Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fang ZP and Zeng XY | [Isolation and identification of flavonoids and organic acids from Gynostemma pentaphyllum Makino]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2619894 |
Kiseleva BS et al. | [Antigenic relations between enteropathogenic Escherichia O151:K, Citrobacter and Hafnia]. | 1981 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:7023147 |
Raginskaia VP | [Nomenclature of the S. coli (E. coli) No. 2624/36 and 5396/38 strains]. | 1975 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:766529 |
Gaziev GM and Baturo AP | [Characteristics of Klebsiella strains isolated from patients with acute intestinal diseases]. | 1986 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:3727877 |
Aldová E and Sourek J | First isolations of Levinea-Citrobacter cultures in Czechoslovakia. | 1975 | Zentralbl Bakteriol Orig A | pmid:1170700 |
Tripathi P et al. | Investigation of effect of alpha-naphthylamine and beta-naphthylamine on organic acids formation of self-sustaining coacervates. | 1979 | Zentralbl Bakteriol Naturwiss | pmid:573037 |
Krausse R and Ullmann U | Studies on the identification of Campylobacter species using biochemical tests and high-performance liquid chromatography. | 1985 | Zentralbl Bakteriol Mikrobiol Hyg A | pmid:3911663 |
Garg DN et al. | The sero-fermentative-phage types of Salmonella weltevreden. | 1980 | Zentralbl Bakteriol A | pmid:7434993 |
Takahashi H et al. | Very-long-chain fatty acid biosynthesis is inhibited by cafenstrole, N,N-diethyl-3-mesitylsulfonyl-1H-1,2,4-triazole-1-carboxamide and its analogs. | 2001 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:11724382 |
Stärk A et al. | Lentinellic acid, a biologically active protoilludane derivative from Lentinellus species (Basidiomycetes). | 1988 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:3388954 |
Schuster M et al. | Production of mycotoxins by Fusarium species isolated in Germany. 2. Time course of deoxynivalenol and 3-acetyldeoxynivalenol formation by Fusarium graminearum in different liquid media. | 1987 | Z Lebensm Unters Forsch | pmid:3439351 |
Du X et al. | [Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors]. | 2012 | Yao Xue Xue Bao | pmid:22645761 |
Turnbull LB et al. | Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man. | 1978 | Xenobiotica | pmid:102086 |
Crisp CE and Look M | Effect of esterification and side-chain alkylation on alteration of translocation characteristics of methamidophos. | 1982 | Xenobiotica | pmid:7147994 |
Pan RN et al. | [Three new serotypes of Salmonella II]. | 1989 | Wei Sheng Wu Xue Bao | pmid:2697972 |
Zhang Y et al. | Organic acids enhance bioavailability of tetracycline in water to Escherichia coli for uptake and expression of antibiotic resistance. | 2014 | Water Res. | pmid:25100186 |
Koval'chuk AV et al. | [Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters]. | 2008 Sep-Oct | Vopr. Virusol. | pmid:19069793 |
Demchuk ML et al. | [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. | 1993 Mar-Apr | Vopr. Med. Khim. | pmid:8511880 |
Lucas RW et al. | Crystallization of Brome mosaic virus and T = 1 Brome mosaic virus particles following a structural transition. | 2001 | Virology | pmid:11485397 |
Djavani M et al. | Gene expression in primate liver during viral hemorrhagic fever. | 2009 | Virol. J. | pmid:19216742 |
McDowell EM | Light and electron microscopic studies of rat kidney after administration of inhibitors of the citric acid cycle in vivo. A morphological and histochemical study of the pars recta during malonate poisoning. | 1974 | Virchows Arch B Cell Pathol | pmid:4210043 |
Giurov B | [Biochemical characteristics of the causative agent of fowl typhoid]. | 1986 | Vet Med Nauki | pmid:3765371 |
Dosch W | Rapid and direct gas chromatographic determination of oxalic acid in urine. | 1979 | Urol. Res. | pmid:505684 |
Davydov VV et al. | [The effect of malonate on lipid biosynthesis in the liver]. | 1992 Nov-Dec | Ukr. Biokhim. Zh. | pmid:1488816 |
Mandrik KA et al. | [Kinetics of the inhibition of succinate dehydrogenase in bull adrenal cortex by malonate and oxaloacetate]. | 1983 Sep-Oct | Ukr. Biokhim. Zh. | pmid:6636310 |
Zinich VN and Zobova NV | [Activation of succinate oxidase in the inner membrane of rat liver mitochondria]. | 1989 May-Jun | Ukr. Biokhim. Zh. | pmid:2546308 |
Davydov VV | [Metabolism of free malonic acid in rat tissues]. | 1991 Jan-Feb | Ukr. Biokhim. Zh. | pmid:2028517 |
Akopova OV et al. | [Estimation of ATP-dependent K(+)-channel contribution to potential-dependent potassium uptake in the rat brain mitochondria]. | 2014 Jan-Feb | Ukr Biochem J | pmid:24834715 |
Lebedev OE et al. | [Inhibitory analysis of the functions of the oxidative metabolic systems of tumor cells in tissue culture]. | 1984 | Tsitologiia | pmid:6474574 |
Tret'iak NN and Kostenko MA | [Use of a histological fixative for extraction of the RNA precursor pool from mollusk nerve tissue]. | 1978 | Tsitologiia | pmid:684853 |
Polygalova OO et al. | [Wheat root cells functioning under inhibition of I and II complexes of mitochondrial respiratory chain]. | 2007 | Tsitologiia | pmid:17926562 |
Valitova IuN et al. | [Respiration of wheat roots during inhibition of phospholipase A2 by 4-bromphenacylbromide]. | 2001 | Tsitologiia | pmid:11552649 |
Davydov VV and FreÄdin MI | [The effect of malonic acid on the rate of fibroblast proliferation in culture]. | 1993 | Tsitologiia | pmid:8322417 |
Bufetov EN et al. | [Effect of malonate on the structural and functional changes of wheat Triticum aestivum L. root cells]. | 2004 | Tsitologiia | pmid:15704878 |
Hagos Y and Wolff NA | Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity. | 2010 | Toxins (Basel) | pmid:22069672 |
el Khoury A and Atoui A | Ochratoxin a: general overview and actual molecular status. | 2010 | Toxins (Basel) | pmid:22069596 |
Aoyama H et al. | Induction of lipid peroxidation in tissues of thallous malonate-treated hamster. | 1988 | Toxicology | pmid:3201472 |
Calkins MJ et al. | Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. | 2010 | Toxicol. Sci. | pmid:20211941 |
Zalups RK and Barfuss DW | Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9465278 |
Funakoshi T et al. | Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine. | 2011 | Toxicol In Vitro | pmid:21664962 |
Yang XL et al. | Photo-induced cytotoxicity of malonic acid [C(60)]fullerene derivatives and its mechanism. | 2002 | Toxicol In Vitro | pmid:11812638 |
Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
Huang EM et al. | Succinate potentiates the action of platelet agonists. | 1984 | Thromb. Res. | pmid:6095483 |
Chen Z et al. | Applications of functionalized fullerenes in tumor theranostics. | 2012 | Theranostics | pmid:22509193 |
Kurakin A | Scale-free flow of life: on the biology, economics, and physics of the cell. | 2009 | Theor Biol Med Model | pmid:19416527 |
Kurakin A | The self-organizing fractal theory as a universal discovery method: the phenomenon of life. | 2011 | Theor Biol Med Model | pmid:21447162 |
Demetrius LA et al. | Cancer proliferation and therapy: the Warburg effect and quantum metabolism. | 2010 | Theor Biol Med Model | pmid:20085650 |
Mackler B et al. | Studies of the development of congenital anomalies in rats. III. Effects of inhibition of mitochondrial energy systems on embryonic development. | 1975 | Teratology | pmid:1198336 |
Crea F et al. | Sequestering ability of polycarboxylic ligands towards dioxouranium(VI). | 2008 | Talanta | pmid:18585146 |
Khurana SC and Gupta CM | Polarography of Cd-malonate-oxalate complex. | 1972 | Talanta | pmid:18961180 |
Dalvi MB and Khopkar SM | Analytical applications of a liquid anion-exchanger for the separation of uranium(IV) in malonate solution. | 1978 | Talanta | pmid:18962334 |
Dalvi MB and Khopkar SM | Solvent extraction of scandium from malonic acid with high molecular-weight amines. | 1979 | Talanta | pmid:18962534 |
Sawant MA and Khopkar SM | Solvent extraction separation of zirconium from malonate solution with high molecular-weight amines. | 1980 | Talanta | pmid:18962638 |
Sawant MA and Khopkar SM | Liquid-liquid extraction of thorium from malonate solution with liquid anion-exchangers. | 1980 | Talanta | pmid:18962706 |
Shah SK and Gupta CM | Mixed-ligand complexes of copper with some amino-acids and malonate. | 1980 | Talanta | pmid:18962788 |
Sagi SR et al. | Thallimetric oxidations-IV Estimation of malonic acid. | 1984 | Talanta | pmid:18963570 |
Suedee R et al. | The use of trichloroacetic acid imprinted polymer coated quartz crystal microbalance as a screening method for determination of haloacetic acids in drinking water. | 2006 | Talanta | pmid:18970752 |
De Stefano C et al. | Binding of fluoride and carbonate by open chain polyammonium cations. | 2004 | Talanta | pmid:18969633 |
Kolb S et al. | The fermenting bacterium Malonomonas rubra is phylogenetically related to sulfur-reducing bacteria and contains a c-type cytochrome similar to those of sulfur and sulfate reducers. | 1998 | Syst. Appl. Microbiol. | pmid:9841124 |
Lewin RA et al. | Effects of various agents on flagellar activity, flagellar autotomy and cell viability in four species of Chlamydomonas (chlorophyta: volvocales). | 1982 | Symp. Soc. Exp. Biol. | pmid:6764045 |
Romanowski MJ et al. | Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. | 2004 | Structure | pmid:15296730 |
Gripp S et al. | [Comparison between 2 methods of determining photon-induced air activity around medical accelerators]. | 1987 | Strahlenther Onkol | pmid:3603367 |
Yaya AR et al. | Synthesis of 17 alpha-substituted ethynylestradiols: potential ligands for drug vectors. | 2010 | Steroids | pmid:20302883 |
Parmentier GG et al. | Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. | 1993 | Steroids | pmid:8212084 |
Wan AS et al. | Long-acting contraceptive agents: levonorgestrel esters of unsaturated acids. | 1983 | Steroids | pmid:6419407 |
Ivanova N et al. | Complete genome sequence of Gordonia bronchialis type strain (3410). | 2010 | Stand Genomic Sci | pmid:21304674 |
Lail K et al. | Complete genome sequence of Spirosoma linguale type strain (1). | 2010 | Stand Genomic Sci | pmid:21304700 |
Pagani I et al. | Complete genome sequence of Marivirga tractuosa type strain (H-43). | 2011 | Stand Genomic Sci | pmid:21677852 |
Chovatia M et al. | Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883). | 2009 | Stand Genomic Sci | pmid:21304665 |
Löhr W et al. | The azure dyes: their purification and physicochemical properties. II. Purification of azure B. | 1975 | Stain Technol | pmid:1145656 |
Prakash M et al. | Crystal growth, structural, optical, dielectric and thermal studies of an amino acid based organic NLO material: L-phenylalanine L-phenylalaninium malonate. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21943710 |
YarbaÅŸi Z et al. | An EPR and optical absorption study of Cu(2+) doped in disodium malonate trihydrate single crystal. | 2009 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:19041279 |
Taha A | Spectral, electrochemical and molecular orbital studies on solvatochromic mixed ligand copper(II) complexes of malonate and diamine derivatives. | 2003 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:12659906 |
Kripal R and Singh DK | ESR and optical study of Cu2+ doped calcium malonate dihydrate. | 2007 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17018262 |
Hu JZ et al. | High resolution 1H spectra of powdered solids observed by Hahn echo pulse sequence with magic-angle spinning. | 1996 | Solid State Nucl Magn Reson | pmid:8925269 |
Liu Q et al. | Structural effect and mechanism of C70-carboxyfullerenes as efficient sensitizers against cancer cells. | 2012 | Small | pmid:22508680 |
Yoshida R | Design of self-oscillating gels and application to biomimetic actuators. | 2010 | Sensors (Basel) | pmid:22294901 |
Ogier de Baulny H and Saudubray JM | Branched-chain organic acidurias. | 2002 | Semin Neonatol | pmid:12069539 |
Zhang L and Sheng C | [Separation of dicarboxylic acid by thin-layer chromatography]. | 1999 | Se Pu | pmid:12552870 |
Kokare BN et al. | Development of a reliable analytical method for liquid anion-exchange extraction and separation of neodymium(III). | 2012 | ScientificWorldJournal | pmid:22701373 |
Michalski R et al. | Application of hyphenated techniques in speciation analysis of arsenic, antimony, and thallium. | 2012 | ScientificWorldJournal | pmid:22654649 |
Moldes D et al. | Role of laccase and low molecular weight metabolites from Trametes versicolor in dye decolorization. | 2012 | ScientificWorldJournal | pmid:22566767 |
Laurido C et al. | Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model. | 2012 | ScientificWorldJournal | pmid:22536130 |
Shi L et al. | Chlorine dioxide-iodide-methyl acetoacetate oscillation reaction investigated by UV-vis and online FTIR spectrophotometric method. | 2012 | ScientificWorldJournal | pmid:22454614 |
Zhang H and Li M | Transcriptional profiling of ESTs from the biocontrol fungus Chaetomium cupreum. | 2012 | ScientificWorldJournal | pmid:22448129 |
Müller SC et al. | The structure of the core of the spiral wave in the belousov-zhabotinskii reaction. | 1985 | Science | pmid:17797290 |
Winfree AT | Scroll-shaped waves of chemical activity in three dimensions. | 1973 | Science | pmid:17835842 |
Nikiforov AA and Ostretsova IB | Effects of metabolic substrates and inhibitors on weak organic anion transport in rat renal proximal tubules. | 1997 May-Jun | Ross Fiziol Zh Im I M Sechenova | pmid:13677672 |
Affranchino JL and Stoppani AO | [Existence of 2 sites of oxidative phosphorylation in Trypanosoma cruzi]. | 1985 | Rev. Argent. Microbiol. | pmid:3916670 |
Prahoveanu E et al. | The effect of malonate on succinic dehydrogenase (SDH) activity during the multiplication of influenza and herpes viruses in the embryonate hen egg. | 1974 | Rev Roum Virol | pmid:4465902 |
Neguţ M et al. | [Value of some enzyme tests used in practice for identification of enterobacteria]. | 1977 Apr-Jun | Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol | pmid:143713 |
Chen AM et al. | Identification of a TRAP transporter for malonate transport and its expression regulated by GtrA from Sinorhizobium meliloti. | 2010 | Res. Microbiol. | pmid:20594941 |
Oswald CB et al. | Disposition of cisplatin derivatives -3H-cis-1,2-diaminocyclohexanedichloroplatinum (II) and 3H-cis-1,2-diaminocyclohexanemalonatoplatinum (II) in BDF1 mice. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2749002 |
Begg AC et al. | Radiosensitization in vitro by cis-diammine (1,1-cyclobutanedicarboxylato) platinum(II) (carboplatin, JM8) and ethylenediammine-malonatoplatinum(II) (JM40). | 1987 | Radiother Oncol | pmid:3303163 |
Sivagnanam K et al. | Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose. | 2011 | Proteome Sci | pmid:22008648 |
Fang X et al. | Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons. | 2011 | Proteome Sci | pmid:21569547 |
Hou Y et al. | Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages. | 2010 | Proteome Sci | pmid:20822545 |
Okoli AS et al. | Effects of human and porcine bile on the proteome of Helicobacter hepaticus. | 2012 | Proteome Sci | pmid:22533459 |
Nam KH et al. | Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure. | 2009 | Proteins | pmid:18831047 |
Hariharan M and Allewell NM | Effects of the T-->R transition on the electrostatic properties of E. coli aspartate transcarbamylase. | 1998 | Proteins | pmid:9714159 |