Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Neoplasms D009369 13 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Abscess D000038 13 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Alzheimer Disease D000544 76 associated lipids
Teratoma D013724 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Kachlicki P et al. Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. 2005 J Mass Spectrom pmid:15971291
pmid:15969532
Fernandez-Gomez FJ et al. Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. 2005 Neuroscience pmid:15964487
Nguyen TH et al. Conformations, energies, and intramolecular hydrogen bonds in dicarboxylic acids: implications for the design of synthetic dicarboxylic acid receptors. 2005 J Comput Chem pmid:15962275
pmid:15941297
pmid:15941271
pmid:15930629
pmid:15917184
Azurmendi HF et al. Half-of-the-sites binding of reactive intermediates and their analogues to 4-oxalocrotonate tautomerase and induced structural asymmetry of the enzyme. 2005 Biochemistry pmid:15909987
Maloney PC et al. Measurement of the substrate dissociation constant of a solubilized membrane carrier. Substrate stabilization of OxlT, the anion exchange protein of Oxalobacter formigenes. 1992 J. Biol. Chem. pmid:1587833
Sebban M et al. Tautomerism and 1H, 13C and 15N NMR spectral assignments of some nitro derivatives of malonic acid diamide. 2005 Magn Reson Chem pmid:15864818
pmid:15864796
pmid:15862280
Mitreva M et al. Investigating hookworm genomes by comparative analysis of two Ancylostoma species. 2005 BMC Genomics pmid:15854223
pmid:15845422
pmid:15845418
Diao ZY et al. [Establishment of the organotypic model of amyotrophic lateral sclerosis from the SD rats' spinal cord]. 2005 Beijing Da Xue Xue Bao pmid:15841139
pmid:15836236
Ishikura S et al. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. 2005 J. Biochem. pmid:15809331
Mokhova EN and Khailova LS Involvement of mitochondrial inner membrane anion carriers in the uncoupling effect of fatty acids. 2005 Biochemistry Mosc. pmid:15807654
pmid:15804432
Scheer JM et al. Malonate-assisted purification of human caspases. 2005 Protein Expr. Purif. pmid:15802232
Kapich AN et al. Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla. 2005 Biochem. Biophys. Res. Commun. pmid:15796893
Kaya K et al. Selective control of toxic Microcystis water blooms using lysine and malonic acid: an enclosure experiment. 2005 Environ. Toxicol. pmid:15793822
pmid:15780274
Bozdech Z and Ginsburg H Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes. 2005 Malar. J. pmid:15774020
pmid:15730253
Hurth MA et al. Impaired pH homeostasis in Arabidopsis lacking the vacuolar dicarboxylate transporter and analysis of carboxylic acid transport across the tonoplast. 2005 Plant Physiol. pmid:15728336
Larson SB et al. Crystallographic structure of the T=1 particle of brome mosaic virus. 2005 J. Mol. Biol. pmid:15713465
Bufetov EN et al. [Effect of malonate on the structural and functional changes of wheat Triticum aestivum L. root cells]. 2004 Tsitologiia pmid:15704878
pmid:15673245
Lee GY et al. Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. 2005 Thromb. Res. pmid:15668191
Thatcher GR et al. Novel nitrates as NO mimetics directed at Alzheimer's disease. 2004 J. Alzheimers Dis. pmid:15665418
Innocenti A et al. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. 2005 Bioorg. Med. Chem. Lett. pmid:15664815
Paucard A et al. Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone. 2005 Fundam Clin Pharmacol pmid:15660960
Fernandez-Gomez FJ et al. Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway. 2005 Br. J. Pharmacol. pmid:15655518
pmid:15649514
Goñi-Allo B et al. In vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or N-methyl-d-aspartate. 2005 Exp. Neurol. pmid:15649488
Xiao R et al. Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. 2005 Mol. Cancer pmid:15644144
pmid:15643906
pmid:15624922
Calkins MJ et al. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15611470
Fatland BL et al. Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis. 2005 Plant Cell pmid:15608338
pmid:15606100
Ma HW et al. Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. 2004 BMC Bioinformatics pmid:15603590
Gunnlaugsson T et al. Synthesis and photophysical evaluation of charge neutral thiourea or urea based fluorescent PET sensors for bis-carboxylates and pyrophosphate. 2005 Org. Biomol. Chem. pmid:15602598
Brandner K et al. The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. 2005 J. Biol. Chem. pmid:15591051
Comer E et al. Allylic ionization versus oxidative addition into vinyl C-X bonds by Pd with polyfunctional olefin templates. 2004 J. Am. Chem. Soc. pmid:15584744
Rahman AS et al. Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series. 2005 J. Biol. Chem. pmid:15583005
Magwene PM and Kim J Estimating genomic coexpression networks using first-order conditional independence. 2004 Genome Biol. pmid:15575966
pmid:15575753
pmid:15575671
Burckhardt BC et al. Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. 2005 Am. J. Physiol. Renal Physiol. pmid:15561973
pmid:15556765
Cornet S et al. Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline. 2004 Eur. J. Pharmacol. pmid:15556143
Morland C et al. Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. 2004 J. Cereb. Blood Flow Metab. pmid:15545916
pmid:15540137
Lin Y et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. 2005 J. Biol. Chem. pmid:15536073
pmid:15524479
Chen H and Harrison PH Investigation of the origin of C2 units in biosynthesis of streptolydigin. 2004 Org. Lett. pmid:15496092
de Rijke E et al. Liquid chromatography coupled to nuclear magnetic resonance spectroscopy for the identification of isoflavone glucoside malonates in T. pratense L. leaves. 2004 J Sep Sci pmid:15495407
pmid:15480454
Towler CS et al. Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'. 2004 J. Am. Chem. Soc. pmid:15479091
Orosa M et al. Analysis and enhancement of astaxanthin accumulation in Haematococcus pluvialis. 2005 Bioresour. Technol. pmid:15474940
Yang L et al. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. 2004 Neurobiol. Dis. pmid:15474362
pmid:15457520
Darvesh AS et al. Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. 2005 J. Pharmacol. Exp. Ther. pmid:15456837
LIFSON N and STOLEN JA Metabolism of C13-carboxyl-labeled malonate by the intact mouse. 1950 Proc. Soc. Exp. Biol. Med. pmid:15440851
pmid:15405491
pmid:15387576
pmid:15387540
Yurgel SN and Kahn ML Dicarboxylate transport by rhizobia. 2004 FEMS Microbiol. Rev. pmid:15374663
Nelson J et al. Steric complementarity in carboxylate anion recognition. 2004 Dalton Trans pmid:15356717
pmid:15350645
Ohshima T Enantioselective total syntheses of several bioactive natural products based on the development of practical asymmetric catalysis. 2004 Chem. Pharm. Bull. pmid:15340187
pmid:15337853
pmid:15326518
pmid:15323800
Burckhardt BC et al. Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. 2004 Cell. Physiol. Biochem. pmid:15319545
pmid:15315452
Maciel EN et al. Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition. 2004 J. Neurochem. pmid:15312158
pmid:15310214
pmid:15303849
Stock I et al. Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. 2004 Clin. Microbiol. Infect. pmid:15301675
Romanowski MJ et al. Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. 2004 Structure pmid:15296730
Stieglitz K et al. Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states. 2004 J. Mol. Biol. pmid:15288791
pmid:15287799
Zalups RK and Ahmad S Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. 2004 J. Am. Soc. Nephrol. pmid:15284288
Solano-Serena F et al. Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway. 2004 J. Appl. Microbiol. pmid:15281945
Gołembiowska K and Dziubina A Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. 2004 Neuropharmacology pmid:15275831
pmid:15258953
pmid:15252513
Wang H and Shooter D Low molecular weight dicarboxylic acids in PM10 in a city with intensive solid fuel burning. 2004 Chemosphere pmid:15251287
Kanki R et al. Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. 2004 Brain Res. pmid:15223368
Zalups RK et al. Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. 2004 Kidney Int. pmid:15200431
pmid:15185315
pmid:15180406
Dickschat JS et al. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. 2004 Chembiochem pmid:15174160
Liu SY et al. Calix[4]arenes containing thiourea and amide moieties: neutral receptors towards alpha,omega-dicarboxylate anions. 2004 Org. Biomol. Chem. pmid:15162208
Fleck J et al. Intrastriatal malonate administration induces convulsive behaviour in rats. 2004 J. Inherit. Metab. Dis. pmid:15159652