Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Boland NI et al. | Characterization of follicular energy metabolism. | 1994 | Hum. Reprod. | pmid:8046010 |
Henshaw R et al. | Malonate produces striatal lesions by indirect NMDA receptor activation. | 1994 | Brain Res. | pmid:8069700 |
Beattie DS et al. | Oxidation of NADH by a rotenone and antimycin-sensitive pathway in the mitochondrion of procyclic Trypanosoma brucei brucei. | 1994 | Mol. Biochem. Parasitol. | pmid:8078526 |
Tassani V et al. | Anaplerotic effect of propionyl carnitine in rat heart mitochondria. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135845 |
Nikiforov AA and Ostretsova IB | Stimulation of weak organic acid uptake in rat renal tubules by cadmium and nystatin. | 1994 | Biochem. Pharmacol. | pmid:8135857 |
Lançar-Benba J et al. | Purification of the rat-liver mitochondrial dicarboxylate carrier by affinity chromatography on immobilized malate dehydrogenase. | 1994 | Biochim. Biophys. Acta | pmid:8142418 |
Jay D et al. | Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. | 1993 | J. Bioenerg. Biomembr. | pmid:8144496 |
Medeiros MH et al. | Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. | 1994 | Arch. Biochem. Biophys. | pmid:8161206 |
Parmentier GG et al. | Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. | 1993 | Steroids | pmid:8212084 |
Karuri AR et al. | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. | 1993 | Br. J. Cancer | pmid:8260358 |
Muralikrishna C and Renganathan V | Peroxidase-catalyzed desulfonation of 3,5-dimethyl-4-hydroxy and 3,5-dimethyl-4-aminobenzenesulfonic acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267618 |
Windsor DP and White IG | Assessment of ram sperm mitochondrial function by quantitative determination of sperm rhodamine 123 accumulation. | 1993 | Mol. Reprod. Dev. | pmid:8286118 |
Valla A et al. | [Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests]. | 1993 | Pharmazie | pmid:8321881 |
Davydov VV and FreÄdin MI | [The effect of malonic acid on the rate of fibroblast proliferation in culture]. | 1993 | Tsitologiia | pmid:8322417 |
Perez J and Jeffries TW | Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. | 1993 | Appl. Biochem. Biotechnol. | pmid:8323262 |
Greene JG et al. | Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. | 1993 | J. Neurochem. | pmid:8360680 |
Taylor RW et al. | Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. | 1993 | Biochim. Biophys. Acta | pmid:8391327 |
Cox DA and Matlib MA | A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. | 1993 | J. Biol. Chem. | pmid:8419373 |
Brand MD et al. | Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. | 1993 | Biochem. J. | pmid:8489502 |
Demchuk ML et al. | [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. | 1993 Mar-Apr | Vopr. Med. Khim. | pmid:8511880 |
Zeevalk GD et al. | Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. | 1995 | J. Pharmacol. Exp. Ther. | pmid:8531072 |
Mattson MP et al. | Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. | 1995 | J. Neurosci. Res. | pmid:8583504 |
Spetale MR et al. | The effect of organophosphorus compounds on respiration by rat liver mitochondria. | 1977 | Farmaco Sci | pmid:858381 |
Pang Z et al. | Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. | 1996 | J. Neurochem. | pmid:8592116 |
Greene JG and Greenamyre JT | Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. | 1996 | J. Neurochem. | pmid:8592134 |
Schulz JB et al. | Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. | 1996 | J. Neurochem. | pmid:8667023 |
Burke TR et al. | 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. | 1996 | J. Med. Chem. | pmid:8676336 |
Schulz JB et al. | Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. | 1996 | Neuroscience | pmid:8684608 |
Bekina RM and Lebedeva AF | [Studies of oxygen uptake (Mehler reactions) in chloroplasts in the presence of silico-molybdic acid]. | 1977 | Biokhimiia | pmid:870090 |
Murrin SF and Nolan RA | Ultrastructural localization of succinate dehydrogenase in a self-parasitic isolate of Saprolegnia megasperma. | 1977 | Can. J. Microbiol. | pmid:871965 |
Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
Albers DS et al. | Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. | 1996 | Brain Res. | pmid:8773791 |
Bazzett TJ et al. | Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. | 1996 | Brain Res. | pmid:8773793 |
Connop BP et al. | Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase. | 1996 | Neuropharmacology | pmid:8793908 |
Klein BY et al. | Opposing effects on mitochondrial membrane potential by malonate and levamisole, whose effect on cell-mediated mineralization is antagonistic. | 1996 | J. Cell. Biochem. | pmid:8825423 |
Arihara K et al. | Contribution of the glycolytic pathway to enzymatic metmyoglobin reduction in myocytes. | 1996 | Biochem. Mol. Biol. Int. | pmid:8850528 |
Podell M et al. | Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. | 1996 | Metab Brain Dis | pmid:8869944 |
Geddes JW et al. | Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. | 1996 May-Aug | Mol. Chem. Neuropathol. | pmid:8871943 |
Hu JZ et al. | High resolution 1H spectra of powdered solids observed by Hahn echo pulse sequence with magic-angle spinning. | 1996 | Solid State Nucl Magn Reson | pmid:8925269 |
Borutaite V et al. | Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. | 1996 | J. Mol. Cell. Cardiol. | pmid:8930814 |
Zeevalk GD et al. | Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. | 1997 | J. Neurochem. | pmid:8978755 |
Chien LF and Brand MD | The effect of chloroform on mitochondrial energy transduction. | 1996 | Biochem. J. | pmid:9003370 |
Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
Woods KM et al. | Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. | 1996 | Ann Trop Med Parasitol | pmid:9039272 |
Connop BP et al. | Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole. | 1997 | J. Neurochem. | pmid:9048766 |
Matthews RT et al. | S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. | 1997 | Exp. Neurol. | pmid:9056390 |
Affourtit C et al. | Kinetic interaction between oxidases and dehydrogenases in plant mitochondria. | 1997 | Biochem. Soc. Trans. | pmid:9056958 |
Zeevalk GD et al. | In vivo vulnerability of dopamine neurons to inhibition of energy metabolism. | 1997 | Eur. J. Pharmacol. | pmid:9059843 |
Magliozzo RS and Marcinkeviciene JA | The role of Mn(II)-peroxidase activity of mycobacterial catalase-peroxidase in activation of the antibiotic isoniazid. | 1997 | J. Biol. Chem. | pmid:9083004 |
Wang R et al. | A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. | 1997 | Bioorg. Med. Chem. | pmid:9158864 |