Malonic acid is a lipid of Fatty Acyls (FA) class. Malonic acid is associated with abnormalities such as Malonic aciduria. The involved functions are known as Vmax, Regulation, Biochemical Pathway, Citric Acid Cycle and intermediary metabolism. Malonic acid often locates in Body tissue, Mitochondria, soluble and NADH dehydrogenase complex. The associated genes with Malonic acid are ACACA gene, ACSF3 gene, Recombinant Proteins, NKS1 gene and Homologous Gene. The related lipids are Fatty Acids and Butyric Acid.
To understand associated biological information of Malonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Malonic acid is suspected in Malonic aciduria and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Malonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Malonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Matthews RT et al. | S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. | 1997 | Exp. Neurol. | pmid:9056390 |
Connop BP et al. | Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole. | 1997 | J. Neurochem. | pmid:9048766 |
Woods KM et al. | Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. | 1996 | Ann Trop Med Parasitol | pmid:9039272 |
Wada H et al. | Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9037098 |
Chien LF and Brand MD | The effect of chloroform on mitochondrial energy transduction. | 1996 | Biochem. J. | pmid:9003370 |
Zeevalk GD et al. | Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. | 1997 | J. Neurochem. | pmid:8978755 |
Borutaite V et al. | Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia. | 1996 | J. Mol. Cell. Cardiol. | pmid:8930814 |
Hu JZ et al. | High resolution 1H spectra of powdered solids observed by Hahn echo pulse sequence with magic-angle spinning. | 1996 | Solid State Nucl Magn Reson | pmid:8925269 |
Geddes JW et al. | Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. | 1996 May-Aug | Mol. Chem. Neuropathol. | pmid:8871943 |
Podell M et al. | Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. | 1996 | Metab Brain Dis | pmid:8869944 |
Arihara K et al. | Contribution of the glycolytic pathway to enzymatic metmyoglobin reduction in myocytes. | 1996 | Biochem. Mol. Biol. Int. | pmid:8850528 |
Klein BY et al. | Opposing effects on mitochondrial membrane potential by malonate and levamisole, whose effect on cell-mediated mineralization is antagonistic. | 1996 | J. Cell. Biochem. | pmid:8825423 |
Connop BP et al. | Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase. | 1996 | Neuropharmacology | pmid:8793908 |
Bazzett TJ et al. | Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. | 1996 | Brain Res. | pmid:8773793 |
Albers DS et al. | Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. | 1996 | Brain Res. | pmid:8773791 |
Lin X et al. | Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets. | 1996 | Biochem. J. | pmid:8761477 |
Murrin SF and Nolan RA | Ultrastructural localization of succinate dehydrogenase in a self-parasitic isolate of Saprolegnia megasperma. | 1977 | Can. J. Microbiol. | pmid:871965 |
Bekina RM and Lebedeva AF | [Studies of oxygen uptake (Mehler reactions) in chloroplasts in the presence of silico-molybdic acid]. | 1977 | Biokhimiia | pmid:870090 |
Schulz JB et al. | Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. | 1996 | Neuroscience | pmid:8684608 |
Burke TR et al. | 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. | 1996 | J. Med. Chem. | pmid:8676336 |