Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Maragos WF and Silverstein FS | The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. | 1995 | Brain Res. Dev. Brain Res. | pmid:7493402 |
Schmehl I et al. | Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. | 1995 | FEBS Lett. | pmid:7498500 |
Greene JG and Greenamyre JT | Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. | 1995 | J. Neurochem. | pmid:7536810 |
Maragos WF and Silverstein FS | Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. | 1995 | J. Neurochem. | pmid:7536812 |
Bazzett TJ et al. | Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum. | 1995 | Exp. Neurol. | pmid:7556544 |
Cheng Y et al. | pH dependence of specific divalent anion binding to the N-lobe of recombinant human transferrin. | 1995 | Biochemistry | pmid:7578099 |
Messam CA et al. | Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. | 1995 | Brain Res. | pmid:7583227 |
Sánchez-Alcázar JA et al. | Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. | 1995 | J. Biol. Chem. | pmid:7592589 |
Schulz JB et al. | Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. | 1995 | J. Cereb. Blood Flow Metab. | pmid:7593355 |
Matalon R et al. | Malonic aciduria and cardiomyopathy. | 1993 | J. Inherit. Metab. Dis. | pmid:7609455 |