl-2,3-dihydro-5H-oxazolo [3, 2-a]pyrimidin-5-one)-6-carboxylate. | 2000 | J Pharm Sci | pmid:11015694 |
Pope FD et al. | Studies of single aerosol particles containing malonic acid, glutaric acid, and their mixtures with sodium chloride. II. Liquid-state vapor pressures of the acids. | 2010 | J Phys Chem A | pmid:20799753 |
Bermúdez E et al. | Mechanism of the organocatalyzed decarboxylative Knoevenagel-Doebner reaction. A theoretical study. | 2010 | J Phys Chem A | pmid:21105640 |
Ghorai S et al. | Spectroscopic evidence of keto-enol tautomerism in deliquesced malonic acid particles. | 2011 | J Phys Chem A | pmid:21480651 |
Beyer KD et al. | Phase diagrams and water activities of aqueous ammonium salts of malonic acid. | 2011 | J Phys Chem A | pmid:21428389 |
Cervellati R et al. | Experimental and mechanistic investigation of an iodomalonic acid-based Briggs-Rauscher oscillator and its perturbations by resorcinol. | 2010 | J Phys Chem A | pmid:21082849 |
Pope FD et al. | Studies of single aerosol particles containing malonic acid, glutaric acid, and their mixtures with sodium chloride. I. Hygroscopic growth. | 2010 | J Phys Chem A | pmid:20361768 |
Beyer KD et al. | Temperature-dependent deliquescence relative humidities and water activities using humidity controlled thermogravimetric analysis with application to malonic acid. | 2014 | J Phys Chem A | pmid:24628358 |
Preska Steinberg A et al. | Target Turing patterns and growth dynamics in the chlorine dioxide-iodine-malonic acid reaction. | 2014 | J Phys Chem A | pmid:24601764 |
Furrow SD and Aurentz DJ | Reactions of iodomalonic acid, diiodomalonic acid, and other organics in the Briggs-Rauscher oscillating system. | 2010 | J Phys Chem A | pmid:20121222 |
Zobrist B et al. | Heterogeneous ice nucleation in aqueous solutions: the role of water activity. | 2008 | J Phys Chem A | pmid:18363389 |
Kim HI and Beauchamp JL | Cluster phase chemistry: collisions of vibrationally excited cationic dicarboxylic acid clusters with water molecules initiate dissociation of cluster components. | 2007 | J Phys Chem A | pmid:17569511 |
Shen J et al. | Ternary phase diagram for the Belousov-Zhabotinsky reaction-induced mechanical oscillation of intelligent PNIPAM colloids. | 2007 | J Phys Chem A | pmid:17994710 |
Riipinen I et al. | Adipic and malonic acid aqueous solutions: surface tensions and saturation vapor pressures. | 2007 | J Phys Chem A | pmid:18044850 |
Kim HI et al. | Cluster phase chemistry: gas-phase reactions of anionic sodium salts of dicarboxylic acid clusters with water molecules. | 2006 | J Phys Chem A | pmid:16789762 |
Hegedüs L et al. | Contribution to the chemistry of the Belousov-Zhabotinsky reaction. Products of the Ferriin-Bromomalonic acid and the Ferriin-Malonic acid reactions. | 2006 | J Phys Chem A | pmid:17125298 |
Wang J et al. | Coexistence of two bifurcation regimes in a closed ferroin-catalyzed Belousov-Zhabotinsky reaction. | 2005 | J Phys Chem A | pmid:16833454 |
Kitahata H et al. | Propagation of photosensitive chemical waves on the circular routes. | 2005 | J Phys Chem A | pmid:16833846 |
Ojha B et al. | 2-Alkylmalonic acid: amphiphilic chelator and a potent inhibitor of metalloenzyme. | 2010 | J Phys Chem B | pmid:20669918 |
Hara Y and Yoshida R | Self-oscillating polymer fueled by organic acid. | 2008 | J Phys Chem B | pmid:18588335 |
Vanag VK et al. | Cross-diffusion in a water-in-oil microemulsion loaded with malonic acid or ferroin. Taylor dispersion method for four-component systems. | 2008 | J Phys Chem B | pmid:18610956 |
Hara Y et al. | Generative force of self-oscillating gel. | 2014 | J Phys Chem B | pmid:24524539 |
Nkuku CA and LeSuer RJ | Electrochemistry in deep eutectic solvents. | 2007 | J Phys Chem B | pmid:17973421 |
Himeno S et al. | Simultaneous determination of phosphonate, phosphate, and diphosphate by capillary electrophoresis using in-capillary complexation with Mo(VI). | 2007 | J Sep Sci | pmid:17566343 |
de Rijke E et al. | Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. | 2004 | J Sep Sci | pmid:15495407 |
Batur M et al. | Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics. | 2012 | J Tradit Chin Med | pmid:22594115 |
Garcia-Fernandez M et al. | Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats. | 2011 | J Transl Med | pmid:21798010 |
Vermeulen RC et al. | Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. | 2010 | J Transl Med | pmid:20937116 |
Wu Q et al. | LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. | 2004 | J. Agric. Food Chem. | pmid:15137811 |
Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
Onisko BC et al. | Identification of fonofos metabolites in Latuca sativa, Beta vulgaris, and Triticum aestivum by packed capillary flow fast atom bombardment tandem mass spectrometry. | 2002 | J. Agric. Food Chem. | pmid:11902934 |
Tsao R et al. | Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages. | 2006 | J. Agric. Food Chem. | pmid:16881680 |
Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
Thatcher GR et al. | Novel nitrates as NO mimetics directed at Alzheimer's disease. | 2004 | J. Alzheimers Dis. | pmid:15665418 |
Zipse H et al. | Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. | 2009 | J. Am. Chem. Soc. | pmid:19128178 |
Wolfenden R et al. | Kinetic challenges facing oxalate, malonate, acetoacetate, and oxaloacetate decarboxylases. | 2011 | J. Am. Chem. Soc. | pmid:21434608 |
Strieter ER et al. | Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation. | 2009 | J. Am. Chem. Soc. | pmid:19199623 |
Bonhomme C et al. | 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. | 2012 | J. Am. Chem. Soc. | pmid:22738329 |
Palaniappan N et al. | cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. | 2008 | J. Am. Chem. Soc. | pmid:18714992 |
Martin CL et al. | Total synthesis of (+/-)-actinophyllic acid. | 2008 | J. Am. Chem. Soc. | pmid:18491907 |
GALAT A | Ethyl formylaminomalonate; an intermediate in the synthesis of amino acids. | 1947 | J. Am. Chem. Soc. | pmid:20292485 |
HAUSER CR et al. | Proportion of ester anion and amide from esters and sodium amide; carbonation of esters; synthesis of malonic acid derivatives. | 1946 | J. Am. Chem. Soc. | pmid:21008319 |
Comer E et al. | Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. | 2004 | J. Am. Chem. Soc. | pmid:15584744 |
Diener MD et al. | (212)Pb@C(60) and its water-soluble derivatives: synthesis, stability, and suitability for radioimmunotherapy. | 2007 | J. Am. Chem. Soc. | pmid:17394315 |
Nelson ME and Priestley ND | Nonactin biosynthesis: the initial committed step is the condensation of acetate (malonate) and succinate. | 2002 | J. Am. Chem. Soc. | pmid:11902879 |
Fortner KC and Shair MD | Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters. | 2007 | J. Am. Chem. Soc. | pmid:17263375 |
Pohl NL et al. | Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. | 2001 | J. Am. Chem. Soc. | pmid:11403625 |
Liang X et al. | Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. | 2002 | J. Am. Chem. Soc. | pmid:12149014 |
Karlsson T et al. | A study of homonuclear dipolar recoupling pulse sequences in solid-state nuclear magnetic resonance. | 2003 | J. Am. Chem. Soc. | pmid:12797814 |
Dickins RS et al. | Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. | 2002 | J. Am. Chem. Soc. | pmid:12392417 |
Towler CS et al. | Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'. | 2004 | J. Am. Chem. Soc. | pmid:15479091 |
Chou HC et al. | Multiple hydrogen bonds tuning guest/host excited-state proton transfer reaction: its application in molecular recognition. | 2004 | J. Am. Chem. Soc. | pmid:14871093 |
Wenzel SC et al. | On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. | 2006 | J. Am. Chem. Soc. | pmid:17076505 |
Trost BM and Lee CB | Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophiles. | 2001 | J. Am. Chem. Soc. | pmid:11457099 |
Sasamoto N et al. | Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolines. | 2006 | J. Am. Chem. Soc. | pmid:17061867 |
Nguyen Q et al. | Rh2(II)-catalyzed intramolecular aliphatic C-H bond amination reactions using aryl azides as the N-atom source. | 2012 | J. Am. Chem. Soc. | pmid:22519742 |
Zalups RK and Ahmad S | Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. | 2004 | J. Am. Soc. Nephrol. | pmid:15284288 |
Rhee EP et al. | Metabolite profiling identifies markers of uremia. | 2010 | J. Am. Soc. Nephrol. | pmid:20378825 |
Wolff NA et al. | Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter. | 2001 | J. Am. Soc. Nephrol. | pmid:11562399 |
Burckhardt BC et al. | The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. | 2002 | J. Am. Soc. Nephrol. | pmid:12397032 |
Sasaki T et al. | A novel macrolide antibiotic, notonesomycin A. | 1986 | J. Antibiot. | pmid:3710911 |
Fukushima K et al. | Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin. | 1982 | J. Antibiot. | pmid:7161187 |
Solano-Serena F et al. | Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. | 2004 | J. Appl. Microbiol. | pmid:15281945 |
WOLFE JB et al. | Malonate oxidation by dry cells and cell-free extracts of Pseudomonas fluorescens. | 1955 | J. Bacteriol. | pmid:14367265 |
RANDLES CI and BIRKELAND JM | The effects of malic and malonic acids on methylene blue reduction by bacteria. | 1947 | J. Bacteriol. | pmid:20344612 |
Koo JH et al. | The malonate decarboxylase operon of Acinetobacter calcoaceticus KCCM 40902 is regulated by malonate and the transcriptional repressor MdcY. | 2000 | J. Bacteriol. | pmid:11053382 |
KOMINEK LA and HALVORSON HO | MODE OF INHIBITION OF SPORULATION OF BACILLUS CEREUS BY ETHYL MALONATE AND ETHYL SUCCINATE. | 1964 | J. Bacteriol. | pmid:14197898 |
GOLLAKOTA KG and HALVORSON HO | BIOCHEMICAL CHANGES OCCURRING DURING SPORULATION OF BACILLUS CEREUS T. II. EFFECT OF ESTERS OF ORGANIC ACIDS ON SPORULATION. | 1963 | J. Bacteriol. | pmid:14047234 |
Hori T and Okuyama H | Variation of oleate/cis-vaccenate ratios and its regulation by substrates in hepatic tissues. | 1987 | J. Biochem. | pmid:3654590 |
Mohri T et al. | Differences of affinity and energetics of the active transport systems for amino acids in Chang liver cells. | 1979 | J. Biochem. | pmid:34597 |
Iwakura M et al. | Studies on regulatory functions of malic enzymes. VI. Purification and molecular properties of NADP-linked malic enzyme from Escherichia coli W. | 1979 | J. Biochem. | pmid:36376 |
HOSOYA N and KAWADA N | Effect of estradiol, nucleotides and bicarbonate on the metabolism of glucose and malonate. | 1961 | J. Biochem. | pmid:13716089 |
Ishikura S et al. | Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. | 2005 | J. Biochem. | pmid:15809331 |
Irikura D et al. | Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme. | 2003 | J. Biochem. | pmid:12761195 |
Kim YS | Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application. | 2002 | J. Biochem. Mol. Biol. | pmid:12359084 |
VujÄić M et al. | A comparative study of DNA binding and cell cycle phase perturbation by the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide N',N'(2) -bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. | 2011 May-Jun | J. Biochem. Mol. Toxicol. | pmid:21671309 |
Jay D et al. | Study of the interaction of cadmium with membrane-bound succinate dehydrogenase. | 1991 | J. Bioenerg. Biomembr. | pmid:2050657 |