Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Reeves CD et al. | Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. | 2001 | Biochemistry | pmid:11747421 |
Van Westerlaak MG et al. | Chronic mitochondrial inhibition induces glutamate-mediated corticomotoneuron death in an organotypic culture model. | 2001 | Exp. Neurol. | pmid:11161628 |
Xia XG et al. | Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation. | 2001 | J. Neurochem. | pmid:11595758 |
Valitova IuN et al. | [Respiration of wheat roots during inhibition of phospholipase A2 by 4-bromphenacylbromide]. | 2001 | Tsitologiia | pmid:11552649 |
Hansson O et al. | Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length. | 2001 | J. Neurochem. | pmid:11520890 |
Piasecka M et al. | Computerized analysis of cytochemical reactions for dehydrogenases and oxygraphic studies as methods to evaluate the function of the mitochondrial sheath in rat spermatozoa. | 2001 | Andrologia | pmid:11167513 |
Hardin CD et al. | Myocardial metabolism of exogenous FDP is consistent with transport by a dicarboxylate transporter. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11709435 |
Wolff NA et al. | Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter. | 2001 | J. Am. Soc. Nephrol. | pmid:11562399 |
Lucas RW et al. | Crystallization of Brome mosaic virus and T = 1 Brome mosaic virus particles following a structural transition. | 2001 | Virology | pmid:11485397 |
Bundy JG et al. | An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress. | 2001 | FEBS Lett. | pmid:11434921 |
Plasterer TN et al. | Survey of human mitochondrial diseases using new genomic/proteomic tools. | 2001 | Genome Biol. | pmid:11423010 |
Kremer L et al. | Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. | 2001 | J. Biol. Chem. | pmid:11373295 |
Lancaster CR et al. | A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction. | 2001 | Eur. J. Biochem. | pmid:11248702 |
Matharu A et al. | Contributions of the substrate-binding arginine residues to maleate-induced closure of the active site of Escherichia coli aspartate aminotransferase. | 2001 | Eur. J. Biochem. | pmid:11248682 |
Ramaseshan M et al. | Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds. | 2000 Nov-Dec | J Comb Chem | pmid:11126291 |
Dobosz M et al. | Synthesis of new derivatives of 3-benzyl-4-R-delta 2-1,2,4-triazolin-5-one and 3,3'-methylidyne bis(4-R-1,2,4-delta 2-triazolin-5-one). | 2000 May-Jun | Acta Pol Pharm | pmid:11143710 |
McCann M et al. | Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates. | 2000 | Met Based Drugs | pmid:18475944 |
Gueguen V et al. | Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. | 2000 | J. Biol. Chem. | pmid:10671542 |
Ruiz-Pérez C et al. | Magnetic coupling through the carbon skeleton of malonate in two polymorphs of ([Cu(bpy)(H2O)][Cu(bpy)(mal)(H2O)])(ClO4)2 (H2mal = malonic acid; bpy = 2,2'-bipyridine). | 2000 | Inorg Chem | pmid:11196779 |
Kamo T et al. | Changes in the content and biosynthesis of phytoalexins in banana fruit. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129580 |
Kavitha J and Subbaraju GV | Synthesis of N-[3,4-dimethoxyphenyl)propanoyl]pyrrole, a metabolite of Piper brachystachyum. | 2000 | J Asian Nat Prod Res | pmid:11252681 |
Ruiz-Pérez C et al. | Ferromagnetism in malonato-bridged copper(II) complexes. Synthesis, crystal structures, and magnetic properties of [[Cu(H2O)3][Cu(mal)2(H2O)]]n and [[Cu(H2O)4]2[Cu(mal)2(H2O)]][Cu(mal)2(H2O)2][[Cu(H2O)4][Cu(mal)2(H2O)2][(H2mal = malonic acid). | 2000 | Inorg Chem | pmid:12526437 |
Zhang Y et al. | A novel alpha-helix-liked metallohelicate series and their structural adjustments for the isomorphous substitution. | 2000 | Inorg Chem | pmid:12526493 |
Garle MJ et al. | Stimulation of dichlorofluorescin oxidation by capsaicin and analogues in RAW 264 monocyte/macrophages: lack of involvement of the vanilloid receptor. | 2000 | Biochem. Pharmacol. | pmid:10660122 |
Lin LZ et al. | Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. | 2000 | J Chromatogr A | pmid:10823504 |
Bew SP et al. | Kinetic resolution of alpha-acetoxy carboxylic acids with homochiral SuperQuats. | 2000 | Chirality | pmid:10824175 |
Sett S et al. | Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone; levamisole gives protection. | 2000 | J. Biosci. | pmid:10824201 |
Kuijt J et al. | Quenched phosphorescence, a new detection method in capillary electrophoresis. | 2000 | Electrophoresis | pmid:10826674 |
Moy LY et al. | Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures. | 2000 | J. Neurochem. | pmid:10737624 |
Guidetti P et al. | In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum. | 2000 | Exp. Neurol. | pmid:10785450 |
Meldrum A et al. | Age-dependence of malonate-induced striatal toxicity. | 2000 | Exp Brain Res | pmid:11045358 |
Hoenke S et al. | Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. | 2000 | Biochemistry | pmid:11052675 |
Koo JH et al. | The malonate decarboxylase operon of Acinetobacter calcoaceticus KCCM 40902 is regulated by malonate and the transcriptional repressor MdcY. | 2000 | J. Bacteriol. | pmid:11053382 |
Tóth V and Emódy L | Proteus virulence: involvement of the pore forming alpha-hemolysin (a short review). | 2000 | Acta Microbiol Immunol Hung | pmid:11056765 |
Ling F et al. | A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA. | 2000 | Nucleic Acids Res. | pmid:11121487 |
Ward OP and Singh A | Enzymatic asymmetric synthesis by decarboxylases. | 2000 | Curr. Opin. Biotechnol. | pmid:11102784 |
Lee HY et al. | Identification and characterization of a novel transcriptional regulator, MatR, for malonate metabolism in Rhizobium leguminosarum bv. trifolii. | 2000 | Eur. J. Biochem. | pmid:11106435 |
Li J and Copeland L | Role of malonate in chickpeas. | 2000 | Phytochemistry | pmid:10963451 |
Aime S et al. | Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI. | 2000 | J. Biol. Inorg. Chem. | pmid:10968620 |
Sawai S et al. | Spontaneous symmetry breaking turing-type pattern formation in a confined Dictyostelium cell mass. | 2000 | Phys. Rev. Lett. | pmid:10970500 |
Jung JW et al. | The active site and substrates binding mode of malonyl-CoA synthetase determined by transferred nuclear Overhauser effect spectroscopy, site-directed mutagenesis, and comparative modeling studies. | 2000 | Protein Sci. | pmid:10933494 |
Chaimbault C et al. | Physicochemical and crystallographic evidence for polymorphism of the racemic ethyl (2-chloromethyl-2,3-dihydro-5H-oxazolo [3, 2-a]pyrimidin-5-one)-6-carboxylate. | 2000 | J Pharm Sci | pmid:11015694 |
Ouyang Q et al. | Transition from spirals to defect-mediated turbulence driven by a doppler instability. | 2000 | Phys. Rev. Lett. | pmid:11017437 |
Andreassen OA et al. | Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant. | 2000 | J. Neurochem. | pmid:10899963 |
Nath R et al. | Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10903889 |
Koo HM and Kim YS | Identification of active-site residues in Bradyrhizobium japonicum malonyl-coenzyme A synthetase. | 2000 | Arch. Biochem. Biophys. | pmid:10871057 |
Dongmei H et al. | Synthesis and analgesic activity of N,N'-dicarbonyltryptamines. | 2000 | Prep. Biochem. Biotechnol. | pmid:10919562 |
Malik N et al. | Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. | 2000 | J Control Release | pmid:10699277 |
Zeevalk GD et al. | Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicity. | 2000 | Neuroscience | pmid:10683571 |
Zeevalk GD et al. | NMDA receptors modulate dopamine loss due to energy impairment in the substantia nigra but not striatum. | 2000 | Exp. Neurol. | pmid:10686083 |
Yang WC et al. | Simultaneous determination of polycarboxylic acids by capillary electrophoresis with a copper electrode. | 2000 | J Chromatogr A | pmid:10670726 |
Burrows KB et al. | Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688597 |
Suraveratum N et al. | Purification and characterization of Plasmodium falciparum succinate dehydrogenase. | 2000 | Mol. Biochem. Parasitol. | pmid:10693744 |
Kaal EC et al. | Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis. | 2000 | J. Neurochem. | pmid:10693948 |
Malcon C et al. | Neuroprotective effects of creatine administration against NMDA and malonate toxicity. | 2000 | Brain Res. | pmid:10727643 |
Uyemura SA et al. | Oxidative phosphorylation, Ca(2+) transport, and fatty acid-induced uncoupling in malaria parasites mitochondria. | 2000 | J. Biol. Chem. | pmid:10734123 |
Klivenyi P et al. | Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. | 2000 | J. Neurosci. | pmid:10627575 |
Lu GW et al. | Alteration of oxygen consumption and energy metabolism during repetitive exposure of mice to hypoxia. | 1999 | Neurochem. Res. | pmid:10344590 |
Hinz W et al. | Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells. | 1999 | FEBS Lett. | pmid:10622736 |
Gao J et al. | Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. | 1999 | J. Lipid Res. | pmid:9869665 |
Hoenke S and Dimroth P | Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected]. | 1999 | Eur. J. Biochem. | pmid:9914491 |
Bruce-Keller AJ et al. | Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. | 1999 | Ann. Neurol. | pmid:9894871 |
Chohnan S et al. | Cloning and characterization of mdc genes encoding malonate decarboxylase from Pseudomonas putida. | 1999 | FEMS Microbiol. Lett. | pmid:10339824 |
Markova OV et al. | The anion-carrier mediated uncoupling effect of dicarboxylic fatty acids in liver mitochondria depends on the position of the second carboxyl group. | 1999 | Biochemistry Mosc. | pmid:10381619 |
Maragos WF et al. | Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. | 1999 | Brain Res. | pmid:10407109 |
Matthews RT et al. | Novel free radical spin traps protect against malonate and MPTP neurotoxicity. | 1999 | Exp. Neurol. | pmid:10222114 |
Handa S et al. | Stereochemical course of biotin-independent malonate decarboxylase catalysis. | 1999 | Arch. Biochem. Biophys. | pmid:10496981 |
Moreno-Sánchez R et al. | Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control. | 1999 | Eur. J. Biochem. | pmid:10491087 |
Tao Y et al. | Effects of glucagon on axoplasmic transport in mouse superior cervical ganglion cells. | 1999 | Neuroreport | pmid:10439471 |
Ferger B et al. | Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation. | 1999 | J. Neurochem. | pmid:10461928 |
Lahnsteiner F et al. | Sperm metabolism of the telost fishes Chalcalburnus chalcoides and Oncorhynchus mykiss and its relation to motility and viability. | 1999 | J. Exp. Zool. | pmid:10451423 |
Kristensen JH et al. | Separation of (2)H MAS NMR spectra by two-dimensional spectroscopy. | 1999 | J. Magn. Reson. | pmid:10423369 |
Palmieri L et al. | Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate. | 1999 | J. Biol. Chem. | pmid:10428783 |
Oyedotun KS and Lemire BD | The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. | 1999 | FEBS Lett. | pmid:9929002 |
Zhang L and Sheng C | [Separation of dicarboxylic acid by thin-layer chromatography]. | 1999 | Se Pu | pmid:12552870 |
O'Brien DP et al. | Malonic aciduria in Maltese dogs: normal methylmalonic acid concentrations and malonyl-CoA decarboxylase activity in fibroblasts. | 1999 | J. Inherit. Metab. Dis. | pmid:10604140 |
Maragos WF et al. | Does dopamine contribute to striatal damage caused by impaired mitochondrial function? | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672263 |
Graf von Roedern E et al. | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). | 1998 | J. Med. Chem. | pmid:9464365 |
Zalups RK and Barfuss DW | Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9465278 |
Lecanu L et al. | Deleterious Ca-independent NOS activity after oxidative stress in rat striatum. | 1998 | Neuroreport | pmid:9512406 |
Buyukgebiz B et al. | Fatal neonatal malonic aciduria. | 1998 | J. Inherit. Metab. Dis. | pmid:9501274 |
Maragos WF et al. | 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. | 1998 | Exp. Neurol. | pmid:9878198 |
Simonyan RA and Skulachev VP | Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein. | 1998 | FEBS Lett. | pmid:9771898 |
Hofrichter M et al. | Oxidative decomposition of malonic acid as basis for the action of manganese peroxidase in the absence of hydrogen peroxide. | 1998 | FEBS Lett. | pmid:9742955 |
Schulz JB et al. | Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. | 1998 | Cell Death Differ. | pmid:10203688 |
Aime S et al. | NMR and luminescence studies on the formation of ternary adducts between HSA and Ln(III)-malonate complexes. | 1998 | Biochim. Biophys. Acta | pmid:9630476 |
Hariharan M and Allewell NM | Effects of the T-->R transition on the electrostatic properties of E. coli aspartate transcarbamylase. | 1998 | Proteins | pmid:9714159 |
Gregg AR et al. | Combined malonic and methylmalonic aciduria with normal malonyl-coenzyme A decarboxylase activity: a case supporting multiple aetiologies. | 1998 | J. Inherit. Metab. Dis. | pmid:9700595 |
Matharu AL et al. | MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. | 1998 | Chem. Biol. | pmid:9862793 |
Kolb S et al. | The fermenting bacterium Malonomonas rubra is phylogenetically related to sulfur-reducing bacteria and contains a c-type cytochrome similar to those of sulfur and sulfate reducers. | 1998 | Syst. Appl. Microbiol. | pmid:9841124 |
Prorok M and Castellino FJ | Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T. | 1998 | J. Biol. Chem. | pmid:9677382 |
Zeevalk GD et al. | Excitotoxicity and oxidative stress during inhibition of energy metabolism. | 1998 | Dev. Neurosci. | pmid:9778583 |
Matthews RT et al. | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. | 1998 | J. Neurosci. | pmid:9412496 |
An JH and Kim YS | A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. | 1998 | Eur. J. Biochem. | pmid:9826185 |
Nikiforov AA and Ostretsova IB | Effects of metabolic substrates and inhibitors on weak organic anion transport in rat renal proximal tubules. | 1997 May-Jun | Ross Fiziol Zh Im I M Sechenova | pmid:13677672 |
Yano S et al. | A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy. | 1997 | Eur. J. Pediatr. | pmid:9177981 |
Guyot MC et al. | Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats. | 1997 | Neuroscience | pmid:9300407 |
Hoenke S et al. | Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. | 1997 | Eur. J. Biochem. | pmid:9208947 |
Wang R et al. | A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. | 1997 | Bioorg. Med. Chem. | pmid:9158864 |
Dimroth P and Hilbi H | Enzymic and genetic basis for bacterial growth on malonate. | 1997 | Mol. Microbiol. | pmid:11902724 |