Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Abscess D000038 13 associated lipids
Alzheimer Disease D000544 76 associated lipids
Bacterial Infections D001424 21 associated lipids
Body Weight D001835 333 associated lipids
Brain Diseases D001927 27 associated lipids
Brain Edema D001929 20 associated lipids
Catalepsy D002375 30 associated lipids
Brain Ischemia D002545 89 associated lipids
Diarrhea D003967 32 associated lipids
Edema D004487 152 associated lipids
Fever D005334 35 associated lipids
Glioma D005910 112 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Hemolysis D006461 131 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Hyperglycemia D006943 21 associated lipids
Hypothyroidism D007037 32 associated lipids
Insulin Resistance D007333 99 associated lipids
Ischemia D007511 18 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Memory Disorders D008569 33 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Neoplasms D009369 13 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Teratoma D013724 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Weight Gain D015430 101 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Shi D et al. A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. 2011 PLoS ONE pmid:22174908
Schiff M et al. Mouse studies to shape clinical trials for mitochondrial diseases: high fat diet in Harlequin mice. 2011 PLoS ONE pmid:22174907
Hench J et al. A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. 2011 PLoS ONE pmid:22162770
Bauwens M et al. Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers. 2012 PLoS ONE pmid:22719886
Hashimoto T et al. Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. 2008 PLoS ONE pmid:18698340
Buck M Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures. 2008 PLoS ONE pmid:18628977
Matar-Merheb R et al. Structuring detergents for extracting and stabilizing functional membrane proteins. 2011 PLoS ONE pmid:21483854
Minato Y et al. Malonate inhibits virulence gene expression in Vibrio cholerae. 2013 PLoS ONE pmid:23675480
Gallo M et al. MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion. 2011 PLoS ONE pmid:21448454
Damrauer SM et al. A20 modulates lipid metabolism and energy production to promote liver regeneration. 2011 PLoS ONE pmid:21437236
Rakhimova E et al. Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection. 2008 PLoS ONE pmid:18301762
Yang L et al. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. 2009 PLoS ONE pmid:19484125
Hagopian K et al. Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. 2010 PLoS ONE pmid:20856881
Sripadi P et al. Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. 2010 PLoS ONE pmid:20830293
Marreddy RK et al. Amino acid accumulation limits the overexpression of proteins in Lactococcus lactis. 2010 PLoS ONE pmid:20436673
Chanumolu SK et al. UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. 2012 PLoS ONE pmid:22431985
Khodadad CL and Foster JS Metagenomic and metabolic profiling of nonlithifying and lithifying stromatolitic mats of Highborne Cay, The Bahamas. 2012 PLoS ONE pmid:22662280
Tomita Y et al. Genome and transcriptome analysis of the food-yeast Candida utilis. 2012 PLoS ONE pmid:22629373
Thein M et al. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. 2012 PLoS ONE pmid:22590556
Wong YH et al. Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. 2012 PLoS ONE pmid:22448242