Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Beal MF et al. | Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. | 1993 | J. Neurochem. | pmid:7689641 |
Klein BY et al. | Selection of malonate-resistant stromal cell-derived osteoprogenitor cells in vitro. | 1993 | J. Cell. Biochem. | pmid:7680046 |
Davolio C and Greenamyre JT | Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. | 1995 | Neurosci. Lett. | pmid:7675303 |
O'Donnell M et al. | Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase. | 1995 | Biochem. Soc. Trans. | pmid:7672393 |
Raginskaia VP | [Nomenclature of the S. coli (E. coli) No. 2624/36 and 5396/38 strains]. | 1975 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:766529 |
Armson A et al. | The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae. | 1995 | Int. J. Parasitol. | pmid:7622334 |
Matalon R et al. | Malonic aciduria and cardiomyopathy. | 1993 | J. Inherit. Metab. Dis. | pmid:7609455 |
Schulz JB et al. | Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. | 1995 | J. Cereb. Blood Flow Metab. | pmid:7593355 |
Sánchez-Alcázar JA et al. | Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. | 1995 | J. Biol. Chem. | pmid:7592589 |
Messam CA et al. | Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. | 1995 | Brain Res. | pmid:7583227 |
Cheng Y et al. | pH dependence of specific divalent anion binding to the N-lobe of recombinant human transferrin. | 1995 | Biochemistry | pmid:7578099 |
Bazzett TJ et al. | Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum. | 1995 | Exp. Neurol. | pmid:7556544 |
Maragos WF and Silverstein FS | Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. | 1995 | J. Neurochem. | pmid:7536812 |
Greene JG and Greenamyre JT | Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. | 1995 | J. Neurochem. | pmid:7536810 |
Schmehl I et al. | Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. | 1995 | FEBS Lett. | pmid:7498500 |
Maragos WF and Silverstein FS | The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. | 1995 | Brain Res. Dev. Brain Res. | pmid:7493402 |
Jocelyn PC | The reduction of diamide by rat liver mitochondria and the role of glutathione. | 1978 | Biochem. J. | pmid:747642 |
Ye B et al. | L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. | 1995 | J. Med. Chem. | pmid:7473554 |
Parvin R et al. | Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. | 1980 | Can. J. Biochem. | pmid:7459685 |
Masterson E and Chader GJ | Pigment epithelial cells in culture. Metabolic pathways required for phagocytosis. | 1981 | Invest. Ophthalmol. Vis. Sci. | pmid:7451071 |
Saint-Macary M and Foucher B | Binding of malonate to the inner membrane of rat liver mitochondria. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437047 |
Garg DN et al. | The sero-fermentative-phage types of Salmonella weltevreden. | 1980 | Zentralbl Bakteriol A | pmid:7434993 |
Koeppen AH et al. | Lipid labeling after intracerebral injection of radioactive malonic acid. | 1980 | J. Neurochem. | pmid:7411143 |
Aizawa M et al. | Immobilized mitochondrial electron transport particle for NADH determination. | 1980 | Biotechnol. Bioeng. | pmid:7407338 |
Kara TC and Patnaik BK | Age-related changes in oxygen consumption and the SDH activity of liver homogenate of male garden lizards: effect of malonate and short-term cold stress. | 1980 | Gerontology | pmid:7390165 |
Tihanyi K et al. | Effect of succinate on aminopyrine N-demethylase activity. | 1980 | Biochim. Biophys. Acta | pmid:7388048 |
Emery T | Malonichrome, a new iron chelate from Fusarium roseum. | 1980 | Biochim. Biophys. Acta | pmid:7388041 |
Konishi K et al. | A Halophilic vibrio isolated from a case of chronic cholecystitis. | 1981 | Microbiol. Immunol. | pmid:7334940 |
Lee KH et al. | Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents. | 1981 | J. Med. Chem. | pmid:7328595 |
Ford WC and Harrison A | The role of oxidative phosphorylation in the generation of ATP in human spermatozoa. | 1981 | J. Reprod. Fertil. | pmid:7277330 |
Alsaadi BM et al. | A pmr study of the effects of pH and anion and metal ion binding of the histidyl residues of ovotransferrin. | 1981 | J. Inorg. Biochem. | pmid:7276935 |
Pritchard DJ | Transdifferentiation of chicken embryo neural retina into pigment epithelium: indications of its biochemical basis. | 1981 | J Embryol Exp Morphol | pmid:7276821 |
Pietrobon D et al. | Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'. | 1981 | Eur. J. Biochem. | pmid:7274216 |
Preuss HG et al. | Correlation between glutamate deamination and glutamine deamidation in rat kidney mitochondria. | 1981 | Nephron | pmid:7266713 |
Ferrero J et al. | Efflux of inorganic phosphate from mammalian non-myelinated nerve fibres. | 1978 | J. Physiol. (Lond.) | pmid:722557 |
Lê-Quôc K et al. | Evidence for the existence of two classes of sulfhydryl groups essential for membrane-bound succinate dehydrogenase activity. | 1981 | Biochemistry | pmid:7225354 |
Kara TC and Patnaik BK | Age-related changes in endogenous respiration, respiration control ratio and malonate inhibition of oxygen consumption of liver homogenate of male garden lizards. | 1981 | Exp. Gerontol. | pmid:7215477 |
Richard C et al. | [Phenotype characteristics of 100 strains of Pseudomonas cepacia. Proposition of a biovars classification (author's transl)]. | 1981 | Ann. Biol. Clin. (Paris) | pmid:7212403 |
Benjamin AM and Verjee ZH | Control of aerobic glycolysis in the brain in vitro. | 1980 | Neurochem. Res. | pmid:7207696 |
Sam CT | Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata. | 1981 | Folia Microbiol. (Praha) | pmid:7203283 |
Wanders RJ et al. | Relationship between the rate of citrulline synthesis and bulk changes in the intramitochondrial ATP/ADP ratio in rat-liver mitochondria. | 1981 | Eur. J. Biochem. | pmid:7202412 |
Kim YS and Kolattukudy PE | Malonyl-CoA decarboxylase from the mammary gland of lactating rat. Purification, properties and subcellular localization. | 1978 | Biochim. Biophys. Acta | pmid:718970 |
Calaf R et al. | [Critical study of the determination of urinary oxalic acid by gas chromatography]. | 1982 | Ann. Biol. Clin. (Paris) | pmid:7165137 |
Fukushima K et al. | Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin. | 1982 | J. Antibiot. | pmid:7161187 |
Crisp CE and Look M | Effect of esterification and side-chain alkylation on alteration of translocation characteristics of methamidophos. | 1982 | Xenobiotica | pmid:7147994 |
Fioravanti CF | Mitochondrial NADH oxidase activity of adult Hymenolepis diminuta (Cestoda). | 1982 | Comp. Biochem. Physiol., B | pmid:7128112 |
Decoux G et al. | [Rapid method for the determination of urinary oxalic acid by gas liquid chromatography (author's transl)]. | 1982 | Clin. Chim. Acta | pmid:7067145 |
Thaller MC et al. | Notes on the appearance of double and triple anomalies in Escherichia coli strains. | 1981 | Boll Ist Sieroter Milan | pmid:7023500 |
Kiseleva BS et al. | [Antigenic relations between enteropathogenic Escherichia O151:K, Citrobacter and Hafnia]. | 1981 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:7023147 |
GubnitskiÄ LS et al. | [Kinetics of fumarate hydratase reaction catalyzed by free cells of Escherichia coli]. | 1981 | Biokhimiia | pmid:7018596 |
Jackson NN et al. | Naturally acquired infections of Klebsiella pneumoniae in Wistar rats. | 1980 | Lab. Anim. | pmid:7007721 |
Bonomi F et al. | Modification of the thermodynamic properties of the electron-transferring groups in mitochondrial succinate dehydrogenase upon binding of succinate. | 1983 | Eur. J. Biochem. | pmid:6884342 |
Cutbush SD et al. | The antitumor complex ethylenediamine platinum (II) malonate: x-ray structure analysis, and studies of its stability in solution. | 1983 | J. Inorg. Biochem. | pmid:6875536 |
Hansen TL and Andersen H | Succinate dehydrogenase activity in cultured human skin fibroblasts and amniotic fluid cells. A methodological study. | 1983 | Histochemistry | pmid:6874423 |
Matern U | Acylhydrolases from parsley (Petroselinum hortense). Relative distribution and properties of four esterases hydrolyzing malonic acid hemiesters of flavonoid glucosides. | 1983 | Arch. Biochem. Biophys. | pmid:6870256 |
Saint-Macary M and Foucher B | Reconstitution of the dicarboxylate exchange activity by incorporation into liposomes of a Triton-extract of mitochondrial rat-liver inner membranes. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6860337 |
Chorev M and Goodman M | Partially modified retro-inverso peptides. Comparative Curtius rearrangements to prepare 1,1-diaminoalkane derivatives. | 1983 | Int. J. Pept. Protein Res. | pmid:6853027 |
Wanders RJ et al. | Bicarbonate and the pathway of glutamate oxidation in isolated rat-liver mitochondria. | 1983 | Eur. J. Biochem. | pmid:6852031 |
Tret'iak NN and Kostenko MA | [Use of a histological fixative for extraction of the RNA precursor pool from mollusk nerve tissue]. | 1978 | Tsitologiia | pmid:684853 |
Liou YF et al. | Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells. | 1983 | Biochim. Biophys. Acta | pmid:6824673 |
Siu GM and Draper HH | Metabolism of malonaldehyde in vivo and in vitro. | 1982 | Lipids | pmid:6808279 |
Bezkorovainy A and Topouzian N | The effect of metal chelators and other metabolic inhibitors on the growth of Bifidobacterium bifidus var. Pennsylvanicus. | 1981 | Clin. Biochem. | pmid:6794942 |
Margolina SM et al. | [Comparative study of the oxygen reduction in photosystem II of the cyanobacteria, Anacystis nidulans and Anabaena variabilis]. | 1980 Nov-Dec | Mikrobiologiia | pmid:6782430 |
Lewin RA et al. | Effects of various agents on flagellar activity, flagellar autotomy and cell viability in four species of Chlamydomonas (chlorophyta: volvocales). | 1982 | Symp. Soc. Exp. Biol. | pmid:6764045 |
Abraham DJ et al. | Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. | 1984 | J. Med. Chem. | pmid:6747995 |
Kotliar AB and Vinogradov AD | [Interaction of succinate dehydrogenase and oxaloacetate]. | 1984 | Biokhimiia | pmid:6733163 |
Kotliar AB and Vinogradov AD | [Dissociation constants of succinate dehydrogenase complexes with succinate, fumarate and malonate]. | 1984 | Biokhimiia | pmid:6722218 |
Ito E et al. | Effects of 2,4-dinitrophenol and other metabolic inhibitors on the thermograms of Ehrlich ascites carcinoma cells registered with a microcalorimeter. | 1984 | Cancer Res. | pmid:6713397 |
Yagi T et al. | Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers. | 1984 | Biochemistry | pmid:6712922 |
Huber KW and Lutz WK | Methylation of DNA by incubation with methylamine and nitrite. | 1984 | Carcinogenesis | pmid:6705144 |
Russell JB and Van Soest PJ | In vitro ruminal fermentation of organic acids common in forage. | 1984 | Appl. Environ. Microbiol. | pmid:6696413 |
Kotlyar AB and Vinogradov AD | Interaction of the membrane-bound succinate dehydrogenase with substrate and competitive inhibitors. | 1984 | Biochim. Biophys. Acta | pmid:6691982 |
Tomaszewska B et al. | Phosphoenolpyruvate carboxylase from the roots of yellow lupin (Lupinus luteus). | 1983 | Acta Biochim. Pol. | pmid:6673422 |
Ogawa H et al. | Xanthommatin formation in rat liver mitochondria and its inhibition by respiratory chain substrates. | 1983 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:6662501 |
Mandrik KA et al. | [Kinetics of the inhibition of succinate dehydrogenase in bull adrenal cortex by malonate and oxaloacetate]. | 1983 Sep-Oct | Ukr. Biokhim. Zh. | pmid:6636310 |
Hegardt FG et al. | Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids. | 1983 | J. Lipid Res. | pmid:6631216 |
Barrett J | Activation of succinate dehydrogenase from adult Fasciola hepatica (Trematoda). | 1978 | Parasitology | pmid:662411 |
Tallitsch RB | Further observations of aldosterone response in barnacle muscle fibers. | 1983 | Am. J. Physiol. | pmid:6614162 |
Kalckar HM and Ullrey DB | Hexose uptake regulation mediated through aerobic pathways: schism in a fibroblast mutant. | 1984 | Fed. Proc. | pmid:6538853 |
Lenartowicz E and Savina MV | Intramitochondrial reductive carboxylation of 2-oxoglutarate in adipose tissue and its contribution to fatty acid synthesis. | 1984 | Int. J. Biochem. | pmid:6530009 |
Kok WT et al. | Determination of oxalic acid in biological matrices by liquid chromatography with amperometric detection. | 1984 | J. Chromatogr. | pmid:6526899 |
van der Vijgh WJ et al. | Determination of ethylenediamineplatinum(II) malonate in infusion fluids, human plasma and urine by high-performance liquid chromatography. | 1984 | J. Chromatogr. | pmid:6511851 |
Boquist L | Alloxan effects on mitochondria: study of oxygen consumption, fluxes of Mg2+, Ca2+, K+ and adenine nucleotides, membrane potential and volume change in vitro. | 1984 | Diabetologia | pmid:6500198 |
Matern U et al. | N-malonyltransferases from peanut. | 1984 | Arch. Biochem. Biophys. | pmid:6497391 |
Robinet D et al. | Separation of haemoglobins using a monodisperse cation exchanger. | 1984 | J. Chromatogr. | pmid:6490765 |
Chen SC | Fluorometric determination of malonic acid with dicyclohexylcarbodiimide. | 1984 | Anal. Biochem. | pmid:6486406 |
Kotlyar AB and Vinogradov AD | Evidence for an essential arginine residue in the substrate binding site of the mammalian succinate dehydrogenase. | 1984 | Biochem. Int. | pmid:6477618 |
Lebedev OE et al. | [Inhibitory analysis of the functions of the oxidative metabolic systems of tumor cells in tissue culture]. | 1984 | Tsitologiia | pmid:6474574 |
Long SD et al. | Succinate dehydrogenase in various tissues of Anodonta couperiana, Elliptio buckleyi and Mercenaria campechiensis (Mollusca: Bivalvia). | 1984 | Comp. Biochem. Physiol., B | pmid:6467909 |
Crossin MC et al. | Perturbation of ribosome subunit interaction by glutaraldehyde fixation. | 1984 | Biophys. Chem. | pmid:6435698 |
Khalifah RG and Morley PJ | A carbon-13 NMR comparative study of metal ion substitutions in human carbonic anhydrase I carboxymethylated at active-site histidine-200. | 1984 | Arch. Biochem. Biophys. | pmid:6431907 |
Mitzen EJ and Koeppen AH | Malonate, malonyl-coenzyme A, and acetyl-coenzyme A in developing rat brain. | 1984 | J. Neurochem. | pmid:6429279 |
Ficsor G et al. | Comparison of methods for detecting mitomycin C- and ethyl nitrosourea-induced germ cell damage in mice: sperm enzyme activities, sperm motility, and testis weight. | 1984 | Environ Mutagen | pmid:6428870 |
Wan AS et al. | Long-acting contraceptive agents: levonorgestrel esters of unsaturated acids. | 1983 | Steroids | pmid:6419407 |
Dahl KH and Dunn MF | Carboxymethylated liver alcohol dehydrogenase: kinetic and thermodynamic characterization of reactions with substrates and inhibitors. | 1984 | Biochemistry | pmid:6397230 |
Lenzen S and Panten U | Characterization of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase in pancreatic islets. | 1983 | Biochem Med | pmid:6360162 |
Christopherson RI et al. | Chorismate mutase-prephenate dehydrogenase from Escherichia coli: spatial relationship of the mutase and dehydrogenase sites. | 1983 | Biochemistry | pmid:6342665 |
Simpson DP | Citrate excretion: a window on renal metabolism. | 1983 | Am. J. Physiol. | pmid:6338740 |
Wozniak AJ et al. | Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents. | 1984 | Cancer Res. | pmid:6318974 |
Ainscough EW et al. | Spectroscopic studies on copper (II) complexes of human lactoferrin. | 1983 | J. Inorg. Biochem. | pmid:6304246 |