Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Oyedotun KS and Lemire BD | The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. | 1999 | FEBS Lett. | pmid:9929002 |
Hoenke S and Dimroth P | Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected]. | 1999 | Eur. J. Biochem. | pmid:9914491 |
Bruce-Keller AJ et al. | Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. | 1999 | Ann. Neurol. | pmid:9894871 |
Maragos WF et al. | 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. | 1998 | Exp. Neurol. | pmid:9878198 |
Gao J et al. | Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. | 1999 | J. Lipid Res. | pmid:9869665 |
Matharu AL et al. | MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. | 1998 | Chem. Biol. | pmid:9862793 |
Kolb S et al. | The fermenting bacterium Malonomonas rubra is phylogenetically related to sulfur-reducing bacteria and contains a c-type cytochrome similar to those of sulfur and sulfate reducers. | 1998 | Syst. Appl. Microbiol. | pmid:9841124 |
An JH and Kim YS | A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. | 1998 | Eur. J. Biochem. | pmid:9826185 |
Zeevalk GD et al. | Excitotoxicity and oxidative stress during inhibition of energy metabolism. | 1998 | Dev. Neurosci. | pmid:9778583 |
Simonyan RA and Skulachev VP | Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein. | 1998 | FEBS Lett. | pmid:9771898 |
Rutkoski A and Jaworski JG | An improved synthesis of malonyl-coenzyme A. | 1978 | Anal. Biochem. | pmid:9762122 |
Bonkowsky HL and Pomeroy JS | Assay of delta-aminolevulinic acid synthetase in homogenates of mouse, rat, and human liver: species differences in requirement for an exogenous succinyl-CoA-generating system. | 1978 | Anal. Biochem. | pmid:9762086 |
Hofrichter M et al. | Oxidative decomposition of malonic acid as basis for the action of manganese peroxidase in the absence of hydrogen peroxide. | 1998 | FEBS Lett. | pmid:9742955 |
Hariharan M and Allewell NM | Effects of the T-->R transition on the electrostatic properties of E. coli aspartate transcarbamylase. | 1998 | Proteins | pmid:9714159 |
Gregg AR et al. | Combined malonic and methylmalonic aciduria with normal malonyl-coenzyme A decarboxylase activity: a case supporting multiple aetiologies. | 1998 | J. Inherit. Metab. Dis. | pmid:9700595 |
Prorok M and Castellino FJ | Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T. | 1998 | J. Biol. Chem. | pmid:9677382 |
Aime S et al. | NMR and luminescence studies on the formation of ternary adducts between HSA and Ln(III)-malonate complexes. | 1998 | Biochim. Biophys. Acta | pmid:9630476 |
Cox RB and Quayle JR | Synthesis and hydrolysis of malyl-coenzyme A by Pseudomonas AM1: an apparent malate synthase activity. | 1976 | J. Gen. Microbiol. | pmid:956773 |
Yu HL et al. | Stimulation of ammonia production and excretion in the rabbit by inorganic phosphate. Study of control mechanisms. | 1976 | J. Clin. Invest. | pmid:956385 |
Lecanu L et al. | Deleterious Ca-independent NOS activity after oxidative stress in rat striatum. | 1998 | Neuroreport | pmid:9512406 |
Buyukgebiz B et al. | Fatal neonatal malonic aciduria. | 1998 | J. Inherit. Metab. Dis. | pmid:9501274 |
Williams DM et al. | Role of copper in mitochondrial iron metabolism. | 1976 | Blood | pmid:947406 |
Zalups RK and Barfuss DW | Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9465278 |
Graf von Roedern E et al. | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). | 1998 | J. Med. Chem. | pmid:9464365 |
Willis CL et al. | Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. | 1997 | Curr. Microbiol. | pmid:9462959 |
Matthews RT et al. | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. | 1998 | J. Neurosci. | pmid:9412496 |
Sonsalla PK et al. | Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra. | 1997 | Brain Res. | pmid:9409726 |
van der Spoel D and Berendsen HJ | Determination of proton transfer rate constants using Ab initio, molecular dynamics and density matrix evolution calculations. | 1996 | Pac Symp Biocomput | pmid:9390263 |
Saris NE | On the mechanism of rebounding of calcium in liver mitochondria. | 1997 | Biol. Chem. | pmid:9372185 |
Korshunov SS et al. | High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. | 1997 | FEBS Lett. | pmid:9369223 |
Guyot MC et al. | Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats. | 1997 | Neuroscience | pmid:9300407 |
Beal MF and Matthews RT | Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. | 1997 | Mol. Aspects Med. | pmid:9266519 |
Garcia-Delgado GA et al. | A comparison of various Haemophilus somnus strains. | 1977 | Can. J. Comp. Med. | pmid:922555 |
Meigs RA and Sheean LA | Mitochondria from human term placenta. III. The role of respiration and energy generation in progesterone biosynthesis. | 1977 | Biochim. Biophys. Acta | pmid:922026 |
Hoenke S et al. | Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. | 1997 | Eur. J. Biochem. | pmid:9208947 |
Yano S et al. | A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy. | 1997 | Eur. J. Pediatr. | pmid:9177981 |
Wang R et al. | A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. | 1997 | Bioorg. Med. Chem. | pmid:9158864 |
Magliozzo RS and Marcinkeviciene JA | The role of Mn(II)-peroxidase activity of mycobacterial catalase-peroxidase in activation of the antibiotic isoniazid. | 1997 | J. Biol. Chem. | pmid:9083004 |
Zeevalk GD et al. | In vivo vulnerability of dopamine neurons to inhibition of energy metabolism. | 1997 | Eur. J. Pharmacol. | pmid:9059843 |
Affourtit C et al. | Kinetic interaction between oxidases and dehydrogenases in plant mitochondria. | 1997 | Biochem. Soc. Trans. | pmid:9056958 |
Matthews RT et al. | S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. | 1997 | Exp. Neurol. | pmid:9056390 |
Connop BP et al. | Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole. | 1997 | J. Neurochem. | pmid:9048766 |
Woods KM et al. | Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. | 1996 | Ann Trop Med Parasitol | pmid:9039272 |
Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
Chien LF and Brand MD | The effect of chloroform on mitochondrial energy transduction. | 1996 | Biochem. J. | pmid:9003370 |
Zeevalk GD et al. | Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. | 1997 | J. Neurochem. | pmid:8978755 |
Borutaite V et al. | Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. | 1996 | J. Mol. Cell. Cardiol. | pmid:8930814 |
Hu JZ et al. | High resolution 1H spectra of powdered solids observed by Hahn echo pulse sequence with magic-angle spinning. | 1996 | Solid State Nucl Magn Reson | pmid:8925269 |
Geddes JW et al. | Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. | 1996 May-Aug | Mol. Chem. Neuropathol. | pmid:8871943 |
Podell M et al. | Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. | 1996 | Metab Brain Dis | pmid:8869944 |
Arihara K et al. | Contribution of the glycolytic pathway to enzymatic metmyoglobin reduction in myocytes. | 1996 | Biochem. Mol. Biol. Int. | pmid:8850528 |
Klein BY et al. | Opposing effects on mitochondrial membrane potential by malonate and levamisole, whose effect on cell-mediated mineralization is antagonistic. | 1996 | J. Cell. Biochem. | pmid:8825423 |
Connop BP et al. | Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase. | 1996 | Neuropharmacology | pmid:8793908 |
Bazzett TJ et al. | Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. | 1996 | Brain Res. | pmid:8773793 |
Albers DS et al. | Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. | 1996 | Brain Res. | pmid:8773791 |
Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
Murrin SF and Nolan RA | Ultrastructural localization of succinate dehydrogenase in a self-parasitic isolate of Saprolegnia megasperma. | 1977 | Can. J. Microbiol. | pmid:871965 |
Bekina RM and Lebedeva AF | [Studies of oxygen uptake (Mehler reactions) in chloroplasts in the presence of silico-molybdic acid]. | 1977 | Biokhimiia | pmid:870090 |
Schulz JB et al. | Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. | 1996 | Neuroscience | pmid:8684608 |
Burke TR et al. | 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. | 1996 | J. Med. Chem. | pmid:8676336 |
Schulz JB et al. | Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. | 1996 | J. Neurochem. | pmid:8667023 |
Greene JG and Greenamyre JT | Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. | 1996 | J. Neurochem. | pmid:8592134 |
Pang Z et al. | Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. | 1996 | J. Neurochem. | pmid:8592116 |
Spetale MR et al. | The effect of organophosphorus compounds on respiration by rat liver mitochondria. | 1977 | Farmaco Sci | pmid:858381 |
Mattson MP et al. | Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. | 1995 | J. Neurosci. Res. | pmid:8583504 |
Zeevalk GD et al. | Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. | 1995 | J. Pharmacol. Exp. Ther. | pmid:8531072 |
Demchuk ML et al. | [Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma]. | 1993 Mar-Apr | Vopr. Med. Khim. | pmid:8511880 |
Brand MD et al. | Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. | 1993 | Biochem. J. | pmid:8489502 |
Cox DA and Matlib MA | A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. | 1993 | J. Biol. Chem. | pmid:8419373 |
Taylor RW et al. | Succinate-cytochrome c reductase: assessment of its value in the investigation of defects of the respiratory chain. | 1993 | Biochim. Biophys. Acta | pmid:8391327 |
Greene JG et al. | Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. | 1993 | J. Neurochem. | pmid:8360680 |
Perez J and Jeffries TW | Role of organic acid chelators in manganese regulation of lignin degradation by Phanerochaete chrysosporium. | 1993 | Appl. Biochem. Biotechnol. | pmid:8323262 |
Davydov VV and FreÄdin MI | [The effect of malonic acid on the rate of fibroblast proliferation in culture]. | 1993 | Tsitologiia | pmid:8322417 |
Valla A et al. | [Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests]. | 1993 | Pharmazie | pmid:8321881 |
Windsor DP and White IG | Assessment of ram sperm mitochondrial function by quantitative determination of sperm rhodamine 123 accumulation. | 1993 | Mol. Reprod. Dev. | pmid:8286118 |
Muralikrishna C and Renganathan V | Peroxidase-catalyzed desulfonation of 3,5-dimethyl-4-hydroxy and 3,5-dimethyl-4-aminobenzenesulfonic acids. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267618 |
Karuri AR et al. | Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. | 1993 | Br. J. Cancer | pmid:8260358 |
Parmentier GG et al. | Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases. | 1993 | Steroids | pmid:8212084 |
Medeiros MH et al. | Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. | 1994 | Arch. Biochem. Biophys. | pmid:8161206 |
Jay D et al. | Inhibition of membrane-bound succinate dehydrogenase by fluorescamine. | 1993 | J. Bioenerg. Biomembr. | pmid:8144496 |
Lançar-Benba J et al. | Purification of the rat-liver mitochondrial dicarboxylate carrier by affinity chromatography on immobilized malate dehydrogenase. | 1994 | Biochim. Biophys. Acta | pmid:8142418 |
Nikiforov AA and Ostretsova IB | Stimulation of weak organic acid uptake in rat renal tubules by cadmium and nystatin. | 1994 | Biochem. Pharmacol. | pmid:8135857 |
Tassani V et al. | Anaplerotic effect of propionyl carnitine in rat heart mitochondria. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8135845 |
Beattie DS et al. | Oxidation of NADH by a rotenone and antimycin-sensitive pathway in the mitochondrion of procyclic Trypanosoma brucei brucei. | 1994 | Mol. Biochem. Parasitol. | pmid:8078526 |
Henshaw R et al. | Malonate produces striatal lesions by indirect NMDA receptor activation. | 1994 | Brain Res. | pmid:8069700 |
Boland NI et al. | Characterization of follicular energy metabolism. | 1994 | Hum. Reprod. | pmid:8046010 |
Reiss U and Rothstein M | Age-related changes in isocitrate lyase from the free living nematode, Turbatrix aceti. | 1975 | J. Biol. Chem. | pmid:803500 |
Beal MF et al. | Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. | 1994 | Ann. Neurol. | pmid:7998775 |
Ray S et al. | Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal. | 1994 | Biochem. J. | pmid:7945267 |
Kim YS and Kim EJ | A plasmid responsible for malonate assimilation in Pseudomonas fluorescens. | 1994 | Plasmid | pmid:7846146 |
Brand MD et al. | The sum of flux control coefficients in the electron-transport chain of mitochondria. | 1994 | Eur. J. Biochem. | pmid:7813471 |
Oldendorf WH et al. | Transient blood-brain barrier passage of polar compounds at low pH. | 1994 | Am. J. Physiol. | pmid:7810722 |
Nieva-Gomez D and Konisky J | Membrane changes in Escherichia coli induced by colicin Ia and agents known to disrupt energy transduction. | 1976 | Biochemistry | pmid:779829 |
Kirschner PB et al. | Basic fibroblast growth factor protects against excitotoxicity and chemical hypoxia in both neonatal and adult rats. | 1995 | J. Cereb. Blood Flow Metab. | pmid:7790410 |
Klein BY et al. | Analysis of cell-mediated mineralization in culture of bone-derived embryonic cells with neurofibromatosis. | 1995 | J. Cell. Biochem. | pmid:7768987 |
Ermayanti TM et al. | Stimulation of synthesis and release of swainosonine from transformed roots of Swainsona galegifolia. | 1994 | Phytochemistry | pmid:7764877 |
Dehning I and Schink B | Anaerobic degradation of malonate via malonyl-CoA by Sporomusa malonica, Klebsiella oxytoca, and Rhodobacter capsulatus. | 1994 | Antonie Van Leeuwenhoek | pmid:7710283 |
Schuster H et al. | Substrate and product binding sites of yeast fatty acid synthase. Stoichiometry and binding kinetics of wild-type and in vitro mutated enzymes. | 1995 | Eur. J. Biochem. | pmid:7705357 |
Davydov VV et al. | [Effect of malonate on various aspects of hepatic metabolism]. | 1994 Oct-Dec | Patol Fiziol Eksp Ter | pmid:7700705 |
Byun HS and Kim YS | Assays for malonate decarboxylase. | 1994 | Anal. Biochem. | pmid:7695096 |