Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Buyukgebiz B et al. | Fatal neonatal malonic aciduria. | 1998 | J. Inherit. Metab. Dis. | pmid:9501274 |
Williams DM et al. | Role of copper in mitochondrial iron metabolism. | 1976 | Blood | pmid:947406 |
Zalups RK and Barfuss DW | Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9465278 |
Graf von Roedern E et al. | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). | 1998 | J. Med. Chem. | pmid:9464365 |
Willis CL et al. | Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. | 1997 | Curr. Microbiol. | pmid:9462959 |
Matthews RT et al. | Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. | 1998 | J. Neurosci. | pmid:9412496 |
Sonsalla PK et al. | Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra. | 1997 | Brain Res. | pmid:9409726 |
van der Spoel D and Berendsen HJ | Determination of proton transfer rate constants using Ab initio, molecular dynamics and density matrix evolution calculations. | 1996 | Pac Symp Biocomput | pmid:9390263 |
Saris NE | On the mechanism of rebounding of calcium in liver mitochondria. | 1997 | Biol. Chem. | pmid:9372185 |
Korshunov SS et al. | High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. | 1997 | FEBS Lett. | pmid:9369223 |