Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shibata N et al. | Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids. | 2014 | Org. Biomol. Chem. | pmid:24445698 |
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Barros-Miñones L et al. | Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. | 2013 | Biochim. Biophys. Acta | pmid:23415811 |
Bew SP et al. | Malonic acid half oxyesters and thioesters: solvent-free synthesis and DFT analysis of their enols. | 2013 | Org. Lett. | pmid:23876089 |
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Li J et al. | Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. | 2013 | Protein Cell | pmid:23807634 |
Karunakaran R et al. | Malonate catabolism does not drive N2 fixation in legume nodules. | 2013 | Appl. Environ. Microbiol. | pmid:23666330 |
Belenki C et al. | Cleavable surfactants to tune the stability of W/O miniemulsions. | 2013 | J Colloid Interface Sci | pmid:23218239 |
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Bao X et al. | A chemical probe for lysine malonylation. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23533089 |
Kumar A et al. | Synergistical neuroprotection of rofecoxib and statins against malonic acid induced Huntington's disease like symptoms and related cognitive dysfunction in rats. | 2013 | Eur. J. Pharmacol. | pmid:23562615 |
MacCrehan WA and White CM | Simplified ultrasonically- and microwave-assisted solvent extractions for the determination of ginsenosides in powdered Panax ginseng rhizomes using liquid chromatography with UV absorbance or electrospray mass spectrometric detection. | 2013 | Anal Bioanal Chem | pmid:23564283 |
Darvas M et al. | Molecular dynamics simulations of the water adsorption around malonic acid aerosol models. | 2013 | Phys Chem Chem Phys | pmid:23702947 |
Zhou S et al. | Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans. | 2013 | Biotechnol. Bioeng. | pmid:23775313 |
Minato Y et al. | Malonate inhibits virulence gene expression in Vibrio cholerae. | 2013 | PLoS ONE | pmid:23675480 |
Zhang X et al. | Atomic force microscopy study of the effects of water-soluble fullerenes on the elasticity of living plant cells. | 2013 | Chem Asian J | pmid:23929723 |
Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
Yuan HN et al. | Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of β-amino esters and anti-HIV drug DPC 083. | 2013 | Chemistry | pmid:24150893 |
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Barros-Miñones L et al. | Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. | 2013 | Br. J. Pharmacol. | pmid:23186227 |
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