Malonic acid

Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Malonic acid?

Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Neoplasms D009369 13 associated lipids
Bacterial Infections D001424 21 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Abscess D000038 13 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Alzheimer Disease D000544 76 associated lipids
Teratoma D013724 4 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Nerve Degeneration D009410 53 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Neurofibromatosis 1 D009456 4 associated lipids
Parkinson Disease D010300 53 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Insulin Resistance D007333 99 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Hemorrhagic Fever with Renal Syndrome D006480 3 associated lipids
Neoplasms, Muscle Tissue D009379 2 associated lipids
Per page 10 20 50 | Total 37

PubChem Associated disorders and diseases

What pathways are associated with Malonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Malonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Malonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Malonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Malonic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Malonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Malonic acid

Download all related citations
Per page 10 20 50 100 | Total 2286
Authors Title Published Journal PubMed Link
Beal MF et al. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. 1993 J. Neurochem. pmid:7689641
Klein BY et al. Selection of malonate-resistant stromal cell-derived osteoprogenitor cells in vitro. 1993 J. Cell. Biochem. pmid:7680046
Davolio C and Greenamyre JT Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. 1995 Neurosci. Lett. pmid:7675303
O'Donnell M et al. Evidence from affinity precipitation that glutamate analogues are bound in a folded conformation to glutamate dehydrogenase. 1995 Biochem. Soc. Trans. pmid:7672393
Raginskaia VP [Nomenclature of the S. coli (E. coli) No. 2624/36 and 5396/38 strains]. 1975 Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:766529
Armson A et al. The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae. 1995 Int. J. Parasitol. pmid:7622334
Matalon R et al. Malonic aciduria and cardiomyopathy. 1993 J. Inherit. Metab. Dis. pmid:7609455
Schulz JB et al. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. 1995 J. Cereb. Blood Flow Metab. pmid:7593355
Sánchez-Alcázar JA et al. Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. 1995 J. Biol. Chem. pmid:7592589
Messam CA et al. Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. 1995 Brain Res. pmid:7583227
Cheng Y et al. pH dependence of specific divalent anion binding to the N-lobe of recombinant human transferrin. 1995 Biochemistry pmid:7578099
Bazzett TJ et al. Chronic administration of malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in rat striatum. 1995 Exp. Neurol. pmid:7556544
Maragos WF and Silverstein FS Inhibition of nitric oxide synthase activity attenuates striatal malonate lesions in rats. 1995 J. Neurochem. pmid:7536812
Greene JG and Greenamyre JT Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. 1995 J. Neurochem. pmid:7536810
Schmehl I et al. Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c. 1995 FEBS Lett. pmid:7498500
Maragos WF and Silverstein FS The mitochondrial inhibitor malonate enhances NMDA toxicity in the neonatal rat striatum. 1995 Brain Res. Dev. Brain Res. pmid:7493402
Jocelyn PC The reduction of diamide by rat liver mitochondria and the role of glutathione. 1978 Biochem. J. pmid:747642
Ye B et al. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. 1995 J. Med. Chem. pmid:7473554
Parvin R et al. Inhibition of mitochondrial carnitine-acylcarnitine translocase by sulfobetaines. 1980 Can. J. Biochem. pmid:7459685
Masterson E and Chader GJ Pigment epithelial cells in culture. Metabolic pathways required for phagocytosis. 1981 Invest. Ophthalmol. Vis. Sci. pmid:7451071
Saint-Macary M and Foucher B Binding of malonate to the inner membrane of rat liver mitochondria. 1980 Biochem. Biophys. Res. Commun. pmid:7437047
Garg DN et al. The sero-fermentative-phage types of Salmonella weltevreden. 1980 Zentralbl Bakteriol A pmid:7434993
Koeppen AH et al. Lipid labeling after intracerebral injection of radioactive malonic acid. 1980 J. Neurochem. pmid:7411143
Aizawa M et al. Immobilized mitochondrial electron transport particle for NADH determination. 1980 Biotechnol. Bioeng. pmid:7407338
Kara TC and Patnaik BK Age-related changes in oxygen consumption and the SDH activity of liver homogenate of male garden lizards: effect of malonate and short-term cold stress. 1980 Gerontology pmid:7390165
Tihanyi K et al. Effect of succinate on aminopyrine N-demethylase activity. 1980 Biochim. Biophys. Acta pmid:7388048
Emery T Malonichrome, a new iron chelate from Fusarium roseum. 1980 Biochim. Biophys. Acta pmid:7388041
Konishi K et al. A Halophilic vibrio isolated from a case of chronic cholecystitis. 1981 Microbiol. Immunol. pmid:7334940
Lee KH et al. Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents. 1981 J. Med. Chem. pmid:7328595
Ford WC and Harrison A The role of oxidative phosphorylation in the generation of ATP in human spermatozoa. 1981 J. Reprod. Fertil. pmid:7277330
Alsaadi BM et al. A pmr study of the effects of pH and anion and metal ion binding of the histidyl residues of ovotransferrin. 1981 J. Inorg. Biochem. pmid:7276935
Pritchard DJ Transdifferentiation of chicken embryo neural retina into pigment epithelium: indications of its biochemical basis. 1981 J Embryol Exp Morphol pmid:7276821
Pietrobon D et al. Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'. 1981 Eur. J. Biochem. pmid:7274216
Preuss HG et al. Correlation between glutamate deamination and glutamine deamidation in rat kidney mitochondria. 1981 Nephron pmid:7266713
Ferrero J et al. Efflux of inorganic phosphate from mammalian non-myelinated nerve fibres. 1978 J. Physiol. (Lond.) pmid:722557
Lê-Quôc K et al. Evidence for the existence of two classes of sulfhydryl groups essential for membrane-bound succinate dehydrogenase activity. 1981 Biochemistry pmid:7225354
Kara TC and Patnaik BK Age-related changes in endogenous respiration, respiration control ratio and malonate inhibition of oxygen consumption of liver homogenate of male garden lizards. 1981 Exp. Gerontol. pmid:7215477
Richard C et al. [Phenotype characteristics of 100 strains of Pseudomonas cepacia. Proposition of a biovars classification (author's transl)]. 1981 Ann. Biol. Clin. (Paris) pmid:7212403
Benjamin AM and Verjee ZH Control of aerobic glycolysis in the brain in vitro. 1980 Neurochem. Res. pmid:7207696
Sam CT Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata. 1981 Folia Microbiol. (Praha) pmid:7203283
Wanders RJ et al. Relationship between the rate of citrulline synthesis and bulk changes in the intramitochondrial ATP/ADP ratio in rat-liver mitochondria. 1981 Eur. J. Biochem. pmid:7202412
Kim YS and Kolattukudy PE Malonyl-CoA decarboxylase from the mammary gland of lactating rat. Purification, properties and subcellular localization. 1978 Biochim. Biophys. Acta pmid:718970
Calaf R et al. [Critical study of the determination of urinary oxalic acid by gas chromatography]. 1982 Ann. Biol. Clin. (Paris) pmid:7165137
Fukushima K et al. Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin. 1982 J. Antibiot. pmid:7161187
Crisp CE and Look M Effect of esterification and side-chain alkylation on alteration of translocation characteristics of methamidophos. 1982 Xenobiotica pmid:7147994
Fioravanti CF Mitochondrial NADH oxidase activity of adult Hymenolepis diminuta (Cestoda). 1982 Comp. Biochem. Physiol., B pmid:7128112
Decoux G et al. [Rapid method for the determination of urinary oxalic acid by gas liquid chromatography (author's transl)]. 1982 Clin. Chim. Acta pmid:7067145
Thaller MC et al. Notes on the appearance of double and triple anomalies in Escherichia coli strains. 1981 Boll Ist Sieroter Milan pmid:7023500
Kiseleva BS et al. [Antigenic relations between enteropathogenic Escherichia O151:K, Citrobacter and Hafnia]. 1981 Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:7023147
GubnitskiÄ­ LS et al. [Kinetics of fumarate hydratase reaction catalyzed by free cells of Escherichia coli]. 1981 Biokhimiia pmid:7018596
Jackson NN et al. Naturally acquired infections of Klebsiella pneumoniae in Wistar rats. 1980 Lab. Anim. pmid:7007721
Bonomi F et al. Modification of the thermodynamic properties of the electron-transferring groups in mitochondrial succinate dehydrogenase upon binding of succinate. 1983 Eur. J. Biochem. pmid:6884342
Cutbush SD et al. The antitumor complex ethylenediamine platinum (II) malonate: x-ray structure analysis, and studies of its stability in solution. 1983 J. Inorg. Biochem. pmid:6875536
Hansen TL and Andersen H Succinate dehydrogenase activity in cultured human skin fibroblasts and amniotic fluid cells. A methodological study. 1983 Histochemistry pmid:6874423
Matern U Acylhydrolases from parsley (Petroselinum hortense). Relative distribution and properties of four esterases hydrolyzing malonic acid hemiesters of flavonoid glucosides. 1983 Arch. Biochem. Biophys. pmid:6870256
Saint-Macary M and Foucher B Reconstitution of the dicarboxylate exchange activity by incorporation into liposomes of a Triton-extract of mitochondrial rat-liver inner membranes. 1983 Biochem. Biophys. Res. Commun. pmid:6860337
Chorev M and Goodman M Partially modified retro-inverso peptides. Comparative Curtius rearrangements to prepare 1,1-diaminoalkane derivatives. 1983 Int. J. Pept. Protein Res. pmid:6853027
Wanders RJ et al. Bicarbonate and the pathway of glutamate oxidation in isolated rat-liver mitochondria. 1983 Eur. J. Biochem. pmid:6852031
Tret'iak NN and Kostenko MA [Use of a histological fixative for extraction of the RNA precursor pool from mollusk nerve tissue]. 1978 Tsitologiia pmid:684853
Liou YF et al. Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells. 1983 Biochim. Biophys. Acta pmid:6824673
Siu GM and Draper HH Metabolism of malonaldehyde in vivo and in vitro. 1982 Lipids pmid:6808279
Bezkorovainy A and Topouzian N The effect of metal chelators and other metabolic inhibitors on the growth of Bifidobacterium bifidus var. Pennsylvanicus. 1981 Clin. Biochem. pmid:6794942
Margolina SM et al. [Comparative study of the oxygen reduction in photosystem II of the cyanobacteria, Anacystis nidulans and Anabaena variabilis]. 1980 Nov-Dec Mikrobiologiia pmid:6782430
Lewin RA et al. Effects of various agents on flagellar activity, flagellar autotomy and cell viability in four species of Chlamydomonas (chlorophyta: volvocales). 1982 Symp. Soc. Exp. Biol. pmid:6764045
Abraham DJ et al. Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. 1984 J. Med. Chem. pmid:6747995
Kotliar AB and Vinogradov AD [Interaction of succinate dehydrogenase and oxaloacetate]. 1984 Biokhimiia pmid:6733163
Kotliar AB and Vinogradov AD [Dissociation constants of succinate dehydrogenase complexes with succinate, fumarate and malonate]. 1984 Biokhimiia pmid:6722218
Ito E et al. Effects of 2,4-dinitrophenol and other metabolic inhibitors on the thermograms of Ehrlich ascites carcinoma cells registered with a microcalorimeter. 1984 Cancer Res. pmid:6713397
Yagi T et al. Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers. 1984 Biochemistry pmid:6712922
Huber KW and Lutz WK Methylation of DNA by incubation with methylamine and nitrite. 1984 Carcinogenesis pmid:6705144
Russell JB and Van Soest PJ In vitro ruminal fermentation of organic acids common in forage. 1984 Appl. Environ. Microbiol. pmid:6696413
Kotlyar AB and Vinogradov AD Interaction of the membrane-bound succinate dehydrogenase with substrate and competitive inhibitors. 1984 Biochim. Biophys. Acta pmid:6691982
Tomaszewska B et al. Phosphoenolpyruvate carboxylase from the roots of yellow lupin (Lupinus luteus). 1983 Acta Biochim. Pol. pmid:6673422
Ogawa H et al. Xanthommatin formation in rat liver mitochondria and its inhibition by respiratory chain substrates. 1983 Hoppe-Seyler's Z. Physiol. Chem. pmid:6662501
Mandrik KA et al. [Kinetics of the inhibition of succinate dehydrogenase in bull adrenal cortex by malonate and oxaloacetate]. 1983 Sep-Oct Ukr. Biokhim. Zh. pmid:6636310
Hegardt FG et al. Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids. 1983 J. Lipid Res. pmid:6631216
Barrett J Activation of succinate dehydrogenase from adult Fasciola hepatica (Trematoda). 1978 Parasitology pmid:662411
Tallitsch RB Further observations of aldosterone response in barnacle muscle fibers. 1983 Am. J. Physiol. pmid:6614162
Kalckar HM and Ullrey DB Hexose uptake regulation mediated through aerobic pathways: schism in a fibroblast mutant. 1984 Fed. Proc. pmid:6538853
Lenartowicz E and Savina MV Intramitochondrial reductive carboxylation of 2-oxoglutarate in adipose tissue and its contribution to fatty acid synthesis. 1984 Int. J. Biochem. pmid:6530009
Kok WT et al. Determination of oxalic acid in biological matrices by liquid chromatography with amperometric detection. 1984 J. Chromatogr. pmid:6526899
van der Vijgh WJ et al. Determination of ethylenediamineplatinum(II) malonate in infusion fluids, human plasma and urine by high-performance liquid chromatography. 1984 J. Chromatogr. pmid:6511851
Boquist L Alloxan effects on mitochondria: study of oxygen consumption, fluxes of Mg2+, Ca2+, K+ and adenine nucleotides, membrane potential and volume change in vitro. 1984 Diabetologia pmid:6500198
Matern U et al. N-malonyltransferases from peanut. 1984 Arch. Biochem. Biophys. pmid:6497391
Robinet D et al. Separation of haemoglobins using a monodisperse cation exchanger. 1984 J. Chromatogr. pmid:6490765
Chen SC Fluorometric determination of malonic acid with dicyclohexylcarbodiimide. 1984 Anal. Biochem. pmid:6486406
Kotlyar AB and Vinogradov AD Evidence for an essential arginine residue in the substrate binding site of the mammalian succinate dehydrogenase. 1984 Biochem. Int. pmid:6477618
Lebedev OE et al. [Inhibitory analysis of the functions of the oxidative metabolic systems of tumor cells in tissue culture]. 1984 Tsitologiia pmid:6474574
Long SD et al. Succinate dehydrogenase in various tissues of Anodonta couperiana, Elliptio buckleyi and Mercenaria campechiensis (Mollusca: Bivalvia). 1984 Comp. Biochem. Physiol., B pmid:6467909
Crossin MC et al. Perturbation of ribosome subunit interaction by glutaraldehyde fixation. 1984 Biophys. Chem. pmid:6435698
Khalifah RG and Morley PJ A carbon-13 NMR comparative study of metal ion substitutions in human carbonic anhydrase I carboxymethylated at active-site histidine-200. 1984 Arch. Biochem. Biophys. pmid:6431907
Mitzen EJ and Koeppen AH Malonate, malonyl-coenzyme A, and acetyl-coenzyme A in developing rat brain. 1984 J. Neurochem. pmid:6429279
Ficsor G et al. Comparison of methods for detecting mitomycin C- and ethyl nitrosourea-induced germ cell damage in mice: sperm enzyme activities, sperm motility, and testis weight. 1984 Environ Mutagen pmid:6428870
Wan AS et al. Long-acting contraceptive agents: levonorgestrel esters of unsaturated acids. 1983 Steroids pmid:6419407
Dahl KH and Dunn MF Carboxymethylated liver alcohol dehydrogenase: kinetic and thermodynamic characterization of reactions with substrates and inhibitors. 1984 Biochemistry pmid:6397230
Lenzen S and Panten U Characterization of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase in pancreatic islets. 1983 Biochem Med pmid:6360162
Christopherson RI et al. Chorismate mutase-prephenate dehydrogenase from Escherichia coli: spatial relationship of the mutase and dehydrogenase sites. 1983 Biochemistry pmid:6342665
Simpson DP Citrate excretion: a window on renal metabolism. 1983 Am. J. Physiol. pmid:6338740
Wozniak AJ et al. Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents. 1984 Cancer Res. pmid:6318974
Ainscough EW et al. Spectroscopic studies on copper (II) complexes of human lactoferrin. 1983 J. Inorg. Biochem. pmid:6304246